AutismKB 2.0

Annotation Detail for ARHGAP4


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Basic Information Top
Gene Symbol:ARHGAP4 ( C1,KIAA0131,RGC1,RhoGAP4,SrGAP4,p115 )
Gene Full Name: Rho GTPase activating protein 4
Band: Xq28
Quick LinksEntrez ID:393; OMIM: 300023; Uniprot ID:RHG04_HUMAN; ENSEMBL ID: ENSG00000089820; HGNC ID: 674
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Signaling by Rho GTPases
Pathway IDPathway Name
200050Regulation of RhoA activity
Pathway IDPathway Name
P00047PDGF signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1902Kidney failure
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of ARHGAP4 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ARHGAP4 mRNAaffects expression 16483693
D002392 Catechin Catechin results in decreased expression of ARHGAP4 mRNAdecreases expression 15465739
D005419 Flavonoids Flavonoids results in decreased expression of ARHGAP4 mRNAdecreases expression 15465739
D010936 Plant Extracts Plant Extracts results in decreased expression of ARHGAP4 mRNAdecreases expression 15465739
C025299 polyphenols polyphenols results in decreased expression of ARHGAP4 mRNAdecreases expression 15465739
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D000544 Alzheimer Disease Plant Extracts 3.0716962711
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.1118218290 18057881 20041841
MESH:D001169 Arthritis, Experimental Plant Extracts 4.1214686799
MESH:D001281 Atrial Fibrillation Amiodarone 4.1319698954 18651412
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.2219483382
MESH:D002545 Brain Ischemia Plant Extracts 5.1916041641
MESH:D002057 Burns, Chemical Plant Extracts 5.869625245
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 2.7818834353
MESH:D006332 Cardiomegaly Plant Extracts 3.9517645561
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9819225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.5518974383
MESH:D003110 Colonic Neoplasms polyphenols 2.7116293270
MESH:D003928 Diabetic Nephropathies Plant Extracts 4.6919706694
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.5515265979 18218290
MESH:D056486 Drug-Induced Liver Injury polyphenols 4.5519370779
MESH:D004487 Edema Plant Extracts 4.1312787963
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 6.2015268973
MESH:D004827 Epilepsy Plant Extracts 3.8719439326 19700373
MESH:D005234 Fatty Liver Amiodarone 9.3914986274
MESH:D005234 Fatty Liver Plant Extracts 9.3915975614
MESH:D006333 Heart Failure Plant Extracts 4.0418097624
MESH:D006529 Hepatomegaly Amiodarone 4.1615265979
MESH:D006561 Herpes Simplex Plant Extracts 5.0910715843
MESH:D015658 HIV Infections Plant Extracts 3.8212878215
MESH:D019584 Hot Flashes Plant Extracts 5.2716566672 14716179 17454163
MESH:D006937 Hypercholesterolemia Amiodarone 4.208137927 9751232
MESH:D020138 Hyperhomocysteinemia Catechin 10.8917292331
MESH:D020138 Hyperhomocysteinemia Plant Extracts 10.8916484555
MESH:D006949 Hyperlipidemias Plant Extracts 4.8215268973 15975614
MESH:D007037 Hypothyroidism Amiodarone 4.9317991464 18020914
MESH:D007249 Inflammation Flavonoids 9.4617296493
MESH:D007249 Inflammation Plant Extracts 9.4612787963 19332304 16366677 15997105
MESH:D007249 Inflammation polyphenols 9.4616366677
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.9212628509 12351151 12584176
MESH:D008064 Lipidoses Amiodarone 3.7315342952 17567588
MESH:D008103 Liver Cirrhosis Plant Extracts 3.8917157831
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 2.6815479170
MESH:D008107 Liver Diseases Plant Extracts 4.8817034775
MESH:D008107 Liver Diseases polyphenols 4.8816698588
MESH:D008113 Liver Neoplasms Plant Extracts 3.2419168119
MESH:D008133 Long QT Syndrome Amiodarone 3.8211989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 3.5712587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.0018516814
MESH:D008175 Lung Neoplasms Plant Extracts 2.6720869020
MESH:D009181 Mycoses Amiodarone 5.4212754197 17974566
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 5.6017168769
MESH:D009765 Obesity Plant Extracts 3.2020132043 19056576
MESH:D010212 Papilloma Plant Extracts 4.9116517061 15173996
MESH:D011471 Prostatic Neoplasms Plant Extracts 4.0314666653 17804756
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9511597910 12832656 12490602
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.5518724381
MESH:D012878 Skin Neoplasms Plant Extracts 3.6015173996 16517061
MESH:D013276 Stomach Ulcer Amiodarone 8.7218087811
MESH:D013276 Stomach Ulcer Plant Extracts 8.7217135157 18193104 15255614 12787963 18237397
MESH:D013610 Tachycardia Amiodarone 4.6711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.5719225199
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 15.0717997062
MESH:D013705 Temporomandibular Joint Disorders polyphenols 15.0717997062
MESH:D013959 Thyroid Diseases Amiodarone 5.2819731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.2819584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.6511989578 17467628
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 5.1618097624
MESH:D020257 Ventricular Remodeling Plant Extracts 5.7818097624
MESH:D014947 Wounds and Injuries Plant Extracts 4.5219894650 20213670
Pathway ID Pathway Name
REACT:14797 Signaling by GPCR
REACT:11044 Signaling by Rho GTPases
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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