Gene Symbol:	LCN2 ( 24p3,MSFI,NGAL )
Gene Full Name:	lipocalin 2
Band:	9q34.11
Quick Links	Entrez ID:3934; OMIM: 600181; Uniprot ID:NGAL_HUMAN; ENSEMBL ID: ENSG00000148346; HGNC ID: 6526
Relate to Another Database:	SFARIGene; denovo-db

Desease ID	Desease Name
1848	Embryoma
1856	Obesity
1883	Polycystic kidney
1944	Breast cancer
2025	Polyarthritis
1999	Thalassemia
2091	Hypertension
2051	Leukemia
2053	Colon cancer
2083	IGA glomerulonephritis
2106	Pancreas cancer
2112	Ovary cancer
2142	Acne
2146	Lupus erythematosus
2237	Neoplasm metastasis

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
C027132	1-anilino-8-naphthalenesulfonate	1-anilino-8-naphthalenesulfonate binds to LCN2 protein	affects binding	16461020
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in increased expression of LCN2 mRNA	increases expression	15982314
D000082	Acetaminophen	Acetaminophen affects the expression of LCN2 mRNA	affects expression	17562736
C103303	alitretinoin	alitretinoin results in increased expression of LCN2 mRNA	increases expression	15982314
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of LCN2 mRNA	affects expression	16483693
C006632	arsenic trioxide	arsenic trioxide results in increased expression of LCN2 mRNA	increases expression	19763917
D001414	Bacitracin	Bacitracin results in increased expression of LCN2 mRNA	increases expression	18289764
C017049	bathophenanthroline disulfonic acid	bathophenanthroline disulfonic acid results in decreased expression of LCN2 mRNA	decreases expression	17350462
C017049	bathophenanthroline disulfonic acid	bathophenanthroline disulfonic acid results in decreased expression of LCN2 protein	decreases expression	17350462
C017049	bathophenanthroline disulfonic acid	ferric ammonium citrate inhibits the reaction [bathophenanthroline disulfonic acid results in decreased expression of LCN2 protein]	decreases expression\|decreases reaction	17350462
C053541	bicalutamide	bicalutamide results in increased expression of LCN2 mRNA	increases expression	15638997
C006780	bisphenol A	bisphenol A results in increased expression of LCN2 mRNA	increases expression	15456929
C053342	brevetoxin	brevetoxin analog results in decreased expression of LCN2 mRNA	decreases expression	14529743
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of LCN2 mRNA	affects expression	17484886
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of LCN2 mRNA]	increases expression\|increases reaction	16006527
C019304	ciprofibrate	ciprofibrate results in increased expression of LCN2 mRNA	increases expression	12771043
D003474	Curcumin	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LCN2 mRNA]	decreases reaction\|increases expression	18200517
D003520	Cyclophosphamide	[Cyclophosphamide co-treated with Mecamylamine] results in increased expression of LCN2 mRNA	affects cotreatment\|increases expression	18433785
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of LCN2 mRNA	increases expression	15331540 18433785
D016572	Cyclosporine	Cyclosporine results in increased expression of LCN2 mRNA	increases expression	20106945
D003676	Deferoxamine	Deferoxamine inhibits the reaction [LCN2 protein results in decreased secretion of VEGFA protein]	decreases reaction\|decreases secretion	17114340
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LCN2 mRNA	affects cotreatment\|increases expression	16054899
D002945	Cisplatin	Cisplatin results in increased expression of LCN2 mRNA	increases expression	18289764
D002945	Cisplatin	Cisplatin results in increased expression of LCN2 protein	increases expression	15033597
D004041	Dietary Fats	Dietary Fats results in decreased expression of LCN2 mRNA	decreases expression	18042831
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of LCN2 mRNA	increases expression	12771043
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of LCN2 mRNA	increases expression	15289156
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of LCN2 mRNA	increases expression	17072980
