AutismKB 2.0

Annotation Detail for LDLR


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:LDLR ( FH,FHC,LDLCQ2 )
Gene Full Name: low density lipoprotein receptor
Band: 19p13.2
Quick LinksEntrez ID:3949; OMIM: 606945; Uniprot ID:LDLR_HUMAN; ENSEMBL ID: ENSG00000130164; HGNC ID: 6547
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05160Hepatitis C
hsa04144Endocytosis
hsa05145Toxoplasmosis
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500798LDL-mediated lipid transport
500795Lipoprotein metabolism
500796Chylomicron-mediated lipid transport
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of lipid/glycolipid metabolism
H00155Hypercholesterolemia, autosomal dominant
Genetic disorders
Desease IDDesease Name
1740Alzheimer's disease
1893Esotropia
1894Abortion
1909Migraine
1918Atherosclerosis
1951Overnutrition
1954Stroke
1994Biliary cancer
2052Infection
Desease Name
cholesterol
CARDIOVASCULAR
Coronary Artery Disease
Diabetes Mellitus
hypercholesterolemia of hypothyroidism
cholesterol, LDL
cirrhosis hepatitis C, chronic
Achilles tendon xanthomas
Alzheimer's disease
myocardial infarction (early onset)
mild familial hypercholesterolemia
normal serum cholesterol levels
hypertension
NEUROLOGICAL
hyperlipidemia
METABOLIC
LDL cholesterol
familial hypercholesterolemia.
obesity
hepatitis C
cholesterol, total
cholesterol, HDL cholesterol, LDL
plasma lipid and apolipoprotein levels
carotid artery intima-media thickness
INFECTION
mild familial hypercholesterolaemia
differential plasma lipoprotein response to simvastatin
Desease Name
Cholesterol, total
LDL cholesterol
Myocardial infarction (early onset)
Desease Name
LDL cholesterol level QTL2
Hypercholesterolemia, familial
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C003585 22-hydroxycholesterol 22-hydroxycholesterol results in decreased expression of LDLR mRNAdecreases expression 16142410
C076996 27-hydroxycholesterol 27-hydroxycholesterol results in decreased activity of LDLR proteindecreases activity 8820113
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of LDLR proteinaffects expression 20106945
D000420 Albuterol LDLR gene SNP affects the susceptibility to Albuterolaffects response to substance 15453913
D000638 Amiodarone Amiodarone promotes the reaction [Triiodothyronine results in increased expression of LDLR mRNA]increases expression|increases reaction 9712728
D000638 Amiodarone Amiodarone results in decreased expression of LDLR mRNAdecreases expression 9712728
D000638 Amiodarone Amiodarone results in decreased expression of LDLR mRNAdecreases expression 9071962
9751232
8137927
D000638 Amiodarone Amiodarone results in decreased expression of LDLR proteindecreases expression 9751232
12538616
9071962
D000638 Amiodarone Triiodothyronine inhibits the reaction [Amiodarone results in decreased expression of LDLR protein]decreases expression|decreases reaction 9071962
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LDLR mRNAaffects expression 16483693
C065179 atorvastatin atorvastatin results in increased activity of LDLR proteinincreases activity 12612140
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of LDLR mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LDLR mRNAdecreases expression 19150397
D001599 Berberine Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]decreases reaction|increases expression 20564506
D001599 Berberine Berberine inhibits the reaction [Risperidone results in increased expression of LDLR mRNA]decreases reaction|increases expression 20564506
C053541 bicalutamide bicalutamide affects the localization of LDLR proteinaffects localization 17440980
D001647 Bile Acids and Salts [CYP27A1 protein results in increased chemical synthesis of Bile Acids and Salts] promotes the reaction [LDLR protein results in increased uptake of Cholesterol]increases chemical synthesis|increases reaction|increases uptake 16477808
D001647 Bile Acids and Salts [CYP27A1 protein results in increased chemical synthesis of Bile Acids and Salts] which results in increased expression of LDLR mRNAincreases chemical synthesis|increases expression 16477808
C027561 butylbenzyl phthalate butylbenzyl phthalate results in decreased expression of LDLR mRNAdecreases expression 15728792
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of LDLR mRNAincreases expression 12414654
D002746 Chlorpromazine Chlorpromazine results in increased expression of LDLR mRNAincreases expression 17052361
D002784 Cholesterol [CYP27A1 protein results in increased chemical synthesis of Bile Acids and Salts] promotes the reaction [LDLR protein results in increased uptake of Cholesterol]increases chemical synthesis|increases reaction|increases uptake 16477808
D002784 Cholesterol LDLR protein results in increased uptake of Cholesterolincreases uptake 16477808
D002784 Cholesterol Cholesterol results in decreased activity of LDLR proteindecreases activity 16317514
16937255
16271152
D002784 Cholesterol Cholesterol results in decreased expression of LDLR mRNAdecreases expression 16317514
16271152
16937255
D002784 Cholesterol Selenium inhibits the reaction [Cholesterol results in decreased activity of LDLR protein]decreases activity|decreases reaction 16937255
D002784 Cholesterol Selenium inhibits the reaction [Cholesterol results in decreased expression of LDLR mRNA]decreases expression|decreases reaction 16937255
D002791 Cholesterol, Dietary Cholesterol, Dietary results in decreased expression of LDLR mRNAdecreases expression 19509184
D002791 Cholesterol, Dietary [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of LDLR mRNAaffects cotreatment|decreases expression 19509184
D003008 Cloprostenol Cloprostenol results in decreased expression of LDLR mRNAdecreases expression 15713365
D003024 Clozapine Clozapine results in increased expression of LDLR mRNAincreases expression 17052361
D003024 Clozapine Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]decreases reaction|increases expression 20564506
D003024 Clozapine Clozapine results in increased expression of LDLR mRNAincreases expression 20564506
D003474 Curcumin Curcumin inhibits the reaction [INSIG2 protein results in decreased expression of LDLR mRNA]decreases expression|decreases reaction 18704882
D003474 Curcumin Curcumin results in increased expression of and results in increased activity of LDLR proteinincreases activity|increases expression 18704882
D003474 Curcumin Curcumin results in increased expression of LDLR mRNAincreases expression 16713233
16963807
18704882
D003474 Curcumin Curcumin results in increased expression of LDLR proteinincreases expression 16963807
D003474 Curcumin Curcumin results in decreased expression of LDLRdecreases expression 18462866
D016572 Cyclosporine Cyclosporine results in increased expression of LDLR mRNAincreases expression 20106945
C036116 desethylamiodarone desethylamiodarone promotes the reaction [Triiodothyronine results in increased expression of LDLR mRNA]increases expression|increases reaction 9712728
C036116 desethylamiodarone desethylamiodarone results in decreased expression of LDLR mRNAdecreases expression 9712728
D017135 Desogestrel [Desogestrel co-treated with Ethinyl Estradiol] results in increased expression of LDLR proteinaffects cotreatment|increases expression 17900441
D017135 Desogestrel Desogestrel results in increased expression of LDLR proteinincreases expression 17900441
D003993 Dibutyl Phthalate Dibutyl Phthalate results in decreased expression of LDLR mRNAdecreases expression 15728792
D003633 Dichlorodiphenyl Dichloroethylene Dichlorodiphenyl Dichloroethylene results in decreased expression of LDLR mRNAdecreases expression 15885261
D004041 Dietary Fats [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of LDLR mRNAaffects cotreatment|decreases expression 19509184
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of LDLR mRNAdecreases expression 15728792
C034171 di-n-pentyl phthalate di-n-pentyl phthalate results in decreased expression of LDLR mRNAdecreases expression 15728792
D000431 Ethanol Ethanol results in increased expression of LDLR mRNAincreases expression 15353170
D004997 Ethinyl Estradiol [Desogestrel co-treated with Ethinyl Estradiol] results in increased expression of LDLR proteinaffects cotreatment|increases expression 17900441
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of LDLR proteinincreases expression 17900441
D004997 Ethinyl Estradiol [Levonorgestrel co-treated with Ethinyl Estradiol] results in decreased expression of LDLR proteinaffects cotreatment|decreases expression 17900441
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of LDLR proteinincreases expression 10729376
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of LDLR mRNAaffects expression 17351261
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of LDLR mRNAincreases expression 16940010
12963437
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of LDLR proteinincreases expression 12475377
D005485 Flutamide Flutamide results in decreased expression of LDLR mRNAdecreases expression 15885261
D005632 Fructose [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of LDLR mRNAaffects cotreatment|decreases expression 19509184
D005707 Gallic Acid Gallic Acid results in increased expression of LDLR mRNAincreases expression 12612140
C106014 gedunin gedunin results in increased expression of LDLR mRNAincreases expression 17010675
C442817 GW 707 GW 707 results in increased activity of LDLR proteinincreases activity 12524230
C442817 GW 707 GW 707 results in increased expression of LDLR mRNAincreases expression 12524230
C442817 GW 707 Oncostatin M promotes the reaction [GW 707 results in increased activity of LDLR protein]increases activity|increases reaction 12524230
C442817 GW 707 Oncostatin M promotes the reaction [GW 707 results in increased expression of LDLR mRNA]increases expression|increases reaction 12524230
C442817 GW 707 Puromycin inhibits the reaction [GW 707 results in increased expression of LDLR mRNA]decreases reaction|increases expression 12524230
D006220 Haloperidol Haloperidol results in increased expression of LDLR mRNAincreases expression 17052361
D017313 Fenretinide Fenretinide results in decreased expression of LDLR mRNAdecreases expression 15958647
C029424 hydrazine hydrazine results in increased expression of LDLR mRNAincreases expression 15282401
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of LDLR mRNAincreases expression 12414654
D006861 Hydrogen Peroxide [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of LDLR mRNAaffects cotreatment|increases expression 18032389
D007529 Isoflavones Isoflavones affects the expression of LDLR mRNAaffects expression 16365062
C016527 isoquercitrin [isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of LDLR mRNAaffects cotreatment|increases expression 18032389
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of LDLR mRNAdecreases expression 18638454
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of LDLR proteindecreases expression 18638454
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of LDLR mRNAincreases expression 12057914
D008148 Lovastatin Lovastatin results in increased expression of LDLR mRNAincreases expression 12524230
D008148 Lovastatin Oncostatin M promotes the reaction [Lovastatin results in increased expression of LDLR mRNA]increases expression|increases reaction 12524230
C015329 lycopene lycopene results in increased expression of LDLR mRNAincreases expression 16886892
D015741 Metribolone Metribolone affects the localization of LDLR proteinaffects localization 17440980
D016912 Levonorgestrel Levonorgestrel affects the expression of LDLR proteinaffects expression 17900441
D016912 Levonorgestrel [Levonorgestrel co-treated with Ethinyl Estradiol] results in decreased expression of LDLR proteinaffects cotreatment|decreases expression 17900441
C076029 olanzapine olanzapine results in increased expression of LDLR mRNAincreases expression 17052361
D053683 Oncostatin M Oncostatin M promotes the reaction [GW 707 results in increased activity of LDLR protein]increases activity|increases reaction 12524230
D053683 Oncostatin M Oncostatin M promotes the reaction [GW 707 results in increased expression of LDLR mRNA]increases expression|increases reaction 12524230
D053683 Oncostatin M Oncostatin M promotes the reaction [Lovastatin results in increased expression of LDLR mRNA]increases expression|increases reaction 12524230
D053683 Oncostatin M Oncostatin M results in increased activity of LDLR proteinincreases activity 12524230
D053683 Oncostatin M Oncostatin M results in increased expression of LDLR mRNAincreases expression 12524230
D010126 Ozone Ozone results in increased expression of LDLR mRNAincreases expression 16330353
D017239 Paclitaxel LDLR protein affects the susceptibility to Paclitaxelaffects response to substance 16217747
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of LDLR mRNAincreases expression 17681415
D010656 Phenylephrine Phenylephrine results in increased expression of LDLR mRNAincreases expression 18158353
C006253 pirinixic acid pirinixic acid affects the expression of LDLR mRNAaffects expression 18445702
D028321 Plant Preparations Plant Preparations affects the expression of LDLR mRNAaffects expression 16251609
D011374 Progesterone Progesterone results in increased expression of LDLR mRNAincreases expression 18037150
18070364
D011374 Progesterone Progesterone affects the expression of LDLR mRNAaffects expression 17251523
D011374 Progesterone Progesterone results in increased expression of LDLR mRNAincreases expression 17170212
D011691 Puromycin Puromycin inhibits the reaction [GW 707 results in increased expression of LDLR mRNA]decreases reaction|increases expression 12524230
D020849 Raloxifene Raloxifene results in increased expression of LDLR mRNAincreases expression 16497877
D012110 Reserpine Reserpine results in increased expression of LDLR proteinincreases expression 10729376
D018967 Risperidone Berberine inhibits the reaction [Risperidone results in increased expression of LDLR mRNA]decreases reaction|increases expression 20564506
D018967 Risperidone Risperidone results in increased expression of LDLR mRNAincreases expression 20564506
D012643 Selenium Selenium deficiency results in decreased activity of LDLR proteindecreases activity 16317514
D012643 Selenium Selenium deficiency results in decreased expression of LDLR mRNAdecreases expression 16317514
D012643 Selenium Selenium inhibits the reaction [Cholesterol results in decreased activity of LDLR protein]decreases activity|decreases reaction 16937255
D012643 Selenium Selenium inhibits the reaction [Cholesterol results in decreased expression of LDLR mRNA]decreases expression|decreases reaction 16937255
D012643 Selenium Selenium results in increased activity of LDLR proteinincreases activity 16271152
D012643 Selenium Selenium results in increased expression of LDLR mRNAincreases expression 16271152
C025462 sulindac sulfide sulindac sulfide results in decreased expression of LDLR mRNAdecreases expression 16184548
C436947 T 113242 T 113242 promotes the reaction [ZBTB17 protein results in increased expression of LDLR mRNA]increases expression|increases reaction 11545736
C436947 T 113242 T 113242 promotes the reaction [ZBTB17 protein results in increased expression of LDLR protein]increases expression|increases reaction 11545736
C436947 T 113242 T 113242 results in increased expression of LDLR mRNAincreases expression 11545736
C436947 T 113242 T 113242 results in increased expression of LDLR proteinincreases expression 11545736
D014284 Triiodothyronine Amiodarone promotes the reaction [Triiodothyronine results in increased expression of LDLR mRNA]increases expression|increases reaction 9712728
D014284 Triiodothyronine desethylamiodarone promotes the reaction [Triiodothyronine results in increased expression of LDLR mRNA]increases expression|increases reaction 9712728
D014284 Triiodothyronine Triiodothyronine results in increased expression of LDLR mRNAincreases expression 9712728
D014284 Triiodothyronine Triiodothyronine inhibits the reaction [Amiodarone results in decreased expression of LDLR protein]decreases expression|decreases reaction 9071962
D014284 Triiodothyronine Triiodothyronine results in increased expression of LDLR mRNAincreases expression 9071962
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the activity of LDLR mRNAaffects activity 18336851
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of LDLR mRNAaffects expression 18336851
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of LDLR proteinaffects expression 18336851
C423915 TO-901317 TO-901317 results in increased expression of LDLR mRNAincreases expression 16142410
C050414 tripterine tripterine results in increased expression of LDLR mRNAincreases expression 17010675
D024483 Vitamin K 3 Vitamin K 3 results in increased expression of LDLR mRNAincreases expression 12414654
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 10.566734493
MESH:D000014 Abnormalities, Drug-Induced Ethanol 10.5617676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 10.5614514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 8.2518287403
MESH:D000138 Acidosis Ethanol 8.2511192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.2617505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 6.9818653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 6.9818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 5.8120127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 5.8114692618
MESH:D000230 Adenocarcinoma Fenretinide 5.8110697514
MESH:D000236 Adenoma Benzo(a)pyrene 2.236695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 7.6816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 7.6816835633
MESH:D000380 Agranulocytosis Clozapine 4.4012649775 16160616 14617031
MESH:D000382 Agricultural Workers' Diseases Dichlorodiphenyl Dichloroethylene 4.1516487989
MESH:D000419 Albuminuria Raloxifene 3.9617451421 17308373
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.6315451040 15451039
MESH:D019973 Alcohol-Related Disorders Curcumin 4.4017887948
MESH:D000505 Alopecia Isoflavones 4.1717569567
MESH:D000544 Alzheimer Disease 27-hydroxycholesterol 13.1320157255 14523054
MESH:D000544 Alzheimer Disease Cholesterol, Dietary 13.1320157255
MESH:D000544 Alzheimer Disease Curcumin 13.1315590663
MESH:D000544 Alzheimer Disease Ozone 13.1315513908
MESH:D000544 Alzheimer Disease Raloxifene 13.1315800139
MESH:D000544 Alzheimer Disease sulindac sulfide 13.1318759972
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.3611748828
MESH:D000853 Anophthalmos Ethanol 4.1615513904
MESH:D001008 Anxiety Disorders Ethanol 3.4611141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.4219183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 7.1920041841 18218290 18057881
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 7.1917460149
MESH:D001161 Arteriosclerosis Cholesterol, Dietary 19.1515552841
MESH:D001161 Arteriosclerosis Dietary Fats 19.1515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 19.1511256880
MESH:D001161 Arteriosclerosis Reserpine 19.1510729376
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.2215885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.1316807698
MESH:D001172 Arthritis, Rheumatoid Ozone 4.1315570426
MESH:D020817 Asperger Syndrome Risperidone 4.9116401163
MESH:D001249 Asthma Albuterol 4.8011991558 9949315
MESH:D001249 Asthma Ozone 4.8017854713 16373670
MESH:D050197 Atherosclerosis marker/mechanism 18450471
MESH:D050197 Atherosclerosis 27-hydroxycholesterol 8.8611166758 9059518
MESH:D050197 Atherosclerosis Cholesterol 8.8616632123
MESH:D050197 Atherosclerosis Curcumin 8.8618704882
MESH:D001281 Atrial Fibrillation Amiodarone 3.3819698954 18651412
MESH:D001289 Attention Deficit Disorder with Hyperactivity Risperidone 4.3118349709
MESH:D001321 Autistic Disorder Haloperidol 2.5119368416 18080171
MESH:D001321 Autistic Disorder olanzapine 2.5117069543 18685284
MESH:D001321 Autistic Disorder Risperidone 2.5116601648 19368416 17929164 16239862 18775368 16379507 18080171 19232924 16730335 17069546 18349709 16948927 15994720 19154706 18026891 15543515 19013209 18278980 15492353 17019624 15930063
MESH:D001327 Autoimmune Diseases Curcumin 3.8419761891
MESH:D001714 Bipolar Disorder Risperidone 4.1419154706 18278980
MESH:D001778 Blood Coagulation Disorders Amiodarone 11.8219483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 11.8219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 11.8212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3015746008
MESH:D001859 Bone Neoplasms Paclitaxel 3.9515867366
MESH:D001862 Bone Resorption Berberine 4.839881647
MESH:D001919 Bradycardia Phenylephrine 3.8815306635
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.6517868700
MESH:D001930 Brain Injuries Progesterone 8.7915665606 15845082 15380490
MESH:D001930 Brain Injuries Raloxifene 8.7916580743
MESH:D002545 Brain Ischemia Curcumin 3.6716770732
MESH:D001932 Brain Neoplasms Curcumin 7.2117596214
MESH:D001932 Brain Neoplasms Fenretinide 7.2116187019
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 7.0120146248 17474063
MESH:D001943 Breast Neoplasms Curcumin 7.0116243823 19250217 18462866 18593918
MESH:D001943 Breast Neoplasms Dichlorodiphenyl Dichloroethylene 7.0115061365
MESH:D001943 Breast Neoplasms Dietary Fats 7.0120435547
MESH:D001943 Breast Neoplasms Fenretinide 7.0116601279
MESH:D001943 Breast Neoplasms Paclitaxel 7.0116115903 15136595 11325840 16244791 18223236 16273361 18234424 18323546
MESH:D001943 Breast Neoplasms Plant Preparations 7.0117398067
MESH:D001943 Breast Neoplasms Progesterone 7.0115562024 16175315 17614352
MESH:D001943 Breast Neoplasms Raloxifene 7.0115758505 15775269 16912660 17440819 17893378 17952589 17242785 15572757 17595753 17049068 16837676 17261762
MESH:D001943 Breast Neoplasms Reserpine 7.0111921183
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.0120435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.1415516495 19059883 18315731 17626835 18417511 16777450 14754758
MESH:D002056 Burns Ethanol 4.0016374292
MESH:D002100 Cachexia Ozone 4.0716183385
MESH:D002277 Carcinoma Curcumin 6.4818593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.4816835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 5.4421507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Ethanol 5.4415763234 15289165 18788625
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 5.4416270382 17159502
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 5.4416313753
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 4.9718414057
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 4.9712391285
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 8.7920419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 8.7918462866
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 8.7916274795
MESH:D002294 Carcinoma, Squamous Cell Plant Preparations 8.7917418620
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.4817572228
MESH:D006332 Cardiomegaly atorvastatin 12.9918360054
MESH:D006332 Cardiomegaly Ethanol 12.9919332462
MESH:D006332 Cardiomegaly Phenylephrine 12.9911754973 17124262 11179087 15728586 16170337 17287366
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 12.9916120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.6215710769 19225199
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 13.4316936243
MESH:D002318 Cardiovascular Diseases Isoflavones 13.4317689850
MESH:D002318 Cardiovascular Diseases Plant Preparations 13.4316862667
MESH:D002318 Cardiovascular Diseases Raloxifene 13.4315775269
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.4118974383
MESH:D016893 Carotid Stenosis Plant Preparations 5.4615158307
MESH:D002375 Catalepsy Haloperidol 4.241977408 15215559
MESH:D002389 Catatonia olanzapine 5.5618071103 16772815
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.9520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 4.9512371664
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 4.8016154183
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.5916835633
MESH:D002779 Cholestasis Cyclosporine 15.0719486331
MESH:D002779 Cholestasis Ethinyl Estradiol 15.0716105132 17333356 16919318 15861022 11677210 17110522 17681005
MESH:D002779 Cholestasis Levonorgestrel 15.0715861022
MESH:D002779 Cholestasis pirinixic acid 15.0719176532
MESH:D002971 Cleft Lip Ethanol 3.1915513904
MESH:D002972 Cleft Palate Ethanol 4.8415513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.8415668235 8697196 12621046 15340226 16354765
MESH:D003072 Cognition Disorders Clozapine 9.5017123785
MESH:D003072 Cognition Disorders Raloxifene 9.5015800139
MESH:D003092 Colitis Curcumin 7.5018200517 16804969 16782535
MESH:D003092 Colitis Selenium 7.5017936198
MESH:D003103 Coloboma Curcumin 3.9418809619
MESH:D003110 Colonic Neoplasms Curcumin 2.3716340194 19359593
MESH:D015179 Colorectal Neoplasms Fenretinide 3.2617273769
MESH:D015179 Colorectal Neoplasms Isoflavones 3.2617116718
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.2618802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.4914669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.2418497527
MESH:D003324 Coronary Artery Disease marker/mechanism 21378990
MESH:D003324 Coronary Artery Disease atorvastatin 5.9516368305
MESH:D003324 Coronary Artery Disease Plant Preparations 5.9515158307
MESH:D003327 Coronary Disease Fructose 4.0118504504
MESH:D019465 Craniofacial Abnormalities Ethanol 2.3611198716 15513904 15451039 10194807 19302082 11873399 15451040
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3620055451 10048152 15322242
MESH:D003456 Cryptorchidism Dibutyl Phthalate 4.8116037377
MESH:D016757 Death, Sudden, Cardiac Haloperidol 9.3920210726
MESH:D016757 Death, Sudden, Cardiac Risperidone 9.3920210726
MESH:D003704 Dementia Haloperidol 8.5411575062
MESH:D003704 Dementia Risperidone 8.5411575062
MESH:D003715 Dengue 27-hydroxycholesterol 5.0119427377
MESH:D003865 Depressive Disorder, Major Raloxifene 3.5917474826
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 5.7716882537
MESH:D003876 Dermatitis, Atopic pirinixic acid 5.7718249437
MESH:D002658 Developmental Disabilities olanzapine 4.2117069543
MESH:D003921 Diabetes Mellitus, Experimental Fructose 3.9418603373
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 8.4716402076
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 8.4718403477
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 8.4718603373
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 8.4717107852
MESH:D003928 Diabetic Nephropathies Curcumin 7.3218204486
MESH:D003928 Diabetic Nephropathies Raloxifene 7.3217451421 17308373 15920148
MESH:D003929 Diabetic Neuropathies Progesterone 3.8417187935
MESH:D006970 Disorders of Excessive Somnolence Clozapine 12.1715331141
MESH:D006970 Disorders of Excessive Somnolence Risperidone 12.1716379507
MESH:D053207 Diurnal Enuresis Risperidone 5.9917822346
MESH:D004314 Down Syndrome Risperidone 4.5618349709
MESH:D056486 Drug-Induced Liver Injury Amiodarone 9.3018218290 15265979
MESH:D056486 Drug-Induced Liver Injury Chlorpromazine 9.3011461765
MESH:D056486 Drug-Induced Liver Injury Ethanol 9.3011566570
MESH:D056486 Drug-Induced Liver Injury Selenium 9.3015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.3020420201
MESH:D004362 Drug Toxicity Plant Preparations 6.7611033412
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.7611462148
MESH:D004381 Duodenal Ulcer Curcumin 3.4217351913
MESH:D050171 Dyslipidemias Clozapine 7.1816402076
MESH:D050171 Dyslipidemias Dietary Fats 7.1818367378
MESH:D004417 Dyspnea Albuterol 9.0220016425
MESH:D004417 Dyspnea Dichlorodiphenyl Dichloroethylene 9.0216487989
MESH:D004487 Edema perfluorooctanoic acid 11.5812083418 17259670
MESH:D004487 Edema pirinixic acid 11.5812083418
MESH:D004487 Edema Raloxifene 11.5815860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.5812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.2215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental 27-hydroxycholesterol 16.8017410599
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 16.8012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 16.8017692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 16.8015845917
MESH:D004715 Endometriosis Progesterone 6.9716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 6.9710568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 3.7317637181 15821434 15328337
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.3720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 11.3716530937
MESH:D004938 Esophageal Neoplasms Ethanol 11.3716704527
MESH:D004938 Esophageal Neoplasms Paclitaxel 11.3716481741
MESH:D004938 Esophageal Neoplasms Plant Preparations 11.3716510608
MESH:D004942 Esophagitis, Peptic Bile Acids and Salts 5.8711346197
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.4911564622
MESH:D005234 Fatty Liver Amiodarone 37.9514986274
MESH:D005234 Fatty Liver Curcumin 37.9519297423
MESH:D005234 Fatty Liver Cyclosporine 37.9519224547
MESH:D005234 Fatty Liver Dietary Fats 37.9518296743 19004024 19551842 17967931
MESH:D005234 Fatty Liver Ethanol 37.9516409862 19236843 18620774
MESH:D005234 Fatty Liver Ethinyl Estradiol 37.9515345470
MESH:D005234 Fatty Liver Fructose 37.9519196556 18395287 18641190
MESH:D005234 Fatty Liver pirinixic acid 37.9519236843 20131406
MESH:D005234 Fatty Liver Raloxifene 37.9517473493
MESH:D005235 Fatty Liver, Alcoholic Ethanol 4.9817920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.6316946407 15451040 15513904 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.8011858732
MESH:D005334 Fever Lipopolysaccharides 3.439205823 11852909
MESH:D005355 Fibrosis Albuterol 26.1115467267
MESH:D005355 Fibrosis Curcumin 26.1118705752
MESH:D005355 Fibrosis Cyclosporine 26.1112168785 12639820
MESH:D005355 Fibrosis Dietary Fats 26.1118296743
MESH:D005355 Fibrosis Fructose 26.1118504504
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 26.1120067830
MESH:D005739 Gas Poisoning Albuterol 5.5220016425
MESH:D005756 Gastritis Ethanol 4.0115046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.0418462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.558708960
MESH:D005909 Glioblastoma Curcumin 6.0617596214
MESH:D005909 Glioblastoma Fenretinide 6.0616187019
MESH:D018149 Glucose Intolerance Fructose 4.7019165636
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.9110696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.1818462866 18829502
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.1220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.1211294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.0511110106
MESH:D006333 Heart Failure atorvastatin 9.3516360360
MESH:D006333 Heart Failure pirinixic acid 9.3520558911
MESH:D006333 Heart Failure Selenium 9.3517162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.7515720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.7916366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.7311000095
MESH:D006505 Hepatitis Dichlorodiphenyl Dichloroethylene 4.4116487989
MESH:D006529 Hepatomegaly Amiodarone 15.3715265979
MESH:D006529 Hepatomegaly perfluorooctanoic acid 15.373609246
MESH:D006529 Hepatomegaly pirinixic acid 15.3716221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.3715340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.3817701891
MESH:D006561 Herpes Simplex Chlorpromazine 4.621682908
MESH:D019584 Hot Flashes Isoflavones 4.3014716179 17290160
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.3616354765 8697196 18606429 15340226 16959395
MESH:D006930 Hyperalgesia Ethanol 6.4418783367
MESH:D006930 Hyperalgesia perfluorooctanoic acid 6.4412083418
MESH:D017588 Hyperandrogenism Flutamide 4.7815356085
MESH:D006937 Hypercholesterolemia marker/mechanism 18450471
MESH:D006937 Hypercholesterolemia 27-hydroxycholesterol 33.4817873880
MESH:D006937 Hypercholesterolemia Amiodarone 33.489751232 8137927
MESH:D006937 Hypercholesterolemia atorvastatin 33.4811583720
MESH:D006937 Hypercholesterolemia Cholesterol 33.4816933029
MESH:D006937 Hypercholesterolemia Cholesterol, Dietary 33.4810876104
MESH:D006937 Hypercholesterolemia Curcumin 33.4818704882
MESH:D006937 Hypercholesterolemia Dietary Fats 33.4821332399
OMIM:143890 HYPERCHOLESTEROLEMIA, AUTOSOMAL DOMINANT marker/mechanism
MESH:D006943 Hyperglycemia pirinixic acid 7.7020558911
MESH:D006943 Hyperglycemia Risperidone 7.7018278980
MESH:D006946 Hyperinsulinism Fructose 4.3314757778 18360027 19008412 18563319 15752949
MESH:D006948 Hyperkinesis Clozapine 4.2416046005
MESH:D006949 Hyperlipidemias Dietary Fats 7.5021332399
MESH:D006949 Hyperlipidemias Fructose 7.5015752949
MESH:D006938 Hyperlipoproteinemia Type II marker/mechanism 12673584
MESH:D006938 Hyperlipoproteinemia Type II atorvastatin 4.6216238680
MESH:D006963 Hyperphagia olanzapine 5.5617933447
MESH:D006973 Hypertension atorvastatin 16.5617042910
MESH:D006973 Hypertension Cyclosporine 16.5610903974
MESH:D006973 Hypertension Fructose 16.5616843071 14568997 14573337 19008412 14633139
MESH:D006973 Hypertension Phenylephrine 16.5612717712 8949925
MESH:D006973 Hypertension Raloxifene 16.5617577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 16.5618670907 18850075
MESH:D015228 Hypertriglyceridemia Fructose 4.4919342510 19799862
MESH:D006984 Hypertrophy Phenylephrine 3.9512791704 18502941
MESH:D007021 Hypospadias Ethinyl Estradiol 3.1516569931 16945680
MESH:D007035 Hypothermia Reserpine 5.631977408
MESH:D007037 Hypothyroidism Amiodarone 3.8618020914 17991464
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.7515869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.8412013081
MESH:D007248 Infertility, Male Dichlorodiphenyl Dichloroethylene 5.5412948891 17192596
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.5417937319
MESH:D007249 Inflammation atorvastatin 18.1816908763
MESH:D007249 Inflammation Curcumin 18.1816956363 18403477 17151092
MESH:D007249 Inflammation Dietary Fats 18.1820412841
MESH:D007249 Inflammation Lipopolysaccharides 18.189205823 17963957 17237260 12878042 17255318
MESH:D007249 Inflammation perfluorooctanoic acid 18.1812083418
MESH:D007249 Inflammation Progesterone 18.1815869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.1812878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.8918200517 18596194
MESH:D007251 Influenza, Human Selenium 3.5216624496
MESH:D007333 Insulin Resistance Berberine 13.9218563319
MESH:D007333 Insulin Resistance Dietary Fats 13.9211836018 18457598
MESH:D007333 Insulin Resistance Fructose 13.9219586609 19342510 18057795 19008412 14573337 19799862 18981581 14757778 14633139 17133782 18563319
MESH:D007333 Insulin Resistance pirinixic acid 13.9216306350
MESH:D007414 Intestinal Neoplasms Curcumin 3.6310783313
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.0117255318
MESH:D007569 Jaw Abnormalities Ethanol 8.1015513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.1016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 1.938314463 10903974 18776723
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 8.0116518626
MESH:D007676 Kidney Failure, Chronic Selenium 8.0116518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.1912371664
MESH:D007859 Learning Disorders Cholesterol 8.0017134702
MESH:D007859 Learning Disorders Ethanol 8.0015451040
MESH:D007889 Leiomyoma Curcumin 9.0918555241
MESH:D007889 Leiomyoma Raloxifene 9.0916973256
MESH:D007938 Leukemia Curcumin 2.8718462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.6016106398
MESH:D015458 Leukemia, T-Cell Curcumin 4.1216106398
MESH:D007970 Leukopenia Lipopolysaccharides 4.0315821434
MESH:D007972 Leukoplakia, Oral Fenretinide 5.3616707609
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.568812269
MESH:D017880 Limb Deformities, Congenital Dichlorodiphenyl Dichloroethylene 7.1512745335
MESH:D017880 Limb Deformities, Congenital Ethanol 7.1517676605
MESH:D008064 Lipidoses Amiodarone 10.5315342952 17567588
MESH:D008064 Lipidoses Chlorpromazine 10.5315342952 17567588
MESH:D008064 Lipidoses Clozapine 10.5317567588
MESH:D008080 Liposarcoma Paclitaxel 4.2017353645
MESH:D008103 Liver Cirrhosis Dietary Fats 5.4618296743
MESH:D008103 Liver Cirrhosis Ethanol 5.4615289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.4218295389
MESH:D008106 Liver Cirrhosis, Experimental atorvastatin 9.0017347453
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 9.0018006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 9.0018166357
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 9.0012878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 9.0015474484
MESH:D008106 Liver Cirrhosis, Experimental Plant Preparations 9.0017724770
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 9.0012878042
MESH:D008107 Liver Diseases Chlorpromazine 4.1114986274
MESH:D008107 Liver Diseases Curcumin 4.1116956363
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.0017347304 17207112
MESH:D008113 Liver Neoplasms Aflatoxin B1 13.9315890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.9320195826 21137059
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 13.9311940454
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 13.9318709148 14757943
MESH:D008113 Liver Neoplasms pirinixic acid 13.9316377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.9316984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 4.338603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 4.3312151625
MESH:D008133 Long QT Syndrome Amiodarone 6.9417391786 15350150 11989578
MESH:D008133 Long QT Syndrome olanzapine 6.9420210726
MESH:D008171 Lung Diseases Amiodarone 6.0012587719
MESH:D008171 Lung Diseases Ozone 6.008266340 19066396
MESH:D017563 Lung Diseases, Interstitial Amiodarone 3.8018516814
MESH:D055370 Lung Injury Lipopolysaccharides 7.0821114838
MESH:D055370 Lung Injury Ozone 7.0820417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 5.3314755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.3318569708 17053015 20464547 18520028 18816296 6695378 20135361 20064080 20869020
MESH:D008175 Lung Neoplasms Curcumin 5.3318462866 16243823 19359593
MESH:D008175 Lung Neoplasms Ozone 5.337614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.3311884234 19555203
MESH:D008223 Lymphoma Curcumin 3.0918462866
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.5414749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.0416173963
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 10.6310697514
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.6311408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Reserpine 10.6311921183
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.6315318939
MESH:D008545 Melanoma Curcumin 6.0417885582 18462866
MESH:D008545 Melanoma Fenretinide 6.0416270382
MESH:D008545 Melanoma Paclitaxel 6.0412025231 12040289 16342250
MESH:D008545 Melanoma Vitamin K 3 6.0419082730
MESH:D008546 Melanoma, Experimental Gallic Acid 5.7419577552
MESH:D008569 Memory Disorders Curcumin 7.6417263510
MESH:D008569 Memory Disorders Ethanol 7.6418411066 15451040
MESH:D001523 Mental Disorders Chlorpromazine 17.5416856516
MESH:D001523 Mental Disorders Clozapine 17.5416856516
MESH:D001523 Mental Disorders Haloperidol 17.5416856516
MESH:D001523 Mental Disorders olanzapine 17.5416856516
MESH:D001523 Mental Disorders Risperidone 17.5416856516 16596465
MESH:D008607 Mental Retardation Risperidone 3.8418349709
MESH:D008654 Mesothelioma Selenium 2.4815107826
MESH:D008659 Metabolic Diseases olanzapine 4.7819142110
MESH:D024821 Metabolic Syndrome X Clozapine 13.0119142101
MESH:D024821 Metabolic Syndrome X Fructose 13.0118497449 17098227 17261469 19165636 16815490
MESH:D024821 Metabolic Syndrome X Risperidone 13.0119142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.1016801185
MESH:D008679 Metaplasia Ozone 4.4210496685
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 4.8715863610
MESH:D019964 Mood Disorders Risperidone 5.1717019624
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 11.5516381670
MESH:D009062 Mouth Neoplasms Fenretinide 11.5516274795
MESH:D009062 Mouth Neoplasms Plant Preparations 11.5517418620
MESH:D009101 Multiple Myeloma Curcumin 9.3719372569
MESH:D009101 Multiple Myeloma Paclitaxel 9.3714749477
MESH:D009101 Multiple Myeloma Raloxifene 9.3716497877
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.2517962980
MESH:D009135 Muscular Diseases atorvastatin 8.5816239165
MESH:D009135 Muscular Diseases pirinixic acid 8.5816239165
MESH:D009175 Mycoplasma Infections Chlorpromazine 5.3110773494
MESH:D009181 Mycoses Amiodarone 4.2212754197 17974566
MESH:D009203 Myocardial Infarction pirinixic acid 1.8319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.4712213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.4216411023
MESH:D009232 Myxoma Raloxifene 4.8716343187
MESH:D009361 Neoplasm Invasiveness Curcumin 3.7318495463
MESH:D009362 Neoplasm Metastasis Paclitaxel 2.9415867366
MESH:D009369 Neoplasms Benzo(a)pyrene 11.7511141357
MESH:D009369 Neoplasms Berberine 11.7512415430
MESH:D009369 Neoplasms Fenretinide 11.7517353921 15958647
MESH:D009369 Neoplasms lycopene 11.7517051425
MESH:D009369 Neoplasms pirinixic acid 11.7517405874
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 3.8512497104
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.7617954296
MESH:D009404 Nephrotic Syndrome atorvastatin 7.8119348381
MESH:D009404 Nephrotic Syndrome Cyclosporine 7.8118481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.5814600291
MESH:D009423 Nervous System Neoplasms Curcumin 4.9418462866
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.0116303764
MESH:D052556 Niemann-Pick Disease, Type C Cholesterol 10.169802331 20557099
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 10.169802331
MESH:D053206 Nocturnal Enuresis Risperidone 5.6417822346
MESH:D009765 Obesity Clozapine 14.9219142110 18515891
MESH:D009765 Obesity Curcumin 14.9219297423
MESH:D009765 Obesity Dietary Fats 14.9221332399 20518802 19632207 20132043 17217161 11836018 18674790 16723640 18457598
MESH:D009765 Obesity Fructose 14.9218585860 17707055
MESH:D009765 Obesity olanzapine 14.9218515891
MESH:D009765 Obesity pirinixic acid 14.9220558911
MESH:D010014 Osteolysis Paclitaxel 4.3115867366
MESH:D010024 Osteoporosis Curcumin 13.3518719352
MESH:D010024 Osteoporosis Isoflavones 13.3516562857
MESH:D010024 Osteoporosis Levonorgestrel 13.3512665316
MESH:D010024 Osteoporosis Raloxifene 13.3519059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.6117823083 15758505 17893378 15579764
MESH:D010051 Ovarian Neoplasms Curcumin 9.1619020741 18462866
MESH:D010051 Ovarian Neoplasms Fenretinide 9.1616133793
MESH:D010051 Ovarian Neoplasms Paclitaxel 9.1611161223
MESH:D010051 Ovarian Neoplasms Progesterone 9.1616525653 17393432
MESH:D010190 Pancreatic Neoplasms Curcumin 7.1217440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms Ethanol 7.1212384795
MESH:D010190 Pancreatic Neoplasms Fenretinide 7.1215580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.0611578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.4412065085
MESH:D010300 Parkinson Disease Cholesterol, Dietary 3.8919014385
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.5612520081
MESH:D010538 Peritonitis Ozone 3.4816369182
MESH:D010954 Plasmacytoma Selenium 4.2015087411
MESH:D011014 Pneumonia Lipopolysaccharides 8.8811605937 12224865
MESH:D011014 Pneumonia Ozone 8.8818929643 18381685 18007984
MESH:D011085 Polycystic Ovary Syndrome Flutamide 4.4015356085
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.9218163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.6512371664
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 7.4517132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.4511896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0817292933
MESH:D011471 Prostatic Neoplasms Berberine 3.0816505103
MESH:D011471 Prostatic Neoplasms bicalutamide 3.0819240160 19011039 17914592 18487222 15638997
MESH:D011471 Prostatic Neoplasms Curcumin 3.0818226269 15129424 18769126 11398177 10851300 18156803 12497104
MESH:D011471 Prostatic Neoplasms Fenretinide 3.0817024972
MESH:D011471 Prostatic Neoplasms Flutamide 3.083169114
MESH:D011471 Prostatic Neoplasms Isoflavones 3.0817571952 16365062 17219775 17374662
MESH:D011471 Prostatic Neoplasms lycopene 3.0817337101 15084515
MESH:D011471 Prostatic Neoplasms Paclitaxel 3.0816356831 17172428 16729912 17136230
MESH:D011471 Prostatic Neoplasms Raloxifene 3.0815731164 16220300 16536755
MESH:D011537 Pruritus Ethinyl Estradiol 7.7915861022 16919318
MESH:D011537 Pruritus Levonorgestrel 7.7915861022
MESH:D011565 Psoriasis Cyclosporine 1.9516882103
MESH:D011595 Psychomotor Agitation Haloperidol 9.6411575062
MESH:D011595 Psychomotor Agitation olanzapine 9.6418685284
MESH:D011618 Psychotic Disorders Clozapine 7.4715331141
MESH:D011618 Psychotic Disorders Haloperidol 7.4711575062
MESH:D011649 Pulmonary Alveolar Proteinosis 27-hydroxycholesterol 5.7115466366
MESH:D011656 Pulmonary Emphysema Curcumin 3.9319168576
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.5611597910 12490602 12832656
MESH:D011693 Purpura Raloxifene 4.8715770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.0219058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.4118379247 10666014
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.2610835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.2018990726
MESH:D012162 Retinal Degeneration Fenretinide 3.8816303925
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.5718045962
MESH:D012509 Sarcoma Curcumin 3.5318462866
MESH:D012559 Schizophrenia Clozapine 6.8320580759 19369910 20521326 17123785 18855531 20521320 11763009 16141801 20107430 20168265 17726453 20452607 11151749 17667964 18806925
MESH:D012559 Schizophrenia Haloperidol 6.831830565 19369910 18513383 20107430
MESH:D012559 Schizophrenia olanzapine 6.8320521326 20107430 17726453
MESH:D012559 Schizophrenia Risperidone 6.8320107430 18278980 19154706
MESH:D012640 Seizures Ethanol 2.729754883
MESH:D018805 Sepsis Curcumin 3.5218389075
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.4118724381
MESH:D012852 Sinusitis Phenylephrine 4.037327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 14.0410029692 19755658
MESH:D012878 Skin Neoplasms Fenretinide 14.0416467112
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 14.0412065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 14.048532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 14.0416192470
MESH:D012893 Sleep Disorders Risperidone 4.8418278980
MESH:D019082 Smith-Lemli-Opitz Syndrome 27-hydroxycholesterol 5.3511254748
OMIM:270800 SPASTIC PARAPLEGIA 5A, AUTOSOMAL RECESSIVE 27-hydroxycholesterol 5.7019812052
MESH:D013088 Spermatocele Ethinyl Estradiol 3.2616709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.6115862959 16503802
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.982093021 20155912
MESH:D013274 Stomach Neoplasms Ethanol 2.9818456281
MESH:D013274 Stomach Neoplasms Paclitaxel 2.9818396642 18506536
MESH:D013276 Stomach Ulcer Amiodarone 8.7218087811
MESH:D013276 Stomach Ulcer Curcumin 8.7216631530 19188055
MESH:D013276 Stomach Ulcer Ethanol 8.7211906479 17189318 16755016 9211565 17918041 9562338
MESH:D020521 Stroke Raloxifene 3.2816837676
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.679754883
MESH:D013610 Tachycardia Amiodarone 3.6511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 19.5219225199
MESH:D017180 Tachycardia, Ventricular Haloperidol 19.5220210726
MESH:D017180 Tachycardia, Ventricular olanzapine 19.5220210726
MESH:D017180 Tachycardia, Ventricular Risperidone 19.5220210726
MESH:D024801 Tauopathies Paclitaxel 4.1416930453
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.5815821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.0011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.5815669648
MESH:D013959 Thyroid Diseases Amiodarone 9.7819731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 9.7812697716
MESH:D013971 Thyrotoxicosis Amiodarone 4.2018020914 19584973
MESH:D013978 Tibial Fractures Raloxifene 4.5219048282
MESH:D016171 Torsades de Pointes Amiodarone 3.5211989578 17467628
MESH:D005879 Tourette Syndrome Risperidone 5.2819154706
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.4517053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 12.4518593936
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 12.4516720286
MESH:D001749 Urinary Bladder Neoplasms Plant Preparations 12.4511251952
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 12.4517572228
MESH:D014565 Urogenital Neoplasms Curcumin 4.5918462866
MESH:D014570 Urologic Diseases Dichlorodiphenyl Dichloroethylene 5.0616487989
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 3.9716154183
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.5714692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 7.5718645019
MESH:D014605 Uveitis Cyclosporine 3.301336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.9112125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.5216837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 8.7714671159 15869587
MESH:D020246 Venous Thrombosis Levonorgestrel 8.7715869587
MESH:D014846 Vulvar Neoplasms Raloxifene 4.8716343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.5615886252
MESH:D015430 Weight Gain Clozapine 18.5320564506 17502770 16141801 20107430 16402076 20521320
MESH:D015430 Weight Gain Dietary Fats 18.5316723640
MESH:D015430 Weight Gain olanzapine 18.5319434072 17933447 20107430
MESH:D015430 Weight Gain Risperidone 18.5316379507 20564506
MESH:D015431 Weight Loss Clozapine 4.4117933447
MESH:D014985 Xerophthalmia Cyclosporine 3.7617120751
Pathway ID Pathway Name
KEGG:04976 Bile secretion
KEGG:04144 Endocytosis
KEGG:05160 Hepatitis C
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:05145 Toxoplasmosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA227
    • No data
    Releated disease ID Related disease Name
    PA447054Stroke
    PA445019Myocardial Infarction
    PA443635Cardiovascular Diseases
    PA444552Hypertension
    PA444517Hyperlipoproteinemia Type II
    PA447159Metabolic Syndrome X
    PA446414Carotid Stenosis
    Releated drug ID Related drug Name
    PA133950441hmg coa reductase inhibitors
    PA449688fluvastatin
    PA448499atenolol
    PA450084irbesartan
    PA448500atorvastatin
    PA450952phospholipids
    PA450480metoprolol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00707 other/unknown Porfimer Antineoplastic Agents;Antiviral Agents;Dermatologic Agents;Photosensitizing Agents
    DB02944 - Alpha-D-Mannose
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved