AutismKB 2.0

Annotation Detail for LCK


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Basic Information Top
Gene Symbol:LCK ( LSK,YT16,p56lck,pp58lck )
Gene Full Name: lymphocyte-specific protein tyrosine kinase
Band: 1p35.2
Quick LinksEntrez ID:3932; OMIM: 153390; Uniprot ID:LCK_HUMAN; ENSEMBL ID: ENSG00000182866; HGNC ID: 6524
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04650Natural killer cell mediated cytotoxicity
hsa05340Primary immunodeficiency
hsa04660T cell receptor signaling pathway
Pathway IDPathway Name
Hemostasis
Signaling in Immune system
HIV Infection
Pathway IDPathway Name
200034IL12-mediated signaling events
200033Signaling events mediated by PTP1B
200187Alpha-synuclein signaling
200017Atypical NF-kappaB pathway
200158IL2 signaling events mediated by STAT5
200121EPHA forward signaling
200127PDGFR-beta signaling pathway
200082IL2-mediated signaling events
200083CXCR4-mediated signaling events
200069Thromboxane A2 receptor signaling
200062TCR signaling in naive CD8+ T cells
200099IL2 signaling events mediated by PI3K
200098Class I PI3K signaling events
200173Ephrin B reverse signaling
200108amb2 Integrin signaling
200022TCR signaling in naive CD4+ T cells
200021Glypican 1 network
200054Regulation of p38-alpha and p38-beta
Pathway IDPathway Name
P00053T cell activation
P00049Parkinson disease
Pathway IDPathway Name
500480Translocation of ZAP-70 to Immunological synapse
500482Downstream TCR signaling
500488PD-1 signaling
500479Phosphorylation of CD3 and TCR zeta chains
500759Nef Mediated CD4 Down-regulation
500755Nef and signal transduction
500478TCR signaling
Related Diseases/Disorders Top
Desease IDDesease Name
H00093Combined immunodeficiencies
Immune system diseases
Primary immunodeficiency
Desease IDDesease Name
1766Renal Cell cancer
1904Diabetes mellitus
1944Breast cancer
2067Primary tumor
2192Lung disease
2239Lymphoma
No data
No data
Desease Name
SCID due to LCK deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of LCK mRNAdecreases expression 12419474
C072876 A 771726 A 771726 inhibits the reaction [TNF protein results in increased activity of LCK protein]decreases reaction|increases activity 9973483
C014949 acetylhydrazine acetylhydrazine results in decreased expression of LCK mRNAdecreases expression 15282401
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of LCK mRNAaffects expression 17331233
C472777 bisperoxovanadium LCK protein affects the reaction [bisperoxovanadium results in increased expression of PTGS2 mRNA]affects reaction|increases expression 12493747
C006780 bisphenol A bisphenol A results in increased expression of LCK mRNAincreases expression 18180321
C471992 bosutinib bosutinib results in decreased activity of LCK proteindecreases activity 17114238
C074702 chromium hexavalent ion LCK protein affects the reaction [chromium hexavalent ion results in increased expression of IL6 mRNA]affects reaction|increases expression 17078813
C074702 chromium hexavalent ion LCK protein affects the reaction [chromium hexavalent ion results in increased phosphorylation of STAT3 protein alternative form]affects reaction|increases phosphorylation 17078813
D003513 Cycloheximide Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of LCK mRNA]decreases reaction|increases expression 11007951
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of LCK mRNAaffects cotreatment|decreases expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of LCK mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of LCK mRNAincreases expression 17942748
C029424 hydrazine hydrazine results in decreased expression of LCK mRNAdecreases expression 15282401
C097613 imatinib imatinib results in decreased phosphorylation of LCK proteindecreases phosphorylation 15100154
D007657 Ketone Bodies Ketone Bodies results in decreased expression of LCK mRNAdecreases expression 16807920
D008727 Methotrexate LCK protein affects the susceptibility to Methotrexateaffects response to substance 16217747
C006253 pirinixic acid pirinixic acid results in decreased expression of LCK mRNAdecreases expression 17426115
D011192 Potassium Dichromate LCK protein affects the reaction [Potassium Dichromate results in increased expression of IL6 mRNA]affects reaction|increases expression 17078813
D011192 Potassium Dichromate LCK protein affects the reaction [Potassium Dichromate results in increased phosphorylation of STAT3 protein alternative form]affects reaction|increases phosphorylation 17078813
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of LCK mRNAaffects cotreatment|decreases expression 17404688
C021747 sodium selenate sodium selenate results in increased expression of LCK mRNAincreases expression 16444006
D013629 Tamoxifen Tamoxifen affects the expression of LCK mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of LCK mRNA]decreases reaction|increases expression 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LCK mRNAincreases expression 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LCK mRNAincreases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4414745880
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 8.2312039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.2315322242 14514962 11752688
MESH:D000015 Abnormalities, Multiple imatinib 5.1518322153
MESH:D000022 Abortion, Spontaneous imatinib 6.1118322153
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8417505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0118653653
MESH:D000230 Adenocarcinoma Estradiol 4.1311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1314692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.5416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.5416835633
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.0310965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8511748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6015885639
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.0717286800
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.4319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.4312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6915746008
MESH:D001859 Bone Neoplasms imatinib 5.2215867366
MESH:D001862 Bone Resorption bisphenol A 3.7611985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2317868700
MESH:D001930 Brain Injuries Progesterone 4.1515665606 15380490 15845082
MESH:D001943 Breast Neoplasms bisphenol A 3.7117123778
MESH:D001943 Breast Neoplasms Estradiol 3.7117261762 12948864 17018787 16675129 14630087 17289903 19861407 18497071
MESH:D001943 Breast Neoplasms imatinib 3.7117614352
MESH:D001943 Breast Neoplasms Methotrexate 3.7116978400
MESH:D001943 Breast Neoplasms Progesterone 3.7116175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tamoxifen 3.7115565566 19103187 19189210 19288272 20135344 18425577 15668708 19289846 19142967 19059307 16202921 17242785 19115204 19066611 19011961 16818667 17893378 18984771 19189212 20065188 19221464 17440819 18815881 20005174 18351453 19200415 19155303 21152245 18855134 18821012 11161223 19244106 19084267 20859285 21138602 18997820 19410462 16873071 20544844 16273361 18629630 19487384 17049068 17261762 20390343
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.7120435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4019066611
MESH:D006528 Carcinoma, Hepatocellular Estradiol 2.9316924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 2.9316924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.8817123778
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3118850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.7018566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0716835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.4715861022 16105132 17110522 17681005 17333356 16919318 11677210
MESH:D002779 Cholestasis pirinixic acid 7.4719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0615668235 15340226 16354765 8697196 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9614669216 17141729
MESH:D019465 Craniofacial Abnormalities imatinib 3.9918322153
MESH:D019465 Craniofacial Abnormalities Methotrexate 3.999562676 12039119
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9920055451 10048152 15322242
MESH:D003550 Cystic Fibrosis Methotrexate 4.1419747007
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2519031437
MESH:D017449 Dermatitis, Allergic Contact Potassium Dichromate 4.2016823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003882 Dermatomyositis Methotrexate 5.0220191521
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6417107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.5219279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.5219279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.3817187935
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6811462148
MESH:D004487 Edema imatinib 10.9819703484
MESH:D004487 Edema pirinixic acid 10.9812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.9811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8016714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.7012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 14.7017692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.7019031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.1518566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.1519155303 16202921 20544844 17893378
MESH:D004715 Endometriosis Progesterone 8.6016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.609294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9311564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.4515345470
MESH:D005234 Fatty Liver pirinixic acid 12.4520131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 12.4514986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4214745880
MESH:D018222 Fibromatosis, Aggressive imatinib 11.4717453242
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 11.4719069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8420067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006086 Graft vs Host Disease Methotrexate 5.0416518429
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2710048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006529 Hepatomegaly pirinixic acid 7.9016221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.9015340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.9315709030
MESH:D019584 Hot Flashes Estradiol 3.6517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.948697196 16959395 15340226 16354765 18606429
MESH:D006943 Hyperglycemia pirinixic acid 3.0820558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7016945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2915869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3612013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4117937319
MESH:D007249 Inflammation Progesterone 7.9715869954
MESH:D007249 Inflammation Tamoxifen 7.9719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.9712200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 11.9016393666
MESH:D007333 Insulin Resistance Estradiol 11.9016393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.9016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2316580747
MESH:D007674 Kidney Diseases Estradiol 6.3615618244
MESH:D007674 Kidney Diseases Potassium Dichromate 6.3619665454
MESH:D007680 Kidney Neoplasms Estradiol 7.0815610895
MESH:D007680 Kidney Neoplasms Tamoxifen 7.0818625569
MESH:D007805 Language Development Disorders Methotrexate 5.009562676
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive imatinib 4.6915748426 15107311 17301526 19208803
MESH:D007951 Leukemia, Myeloid imatinib 5.0017236224
MESH:D008064 Lipidoses Tamoxifen 3.0817567588 15342952
MESH:D008103 Liver Cirrhosis Methotrexate 3.6414986274
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.6014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental imatinib 6.6016596278
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.6015474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.6018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.6012878042
MESH:D008113 Liver Neoplasms pirinixic acid 7.0916377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 7.0916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.0916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.0412151625
MESH:D008171 Lung Diseases chromium hexavalent ion 4.5516775837
MESH:D017563 Lung Diseases, Interstitial Methotrexate 4.9218516814
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.9117365036
MESH:D008175 Lung Neoplasms chromium hexavalent ion 3.5116876463 16570259
MESH:D008175 Lung Neoplasms Tamoxifen 3.5118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5119555203 11884234
MESH:D008223 Lymphoma Methotrexate 3.8717352296
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.5617203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.5611408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.5619196722 11731420 16827153 14580682 19196723
MESH:D020149 Manganese Poisoning Estradiol 12.2919453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.2919453300
MESH:D008545 Melanoma Tamoxifen 1.8719393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0715990972
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1416166281 16966607 18303189
MESH:D052016 Mucositis Methotrexate 5.1717488658
MESH:D009135 Muscular Diseases pirinixic acid 3.4016239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.9716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.9716411023
MESH:D009362 Neoplasm Metastasis imatinib 6.1215867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.1219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4819410462
MESH:D009369 Neoplasms pirinixic acid 1.9017405874
MESH:D009376 Neoplasms, Hormone-Dependent imatinib 10.8317614352
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 10.8319200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6217289903
MESH:D009421 Nervous System Malformations bisphenol A 15.7411399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 15.7416427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.7414600291
MESH:D009669 Nose Neoplasms chromium hexavalent ion 5.0116876463
MESH:D009765 Obesity pirinixic acid 1.7920558911
MESH:D010014 Osteolysis imatinib 5.6315867366
MESH:D010049 Ovarian Diseases bisphenol A 4.8811985600
MESH:D010051 Ovarian Neoplasms Estradiol 4.7619401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.7617393432 16525653
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5811578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.4011550810
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.7810923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma imatinib 4.4212476293
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.1510548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.1511896295 11118676 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.2120887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.2120887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.5916740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.5916740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.2015861022 16919318
MESH:D011565 Psoriasis Methotrexate 3.4017410198
MESH:D011629 Puberty, Precocious bisphenol A 4.6810548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9917365031 15814490 17322281 17975199
MESH:D051437 Renal Insufficiency Methotrexate 4.6017352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.3319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8218045962
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.2116709447
MESH:D013088 Spermatocele Tamoxifen 11.2116709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.5115862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.5119457130
MESH:D013274 Stomach Neoplasms imatinib 3.2015786421
MESH:D019966 Substance-Related Disorders bisphenol A 3.8816684133 16045194
MESH:D013576 Syndactyly Methotrexate 4.939562676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0615669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D013964 Thyroid Neoplasms imatinib 4.3416940797
MESH:D013978 Tibial Fractures Estradiol 4.5819048282
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.3116712894 17572228 8653321
MESH:D014591 Uterine Diseases bisphenol A 4.9014652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1914692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4415869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
Pathway ID Pathway Name
REACT:604 Hemostasis
REACT:6185 HIV Infection
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04380 Osteoclast differentiation
KEGG:05340 Primary immunodeficiency
REACT:6900 Signaling in Immune system
KEGG:04660 T cell receptor signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30307
    • No data
    Releated disease ID Related disease Name
    PA444818Lung Neoplasms
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA451578tacrolimus
    PA10804imatinib
    PA164743471adenosine triphosphate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01254 multitarget Dasatinib Protein Kinase Inhibitors
    DB01830 - {4-[2-Acetylamino-2-(3-Carbamoyl-2-Cyclohexylmethoxy-6,7,8,9-Tetrahydro-5h-Benzocyclohepten-5ylcarbamoyl)-Ethyl]-2-Phosphono-Phenyl}-Phosphonic Acid
    DB02010 - Staurosporine Enzyme Inhibitors
    DB03023 - 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
    DB04003 - (4-{2-Acetylamino-2-[1-(3-Carbamoyl-4-Cyclohexylmethoxy-Phenyl)-Ethylcarbamoyl}-Ethyl}-2-Phosphono-Phenoxy)-Acetic Acid
    DB04395 - Phosphoaminophosphonic Acid-Adenylate Ester
    DB06925 - 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
    DB07146 - 2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE
    DB07297 - 5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE
    DB08055 - N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
    DB08056 - N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
    DB08057 - N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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