D004958	Estradiol	[Estradiol co-treated with Medroxyprogesterone Acetate] results in decreased expression of LCN2 mRNA	affects cotreatment\|decreases expression	15866426
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LCN2 mRNA	affects cotreatment\|increases expression	19619570
D004958	Estradiol	Estradiol promotes the reaction [ESR1 protein binds to LCN2 promoter]	affects binding\|increases reaction	19698761
D004958	Estradiol	Estradiol results in increased expression of LCN2 mRNA	increases expression	19619570
D004958	Estradiol	Estradiol affects the expression of LCN2 mRNA	affects expression	15598610
D004958	Estradiol	Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of LCN2 mRNA]	decreases reaction\|increases expression	16977382
D004958	Estradiol	Estradiol results in increased expression of LCN2 mRNA	increases expression	16684588 15289156
D004958	Estradiol	Estradiol results in increased expression of LCN2 mRNA	increases expression	15456929
D000431	Ethanol	Ethanol results in decreased expression of LCN2 mRNA	decreases expression	16946407
D004997	Ethinyl Estradiol	Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of LCN2 mRNA]	decreases reaction\|increases expression	12072388
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of LCN2 mRNA	increases expression	16467188 17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LCN2 mRNA	affects cotreatment\|increases expression	17942748
C013531	ferric ammonium citrate	ferric ammonium citrate inhibits the reaction [bathophenanthroline disulfonic acid results in decreased expression of LCN2 protein]	decreases expression\|decreases reaction	17350462
D019833	Genistein	Genistein results in increased expression of LCN2 mRNA	increases expression	15289156
D005839	Gentamicins	Gentamicins results in increased expression of and results in increased secretion of LCN2 protein	increases expression\|increases secretion	19349640
D005839	Gentamicins	Gentamicins results in increased expression of LCN2 mRNA	increases expression	18289764 19349640
D006581	Hexachlorobenzene	Hexachlorobenzene results in increased expression of LCN2 mRNA	increases expression	15159207
D017313	Fenretinide	Fenretinide results in increased expression of LCN2 mRNA	increases expression	16671099
D017313	Fenretinide	Fenretinide results in increased expression of LCN2 protein	increases expression	16671099
D007501	Iron	Iron results in increased expression of LCN2 mRNA	increases expression	17350462
D007501	Iron	Iron results in increased expression of LCN2 protein	increases expression	17350462
D007501	Iron	LCN2 protein affects the metabolism of Iron	affects metabolic processing	17194590
D007501	Iron	LCN2 protein binds to and affects the transport of Iron	affects binding\|affects transport	17350462
D007501	Iron	LCN2 protein binds to Iron	affects binding	17114340
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LCN2 mRNA	affects cotreatment\|increases expression	16054899
D007654	Ketoconazole	Ketoconazole results in decreased expression of LCN2 mRNA	decreases expression	18289764
D008070	Lipopolysaccharides	Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of LCN2 mRNA]	decreases reaction\|increases expression	16977382
D008070	Lipopolysaccharides	LCN2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]	decreases reaction\|increases expression	18292240
D008070	Lipopolysaccharides	LCN2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of CSF2 mRNA]	decreases reaction\|increases expression	18292240
D008070	Lipopolysaccharides	LCN2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]	decreases reaction\|increases expression	18292240
D008070	Lipopolysaccharides	LCN2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]	decreases reaction\|increases expression	18292240
D008070	Lipopolysaccharides	LCN2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]	decreases reaction\|increases expression	18292240
D008070	Lipopolysaccharides	LCN2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]	decreases reaction\|increases expression	18292240
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of LCN2 mRNA	increases expression	18292240 16977382 17321000
D008464	Mecamylamine	[Cyclophosphamide co-treated with Mecamylamine] results in increased expression of LCN2 mRNA	affects cotreatment\|increases expression	18433785
D017258	Medroxyprogesterone Acetate	[Estradiol co-treated with Medroxyprogesterone Acetate] results in decreased expression of LCN2 mRNA	affects cotreatment\|decreases expression	15866426
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of LCN2 mRNA	increases expression	17412507
D009020	Morphine	Morphine results in increased expression of LCN2 mRNA	increases expression	20144693
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of LCN2 mRNA	increases expression	18289764
C029938	nickel sulfate	nickel sulfate results in increased expression of LCN2 mRNA	increases expression	16100012
C042763	olive oil	olive oil analog affects the expression of LCN2 mRNA	affects expression	17349074
D010126	Ozone	Ozone results in increased expression of LCN2 mRNA	increases expression	17095637 12763052
D010126	Ozone	TTPA protein affects the reaction [Ozone results in increased expression of LCN2 mRNA]	affects reaction\|increases expression	19555225
C041786	palm oil	palm oil results in decreased expression of LCN2 mRNA	decreases expression	18042831
D010634	Phenobarbital	Phenobarbital results in increased expression of LCN2 mRNA	increases expression	19270015
C006253	pirinixic acid	pirinixic acid results in decreased expression of LCN2 mRNA	decreases expression	17321000
C006253	pirinixic acid	pirinixic acid results in increased expression of LCN2 mRNA	increases expression	18445702
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in decreased expression of LCN2 mRNA]	affects reaction\|decreases expression	17321000
D011374	Progesterone	Progesterone affects the expression of LCN2 mRNA	affects expression	17251523
D020849	Raloxifene	Raloxifene affects the expression of LCN2 mRNA	affects expression	14699072
D015474	Isotretinoin	Isotretinoin results in increased expression of LCN2 mRNA	increases expression	15982314
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LCN2 mRNA	affects cotreatment\|increases expression	16054899
D017632	Asbestos, Serpentine	Asbestos, Serpentine results in increased expression of LCN2 mRNA	increases expression	16251409
D013629	Tamoxifen	Tamoxifen affects the expression of LCN2 mRNA	affects expression	14699072
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LCN2 mRNA	affects cotreatment\|increases expression	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of LCN2 mRNA	increases expression	19619570
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LCN2 mRNA	affects cotreatment\|increases expression	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of LCN2 mRNA]	decreases reaction\|increases expression	15667827
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of LCN2 mRNA	decreases expression	16611356
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of LCN2 mRNA	increases expression	17949056
D014212	Tretinoin	Tretinoin metabolite results in increased expression of LCN2 mRNA	increases expression	15982314
D014212	Tretinoin	Tretinoin results in increased expression of LCN2 mRNA	increases expression	15982314 16249480
D014212	Tretinoin	Tretinoin results in increased expression of LCN2 protein	increases expression	16671099
D014212	Tretinoin	Tretinoin results in increased secretion of LCN2 protein	increases secretion	16671099
D014302	Trinitrobenzenesulfonic Acid	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LCN2 mRNA]	decreases reaction\|increases expression	18200517
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of LCN2 mRNA	increases expression	17982090 18200517
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of LCN2 mRNA	affects expression	21346803
D014640	Vancomycin	Vancomycin results in increased expression of LCN2 mRNA	increases expression	18289764
C025643	vinclozolin	vinclozolin affects the expression of LCN2 mRNA	affects expression	19015723

Drugbank ID	Action	Drug Name	Description
DB01631	-	Methyl Nonanoate (Ester)	Antifungal Agents
DB01672	-	2,3-Dihydroxy-Benzoic Acid	Iron Chelating Agents
DB01926	-	Carboxymycobactin S
DB02710	-	2,3,-Dihydroxybenzoylserine
DB02944	-	Alpha-D-Mannose
DB04043	-	Carboxymycobactin T
DB04476	-	Trencam-3,2-Hopo

Disease ID	Disease Name	Inference Chemical Name	Inference Score	Publication
MESH:D000008	Abdominal Neoplasms	Tamoxifen	3.93	14745880
MESH:D000014	Abnormalities, Drug-Induced	Ethanol	20.38	18926900 17676605
MESH:D000014	Abnormalities, Drug-Induced	Isotretinoin	20.38	18769834
MESH:D000014	Abnormalities, Drug-Induced	Phenobarbital	20.38	6195326
MESH:D000014	Abnormalities, Drug-Induced	Tetrachlorodibenzodioxin	20.38	15322242 14514962 11752688
MESH:D000014	Abnormalities, Drug-Induced	Trinitrotoluene	20.38	7525203
MESH:D000015	Abnormalities, Multiple	Isotretinoin	4.44	18769834
MESH:D000138	Acidosis	Ammonium Chloride	8.48	18287403
MESH:D000138	Acidosis	Ethanol	8.48	11192467
MESH:D017486	Acneiform Eruptions	Isotretinoin	5.67	16232082
MESH:D000152	Acne Vulgaris	Ethinyl Estradiol	9.96	17505938
MESH:D000152	Acne Vulgaris	Isotretinoin	9.96	16185265 18769834
MESH:D058186	Acute Kidney Injury	Cisplatin	7.36	17670903 15814532 12690470
MESH:D058186	Acute Kidney Injury	Gentamicins	7.36	11274264
MESH:D055371	Acute Lung Injury	Lipopolysaccharides	12.13	18653653 11850527
MESH:D055371	Acute Lung Injury	nickel sulfate	12.13	12718980 11954676 16100012 19131640
MESH:D055371	Acute Lung Injury	pirinixic acid	12.13	18653653
MESH:D000230	Adenocarcinoma	arsenic trioxide	21.29	11798837 19825857
MESH:D000230	Adenocarcinoma	Cisplatin	21.29	17638652 11798837
MESH:D000230	Adenocarcinoma	Dimethylnitrosamine	21.29	16033868
MESH:D000230	Adenocarcinoma	Estradiol	21.29	11473722
MESH:D000230	Adenocarcinoma	Ethinyl Estradiol	21.29	14692618
MESH:D000230	Adenocarcinoma	Fenretinide	21.29	10697514
MESH:D000230	Adenocarcinoma	Genistein	21.29	11473722
MESH:D000230	Adenocarcinoma	Methylnitrosourea	21.29	15688392 15113128
MESH:D000236	Adenoma	Diethylnitrosamine	5.71	10737359 6695378
MESH:D000236	Adenoma	Dimethylnitrosamine	5.71	19555203
MESH:D018248	Adenoma, Liver Cell	Diethylnitrosamine	19.95	18056438 19052882 16434500 19061943 17162532 17620307
MESH:D018248	Adenoma, Liver Cell	Phenobarbital	19.95	17620307
MESH:D018248	Adenoma, Liver Cell	pirinixic acid	19.95	16434500
MESH:D018248	Adenoma, Liver Cell	Tetrachlorodibenzodioxin	19.95	16835633
MESH:D000419	Albuminuria	Raloxifene	4.02	17308373 17451421
MESH:D020268	Alcohol-Induced Disorders, Nervous System	Ethanol	4.71	15451039 15451040
MESH:D000437	Alcoholism	Mecamylamine	5.17	20201817
MESH:D019973	Alcohol-Related Disorders	Curcumin	4.47	17887948
MESH:D000505	Alopecia	Tretinoin	3.13	15955085
MESH:D019896	alpha 1-Antitrypsin Deficiency	Iron	5.05	16640825
MESH:D000544	Alzheimer Disease	Curcumin	10.64	15590663
MESH:D000544	Alzheimer Disease	Iron	10.64	16563566 16640825
MESH:D000544	Alzheimer Disease	Ozone	10.64	15513908

Releated drug ID	Related drug Name
PA450379	mercaptopurine
PA450428	methotrexate

AutismKB 2.0

Annotation Detail for LCN2

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics