AutismKB 2.0

Annotation Detail for ARHGAP5


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Basic Information Top
Gene Symbol:ARHGAP5 ( GFI2,RhoGAP5,p190-B,p190BRhoGAP )
Gene Full Name: Rho GTPase activating protein 5
Band: 14q12
Quick LinksEntrez ID:394; OMIM: 602680; Uniprot ID:RHG05_HUMAN; ENSEMBL ID: ENSG00000100852; HGNC ID: 675
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04510Focal adhesion
Pathway IDPathway Name
Signaling by Rho GTPases
Pathway IDPathway Name
200190RAC1 signaling pathway
200050Regulation of RhoA activity
Pathway IDPathway Name
P00047PDGF signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ARHGAP5 mRNAaffects expression 21346803
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of ARHGAP5 mRNAdecreases expression 12419474
C006632 arsenic trioxide arsenic trioxide results in increased expression of ARHGAP5 mRNAincreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ARHGAP5 mRNAdecreases expression 19150397
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ARHGAP5 mRNAaffects cotreatment|decreases expression 16054899
D003907 Dexamethasone EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ARHGAP5 mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
D003907 Dexamethasone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ARHGAP5 mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ARHGAP5 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ARHGAP5 mRNA]decreases reaction|increases expression 17942915
D002117 Calcitriol Calcitriol results in increased expression of ARHGAP5 mRNAincreases expression 16002434
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of ARHGAP5 mRNAaffects cotreatment|increases expression 17183730
C051890 irinotecan irinotecan metabolite results in decreased expression of ARHGAP5 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan metabolite results in increased expression of ARHGAP5 mRNAincreases expression 15956246
C051890 irinotecan irinotecan results in decreased expression of ARHGAP5 mRNAdecreases expression 15956246
C051890 irinotecan irinotecan results in increased expression of ARHGAP5 mRNAincreases expression 15956246
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ARHGAP5 mRNAaffects cotreatment|decreases expression 16054899
D015056 1-Methyl-3-isobutylxanthine EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ARHGAP5 mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
D015056 1-Methyl-3-isobutylxanthine Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ARHGAP5 mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ARHGAP5 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of ARHGAP5 mRNAdecreases expression 18445702
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ARHGAP5 mRNAaffects cotreatment|decreases expression 16054899
C089730 rosiglitazone EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ARHGAP5 mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
C089730 rosiglitazone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ARHGAP5 mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
C017947 sodium arsenite sodium arsenite results in decreased expression of ARHGAP5 mRNAdecreases expression 12760830
C017947 sodium arsenite sodium arsenite results in increased expression of ARHGAP5 mRNAincreases expression 16322246
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of ARHGAP5 mRNAaffects expression 18691609
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ARHGAP5 mRNA]affects cotreatment|decreases expression|decreases reaction 16054899
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of ARHGAP5 mRNAaffects cotreatment|increases expression 17183730
C025643 vinclozolin vinclozolin affects the expression of ARHGAP5 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.3815322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.388875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9319490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.2911798837 19825857
MESH:D000236 Adenoma Diethylnitrosamine 2.856695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.4119061943 19052882 17620307 16434500 18056438 17162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.4116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.4116835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9317306315 16712894
MESH:D000544 Alzheimer Disease rosiglitazone 2.8519621015
MESH:D000550 Amblyopia Valproic Acid 5.2617688650
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.1010965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D001008 Anxiety Disorders Valproic Acid 8.8617497229
MESH:D001008 Anxiety Disorders vinclozolin 8.8619015723
MESH:D001169 Arthritis, Experimental Dexamethasone 3.5417659584
MESH:D001321 Autistic Disorder Valproic Acid 2.0018316065 18775368 17507914 16609825 18940202 17157402 18985861 17688650 15238991 18177632 20603192 18558336 19232924 19460635 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 3.0820046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.3116206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.3119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.3112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.0315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.038888407
MESH:D001943 Breast Neoplasms Calcitriol 1.8811237771
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8817474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3411589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.5916705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.5915073043 16217749 11135700 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.5919052882 19519916 16569478 16779866 18210153 18785209 20727157 16807293 17978847 19539802 19171122 20007298 16935385 11831363 20214788 20084675 17138121 19701751 17761372 18393292 3084413 19822196 19208518 21159647 17173139 20524982 18506893 20512989 16288022 18056438 16328049 10737359 16502159 17055752 18691550 19335982 3581430 20935162 17162532 10672840 18971187 18978308 17428255 20101231 19383236 18665156 16681979 19394651 19107877 18788625 20514400 16830150 19418558 16698587 16878318 18494052 16540662 20432363 19919837
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.5915276417 17306315 16507464
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1212490120
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.8111237771
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.8118572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3716120746 18850075 18670907
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.056135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.0520889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.0521159647 2727394 17174075 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 16.0519524636 20056578
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7120734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.3319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.3316835633
MESH:D002779 Cholestasis pirinixic acid 2.8319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1016354765 15340226 8697196 12621046 15668235
MESH:D003110 Colonic Neoplasms Dexamethasone 4.0615824018
MESH:D003110 Colonic Neoplasms irinotecan 4.0617287894 17725105
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6820501625
MESH:D015179 Colorectal Neoplasms irinotecan 2.6818509181 16391804 15273666 18259882 17454858 17159606 16303861
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0617141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.4310525206
MESH:D019465 Craniofacial Abnormalities Dexamethasone 5.4317728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.4310048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.4317688650 8888407 16575769
MESH:D003456 Cryptorchidism vinclozolin 4.3514966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1015213294
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.4212438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.3017446233
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.1720387270
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 7.1712642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.1717107852
MESH:D003967 Diarrhea Dexamethasone 3.717237001
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.9818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.9819107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.9820420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 8.981733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D004421 Dystonia Valproic Acid 4.061851702
MESH:D004485 Eczema Dexamethasone 4.4712438553
MESH:D004487 Edema Dexamethasone 16.5219703484
MESH:D004487 Edema pirinixic acid 16.5212083418
MESH:D004487 Edema rosiglitazone 16.5212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 16.5212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9316714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.9415138306
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.029294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.173659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.9516628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9418234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.596426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.317750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.083659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1516302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4620426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.4612903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver arsenic trioxide 24.7415073043
MESH:D005234 Fatty Liver Diethylnitrosamine 24.7420387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 24.7419236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 24.7419196556
MESH:D005234 Fatty Liver Valproic Acid 24.7414986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005315 Fetal Diseases Valproic Acid 4.9216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.1418558336 8888407
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9620067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2716904648
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3316417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7016452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006529 Hepatomegaly pirinixic acid 8.3116221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.3115340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.077520565
MESH:D006689 Hodgkin Disease sodium arsenite 3.1612676792
MESH:D006849 Hydrocephalus Valproic Acid 4.8917688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.088697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia rosiglitazone 3.9212083418
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006973 Hypertension Dexamethasone 5.2517042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2518850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.6416612254
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.4718306037
MESH:D007248 Infertility, Male sodium arsenite 6.8515346721 12646999
MESH:D007248 Infertility, Male vinclozolin 6.8516467254
MESH:D007249 Inflammation Dexamethasone 12.028960868 11099482
MESH:D007249 Inflammation Diethylnitrosamine 12.0218785209
MESH:D007249 Inflammation rosiglitazone 12.0212083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.0212200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 7.5116306350
MESH:D007333 Insulin Resistance rosiglitazone 7.5116306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.4718306037
MESH:D007674 Kidney Diseases sodium arsenite 2.8020008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 2.9816705839
MESH:D007938 Leukemia arsenic trioxide 2.8315070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8017077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7619077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9117050201 16968895 19850784 20471514 16467208
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9116294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2219225113 11468182 16966277 17712046 16330433 12712474 16331271 17217047 11161223 12018890 15748426 17107899 16823087 19642359 12679006 16112521 16891316 15336539 17869043 19035177 9834237 19075265 15213294 15622746 17649720
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3616882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7516417039
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8218665156 19638242 20032147 18407596 18522880
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 4.9916718785
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9915474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 4.9915980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9912878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1017034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 18.017678174
MESH:D008113 Liver Neoplasms arsenic trioxide 18.0114682389
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.0120492335 20118626 19690152 19255062 19426721 21167192 19073162 19996281 19427195 19850985 10737359 19256749 16942905 19090486 21047994 18978307 20405173 2862719 12112319 20583210 18648771 21071580 18754104 19833225 18977376 19642983 21278145 20434301 19294768 19551842 18644402 15885732 19812893 20501860 12771043 2422723 15175105 9163691 20137499 19254457 20452335 20101389 19638242 19499222
MESH:D008113 Liver Neoplasms pirinixic acid 18.0115890375 20007298 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 18.0116712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.0116984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.136135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.1320377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.1318775883 16842330 18544905 2563599 18079962 19009564 18164116 17174075 3124819 17942915 18253720 19539802 19126423 17854601 19004024 18308698 19519916 21159647 9362446 18282651 18093689 16267830
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.1312151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3515213294
MESH:D008171 Lung Diseases sodium arsenite 3.1719095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2917228818
MESH:D008175 Lung Neoplasms arsenic trioxide 6.6011798837 19825857
MESH:D008175 Lung Neoplasms Dexamethasone 6.6015824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.6021163286 20512841 6695378 20970405
MESH:D008175 Lung Neoplasms sodium arsenite 6.6015276417 17306315 19931552 17077188 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.6019555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 3.3916827153
MESH:D008545 Melanoma sodium arsenite 2.0316487513 19082730
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.3817261469
MESH:D008881 Migraine Disorders Valproic Acid 3.1918765137 18803445
MESH:D052016 Mucositis irinotecan 5.0317159606
MESH:D009101 Multiple Myeloma arsenic trioxide 7.4415949261 11468182 19417148 14977855 19549372
MESH:D009101 Multiple Myeloma Dexamethasone 7.4415867202 16118317 15744524
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.038888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 12.3816882451 16105982
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 12.389809623
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 12.3817596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9516411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.8818551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9716624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.963581430 9029167
MESH:D009362 Neoplasm Metastasis irinotecan 5.9618259882
MESH:D009369 Neoplasms pirinixic acid 4.9417405874
MESH:D009369 Neoplasms sodium arsenite 4.9411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6820056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2214600291
MESH:D009436 Neural Tube Defects arsenic trioxide 12.1810525206
MESH:D009436 Neural Tube Defects sodium arsenite 12.1812854658
MESH:D009436 Neural Tube Defects Valproic Acid 12.1816359493 8888407
MESH:D009447 Neuroblastoma irinotecan 3.488761367
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3420387270
MESH:D017599 Neuroectodermal Tumors irinotecan 4.758761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1520387270
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4316049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.9112452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.9117306315 15276417
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.2815580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.2816540662
MESH:D010235 Paraganglioma arsenic trioxide 4.1719927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.5311550810
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.552563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.5421297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.3711222880 11118676 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 16.3720603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 16.3719015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.9518220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.8015572423
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6319131511
MESH:D011471 Prostatic Neoplasms Calcitriol 2.6316644109 18247401 15754350 16289102 12479363
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6316039940
MESH:D011472 Prostatitis vinclozolin 4.9518629315
MESH:D019310 Pseudolymphoma Valproic Acid 4.5711422049 12752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.0218379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.1819155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9716646077
MESH:D012559 Schizophrenia Valproic Acid 2.0719110320 15737665
MESH:D012640 Seizures 2,6-dinitrotoluene 5.9518551238
MESH:D012640 Seizures Valproic Acid 5.9514763951 17978042 3137016 11738929 1511512 16876388 11044598 15475178
MESH:D012878 Skin Neoplasms sodium arsenite 5.6019524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6016192470
MESH:D016135 Spinal Dysraphism sodium arsenite 9.5512854658
MESH:D016135 Spinal Dysraphism Valproic Acid 9.5519490988
MESH:D013226 Status Epilepticus Valproic Acid 4.5712833885
MESH:D013272 Stomach Diseases Dexamethasone 4.3415472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.4417007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.4418456281
MESH:D013274 Stomach Neoplasms irinotecan 3.4415723263
MESH:D013276 Stomach Ulcer Dexamethasone 3.4915138204
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.2019014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.207505956
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9815213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.2617262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.543119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.3416049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.3412845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.3416452187 16712894 11723127 17306315
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.668888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3410091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.7711813266
MESH:D014605 Uveitis Dexamethasone 4.851336536
MESH:D014652 Vascular Diseases sodium arsenite 4.4417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
Pathway ID Pathway Name
KEGG:04510 Focal adhesion
KEGG:04670 Leukocyte transendothelial migration
REACT:11044 Signaling by Rho GTPases
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24959
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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