AutismKB 2.0

Annotation Detail for LCP2


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Basic Information Top
Gene Symbol:LCP2 ( SLP-76,SLP76 )
Gene Full Name: lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
Band: 5q35.1
Quick LinksEntrez ID:3937; OMIM: 601603; Uniprot ID:LCP2_HUMAN; ENSEMBL ID: ENSG00000043462; HGNC ID: 6529
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
Pathway IDPathway Name
Hemostasis
Signaling in Immune system
Pathway IDPathway Name
200003Fc-epsilon receptor I signaling in mast cells
200129JNK signaling in the CD4+ TCR pathway
200062TCR signaling in naive CD8+ T cells
200022TCR signaling in naive CD4+ T cells
Pathway IDPathway Name
P00053T cell activation
Pathway IDPathway Name
500481Generation of second messenger molecules
500294GPVI-mediated activation cascade
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1712Yersinia infection
1781Rheumatoid arthritis
1923Generalized anxiety disorder
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of LCP2 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of LCP2 mRNAdecreases expression 17879257
C006780 bisphenol A bisphenol A results in increased expression of LCP2 mRNAincreases expression 17010207
D003474 Curcumin Curcumin results in increased expression of LCP2 mRNAincreases expression 17198877
D019833 Genistein Genistein results in increased expression of LCP2 mRNAincreases expression 17010207
C025256 nonylphenol nonylphenol results in increased expression of LCP2 mRNAincreases expression 17010207
C093973 PD 98059 PD 98059 inhibits the reaction [Tretinoin results in increased expression of LCP2 protein]decreases reaction|increases expression 16439309
D020058 Styrene Styrene results in decreased expression of LCP2 mRNAdecreases expression 15212811
D020058 Styrene Styrene results in decreased expression of LCP2 proteindecreases expression 15212811
D014212 Tretinoin [LCP2 protein co-treated with CSF1R protein] promotes the reaction [Tretinoin results in increased expression of PXN protein]affects cotreatment|increases expression|increases reaction 16439309
D014212 Tretinoin [LCP2 protein co-treated with CSF1R protein] promotes the reaction [Tretinoin results in increased phosphorylation of MAPK1 protein]affects cotreatment|increases phosphorylation|increases reaction 16439309
D014212 Tretinoin [LCP2 protein co-treated with CSF1R protein] promotes the reaction [Tretinoin results in increased phosphorylation of MAPK3 protein]affects cotreatment|increases phosphorylation|increases reaction 16439309
D014212 Tretinoin PD 98059 inhibits the reaction [Tretinoin results in increased expression of LCP2 protein]decreases reaction|increases expression 16439309
D014212 Tretinoin Tretinoin results in increased expression of LCP2 proteinincreases expression 16439309
D014212 Tretinoin Tretinoin results in increased phosphorylation of LCP2 proteinincreases phosphorylation 16439309
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5720464547 20127859
MESH:D000230 Adenocarcinoma Genistein 4.5711473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D019973 Alcohol-Related Disorders Curcumin 5.4017887948
MESH:D000505 Alopecia Tretinoin 3.7815955085
MESH:D000544 Alzheimer Disease Curcumin 2.6515590663
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.1916412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.8716807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.8716292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D050197 Atherosclerosis Curcumin 3.4318704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Curcumin 4.7519761891
MESH:D001471 Barrett Esophagus Tretinoin 4.6416935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8116197459 16206674
MESH:D001862 Bone Resorption bisphenol A 4.0711985600
MESH:D002545 Brain Ischemia Curcumin 4.6116770732
MESH:D001932 Brain Neoplasms Curcumin 4.1317596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.0620146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 3.0617123778
MESH:D001943 Breast Neoplasms Curcumin 3.0619250217 16243823 18593918 18462866
MESH:D001943 Breast Neoplasms Genistein 3.0617200150 16873071 16541309
MESH:D001943 Breast Neoplasms Styrene 3.0615986119
MESH:D001943 Breast Neoplasms Tretinoin 3.0616166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8816813970
MESH:D002277 Carcinoma Curcumin 4.0018593918
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4816168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.733084413
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.7316924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.731917145
MESH:D002278 Carcinoma in Situ bisphenol A 5.2717123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0418414057
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.8720419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 7.8718462866
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.8716051514 16096774
MESH:D002318 Cardiovascular Diseases Genistein 3.4416332659
MESH:D002386 Cataract Acetaminophen 7.6010977129
MESH:D002386 Cataract Tretinoin 7.6017460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8816129372
MESH:D002822 Choriocarcinoma Tretinoin 5.4816461808
MESH:D002972 Cleft Palate Tretinoin 2.749407595
MESH:D003092 Colitis Curcumin 10.5216804969 18200517 16782535
MESH:D003092 Colitis Tretinoin 10.5217035595
MESH:D003103 Coloboma Curcumin 4.7618809619
MESH:D003110 Colonic Neoplasms Curcumin 4.0619359593 16340194
MESH:D003110 Colonic Neoplasms Genistein 4.0617182828
MESH:D016510 Corneal Neovascularization Curcumin 5.1618497527
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.839211117 16925845 9142499 10589399 9224671 17551590 9125849 8800419 9664655 14991402
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.8518403477
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.8516647724
MESH:D003928 Diabetic Nephropathies Curcumin 4.1918204486
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6319164858 11743745 2444490 19416960 17562736 17906064 15619225 11739529 10663392 19085960 10774834 15968718 16393943 14725611 12392966 18713872 16485898 12705907 12594235 16177239 11529661 16081117 19370779 14986274 19923254 10915739 11421492 16781746 12540782 12958197 19420014 11287661 12153990 16109766 14550746 18071297 17522070 19739265 11461765 16227642 11834606
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004381 Duodenal Ulcer Curcumin 4.2817351913
MESH:D004489 Edema, Cardiac Tretinoin 4.7818230668
MESH:D004714 Endometrial Hyperplasia Genistein 4.8716402032
MESH:D016889 Endometrial Neoplasms Genistein 7.9811473722
MESH:D016889 Endometrial Neoplasms Tretinoin 7.9816569247
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0516530937
MESH:D005124 Eye Abnormalities Tretinoin 3.7316938888 9664655
MESH:D005234 Fatty Liver Curcumin 3.9019297423
MESH:D005355 Fibrosis Curcumin 9.8818705752
MESH:D005355 Fibrosis Tretinoin 9.8817994277
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.9518462866
MESH:D005909 Glioblastoma Curcumin 12.7017596214
MESH:D005909 Glioblastoma Genistein 12.7016598420
MESH:D005909 Glioblastoma Tretinoin 12.7017312396
MESH:D006258 Head and Neck Neoplasms Curcumin 8.3418462866 18829502
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.3416096774
MESH:D034381 Hearing Loss Styrene 5.5817420221
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9820471113
MESH:D006330 Heart Defects, Congenital Tretinoin 6.989664655 14991402
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.3017701891
MESH:D006930 Hyperalgesia Acetaminophen 8.1816870215
MESH:D006930 Hyperalgesia Tretinoin 8.1816870215
MESH:D006937 Hypercholesterolemia Curcumin 4.2618704882
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8316778211
MESH:D007249 Inflammation Curcumin 2.9818403477 17151092 16956363
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2818200517 18596194
MESH:D007333 Insulin Resistance bisphenol A 3.4116393666
MESH:D007410 Intestinal Diseases Tretinoin 4.0217994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.4110783313
MESH:D007569 Jaw Abnormalities Tretinoin 4.1117551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.3015629191 12587719
MESH:D007889 Leiomyoma Curcumin 4.7918555241
MESH:D007938 Leukemia Curcumin 11.0918462866
MESH:D007938 Leukemia Genistein 11.0917468513 18980019
MESH:D007938 Leukemia Tretinoin 11.0917143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.4116106398
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 5.5116972261
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9016932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1017596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2817294898 16140955 9834237 12679006 19642359 15748426 19035177 17506722 17361223 17712046 16891316 16331271 19075265 19225113 16823087 17368321 19029980 16766008 17301526 17217047 17649720 16935935 16788101 17107899 17339181
MESH:D015458 Leukemia, T-Cell Curcumin 5.0016106398
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.459224671
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 3.7418705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.7417823541
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.7416248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 4.2419014921 16611625 19784758 12587719 19460945 11587558 16610002 12969438
MESH:D008107 Liver Diseases Curcumin 4.2416956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1020195826 21137059
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.8220135361 20464547 18520028 18816296 6695378 18569708 20064080 20869020 17053015
MESH:D008175 Lung Neoplasms Curcumin 3.8218462866 19359593 16243823
MESH:D008175 Lung Neoplasms Styrene 3.8212562636
MESH:D008223 Lymphoma Curcumin 3.7318462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.9516173963
MESH:D015674 Mammary Neoplasms, Animal Styrene 5.7412562636
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0614578162 12929590
MESH:D008527 Medulloblastoma Tretinoin 2.8517453147
MESH:D008545 Melanoma Curcumin 3.5817885582 18462866
MESH:D008545 Melanoma Tretinoin 3.5816752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008569 Memory Disorders Curcumin 4.3917263510
MESH:D008591 Meningomyelocele Tretinoin 4.6816940565
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009101 Multiple Myeloma Curcumin 3.6519372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.2017962980
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1917596541
MESH:D009203 Myocardial Infarction Genistein 2.9317141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.8217141266
MESH:D009361 Neoplasm Invasiveness Curcumin 4.6118495463
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2911141357
MESH:D009369 Neoplasms Tretinoin 5.2916594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.8512497104
MESH:D009421 Nervous System Malformations bisphenol A 17.9316427766 11399458
MESH:D009421 Nervous System Malformations Genistein 17.9316427766
MESH:D009421 Nervous System Malformations Tretinoin 17.939125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.9518462866
MESH:D009436 Neural Tube Defects Tretinoin 3.189142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity Curcumin 2.7919297423
MESH:D010024 Osteoporosis Curcumin 7.7618719352
MESH:D010024 Osteoporosis Genistein 7.7619401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3116169203
MESH:D010049 Ovarian Diseases bisphenol A 5.2711985600
MESH:D010051 Ovarian Neoplasms Curcumin 8.3019020741 18462866
MESH:D010051 Ovarian Neoplasms Genistein 8.3019005980
MESH:D010051 Ovarian Neoplasms Tretinoin 8.3016936753
MESH:D010146 Pain Acetaminophen 7.1616870215
MESH:D010146 Pain Tretinoin 7.1616870215
MESH:D010190 Pancreatic Neoplasms Curcumin 5.6519196508 19401701 17440100
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.6515976015
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.2410548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4120887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0817292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0816740699
MESH:D011471 Prostatic Neoplasms Curcumin 2.0811398177 18769126 18156803 10851300 12497104 18226269 15129424
MESH:D011471 Prostatic Neoplasms Genistein 2.0816925846 15378649 15256057
MESH:D011507 Proteinuria Tretinoin 3.8216636307
MESH:D011625 Pterygium Tretinoin 5.0816723453
MESH:D011629 Puberty, Precocious bisphenol A 5.0710548101
MESH:D011656 Pulmonary Emphysema Curcumin 4.7219168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.2518379247 10666014
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3216116481 16283617
MESH:D012509 Sarcoma Curcumin 4.3118462866
MESH:D018805 Sepsis Curcumin 4.2518389075
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.9710029692 19755658
MESH:D012878 Skin Neoplasms Tretinoin 5.9716467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3920155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.3917261132
MESH:D013276 Stomach Ulcer Curcumin 3.7016631530 19188055
MESH:D019966 Substance-Related Disorders bisphenol A 4.2716045194 16684133
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1816026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9816051514
MESH:D014376 Tuberculosis Tretinoin 3.3416040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.4317053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.4318593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.5518462866
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8716129372
MESH:D014591 Uterine Diseases bisphenol A 5.3314652134
MESH:D014604 Uveal Neoplasms Tretinoin 4.9316752155
MESH:D014820 Vitiligo Tretinoin 4.2916761959
MESH:D009396 Wilms Tumor Tretinoin 4.1516287080
Pathway ID Pathway Name
KEGG:04664 Fc epsilon RI signaling pathway
REACT:604 Hemostasis
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04380 Osteoclast differentiation
REACT:6900 Signaling in Immune system
KEGG:04660 T cell receptor signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30313
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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