AutismKB 2.0

Annotation Detail for LCP1


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Basic Information Top
Gene Symbol:LCP1 ( CP64,DKFZp781A23186,FLJ25423,FLJ26114,FLJ39956,L-PLASTIN,LC64P,LPL,PLS2 )
Gene Full Name: lymphocyte cytosolic protein 1 (L-plastin)
Band: 13q14.13
Quick LinksEntrez ID:3936; OMIM: 153430; Uniprot ID:PLSL_HUMAN; ENSEMBL ID: ENSG00000136167; HGNC ID: 6528
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
2053Colon cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of LCP1 mRNAincreases expression 14729362
C059041 calyculin A calyculin A results in increased phosphorylation of LCP1 proteinincreases phosphorylation 14769871
C059041 calyculin A KT 5926 inhibits the reaction [calyculin A results in increased phosphorylation of LCP1 protein]decreases reaction|increases phosphorylation 14769871
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of LCP1 mRNAaffects expression 17484886
D003474 Curcumin Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LCP1 mRNA]decreases reaction|increases expression 18200517
D004041 Dietary Fats Dietary Fats results in decreased expression of LCP1 mRNAdecreases expression 18042831
C063769 KT 5926 KT 5926 inhibits the reaction [calyculin A results in increased phosphorylation of LCP1 protein]decreases reaction|increases phosphorylation 14769871
C063769 KT 5926 KT 5926 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of LCP1 protein]decreases reaction|increases phosphorylation 14769871
C041786 palm oil palm oil results in decreased expression of LCP1 mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of LCP1 mRNAdecreases expression 20059764
18445702
17426115
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of LCP1 mRNA]decreases expression|increases reaction 20059764
D013755 Tetradecanoylphorbol Acetate KT 5926 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of LCP1 protein]decreases reaction|increases phosphorylation 14769871
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased phosphorylation of LCP1 proteinincreases phosphorylation 14769871
D014302 Trinitrobenzenesulfonic Acid Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LCP1 mRNA]decreases reaction|increases expression 18200517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of LCP1 mRNAincreases expression 18200517
C025643 vinclozolin vinclozolin affects the expression of LCP1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D019973 Alcohol-Related Disorders Curcumin 5.3017887948
MESH:D000544 Alzheimer Disease Curcumin 2.6415590663
MESH:D001008 Anxiety Disorders vinclozolin 3.7519015723
MESH:D001161 Arteriosclerosis Dietary Fats 4.0615238619
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7616807698
MESH:D050197 Atherosclerosis Curcumin 3.4018704882
MESH:D001327 Autoimmune Diseases Curcumin 4.6719761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2919483382
MESH:D002545 Brain Ischemia Curcumin 4.5216770732
MESH:D001932 Brain Neoplasms Curcumin 4.0717596214
MESH:D001943 Breast Neoplasms Curcumin 2.3516243823 19250217 18462866 18593918
MESH:D001943 Breast Neoplasms Dietary Fats 2.3520435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9516227642 16011737 15700767 16124888 16097048 16050911 15673190 16192424 15721981 3786805 18705752 10355542
MESH:D002277 Carcinoma Curcumin 3.9518593918
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8418788625
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0218414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 5.1918462866
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 5.1918922899
MESH:D002779 Cholestasis pirinixic acid 2.9319176532
MESH:D003092 Colitis Curcumin 10.5518200517 16804969 16782535
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 10.5516782535 11698051 16804969 16867261 16474422 18023891 18200517 17991707 17936198
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.4817276891
MESH:D003103 Coloboma Curcumin 4.6918809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5216340194 19359593
MESH:D016510 Corneal Neovascularization Curcumin 5.0718497527
MESH:D003456 Cryptorchidism vinclozolin 4.5014966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7318403477
MESH:D003928 Diabetic Nephropathies Curcumin 4.1318204486
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.0710092053 17522070 15998439 16177239 6884620 4309450 3732212 15968718 7179309 19085960 7120509 9327722 15027814 21278145 19336974 2869522 3786805 10915739 11566570 16227642 6623471 7440962
MESH:D004381 Duodenal Ulcer Curcumin 4.2117351913
MESH:D050171 Dyslipidemias Dietary Fats 3.5518367378
MESH:D004487 Edema pirinixic acid 7.4612083418
MESH:D004487 Edema Tetradecanoylphorbol Acetate 7.467812673 16716910 8113982 11698051 8273558 15177302 9599246
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.0012631006 61145 16045604 19224547 15959796 17595544 12795759 16239168
MESH:D005234 Fatty Liver Curcumin 20.0019297423
MESH:D005234 Fatty Liver Dietary Fats 20.0017967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver pirinixic acid 20.0019236843 20131406
MESH:D005355 Fibrosis Carbon Tetrachloride 22.8018705752
MESH:D005355 Fibrosis Curcumin 22.8018705752
MESH:D005355 Fibrosis Dietary Fats 22.8018296743
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 22.8017994277
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.8718462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5216417039
MESH:D005909 Glioblastoma Curcumin 3.5617596214
MESH:D006258 Head and Neck Neoplasms Curcumin 3.7518829502 18462866
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.1719772884 16221962 19176532 18467677
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.2217701891
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006937 Hypercholesterolemia Curcumin 9.7018704882
MESH:D006937 Hypercholesterolemia Dietary Fats 9.7021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.7621332399
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007248 Infertility, Male vinclozolin 3.1316467254
MESH:D007249 Inflammation Curcumin 8.9218403477 17151092 16956363
MESH:D007249 Inflammation Dietary Fats 8.9220412841
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 8.9211698051 8273558 15177302 7812673 7562506
MESH:D015212 Inflammatory Bowel Diseases Curcumin 6.8518200517 18596194
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 6.8518200517
MESH:D007333 Insulin Resistance Dietary Fats 7.5418457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.5416306350
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.7817994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.3510783313
MESH:D007889 Leiomyoma Curcumin 4.7218555241
MESH:D007938 Leukemia Curcumin 3.3018462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.3416106398
MESH:D015458 Leukemia, T-Cell Curcumin 4.9216106398
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9316417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.8716943688 16239168 11408273 17334410 16221502 17174718 17157831 11903743 21278145
MESH:D008103 Liver Cirrhosis Dietary Fats 6.8718296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.6015362042 17714472 18339082 18395914 18429990 16015684 15123356 12649538 16027843 18472094 18205269 15730626 18395095 18210741 12609069 15925388 13678700 12445418 17766677 14620537 16097048 12632514 14724832 17481882 11481614 17698563 17900296 12389079 16033810 12666154 18187930 16248980 15650968 18054572 15052691 17557913 18317297 12546737 20821823 15818738 15057751 16638106 18166357 15996030 15893842 15338365 18279442 12586293 17721639 18006644 17631135 12741479 12632512 17805973 10355542 18472332 16192424 18412020 18156304 15370692 14716496 15931870 12667390 17761835 12958196 17922224 18481824 14748882 17525996 16136751 18263696 17708605 14716833 18251166 18418968 17823541 17565644 12898905 16116963 18376398 15876570 14512876 12445421 17869086 15959796 18277467 17640975 15673190 18705752 17976157 16011737 17944888 18420326
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 3.6018006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6015474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.3717285989 16964402 16246199 15830285 15720792
MESH:D008107 Liver Diseases Curcumin 4.3716956363
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8216899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.5919294768
MESH:D008113 Liver Neoplasms pirinixic acid 4.5916377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.6915583823 12014681
MESH:D008175 Lung Neoplasms Curcumin 2.9319359593 16243823 18462866
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 2.9311807781
MESH:D008223 Lymphoma Curcumin 3.6818462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.8716173963
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 3.448985016
MESH:D008545 Melanoma Curcumin 2.4317885582 18462866
MESH:D008569 Memory Disorders Curcumin 4.3117263510
MESH:D009101 Multiple Myeloma Curcumin 3.6119372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.1117962980
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009361 Neoplasm Invasiveness Curcumin 4.5318495463
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.7512497104
MESH:D009423 Nervous System Neoplasms Curcumin 5.8518462866
MESH:D009765 Obesity Curcumin 7.6219297423
MESH:D009765 Obesity Dietary Fats 7.6217217161 11836018 19632207 20518802 18457598 16723640 21332399 18674790 20132043
MESH:D009765 Obesity pirinixic acid 7.6220558911
MESH:D010024 Osteoporosis Curcumin 3.5518719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.8519020741 18462866
MESH:D010190 Pancreatic Neoplasms Curcumin 5.8319401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 5.8315976015
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.3517698068
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.4712065085 18922899 8330346 18404319
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.0918042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.1318220299
MESH:D011471 Prostatic Neoplasms Curcumin 3.6618769126 18226269 15129424 11398177 10851300 12497104 18156803
MESH:D011472 Prostatitis vinclozolin 5.1318629315
MESH:D011656 Pulmonary Emphysema Curcumin 4.6619168576
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.1718379247 10666014
MESH:D012509 Sarcoma Curcumin 4.2518462866
MESH:D018805 Sepsis Curcumin 4.1918389075
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.258532709
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 6.2518404319 8985016 12065085 11807781 8330346
MESH:D013276 Stomach Ulcer Curcumin 3.6316631530 19188055
MESH:D001749 Urinary Bladder Neoplasms Curcumin 2.9318593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.4618462866
MESH:D015430 Weight Gain Dietary Fats 3.8616723640
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30312
    • Releated gene ID Related gene Name
    PA24910APP
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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