AutismKB 2.0

Annotation Detail for LCAT


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Basic Information Top
Gene Symbol:LCAT ( - )
Gene Full Name: lecithin-cholesterol acyltransferase
Band: 16q22.1
Quick LinksEntrez ID:3931; OMIM: 606967; Uniprot ID:LCAT_HUMAN; ENSEMBL ID: ENSG00000213398; HGNC ID: 6522
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00564Glycerophospholipid metabolism
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500797HDL-mediated lipid transport
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of lipid/glycolipid metabolism
H00158Lecithin:cholesterol acyltransferase deficiency
Genetic disorders
Desease IDDesease Name
1904Diabetes mellitus
1918Atherosclerosis
2097Hyperlipidemia
Desease Name
HDL cholesterol
lipid metabolism disorders
atherosclerosis, coronary
CARDIOVASCULAR
fish eye disease
atherosclerosis, coronary cholesterol, HDL
METABOLIC
dominant effect on HDL-cholesterol
Desease Name
HDL cholesterol
Desease Name
Norum disease
Fish-eye disease
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C017251 1,2-oleoylphosphatidylcholine LCAT protein binds to 1,2-oleoylphosphatidylcholineaffects binding 16780378
C076996 27-hydroxycholesterol LCAT protein results in increased metabolism of 27-hydroxycholesterolincreases metabolic processing 7744831
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of LCAT mRNAdecreases expression 12419474
D024502 alpha-Tocopherol [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]affects cotreatment|decreases activity|decreases reaction 19595682
D000638 Amiodarone Amiodarone affects the expression of LCAT mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LCAT mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of LCAT mRNAaffects expression 19483382
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of LCAT mRNAincreases expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of LCAT mRNAdecreases expression 12419474
D002713 Chlorine Chlorine results in decreased expression of LCAT mRNAdecreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of LCAT mRNAaffects cotreatment|affects expression 18636392
D002791 Cholesterol, Dietary [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of LCAT mRNAaffects cotreatment|increases expression 19509184
D002994 Clofibrate Clofibrate affects the expression of LCAT mRNAaffects expression 19483382
D002995 Clofibric Acid Clofibric Acid affects the expression of LCAT mRNAaffects expression 17602206
D003300 Copper Copper results in decreased activity of LCAT proteindecreases activity 7751820
C521776 Desmodium gangeticum extract Desmodium gangeticum extract inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]decreases activity|decreases reaction 15740881
D004041 Dietary Fats [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of LCAT mRNAaffects cotreatment|increases expression 19509184
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of LCAT mRNAdecreases expression 19638242
D005001 Ethionine Ethionine affects the expression of LCAT mRNAaffects expression 19483382
D005419 Flavonoids Flavonoids results in decreased expression of LCAT mRNAdecreases expression 18035473
D005419 Flavonoids Flavonoids results in increased expression of LCAT mRNAincreases expression 18035473
D005632 Fructose [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of LCAT mRNAaffects cotreatment|increases expression 19509184
C056933 fumonisin B1 fumonisin B1 results in decreased expression of LCAT mRNAdecreases expression 16221962
C039281 furan furan results in decreased expression of LCAT mRNAdecreases expression 15120968
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of LCAT mRNAdecreases expression 12419474
D007545 Isoproterenol Desmodium gangeticum extract inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]decreases activity|decreases reaction 15740881
D007545 Isoproterenol Isoproterenol results in decreased activity of LCAT proteindecreases activity 19595682
15740881
D007545 Isoproterenol [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]affects cotreatment|decreases activity|decreases reaction 19595682
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of LCAT mRNAdecreases expression 12057914
D009151 Mustard Gas Mustard Gas results in increased expression of LCAT mRNAincreases expression 15674843
D019829 Nevirapine Nevirapine results in increased expression of LCAT proteinincreases expression 19667106
D009853 Omeprazole Omeprazole affects the expression of LCAT mRNAaffects expression 19483382
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of LCAT mRNAaffects cotreatment|affects expression 18636392
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of LCAT mRNAdecreases expression 17681415
D010672 Phenytoin Phenytoin results in increased expression of LCAT mRNAincreases expression 15136057
C006253 pirinixic acid pirinixic acid affects the expression of LCAT mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid results in increased expression of LCAT mRNAincreases expression 16940010
C025299 polyphenols polyphenols results in decreased expression of LCAT mRNAdecreases expression 16293270
D011441 Propylthiouracil Propylthiouracil affects the expression of LCAT mRNAaffects expression 19483382
D011794 Quercetin [Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]affects cotreatment|decreases activity|decreases reaction 19595682
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LCAT mRNAincreases expression 18796159
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LCAT mRNAincreases expression 18465118
D013853 Thioacetamide Thioacetamide affects the expression of LCAT mRNAaffects expression 19483382
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased activity of LCAT proteindecreases activity 7751820
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 7.386195326 9677735 9118846 3425630 10563481 8986270
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.3814514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.1718287403
MESH:D055371 Acute Lung Injury Chlorine 13.2320601635
MESH:D055371 Acute Lung Injury Lipopolysaccharides 13.2318653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 13.2318653653
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.1315814487
MESH:D000236 Adenoma Diethylnitrosamine 2.626695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.9919061943 17162532 17620307 18056438 19052882 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.9916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.9916835633
MESH:D000544 Alzheimer Disease 27-hydroxycholesterol 8.7820157255 14523054
MESH:D000544 Alzheimer Disease Cholesterol, Dietary 8.7820157255
MESH:D000544 Alzheimer Disease Copper 8.7817119284 16886094 16325427 16866297 16962711 16410023
MESH:D000544 Alzheimer Disease Ozone 8.7815513908
MESH:D000647 Amnesia Desmodium gangeticum extract 6.5416946593
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 7.7010965797
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 7.7010694572
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6111748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.8917084956
MESH:D018798 Anemia, Iron-Deficiency Copper 4.5416614410
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.4618218290 18057881 20041841
MESH:D001161 Arteriosclerosis Cholesterol, Dietary 9.4115552841
MESH:D001161 Arteriosclerosis Dietary Fats 9.4115238619
MESH:D001172 Arthritis, Rheumatoid Ozone 4.6515570426
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 4.6519898480
MESH:D001249 Asthma Mustard Gas 4.6410378619
MESH:D001249 Asthma Ozone 4.6417854713 16373670
MESH:D001260 Ataxia Telangiectasia Quercetin 4.5815336622
MESH:D050197 Atherosclerosis 27-hydroxycholesterol 6.779059518 11166758
MESH:D050197 Atherosclerosis Phenytoin 6.7715136057
MESH:D001281 Atrial Fibrillation Amiodarone 3.6118651412 19698954
MESH:D001327 Autoimmune Diseases Quercetin 4.0219761891
MESH:D001768 Blister Mustard Gas 4.7619167455
MESH:D001778 Blood Coagulation Disorders Amiodarone 51.3019483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 51.3019483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 51.3019483382
MESH:D001778 Blood Coagulation Disorders Ethionine 51.3019483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 51.3019483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 51.3019483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 51.3019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 51.3012125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 51.3019483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5115746008
MESH:D001919 Bradycardia Isoproterenol 4.796740701
MESH:D001932 Brain Neoplasms Copper 4.2217079463
MESH:D001943 Breast Neoplasms Copper 2.2115986119 17079463
MESH:D001943 Breast Neoplasms Dietary Fats 2.2120435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2117474063
MESH:D001943 Breast Neoplasms Quercetin 2.2118628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2120435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3718315731 16777450 18417511 19059883 15516495 17626835 14754758
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.7615286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.5817687719 10378619
MESH:D002100 Cachexia Ozone 4.3516183385
MESH:D002105 Cadmium Poisoning Quercetin 5.1416962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4916835633
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 6.061701930
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.0619171122 18785209 20727157 16681979 18210153 19919837 19052882 10737359 17173139 17428255 16569478 18494052 3084413 19107877 18506893 18971187 16779866 3581430 16288022 20524982 16878318 16698587 17138121 20101231 21159647 16830150 20214788 20084675 16935385 18665156 17978847 19394651 19701751 16540662 20514400 20512989 17761372 17162532 16502159 16807293 16328049 19418558 18393292 19822196 18788625 18056438 19539802 20007298 17055752 20935162 10672840 18691550 19208518 19519916 11831363 19383236 19335982 20432363 18978308
MESH:D006528 Carcinoma, Hepatocellular Quercetin 6.0619519916 12508355
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 6.0617997003
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.2811212258
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.5717234771
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 3.0911212258
MESH:D006332 Cardiomegaly Copper 14.5717327471
MESH:D006332 Cardiomegaly Isoproterenol 14.577544033 11179087
MESH:D006332 Cardiomegaly Quercetin 14.5719794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 14.5718670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7515710769 19225199
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.2416936243
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.6918974383
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.7020889678
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 9.701399818
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 9.707505956 2727394 17174075 21159647
MESH:D002493 Central Nervous System Diseases Phenytoin 4.914080065
MESH:D002637 Chest Pain Omeprazole 4.7115447763
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 14.2119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 14.2116835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 14.2118291259
MESH:D002779 Cholestasis pirinixic acid 2.5419176532
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.4711748493
MESH:D002971 Cleft Lip Phenytoin 3.942227380
MESH:D002972 Cleft Palate Phenytoin 5.582227380 6862529 1687470 10789828 6856622 3877104
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.588697196 15668235 16354765 12621046 15340226
MESH:D003103 Coloboma Phenytoin 4.809212184
MESH:D003110 Colonic Neoplasms polyphenols 3.7816293270
MESH:D003110 Colonic Neoplasms Quercetin 3.7819440933 11134977 19056647 16640504 17191121 15741050 17148506
MESH:D015179 Colorectal Neoplasms Quercetin 2.1818852136 18095365
MESH:D000013 Congenital Abnormalities Phenytoin 8.2910627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.2914669216 17141729
MESH:D003327 Coronary Disease Fructose 4.2218504504
MESH:D019465 Craniofacial Abnormalities Phenytoin 2.719212184 8986270 19952982
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7110048152 15322242 20055451
MESH:D003715 Dengue 27-hydroxycholesterol 5.2919427377
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003921 Diabetes Mellitus, Experimental Desmodium gangeticum extract 12.5017431824
MESH:D003921 Diabetes Mellitus, Experimental Fructose 12.5018603373
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 12.5019496084
MESH:D003924 Diabetes Mellitus, Type 2 alpha-Tocopherol 9.4316506275
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.4320387270
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 9.4318603373
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.4317107852
OMIM:607208 DRAVET SYNDROME Phenytoin 5.0011748493
MESH:D003875 Drug Eruptions Phenytoin 5.1115024534
MESH:D056486 Drug-Induced Liver Injury Amiodarone 16.6718218290 15265979
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 16.6719107877
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 16.6716221962
MESH:D056486 Drug-Induced Liver Injury Nevirapine 16.6714986274
MESH:D056486 Drug-Induced Liver Injury polyphenols 16.6719370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 16.6720420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 16.6712963478
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4711462148
MESH:D004381 Duodenal Ulcer Desmodium gangeticum extract 8.8615991576
MESH:D004381 Duodenal Ulcer Omeprazole 8.8616613094 15991576 21218061 17151854
MESH:D050171 Dyslipidemias Clofibrate 7.8816707586
MESH:D050171 Dyslipidemias Dietary Fats 7.8818367378
MESH:D004417 Dyspnea Chlorine 4.2320016425
MESH:D004487 Edema Mustard Gas 13.6011402378 9260866 11428647 11428631
MESH:D004487 Edema perfluorooctanoic acid 13.6012083418 17259670
MESH:D004487 Edema pirinixic acid 13.6012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.6011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5018230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental 27-hydroxycholesterol 8.8617410599
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 8.8617654737
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.6810568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.0015821434 15328337 17637181
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 4.8220235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 5.831399206 6251365
MESH:D004828 Epilepsies, Partial Phenytoin 4.5211558140 17116037
MESH:D004827 Epilepsy Phenytoin 3.7320417680 11434505 821787
MESH:D017029 Epilepsy, Complex Partial Phenytoin 4.917750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 4.673659116
MESH:D004890 Erythema Mustard Gas 4.769357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7116302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 1.9720426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7211564622
MESH:D005218 Fat Necrosis Thioacetamide 5.3216456712
MESH:D005234 Fatty Liver Amiodarone 26.1714986274
MESH:D005234 Fatty Liver Clofibrate 26.1719224547
MESH:D005234 Fatty Liver Dietary Fats 26.1719551842 17967931 19004024 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 26.1720387270 21071580
MESH:D005234 Fatty Liver Fructose 26.1718395287 19196556 18641190
MESH:D005234 Fatty Liver pirinixic acid 26.1719236843 20131406
MESH:D005313 Fetal Death Phenytoin 9.4610627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 9.4611858732
MESH:D005334 Fever Lipopolysaccharides 3.6711852909 9205823
MESH:D005355 Fibrosis Dietary Fats 18.0718296743
MESH:D005355 Fibrosis Fructose 18.0718504504
MESH:D005355 Fibrosis Quercetin 18.0719474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.0720067830
MESH:D005739 Gas Poisoning Chlorine 4.6120016425
MESH:D005885 Gingival Hyperplasia Phenytoin 5.279029455
MESH:D019214 Gingival Overgrowth Phenytoin 5.8316390469 14659971
MESH:D005909 Glioblastoma Quercetin 3.1419804834
MESH:D005910 Glioma Quercetin 2.8917643826
MESH:D018149 Glucose Intolerance Fructose 4.9619165636
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1210048152 11294989
MESH:D006333 Heart Failure Isoproterenol 6.5618097624
MESH:D006333 Heart Failure pirinixic acid 6.5620558911
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.0416366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9811000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.2218665440 15929193 17276928
MESH:D006505 Hepatitis Thioacetamide 3.8416456712
MESH:D006521 Hepatitis, Chronic Copper 4.8817338147
MESH:D006527 Hepatolenticular Degeneration Copper 4.7819888908 16607473 17182432 17276780 17109627
MESH:D006529 Hepatomegaly Amiodarone 23.0615265979
MESH:D006529 Hepatomegaly fumonisin B1 23.0616221962
MESH:D006529 Hepatomegaly perfluorooctanoic acid 23.063609246
MESH:D006529 Hepatomegaly pirinixic acid 23.0616221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 23.0615340226 16120746 12621046
MESH:D015658 HIV Infections Nevirapine 4.6811141242
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.648697196 16959395 15340226 16354765 18606429
MESH:D006930 Hyperalgesia perfluorooctanoic acid 3.5512083418
MESH:D006937 Hypercholesterolemia 27-hydroxycholesterol 19.0517873880
MESH:D006937 Hypercholesterolemia Amiodarone 19.058137927 9751232
MESH:D006937 Hypercholesterolemia Cholesterol, Dietary 19.0510876104
MESH:D006937 Hypercholesterolemia Dietary Fats 19.0521332399
MESH:D006943 Hyperglycemia pirinixic acid 8.1120558911
MESH:D006943 Hyperglycemia Quercetin 8.1111834736 18262572
MESH:D020138 Hyperhomocysteinemia Phenytoin 4.3410459572
MESH:D006946 Hyperinsulinism Fructose 4.5714757778 18563319 19008412 15752949 18360027
MESH:D006949 Hyperlipidemias Dietary Fats 8.3521332399
MESH:D006949 Hyperlipidemias Fructose 8.3515752949
MESH:D006973 Hypertension Fructose 7.8416843071 14568997 14633139 19008412 14573337
MESH:D006973 Hypertension Quercetin 7.8418356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.8418850075 18670907
MESH:D015228 Hypertriglyceridemia Fructose 4.7419799862 19342510
MESH:D006984 Hypertrophy Isoproterenol 4.8412791704
MESH:D007022 Hypotension Isoproterenol 4.446740701
MESH:D007037 Hypothyroidism Amiodarone 10.3317991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 10.3318031379 8137927
MESH:D007249 Inflammation Desmodium gangeticum extract 33.2117604372 15507346
MESH:D007249 Inflammation Dietary Fats 33.2120412841
MESH:D007249 Inflammation Diethylnitrosamine 33.2118785209
MESH:D007249 Inflammation Flavonoids 33.2117296493
MESH:D007249 Inflammation Lipopolysaccharides 33.2117255318 17237260 9205823 12878042 17963957
MESH:D007249 Inflammation Mustard Gas 33.219260866 16001271 11428620 17524151 8975870 11428631 9357497 11428647 11402378
MESH:D007249 Inflammation perfluorooctanoic acid 33.2112083418
MESH:D007249 Inflammation polyphenols 33.2116366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 33.2112878042 12200463
MESH:D007249 Inflammation Tobacco Smoke Pollution 33.2118590791
MESH:D007251 Influenza, Human Quercetin 4.1116624496
MESH:D007333 Insulin Resistance Dietary Fats 10.9511836018 18457598
MESH:D007333 Insulin Resistance Fructose 10.9518563319 14757778 14633139 19008412 18057795 17133782 19586609 19342510 18981581 19799862 14573337
MESH:D007333 Insulin Resistance pirinixic acid 10.9516306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.2717255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.9816580747
MESH:D007627 Keloid Quercetin 4.5717086741
MESH:D007674 Kidney Diseases Quercetin 2.8716962696
MESH:D007676 Kidney Failure, Chronic Copper 9.2316518626
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 9.2316518626
MESH:D007859 Learning Disorders Copper 4.4117134702
MESH:D007863 Lecithin Acyltransferase Deficiency marker/mechanism
OMIM:245900 LECITHIN:CHOLESTEROL ACYLTRANSFERASE DEFICIENCY marker/mechanism
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.7819248655
MESH:D007898 Leishmaniasis, Visceral Desmodium gangeticum extract 5.031470668 15763367 16099649
MESH:D007938 Leukemia Quercetin 2.9617468513
MESH:D007970 Leukopenia Lipopolysaccharides 4.3015821434
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.838812269
MESH:D008064 Lipidoses Amiodarone 3.2315342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 5.8918296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.8918407596 20032147 19638242 18522880 18665156
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 6.1412878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.1415474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 6.1412741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.1412878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 6.1412679928 18380797 15075984 16126171 18395095 17355460 12557150 18263696 15334695 15316131 16511523 15474484 12085344 11682029 12531686 18032466 16248980 15095483 15288473 15078482 18458672 15158331 15465738 11172339 10677585 16343077 16098781 15288472 18606216 17629604 15362042 18295389 16489207 17127702 11481614 17292413 18615449 18031379 18416461 15716488 14739098 12175628 17050028 12891558 16097051
MESH:D008107 Liver Diseases Diethylnitrosamine 8.5417034775
MESH:D008107 Liver Diseases Phenytoin 8.5414986274
MESH:D008107 Liver Diseases polyphenols 8.5416698588
MESH:D008107 Liver Diseases Thioacetamide 8.5416337175 18374380 15158337
MESH:D017114 Liver Failure, Acute Thioacetamide 3.9715633222 15313186 17276928 12479984
MESH:D008113 Liver Neoplasms Clofibric Acid 19.4217602206
MESH:D008113 Liver Neoplasms Copper 19.4220302851
MESH:D008113 Liver Neoplasms Diethylnitrosamine 19.4220405173 19638242 21167192 18977376 19256749 19426721 9163691 19690152 20118626 18754104 19551842 12112319 20492335 20137499 19642983 18644402 15885732 12771043 20434301 19294768 21047994 21278145 19850985 19073162 2862719 19499222 21071580 19812893 19090486 20452335 18978307 20101389 2422723 19254457 19996281 18648771 19427195 15175105 10737359 19833225 16942905 20583210 19255062 20501860
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 19.4218709148 14757943
MESH:D008113 Liver Neoplasms pirinixic acid 19.4216377806 20007298 15890375
MESH:D008113 Liver Neoplasms Quercetin 19.4218980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 19.4216984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 8.4119539802 16842330 18775883 3124819 18544905 18282651 16267830 18253720 18079962 17174075 19009564 19126423 17942915 2563599 18164116 18308698 18093689 19004024 21159647 9362446 17854601 19519916
MESH:D008114 Liver Neoplasms, Experimental Quercetin 8.4119519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.4112151625
MESH:D008133 Long QT Syndrome Amiodarone 3.2817391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 10.8812587719
MESH:D008171 Lung Diseases Mustard Gas 10.8818702808 18161513
MESH:D008171 Lung Diseases Ozone 10.888266340 19066396
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.0818516814
MESH:D055370 Lung Injury Lipopolysaccharides 7.9721114838
MESH:D055370 Lung Injury Ozone 7.9720417186
MESH:D008175 Lung Neoplasms alpha-Tocopherol 9.8216401635
MESH:D008175 Lung Neoplasms Diethylnitrosamine 9.826695378 21163286 20512841 20970405
MESH:D008175 Lung Neoplasms Mustard Gas 9.823148597 8781369
MESH:D008175 Lung Neoplasms Ozone 9.827614698 8597069
MESH:D008175 Lung Neoplasms Quercetin 9.8216280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 9.8211884234 19555203
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 9.8216288123 3440675 12111688 11091918
MESH:D007706 Menkes Kinky Hair Syndrome Copper 5.4917268249 17109627
MESH:D008607 Mental Retardation Phenytoin 3.539212184
MESH:D024821 Metabolic Syndrome X Fructose 4.5018497449 17098227 19165636 17261469 16815490
MESH:D008679 Metaplasia Ozone 4.7010496685
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 4.0515006635
MESH:D009135 Muscular Diseases pirinixic acid 3.1216239165
MESH:D009181 Mycoses Amiodarone 4.5017974566 12754197
MESH:D009203 Myocardial Infarction alpha-Tocopherol 16.1119595682
MESH:D009203 Myocardial Infarction Desmodium gangeticum extract 16.1115740881
MESH:D009203 Myocardial Infarction Isoproterenol 16.1116538859 19595682 16697266 16584858 17052832 19172585 15740881
MESH:D009203 Myocardial Infarction pirinixic acid 16.1119151258
MESH:D009203 Myocardial Infarction Quercetin 16.1119595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.4416411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 7.4419207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 5.1317484760
MESH:D009224 Myotonia Congenita Phenytoin 5.021896199
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.403581430 9029167
MESH:D009369 Neoplasms pirinixic acid 4.3917405874
MESH:D009369 Neoplasms Quercetin 4.3915185748
MESH:D009376 Neoplasms, Hormone-Dependent Nevirapine 5.7419152342
MESH:D009389 Neovascularization, Pathologic Copper 4.5617308104
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.8414600291
MESH:D009436 Neural Tube Defects Phenytoin 3.879118846
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.0220387270
MESH:D020078 Neurogenic Inflammation Quercetin 4.0017929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7120387270
MESH:D009503 Neutropenia Mustard Gas 3.6116761898 7688884
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 10.789802331
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 10.789802331
MESH:D009765 Obesity Dietary Fats 6.8718674790 21332399 17217161 16723640 11836018 20518802 19632207 18457598 20132043
MESH:D009765 Obesity Fructose 6.8718585860 17707055
MESH:D009765 Obesity pirinixic acid 6.8720558911
MESH:D010018 Osteomalacia Phenytoin 5.0217016548
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 3.8619495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.6119005980
MESH:D010146 Pain Desmodium gangeticum extract 6.9115507346
MESH:D010146 Pain Phenytoin 6.9115215642
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 4.8816540662
MESH:D010190 Pancreatic Neoplasms Quercetin 4.8816965848
MESH:D010212 Papilloma Hydrogen Peroxide 3.7112065085
MESH:D010300 Parkinson Disease Cholesterol, Dietary 4.0219014385
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8512520081
MESH:D010538 Peritonitis Ozone 3.7516369182
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.1011550810
MESH:D011014 Pneumonia Lipopolysaccharides 9.7911605937 12224865
MESH:D011014 Pneumonia Ozone 9.7918929643 18381685 18007984
MESH:D011041 Poisoning Mustard Gas 3.4415727166
MESH:D017689 Polydactyly Phenytoin 4.719212184
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1818163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.132563599
MESH:D011230 Precancerous Conditions Quercetin 8.1319056647
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 8.3617132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.3611118676 11222880 11399792 11896295
MESH:D011471 Prostatic Neoplasms Copper 3.1717308104 17079463
MESH:D011471 Prostatic Neoplasms Nevirapine 3.1719152342
MESH:D011471 Prostatic Neoplasms Quercetin 3.1714715546 17292933
MESH:D011537 Pruritus Mustard Gas 3.7018058305
MESH:D019310 Pseudolymphoma Phenytoin 5.1412752131 1419762 8603615
MESH:D011649 Pulmonary Alveolar Proteinosis 27-hydroxycholesterol 5.9915466366
MESH:D011654 Pulmonary Edema Isoproterenol 4.8510903255
MESH:D011657 Pulmonary Eosinophilia alpha-Tocopherol 5.5914606601
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.3112490602 12832656 11597910
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.3110334151 17266442 17720292 17894541 17620002
MESH:D015427 Reperfusion Injury Desmodium gangeticum extract 6.5318380926
MESH:D015427 Reperfusion Injury pirinixic acid 6.5319058328
MESH:D012120 Respiration Disorders Chlorine 4.8118579056
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.4710835634
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.2418410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4618990726
MESH:D012174 Retinitis Pigmentosa alpha-Tocopherol 3.8516849425
MESH:D012554 Schistosomiasis japonica Quercetin 5.1416862918
MESH:D012559 Schizophrenia Copper 3.0316842975
MESH:D012640 Seizures Phenytoin 3.4815946322 16876388 10029267 3691417 3137016 9844417 11044598 19919933
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.6918724381
MESH:D012871 Skin Diseases Mustard Gas 2.6112880345 16961503 15451306
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 12.0212065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.028532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.0216192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 12.0218590791
MESH:D019082 Smith-Lemli-Opitz Syndrome 27-hydroxycholesterol 5.6311254748
OMIM:270800 SPASTIC PARAPLEGIA 5A, AUTOSOMAL RECESSIVE 27-hydroxycholesterol 5.9819812052
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 4.7720235791
MESH:D013272 Stomach Diseases Omeprazole 4.2218545984
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013276 Stomach Ulcer Amiodarone 10.4118087811
MESH:D013276 Stomach Ulcer Desmodium gangeticum extract 10.4115991576
MESH:D013276 Stomach Ulcer Omeprazole 10.4110750652 18237397 16755016 17977527 15991576 11906479
MESH:D013610 Tachycardia Amiodarone 3.9211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8219225199
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.8517997062
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.8215821434
MESH:D013959 Thyroid Diseases Amiodarone 10.7119731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.7112697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.427505956
MESH:D013964 Thyroid Neoplasms Propylthiouracil 6.4215710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.4719584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 3.8011989578 17467628
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.0416720314
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 5.0412846360
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1912125929
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 4.7318097624
MESH:D020257 Ventricular Remodeling Isoproterenol 5.2918097624
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8515886252
MESH:D015430 Weight Gain Dietary Fats 3.4116723640
Pathway ID Pathway Name
KEGG:00564 Glycerophospholipid metabolism
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA226
    • No data
    No data
    Releated drug ID Related drug Name
    PA450952phospholipids
    PA145007158torcetrapib
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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