AutismKB 2.0

Annotation Detail for LASP1


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Basic Information Top
Gene Symbol:LASP1 ( Lasp-1,MLN50 )
Gene Full Name: LIM and SH3 protein 1
Band: 17q12
Quick LinksEntrez ID:3927; OMIM: 602920; Uniprot ID:LASP1_HUMAN; ENSEMBL ID: ENSG00000002834; HGNC ID: 6513
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of LASP1 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LASP1 mRNAaffects expression 16483693
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in increased expression of LASP1 mRNAincreases expression 15912405
C423222 cotylenin A cotylenin A results in increased expression of LASP1 mRNAincreases expression 16129123
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LASP1 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil LASP1 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
C056933 fumonisin B1 fumonisin B1 results in increased expression of LASP1 mRNAincreases expression 16221962
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of LASP1 mRNAaffects cotreatment|increases expression 17183730
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of LASP1 mRNAincreases expression 16849584
D007657 Ketone Bodies Ketone Bodies results in decreased expression of LASP1 mRNAdecreases expression 16807920
C006253 pirinixic acid pirinixic acid results in decreased expression of LASP1 mRNAdecreases expression 18445702
D012645 Selenomethionine Selenomethionine affects the expression of LASP1 mRNAaffects expression 17222674
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of LASP1 mRNAaffects binding|decreases expression 16214954
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LASP1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LASP1 mRNAdecreases expression 18796159
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LASP1 mRNAdecreases expression 18796159
15644576
D014212 Tretinoin Tretinoin results in increased expression of LASP1 mRNAincreases expression 16129123
D014303 Trinitrotoluene Trinitrotoluene affects the expression of LASP1 mRNAaffects expression 21346803
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of LASP1 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 14.4311752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 14.437525203
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 14.438875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9319490988
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3414692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.3417638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.9716835633
MESH:D000505 Alopecia Tretinoin 3.6215955085
MESH:D000550 Amblyopia Valproic Acid 5.2617688650
MESH:D000740 Anemia Fluorouracil 8.6916511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.6911748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.5717497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.2115885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.2116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2616292516
MESH:D001249 Asthma Tretinoin 2.3416456186
MESH:D001321 Autistic Disorder marker/mechanism 17376794
MESH:D001321 Autistic Disorder Valproic Acid 2.0018940202 17157402 18985861 18396377 18558336 19460635 15238991 19232924 17507914 17688650 20603192 18775368 18316065 16609825 18177632
MESH:D001471 Barrett Esophagus Tretinoin 4.4116935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.0820046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.3019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.3012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.3016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.0315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.038888407
MESH:D001943 Breast Neoplasms Fluorouracil 1.8619217205 18608205 15136595 18357371 16110121 16557594 16595493
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8620435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8616166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6116813970
MESH:D002276 Carcinoid Tumor Fluorouracil 4.7016051944
MESH:D002277 Carcinoma Fluorouracil 8.1917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.1916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1916168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6216705839
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.6217045692 16799960 16332177 17971768 17088986 18930000
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.621917145
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0218695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.7316280240 16757204 18986760 17066447
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.7316096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3718850075 18670907 16120746
MESH:D002386 Cataract Tretinoin 7.7017460283
MESH:D002386 Cataract Trinitrotoluene 7.7015817613 14694615
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6116129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7120734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.7515861022 16919318 17110522 16105132 11677210 17681005 17333356
MESH:D002779 Cholestasis pirinixic acid 7.7519176532
MESH:D002822 Choriocarcinoma Tretinoin 5.1916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.7712621046 8697196 15668235 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 5.779407595
MESH:D003092 Colitis Tretinoin 3.7217035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2317172411 16510598 16340194 15001691 17287894 17725105 17169374 17016597 18772588 17018589
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017695437 16524972 17255274 14970324 15148649 15289873 18383874 17094418 18802399 17016601 17454858 16391804 20501625 16282729 16331619 18448328 18509181 17594712 16303861 18288408 17401013 18949393
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.2817141729 14669216
MESH:D000013 Congenital Abnormalities Trinitrotoluene 9.2815095906
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7610048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.7614991402 16925845 8800419 17551590 9142499 10589399 9125849 9664655 9211117 9224671
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.768888407 17688650 16575769
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.2718551238
MESH:D003490 Cyanosis Trinitrotoluene 11.2718551238
MESH:D007644 Darier Disease Fluorouracil 4.8116733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.0618551238 21346803
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 12.0616221962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.0620420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 12.0621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 12.061733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D004421 Dystonia Valproic Acid 4.061851702
MESH:D004487 Edema pirinixic acid 6.5512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.0518230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.0518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2012538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1116569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.173659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.9516628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9418234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.596426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.317750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.083659116
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4516337965 16785472 16481741 17638652 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.8411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.849664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.0915345470
MESH:D005234 Fatty Liver pirinixic acid 13.0920131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 13.0919224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005315 Fetal Diseases Valproic Acid 4.9216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.148888407 18558336
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.6620067830
MESH:D005355 Fibrosis Tretinoin 8.6617994277
MESH:D005909 Glioblastoma Tretinoin 3.0117312396
MESH:D005910 Glioma Fluorouracil 2.8716145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.8018337622 15162350 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.8016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1916084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5410048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.549664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006529 Hepatomegaly fumonisin B1 20.8816221962
MESH:D006529 Hepatomegaly pirinixic acid 20.8816221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 20.8815340226 16120746 12621046
MESH:D006529 Hepatomegaly Trinitrotoluene 20.8815817613
MESH:D006849 Hydrocephalus Valproic Acid 4.8917688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.088697196 16959395 15340226 16354765 18606429
MESH:D006930 Hyperalgesia Tretinoin 3.2116870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9118670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.6416612254
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9017937319
MESH:D007248 Infertility, Male Trinitrotoluene 6.9012150543
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8612878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.6316306350
MESH:D007410 Intestinal Diseases Tretinoin 3.7817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.9516580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.9515992940 17551590
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.4916705839
MESH:D007680 Kidney Neoplasms Fluorouracil 7.4916985049
MESH:D007938 Leukemia Tretinoin 2.7717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7016932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8916294345 17596541 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.8916294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1517368321 17649720 16140955 17712046 15748426 17339181 17506722 17107899 12679006 9834237 17217047 16891316 16766008 16823087 19225113 19075265 16331271 19035177 19029980 17361223 16935935 16788101 17301526 17294898 19642359
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.319224671
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.4016248980 18397230
MESH:D008113 Liver Neoplasms Fluorouracil 7.3815113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 7.3820007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.3816984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1112151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2917228818
MESH:D008175 Lung Neoplasms Fluorouracil 2.3415246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3419555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.8115086387
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma Tretinoin 1.9416752155
MESH:D008591 Meningomyelocele Tretinoin 4.4416940565
MESH:D008881 Migraine Disorders Valproic Acid 3.1918803445 18765137
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6318986760 16757204
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.038888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.4017596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.4017596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9516411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.7518551238
MESH:D009336 Necrosis Trinitrotoluene 10.7518551238
MESH:D009369 Neoplasms Fluorouracil 8.2618600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 8.2617405874
MESH:D009369 Neoplasms Tretinoin 8.2616946489 16594593
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.5414600291
MESH:D009421 Nervous System Malformations Tretinoin 9.549125849
MESH:D009436 Neural Tube Defects Tretinoin 7.319142499
MESH:D009436 Neural Tube Defects Valproic Acid 7.3116359493 8888407
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4416436463
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.2316049721 12819281
MESH:D009784 Occupational Diseases Trinitrotoluene 9.2314694615 17852074 12819281
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3516936753
MESH:D010146 Pain Tretinoin 2.9016870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.3415113037 16929163 19003803 16500647
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.3415976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.5311399792 11118676 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.5320603192
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.4218626508 19082440
MESH:D011507 Proteinuria Tretinoin 3.6116636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.3315861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.5712752131 11422049
MESH:D011625 Pterygium Tretinoin 4.8116723453
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0118286688 18722050 16160472 15538739
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.8916283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.8919155313
MESH:D012559 Schizophrenia Valproic Acid 2.0719110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 9.9518551238
MESH:D012640 Seizures Trinitrotoluene 9.9518551238
MESH:D012640 Seizures Valproic Acid 9.951511512 17978042 14763951 11738929 3137016 15475178 11044598 16876388
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5616192470
MESH:D012878 Skin Neoplasms Tretinoin 5.5616467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.7819490988
MESH:D013163 Splenomegaly Trinitrotoluene 5.2115817613
MESH:D013226 Status Epilepticus Valproic Acid 4.5712833885
MESH:D013274 Stomach Neoplasms Fluorouracil 2.5117522103 19084572 16424979 19015929 17498489 15786421 16951190 18396642 18567086 17172411
MESH:D013274 Stomach Neoplasms Tretinoin 2.5117261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0317045167 16026305
MESH:D014062 Tongue Neoplasms Fluorouracil 9.8416280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.8416051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.2617262798
MESH:D014376 Tuberculosis Tretinoin 3.2316040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.543119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.2916049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.668888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.3310091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.4616803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.4616129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.6416752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5415869587 14671159
MESH:D014820 Vitiligo Tretinoin 4.0716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
MESH:D009396 Wilms Tumor Tretinoin 3.9716287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30298
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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