AutismKB 2.0

Annotation Detail for LEP


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Basic Information Top
Gene Symbol:LEP ( FLJ94114,OB,OBS )
Gene Full Name: leptin
Band: 7q32.1
Quick LinksEntrez ID:3952; OMIM: 164160; Uniprot ID:LEP_HUMAN; ENSEMBL ID: ENSG00000174697; HGNC ID: 6553
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04920Adipocytokine signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
No data
Pathway IDPathway Name
200033Signaling events mediated by PTP1B
200172HIF-1-alpha transcription factor network
No data
Pathway IDPathway Name
500141Synthesis, Secretion, and Deacylation of Ghrelin
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1703Fatty liver
1711Familial Mediterranean fever
1721Female reproductive system disorder
1727Pancreas disease
1731Growth retardation
1745Huntington disease
1749Transient hypertension of pregnancy
1784Choriocarcinoma
1804Chronic obstructive airway disease
1809HIV infection
1831Prostate cancer
1842Sickle cell disease
1848Embryoma
1856Obesity
1869Behcet syndrome
1877Multiple sclerosis
1889Hyperinsulinism
1918Atherosclerosis
1944Breast cancer
1964Primary biliary cirrhosis
2025Polyarthritis
1983Down syndrome
1986Eating disorder
1997Dental plaque
1841Stomach cancer
2006Anorexia nervosa
2022Liver cancer
1764Purpura, Thrombocytopenic, Idiopathic
2032Kidney disease
2043Advanced cancer
2047Rett syndrome
2051Leukemia
2053Colon cancer
2066Lung cancer
2069Schizophrenia
2070Cholelithiasis
2074Asthma
2078Narcolepsy
2122Protein-energy malnutrition
2124Autistic disorder
2136Hypothyroidism
2138Osteoporosis
2151Neuroblastoma
2189Ankylosing spondylitis
2193Helicobacter infection
2233Cirrhosis
2238Lipodystrophy
2240Anemia
2241Infertility
2255Intermediate coronary syndrome
2256Aortic aneurysm
Desease Name
leptin expression
AGING
body mass leptin obesity
CARDIOVASCULAR
leptin
prostate cancer
CANCER
PSYCH
age of menarche
Weight Gain
PHARMACOGENOMIC
body mass
hypertension
BMI
schizophrenia
METABOLIC
lung cancer
obesity
depression
insulin
body fat
diabetes, type 2
heart disease risk factors hypertension leptin obesity
fat mass
Overweight
No data
Desease Name
Obesity, severe, due to leptin deficiency
Obesity, morbid, with hypogonadism
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C097240 15-deoxy-delta(12,14)-prostaglandin J2 [15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PPARG protein] which results in decreased secretion of LEP proteinaffects binding|decreases secretion|increases activity 16037295
C076996 27-hydroxycholesterol 27-hydroxycholesterol results in decreased expression of LEP mRNAdecreases expression 20157255
C076996 27-hydroxycholesterol 27-hydroxycholesterol results in decreased expression of LEP proteindecreases expression 20157255
C076996 27-hydroxycholesterol LEP protein inhibits the reaction [27-hydroxycholesterol results in increased expression of APP protein]decreases reaction|increases expression 20157255
C076996 27-hydroxycholesterol LEP protein inhibits the reaction [27-hydroxycholesterol results in increased expression of MAPT protein modified form]decreases reaction|increases expression 20157255
C076996 27-hydroxycholesterol LEP protein inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of MAPT protein]decreases reaction|increases phosphorylation 20157255
C097869 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [SR 58611A results in decreased expression of LEP mRNA]decreases expression|decreases reaction 9718277
D000079 Acetaldehyde Acetaldehyde inhibits the reaction [LEP protein results in increased expression of ADIPOR2 protein]decreases reaction|increases expression 17949463
D000079 Acetaldehyde LEP protein affects the reaction [Acetaldehyde results in increased expression of ADIPOQ protein]affects reaction|increases expression 17949463
D000079 Acetaldehyde LEP protein affects the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA]affects reaction|increases expression 15130784
D000079 Acetaldehyde LEP protein affects the reaction [Acetaldehyde results in increased expression of TGFB1 protein]affects reaction|increases expression 15130784
D000082 Acetaminophen Acetaminophen affects the expression of LEP mRNAaffects expression 17562736
C056165 acetovanillone acetovanillone inhibits the reaction [LEP protein affects the abundance of Calcium]affects abundance|decreases reaction 16380530
C056165 acetovanillone acetovanillone inhibits the reaction [LEP protein results in increased abundance of Superoxides]decreases reaction|increases abundance 16380530
C056165 acetovanillone acetovanillone inhibits the reaction [LEP protein results in increased expression of NCF1 protein]decreases reaction|increases expression 16380530
C056165 acetovanillone acetovanillone inhibits the reaction [LEP protein results in increased expression of NCF2 protein]decreases reaction|increases expression 16380530
C081628 advanced glycation end products-bovine serum albumin [advanced glycation end products-bovine serum albumin binds to CD36 protein] which results in decreased expression of LEP mRNAaffects binding|decreases expression 16037295
C081628 advanced glycation end products-bovine serum albumin [advanced glycation end products-bovine serum albumin binds to CD36 protein] which results in decreased expression of LEP proteinaffects binding|decreases expression 16037295
C081628 advanced glycation end products-bovine serum albumin advanced glycation end products-bovine serum albumin results in decreased expression of LEP mRNAdecreases expression 16037295
C081628 advanced glycation end products-bovine serum albumin advanced glycation end products-bovine serum albumin results in decreased expression of LEP proteindecreases expression 16037295
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LEP mRNAaffects expression 16483693
C078814 anandamide LEP protein results in decreased abundance of anandamidedecreases abundance 16154199
C078814 anandamide LEP protein results in decreased activity of anandamidedecreases activity 16154199
C078814 anandamide LEP protein results in decreased transport of anandamidedecreases transport 16154199
D047310 Apigenin Apigenin results in increased expression of LEP mRNAincreases expression 18359623
D047310 Apigenin Apigenin results in increased expression of LEP proteinincreases expression 18359623
D016718 Arachidonic Acid Arachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA]decreases expression|increases reaction 19063610
C081565 arachidonyltrifluoromethane arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA]decreases expression|decreases reaction 19063610
D001218 Aspartame Aspartame results in decreased expression of LEP proteindecreases expression 11890951
C006780 bisphenol A bisphenol A results in increased expression of LEP mRNAincreases expression 18359623
18417718
C087220 BQ 610 BQ 610 inhibits the reaction [Indomethacin results in increased expression of LEP protein]decreases reaction|increases expression 16280098
C087220 BQ 610 BQ 610 results in decreased expression of LEP proteindecreases expression 16391412
C086539 BQ 788 BQ 788 inhibits the reaction [LEP protein affects the abundance of Calcium]affects abundance|decreases reaction 16380530
C086539 BQ 788 BQ 788 inhibits the reaction [LEP protein results in increased abundance of Superoxides]decreases reaction|increases abundance 16380530
C086539 BQ 788 BQ 788 inhibits the reaction [LEP protein results in increased expression of NCF1 protein]decreases reaction|increases expression 16380530
C086539 BQ 788 BQ 788 inhibits the reaction [LEP protein results in increased expression of NCF2 protein]decreases reaction|increases expression 16380530
C086539 BQ 788 [PD 98059 co-treated with BQ 788] results in decreased expression of LEP proteinaffects cotreatment|decreases expression 16391412
C057368 BRL 37344 BRL 37344 results in decreased expression of LEP mRNAdecreases expression 9002984
C057368 BRL 37344 BRL 37344 results in decreased expression of LEP proteindecreases expression 9002984
C057368 BRL 37344 BRL 37344 results in decreased stability of LEP mRNAdecreases stability 9002984
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]decreases reaction|increases expression 16822543
D002118 Calcium acetovanillone inhibits the reaction [LEP protein affects the abundance of Calcium]affects abundance|decreases reaction 16380530
D002118 Calcium BQ 788 inhibits the reaction [LEP protein affects the abundance of Calcium]affects abundance|decreases reaction 16380530
D002118 Calcium cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein affects the abundance of Calcium]affects abundance|decreases reaction 16380530
D002118 Calcium LEP protein affects the abundance of Calciumaffects abundance 16380530
D002118 Calcium LEP protein results in decreased abundance of Calciumdecreases abundance 14657008
D002118 Calcium Calcium affects the expression of LEP mRNAaffects expression 15913539
D002251 Carbon Tetrachloride LEP protein affects the reaction [Carbon Tetrachloride results in increased activity of STAT3 protein]affects reaction|increases activity 12730884
D002251 Carbon Tetrachloride LEP protein affects the reaction [Carbon Tetrachloride results in increased degradation of NFKBIA protein]affects reaction|increases degradation 12730884
D002251 Carbon Tetrachloride LEP protein affects the reaction [Carbon Tetrachloride results in increased expression of CCND1 protein]affects reaction|increases expression 12730884
D002251 Carbon Tetrachloride LEP protein affects the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]affects reaction|increases expression 12730884
D002251 Carbon Tetrachloride LEP protein affects the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]affects reaction|increases expression 12730884
D002251 Carbon Tetrachloride LEP protein affects the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]affects reaction|increases expression 12586293
D002251 Carbon Tetrachloride LEP protein affects the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]affects reaction|increases expression 12730884
D002251 Carbon Tetrachloride LEP protein affects the reaction [Carbon Tetrachloride results in increased expression of TNF protein]affects reaction|increases expression 12730884
D002251 Carbon Tetrachloride LEP protein affects the reaction [Carbon Tetrachloride results in increased localization of RELA protein]affects reaction|increases localization 12730884
D002251 Carbon Tetrachloride LEP protein promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]increases expression|increases reaction 11481614
D002251 Carbon Tetrachloride LEP protein promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]increases expression|increases reaction 11481614
D002251 Carbon Tetrachloride LEP protein promotes the reaction [Carbon Tetrachloride results in increased expression of SERPINH1 mRNA]increases expression|increases reaction 11481614
D002251 Carbon Tetrachloride LEP protein promotes the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]increases expression|increases reaction 11481614
D002251 Carbon Tetrachloride [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP proteinaffects cotreatment|increases expression 18227024
D002251 Carbon Tetrachloride [Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP mRNAaffects cotreatment|increases expression 14758566
D002251 Carbon Tetrachloride [Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP proteinaffects cotreatment|increases expression 14758566
D002251 Carbon Tetrachloride Drugs, Chinese Herbal inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein]affects cotreatment|decreases reaction|increases expression 18227024
D002569 Cerulenin LEP protein affects the susceptibility to Ceruleninaffects response to substance 11289036
D002791 Cholesterol, Dietary Cholesterol, Dietary results in decreased expression of LEP mRNAdecreases expression 20157255
D002791 Cholesterol, Dietary Cholesterol, Dietary results in decreased expression of LEP proteindecreases expression 20157255
D002857 Chromium Chromium results in decreased expression of LEP proteindecreases expression 17114815
D003024 Clozapine LEP protein affects the susceptibility to Clozapineaffects response to substance 17502770
D003024 Clozapine Clozapine results in increased expression of LEP proteinincreases expression 16402076
C072247 cyclo(Trp-Asp-Pro-Val-Leu) cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein affects the abundance of Calcium]affects abundance|decreases reaction 16380530
C072247 cyclo(Trp-Asp-Pro-Val-Leu) cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein results in increased abundance of Superoxides]decreases reaction|increases abundance 16380530
C072247 cyclo(Trp-Asp-Pro-Val-Leu) cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein results in increased expression of NCF1 protein]decreases reaction|increases expression 16380530
C072247 cyclo(Trp-Asp-Pro-Val-Leu) cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein results in increased expression of NCF2 protein]decreases reaction|increases expression 16380530
D018119 Stavudine Stavudine results in decreased expression of LEP proteindecreases expression 17668557
D003609 Dactinomycin Dactinomycin inhibits the reaction [LEP protein results in increased expression of COL1A2 mRNA]decreases reaction|increases expression 12704794
C014347 decitabine decitabine results in decreased methylation of LEP promoterdecreases methylation 17502362
C014347 decitabine decitabine results in increased expression of LEP mRNAincreases expression 17502362
C014347 decitabine [decitabine results in increased expression of LEP mRNA] which results in increased expression of MMP13 mRNAincreases expression 17502362
C014347 decitabine trichostatin A promotes the reaction [decitabine results in increased expression of LEP mRNA]increases expression|increases reaction 17502362
D003994 Bucladesine Bucladesine results in decreased expression of LEP mRNAdecreases expression 9002984
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNAaffects cotreatment|decreases expression 16931933
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNAaffects cotreatment|decreases expression 16931933
D004041 Dietary Fats Dietary Fats results in increased expression of LEP mRNAincreases expression 20132043
D004041 Dietary Fats Dietary Fats results in increased expression of LEP proteinincreases expression 21332399
D004041 Dietary Fats orlistat inhibits the reaction [Dietary Fats results in increased expression of LEP protein]decreases reaction|increases expression 21332399
D004041 Dietary Fats Plant Extracts inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA]decreases reaction|increases expression 20132043
D019422 Dietary Sucrose Dietary Sucrose results in increased expression of LEP proteinincreases expression 18627777
D002117 Calcitriol LEP protein results in decreased abundance of Calcitrioldecreases abundance 14657008
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of LEP mRNAincreases expression 15798949
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of LEP proteinincreases expression 15798949
C007517 diphenyleneiodonium diphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of LEP protein]decreases expression|decreases reaction 17668557
C007517 diphenyleneiodonium diphenyleneiodonium inhibits the reaction [lopinavir results in decreased expression of LEP protein]decreases expression|decreases reaction 17668557
C007517 diphenyleneiodonium diphenyleneiodonium inhibits the reaction [Nelfinavir results in decreased expression of LEP protein]decreases expression|decreases reaction 17668557
C007517 diphenyleneiodonium diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of LEP protein]decreases expression|decreases reaction 17668557
D004280 Dobutamine Dobutamine results in decreased secretion of LEP proteindecreases secretion 11022189
D004280 Dobutamine Dobutamine results in decreased expression of LEP mRNAdecreases expression 9002984
D004280 Dobutamine Dobutamine results in decreased expression of LEP proteindecreases expression 9002984
D004281 Docosahexaenoic Acids Docosahexaenoic Acids results in decreased expression of LEP mRNAdecreases expression 15949695
D004281 Docosahexaenoic Acids Docosahexaenoic Acids results in decreased expression of LEP mRNAdecreases expression 15949695
D004365 Drugs, Chinese Herbal Drugs, Chinese Herbal inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein]affects cotreatment|decreases reaction|increases expression 18227024
D004365 Drugs, Chinese Herbal Drugs, Chinese Herbal results in increased expression of LEP proteinincreases expression 18227024
D015118 Eicosapentaenoic Acid Eicosapentaenoic Acid results in decreased expression of LEP mRNAdecreases expression 15949695
D015118 Eicosapentaenoic Acid Eicosapentaenoic Acid results in decreased expression of LEP mRNAdecreases expression 15949695
D004958 Estradiol Estradiol results in increased expression of LEP mRNAincreases expression 18359623
D000431 Ethanol [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP proteinaffects cotreatment|increases expression 18227024
D000431 Ethanol Drugs, Chinese Herbal inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein]affects cotreatment|decreases reaction|increases expression 18227024
D015525 Fatty Acids, Omega-3 Fatty Acids, Omega-3 results in decreased expression of LEP mRNAdecreases expression 15949695
D005280 Fenoterol Fenoterol results in decreased secretion of LEP proteindecreases secretion 11022189
D005576 Forskolin Forskolin results in decreased expression of LEP mRNAdecreases expression 9002984
D005620 Freund's Adjuvant Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]decreases reaction|increases expression 16822543
D005632 Fructose Fructose results in increased expression of LEP mRNAincreases expression 19165636
11741341
D005632 Fructose Fructose results in increased expression of LEP proteinincreases expression 18627777
D005632 Fructose Fructose results in increased secretion of LEP proteinincreases secretion 19165636
D019833 Genistein Genistein results in decreased expression of LEP mRNAdecreases expression 18359623
D019833 Genistein Genistein results in decreased expression of LEP proteindecreases expression 18359623
D005947 Glucose Glucose results in increased expression of LEP proteinincreases expression 18627777
D019469 Indinavir diphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of LEP protein]decreases expression|decreases reaction 17668557
D019469 Indinavir Indinavir results in decreased expression of LEP proteindecreases expression 17668557
D019469 Indinavir [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNAaffects cotreatment|decreases expression 16931933
D007213 Indomethacin BQ 610 inhibits the reaction [Indomethacin results in increased expression of LEP protein]decreases reaction|increases expression 16280098
D007213 Indomethacin EDN1 protein promotes the reaction [Indomethacin results in increased expression of LEP protein]increases expression|increases reaction 16280098
D007213 Indomethacin Indomethacin results in increased expression of LEP proteinincreases expression 16280098
D007213 Indomethacin LEP protein inhibits the reaction [Indomethacin results in decreased activity of GSR protein]decreases activity|decreases reaction 18181030
D007545 Isoproterenol Isoproterenol results in decreased secretion of LEP proteindecreases secretion 11022189
D007545 Isoproterenol Propranolol inhibits the reaction [Isoproterenol results in decreased secretion of LEP protein]decreases reaction|decreases secretion 11022189
D001556 Lindane Lindane affects the expression of LEP mRNAaffects expression 17785943
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of LEP mRNAdecreases expression 12057914
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of LEP mRNAincreases expression 12057914
D008070 Lipopolysaccharides Lipopolysaccharides inhibits the reaction [Thioacetamide results in increased expression of LEP protein]decreases reaction|increases expression 17621560
C112035 lopinavir diphenyleneiodonium inhibits the reaction [lopinavir results in decreased expression of LEP protein]decreases expression|decreases reaction 17668557
C112035 lopinavir lopinavir results in decreased expression of LEP proteindecreases expression 17668557
D008345 Manganese LEP gene mutant form results in decreased abundance of Manganesedecreases abundance 10965932
D016210 Methacholine Chloride LEP gene mutant form results in increased susceptibility to Methacholine Chlorideincreases response to substance 12794034
D008770 Methylnitrosourea Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]decreases reaction|increases expression 16822543
D008770 Methylnitrosourea Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]decreases reaction|increases expression 16822543
D008770 Methylnitrosourea IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]decreases reaction|increases expression 16822543
D008770 Methylnitrosourea Methylnitrosourea results in increased expression of LEP proteinincreases expression 16822543
D019888 Nelfinavir diphenyleneiodonium inhibits the reaction [Nelfinavir results in decreased expression of LEP protein]decreases expression|decreases reaction 17668557
D019888 Nelfinavir Nelfinavir results in decreased expression of LEP proteindecreases expression 17668557
C025256 nonylphenol nonylphenol results in increased expression of LEP mRNAincreases expression 18417718
D019301 Oleic Acid Oleic Acid results in decreased expression of LEP mRNAdecreases expression 9002984
C474055 octylphenol octylphenol results in decreased expression of LEP proteindecreases expression 18417718
C474055 octylphenol octylphenol results in increased expression of LEP mRNAincreases expression 18417718
D019319 Okadaic Acid Okadaic Acid affects the expression of LEP mRNAaffects expression 10628429
C055122 orlistat orlistat inhibits the reaction [Dietary Fats results in increased expression of LEP protein]decreases reaction|increases expression 21332399
D010126 Ozone LEP gene mutant form promotes the reaction [Ozone results in increased expression of CCL11 protein]increases expression|increases reaction 12794034
D010126 Ozone LEP gene mutant form promotes the reaction [Ozone results in increased expression of CXCL1 protein]increases expression|increases reaction 12794034
D010126 Ozone LEP gene mutant form promotes the reaction [Ozone results in increased expression of IL6 protein]increases expression|increases reaction 12794034
D010126 Ozone LEP gene mutant form results in increased susceptibility to Ozoneincreases response to substance 16002559
12794034
D010126 Ozone LEP protein results in increased susceptibility to Ozoneincreases response to substance 12794034
C093973 PD 98059 [PD 98059 co-treated with BQ 788] results in decreased expression of LEP proteinaffects cotreatment|decreases expression 16391412
D010622 Phencyclidine Phencyclidine results in increased expression of LEP mRNAincreases expression 12105081
D010634 Phenobarbital [Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP mRNAaffects cotreatment|increases expression 14758566
D010634 Phenobarbital [Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP proteinaffects cotreatment|increases expression 14758566
D010710 Phosphates LEP protein results in decreased abundance of Phosphatesdecreases abundance 14657008
C008890 phosphoramidon phosphoramidon results in decreased expression of LEP proteindecreases expression 16391412
C006253 pirinixic acid pirinixic acid inhibits the reaction [rosiglitazone results in increased expression of LEP protein]decreases reaction|increases expression 16306350
C108475 pitavastatin pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA]decreases reaction|increases expression 18323514
C108475 pitavastatin pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of IL6 mRNA]decreases reaction|increases expression 18323514
C108475 pitavastatin pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of TNF mRNA]decreases reaction|increases expression 18323514
D010936 Plant Extracts Plant Extracts inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA]decreases reaction|increases expression 20132043
D017035 Pravastatin Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA]decreases reaction|increases expression 18323514
D017035 Pravastatin Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of IL6 mRNA]decreases reaction|increases expression 18323514
D017035 Pravastatin Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of TNF mRNA]decreases reaction|increases expression 18323514
D011374 Progesterone [LEP protein co-treated with IGF1 protein] results in increased abundance of Progesteroneaffects cotreatment|increases abundance 17154301
D011374 Progesterone Progesterone results in decreased secretion of LEP proteindecreases secretion 16048798
D011374 Progesterone Progesterone results in increased expression of LEP mRNAincreases expression 15713686
D011433 Propranolol Propranolol inhibits the reaction [Isoproterenol results in decreased secretion of LEP protein]decreases reaction|decreases secretion 11022189
D019438 Ritonavir diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of LEP protein]decreases expression|decreases reaction 17668557
D019438 Ritonavir Ritonavir results in decreased expression of LEP proteindecreases expression 17668557
C089730 rosiglitazone rosiglitazone results in decreased expression of LEP mRNAdecreases expression 15949695
C089730 rosiglitazone pirinixic acid inhibits the reaction [rosiglitazone results in increased expression of LEP protein]decreases reaction|increases expression 16306350
D012406 Roxarsone Roxarsone results in decreased expression of LEP mRNAdecreases expression 18414637
D019258 Saquinavir [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNAaffects cotreatment|decreases expression 16931933
D012643 Selenium LEP gene mutant form results in decreased abundance of Seleniumdecreases abundance 10965932
C076252 SR 58611A 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [SR 58611A results in decreased expression of LEP mRNA]decreases expression|decreases reaction 9718277
C076252 SR 58611A SR 58611A results in decreased expression of LEP mRNAdecreases expression 9718277
D013481 Superoxides acetovanillone inhibits the reaction [LEP protein results in increased abundance of Superoxides]decreases reaction|increases abundance 16380530
D013481 Superoxides BQ 788 inhibits the reaction [LEP protein results in increased abundance of Superoxides]decreases reaction|increases abundance 16380530
D013481 Superoxides cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein results in increased abundance of Superoxides]decreases reaction|increases abundance 16380530
D013481 Superoxides LEP protein results in increased abundance of Superoxidesincreases abundance 16380530
D013549 Sweetening Agents Sweetening Agents results in increased expression of LEP proteinincreases expression 18627777
C001803 tempol tempol inhibits the reaction [LEP protein results in decreased activity of PON1 protein]decreases activity|decreases reaction 15829432
D013726 Terbutaline Terbutaline results in decreased expression of LEP mRNAdecreases expression 9002984
D013726 Terbutaline Terbutaline results in decreased expression of LEP proteindecreases expression 9002984
D013749 Tetrachlorodibenzodioxin Arachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA]decreases expression|increases reaction 19063610
D013749 Tetrachlorodibenzodioxin arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA]decreases expression|decreases reaction 19063610
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LEP mRNAdecreases expression 19063610
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of AGRP mRNAaffects cotreatment|affects expression 15977195
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of CARTPT mRNAaffects cotreatment|affects expression 15977195
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of HCRT mRNAaffects cotreatment|affects expression 15977195
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of HCRTR2 mRNAaffects cotreatment|affects expression 15977195
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of HDC mRNAaffects cotreatment|affects expression 15977195
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of INSR mRNAaffects cotreatment|affects expression 15977195
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of MC4R mRNAaffects cotreatment|affects expression 15977195
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of NPY5R mRNAaffects cotreatment|affects expression 15977195
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of NPY mRNAaffects cotreatment|affects expression 15977195
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of PMCH mRNAaffects cotreatment|affects expression 15977195
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of POMC mRNAaffects cotreatment|affects expression 15977195
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of SDC3 mRNAaffects cotreatment|affects expression 15977195
D013853 Thioacetamide LEP gene mutant form results in decreased susceptibility to Thioacetamidedecreases response to substance 12085344
D013853 Thioacetamide LEP protein affects the reaction [Thioacetamide results in increased expression of ACTA2 protein]affects reaction|increases expression 12085344
D013853 Thioacetamide LEP protein affects the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]affects reaction|increases expression 12085344
D013853 Thioacetamide LEP protein affects the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]affects reaction|increases expression 12085344
D013853 Thioacetamide LEP protein promotes the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]increases expression|increases reaction 11481614
D013853 Thioacetamide LEP protein results in increased susceptibility to Thioacetamideincreases response to substance 12085344
D013853 Thioacetamide [Thioacetamide co-treated with LEP protein] results in increased expression of COL1A1 mRNAaffects cotreatment|increases expression 16097051
D013853 Thioacetamide Lipopolysaccharides inhibits the reaction [Thioacetamide results in increased expression of LEP protein]decreases reaction|increases expression 17621560
D013853 Thioacetamide Thioacetamide results in increased expression of LEP proteinincreases expression 17621560
C012589 trichostatin A trichostatin A promotes the reaction [decitabine results in increased expression of LEP mRNA]increases expression|increases reaction 17502362
C012589 trichostatin A trichostatin A results in increased expression of LEP mRNAincreases expression 17502362
C057693 troglitazone [troglitazone binds to and results in increased activity of PPARG protein] which results in decreased secretion of LEP proteinaffects binding|decreases secretion|increases activity 16037295
D014638 Vanadates Vanadates results in increased expression of LEP proteinincreases expression 11899024
D014639 Vanadium Vanadium promotes the reaction [LEP protein results in increased expression of UCP1 protein]increases expression|increases reaction 16195403
D014639 Vanadium Vanadium promotes the reaction [LEP protein results in increased phosphorylation of STAT3 protein]increases phosphorylation|increases reaction 16195403
D014801 Vitamin A LEP gene mutant form promotes the reaction [Vitamin A results in increased expression of UCP1 mRNA]increases expression|increases reaction 16493122
D015215 Zidovudine Zidovudine results in decreased expression of LEP proteindecreases expression 17668557
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNAaffects cotreatment|decreases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNAaffects cotreatment|decreases expression 16931933
D015032 Zinc LEP gene mutant form results in decreased abundance of Zincdecreases abundance 10965932
D015054 Zymosan LEP protein affects the susceptibility to Zymosanaffects response to substance 15142272
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 13.6218926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 13.626195326
MESH:D000014 Abnormalities, Drug-Induced Terbutaline 13.6214610225
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.6215322242 11752688 14514962
MESH:D000015 Abnormalities, Multiple Vitamin A 4.1010992263
MESH:D000038 Abscess Drugs, Chinese Herbal 5.4515043669
MESH:D000138 Acidosis Ammonium Chloride 7.6918287403
MESH:D000138 Acidosis Ethanol 7.6911192467
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.009612607
MESH:D000169 Acrodermatitis Zinc 4.5616889938 17190629 17202136
MESH:D058186 Acute Kidney Injury Superoxides 4.3518460982
MESH:D055371 Acute Lung Injury Lipopolysaccharides 6.4518653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 6.4518653653
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 10.1916033868
MESH:D000230 Adenocarcinoma Estradiol 10.1911473722
MESH:D000230 Adenocarcinoma Genistein 10.1911473722
MESH:D000230 Adenocarcinoma Indomethacin 10.1916537180
MESH:D000230 Adenocarcinoma Methylnitrosourea 10.1915688392 15113128
MESH:D000236 Adenoma Dimethylnitrosamine 5.3219555203
MESH:D000236 Adenoma Indomethacin 5.3211497255
MESH:D018248 Adenoma, Liver Cell Phenobarbital 12.4517620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 12.4516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 12.4516835633
MESH:D000380 Agranulocytosis Clozapine 4.2312649775 14617031 16160616
MESH:D000382 Agricultural Workers' Diseases Lindane 3.5612661182
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.4615451040 15451039
MESH:D016301 Alveolar Bone Loss Indomethacin 4.5117225004
MESH:D000544 Alzheimer Disease therapeutic 20157255
MESH:D000544 Alzheimer Disease 27-hydroxycholesterol 14.8420157255 14523054
MESH:D000544 Alzheimer Disease Cholesterol, Dietary 14.8420157255
MESH:D000544 Alzheimer Disease Indomethacin 14.8415579461 17627676
MESH:D000544 Alzheimer Disease Ozone 14.8415513908
MESH:D000544 Alzheimer Disease Plant Extracts 14.8416962711
MESH:D000544 Alzheimer Disease rosiglitazone 14.8419621015
MESH:D000544 Alzheimer Disease Zinc 14.8416410023 16325427 16580781 17119284
MESH:D000686 Amyloidosis Terbutaline 4.827986221
MESH:D000740 Anemia Drugs, Chinese Herbal 15.2017963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 15.2011748828
MESH:D000740 Anemia Vitamin A 15.2016960172
MESH:D000740 Anemia Zymosan 15.2018664788
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.0516960172
MESH:D000755 Anemia, Sickle Cell Aspartame 9.7211372003
MESH:D000755 Anemia, Sickle Cell Zinc 9.7216916123
MESH:D000756 Anemia, Sideroblastic Manganese 8.7216910769
MESH:D000756 Anemia, Sideroblastic Superoxides 8.7216910769
MESH:D000787 Angina Pectoris Drugs, Chinese Herbal 4.5611477813
MESH:D000799 Angioedema Acetaminophen 2.9910982225
MESH:D000853 Anophthalmos Ethanol 3.9915513904
MESH:D000860 Anoxia Oleic Acid 5.0615090967
MESH:D001004 Anus Diseases Drugs, Chinese Herbal 5.1115043669
MESH:D001008 Anxiety Disorders Ethanol 3.3111141031
MESH:D001014 Aortic Aneurysm Indomethacin 4.0410231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.0510388637
MESH:D001161 Arteriosclerosis Cholesterol, Dietary 7.9615552841
MESH:D001161 Arteriosclerosis Dietary Fats 7.9615238619
MESH:D018771 Arthralgia Indomethacin 4.312160914
MESH:D001169 Arthritis, Experimental marker/mechanism 15142272
MESH:D001169 Arthritis, Experimental Plant Extracts 6.1114686799
MESH:D001169 Arthritis, Experimental Zymosan 6.1117659584 15142272 15944321 15188379 16872482
MESH:D015210 Arthritis, Gouty Drugs, Chinese Herbal 4.9019655406
MESH:D001172 Arthritis, Rheumatoid Aspartame 5.9510777254
MESH:D001172 Arthritis, Rheumatoid Indomethacin 5.9511248219
MESH:D001172 Arthritis, Rheumatoid Ozone 5.9515570426
MESH:D001249 Asthma Acetaldehyde 8.429600491
MESH:D001249 Asthma Ozone 8.4217854713 16373670
MESH:D001249 Asthma Vitamin A 8.4216732791
MESH:D001249 Asthma Zinc 8.4217085522
MESH:D050197 Atherosclerosis 27-hydroxycholesterol 3.889059518 11166758
MESH:D001289 Attention Deficit Disorder with Hyperactivity Fatty Acids, Omega-3 4.2018448859
MESH:D001321 Autistic Disorder marker/mechanism 17347881
MESH:D001321 Autistic Disorder Acetaminophen 3.6218445737
MESH:D001321 Autistic Disorder Arachidonic Acid 3.6218582451
MESH:D001321 Autistic Disorder Docosahexaenoic Acids 3.6218582451
MESH:D001321 Autistic Disorder Fatty Acids, Omega-3 3.6216920077
MESH:D001321 Autistic Disorder Propranolol 3.6218766980
MESH:D001321 Autistic Disorder Terbutaline 3.6217400887 16417856
MESH:D001477 Bartter Syndrome Indomethacin 4.1610684365
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.9319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.9312125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 10.9319483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 2.9315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.1615746008
MESH:D019046 Bone Marrow Neoplasms Dactinomycin 4.6814601052
MESH:D001862 Bone Resorption bisphenol A 11.7211985600
MESH:D001862 Bone Resorption Drugs, Chinese Herbal 11.729881647
MESH:D001862 Bone Resorption Freund's Adjuvant 11.7216769263
MESH:D001919 Bradycardia Isoproterenol 8.556740701
MESH:D001919 Bradycardia Propranolol 8.556740701
MESH:D001929 Brain Edema Indomethacin 4.1711481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.4817868700
MESH:D001930 Brain Injuries Progesterone 8.3115665606 15845082 15380490
MESH:D001930 Brain Injuries Zinc 8.3117109824
MESH:D002545 Brain Ischemia Indomethacin 7.7412524144
MESH:D002545 Brain Ischemia Plant Extracts 7.7416041641
MESH:D001943 Breast Neoplasms Apigenin 10.0617132221 16541309
MESH:D001943 Breast Neoplasms bisphenol A 10.0617123778
MESH:D001943 Breast Neoplasms Calcitriol 10.0611237771
MESH:D001943 Breast Neoplasms Chromium 10.0615986119
MESH:D001943 Breast Neoplasms decitabine 10.0618320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 10.0620435547
MESH:D001943 Breast Neoplasms Estradiol 10.0617018787 12948864 17261762 19861407 14630087 17289903 18497071 16675129
MESH:D001943 Breast Neoplasms Genistein 10.0616873071 16541309 17200150
MESH:D001943 Breast Neoplasms Indomethacin 10.0617401462
MESH:D001943 Breast Neoplasms Lindane 10.0614688026
MESH:D001943 Breast Neoplasms Methylnitrosourea 10.0616253758 14633655 11306469
MESH:D001943 Breast Neoplasms Progesterone 10.0617614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 10.0620435547
MESH:D001943 Breast Neoplasms Vanadium 10.0615565634
MESH:D016535 Bronchial Hyperreactivity Ozone 2.9915516495 19059883 18417511 17626835 18315731 16777450 14754758
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 4.7617377406 17426644
MESH:D019121 Burkholderia Infections orlistat 5.7817874328
MESH:D002056 Burns Ethanol 8.6516374292
MESH:D002056 Burns Indomethacin 8.6510459503
MESH:D002057 Burns, Chemical Plant Extracts 4.489625245
MESH:D002100 Cachexia Indomethacin 9.6011239499 16537180 15141370 15625704
MESH:D002100 Cachexia Ozone 9.6016183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.6216111702
MESH:D019559 Capillary Leak Syndrome Terbutaline 5.0011713377 9428835
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 2.9615700767 16124888 10355542 3786805 16227642 16011737 15673190 16097048 15721981 16050911 16192424 18705752
MESH:D002277 Carcinoma Dimethylnitrosamine 6.0519555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.0516835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 17.933084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 17.9318788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 17.9316924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 17.9318788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular Genistein 17.9316924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 17.9316391822
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 17.936705139 17173139 20007298 20935162 1701930
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 17.9318834353
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 17.9317997003
MESH:D006528 Carcinoma, Hepatocellular Vanadium 17.9316878318 16830150
MESH:D002278 Carcinoma in Situ bisphenol A 4.1417123778
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 3.8911053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.5114736730 18791128 11352223
MESH:D002292 Carcinoma, Renal Cell Indomethacin 2.9017341418
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 10.6311237771
MESH:D002294 Carcinoma, Squamous Cell decitabine 10.6319215824
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 10.6316033868
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 10.6315482327 12636206
MESH:D002294 Carcinoma, Squamous Cell Zinc 10.6316543248
MESH:D006332 Cardiomegaly Ethanol 11.9319332462
MESH:D006332 Cardiomegaly Isoproterenol 11.937544033 11179087
MESH:D006332 Cardiomegaly Plant Extracts 11.9317645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 11.9318850075 18670907 16120746
MESH:D002310 Cardiomyopathy, Alcoholic Acetaldehyde 5.6210525098
MESH:D002318 Cardiovascular Diseases Genistein 5.4916332659
MESH:D002318 Cardiovascular Diseases Zinc 5.4916936243
MESH:D002386 Cataract Acetaminophen 5.6610977129
MESH:D002386 Cataract Methylnitrosourea 5.6612484553
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.9218566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 7.927505956 2727394
MESH:D002471 Cell Transformation, Neoplastic Vanadium 7.9217174075
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.434080065
MESH:D015362 Child Nutrition Disorders Vitamin A 4.6216153327
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.1216835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 7.1218291259
MESH:D002764 Cholecystitis Indomethacin 4.3111181007
MESH:D002779 Cholestasis pirinixic acid 6.0619176532
MESH:D002779 Cholestasis Vitamin A 6.0616175620
MESH:D002916 Chylothorax orlistat 5.7817003701
MESH:D002971 Cleft Lip Ethanol 3.0715513904
MESH:D002972 Cleft Palate Ethanol 7.3615513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 7.3612621046 8697196 15668235 15340226 16354765
MESH:D002972 Cleft Palate Vitamin A 7.3616054864
MESH:D003072 Cognition Disorders Clozapine 4.1417123785
MESH:D003092 Colitis Selenium 2.9717936198
MESH:D003110 Colonic Neoplasms marker/mechanism 17354198
MESH:D003110 Colonic Neoplasms decitabine 8.4117616700
MESH:D003110 Colonic Neoplasms Genistein 8.4117182828
MESH:D003110 Colonic Neoplasms Indomethacin 8.4115936596 15963497 11260862 15625704 15786552 15637740
MESH:D003110 Colonic Neoplasms Vanadium 8.4118155637
MESH:D003110 Colonic Neoplasms Vitamin A 8.4117219422 16267017
MESH:D015179 Colorectal Neoplasms decitabine 2.4718981723
MESH:D015179 Colorectal Neoplasms Indomethacin 2.4718059344 12606626 17054584 11197048
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.3314669216 17141729
MESH:D003327 Coronary Disease Fructose 3.8718504504
MESH:D018352 Coronavirus Infections Indomethacin 4.8617302372
MESH:D003371 Cough Terbutaline 4.7119679606
MESH:D019465 Craniofacial Abnormalities Ethanol 4.2219302082 15513904 15451039 11198716 11873399 10194807 15451040
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.2220055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin A 4.2210992263
MESH:D019465 Craniofacial Abnormalities Zinc 4.2219302082
MESH:D003550 Cystic Fibrosis Docosahexaenoic Acids 3.9419747007
MESH:D003715 Dengue 27-hydroxycholesterol 4.8419427377
MESH:D003731 Dental Caries Aspartame 6.068955999
MESH:D017449 Dermatitis, Allergic Contact Aspartame 3.9614996049
MESH:D003876 Dermatitis, Atopic pirinixic acid 1.9618249437
MESH:D048909 Diabetes Complications orlistat 4.9819207292
MESH:D003920 Diabetes Mellitus rosiglitazone 7.1617446233
MESH:D003920 Diabetes Mellitus Zinc 7.1616479319
MESH:D003921 Diabetes Mellitus, Experimental Fructose 3.7918603373
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.1716506275
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 13.1716402076
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 13.1718603373
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 13.1716647724
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 13.1712642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 13.1717107852
MESH:D003924 Diabetes Mellitus, Type 2 troglitazone 13.1716023994
MESH:D003925 Diabetic Angiopathies troglitazone 4.8112601628
MESH:D003928 Diabetic Nephropathies Estradiol 6.7619279558
MESH:D003928 Diabetic Nephropathies Plant Extracts 6.7619706694
MESH:D003929 Diabetic Neuropathies Progesterone 3.6717187935
MESH:D003967 Diarrhea Indomethacin 6.037237001 7907874
MESH:D003967 Diarrhea orlistat 6.0320002075
MESH:D006970 Disorders of Excessive Somnolence Clozapine 4.6915331141
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 21.7715968718 12594235 11834606 19164858 11287661 10774834 16109766 16177239 12958197 19420014 11421492 16393943 17522070 18713872 14725611 11743745 17906064 11739529 18071297 16485898 10915739 2444490 14986274 19370779 19085960 12392966 19416960 19923254 12540782 12153990 16081117 10663392 16227642 17562736 12705907 15619225 11461765 14550746 11529661 19739265 16781746
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 21.773786805 2869522 7120509 16227642 11566570 17522070 6623471 9327722 19336974 4309450 7179309 3732212 15027814 15968718 6884620 21278145 10092053 10915739 15998439 7440962 16177239 19085960
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 21.778172417
MESH:D056486 Drug-Induced Liver Injury Drugs, Chinese Herbal 21.7715027814
MESH:D056486 Drug-Induced Liver Injury Ethanol 21.7711566570
MESH:D056486 Drug-Induced Liver Injury Ritonavir 21.7714986274
MESH:D056486 Drug-Induced Liver Injury Selenium 21.7715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 21.7720420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 21.7712963478
MESH:D056486 Drug-Induced Liver Injury troglitazone 21.7714986274
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.2419426721
MESH:D004362 Drug Toxicity Lamivudine 14.2915040536
MESH:D004362 Drug Toxicity Stavudine 14.2915040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 14.2911462148
MESH:D004362 Drug Toxicity Zidovudine 14.2915040536
MESH:D015352 Dry Eye Syndromes Vitamin A 4.9616146918
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.3018446180 16326151 18043480 16133044 12774134 17190690
MESH:D004381 Duodenal Ulcer Indomethacin 3.3417045617 11595431 17151854 17329845 11535926 11595415 17202747 10671773 11991626 16699067 17351913
MESH:D050171 Dyslipidemias Clozapine 6.6916402076
MESH:D050171 Dyslipidemias Dietary Fats 6.6918367378
MESH:D004421 Dystonia Phenobarbital 3.221851702
MESH:C538011 Eales disease Vitamin A 4.769068938
MESH:D004480 Ectromelia Vitamin A 4.9616054864
MESH:D004487 Edema Arachidonic Acid 21.159599246 9831321 7990266 15177302 16716910 11698051
MESH:D004487 Edema Indomethacin 21.1516100529 19703484 7907874 7990266 10653021 8273558 8985016
MESH:D004487 Edema pirinixic acid 21.1512083418
MESH:D004487 Edema Plant Extracts 21.1512787963
MESH:D004487 Edema rosiglitazone 21.1512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 21.1512711302 11000095
MESH:D004487 Edema Zymosan 21.157907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.0415322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental 15-deoxy-delta(12,14)-prostaglandin J2 15.5616844232
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental 27-hydroxycholesterol 15.5617410599
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 15.5615138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 15.5617692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 11.1819294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 11.1819294695
MESH:D004714 Endometrial Hyperplasia Genistein 3.7516402032
MESH:D016889 Endometrial Neoplasms Estradiol 5.4811473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 5.4811473722
MESH:D004715 Endometriosis Indomethacin 10.9915652904
MESH:D004715 Endometriosis Progesterone 10.9916134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 10.9910568697 9294722
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 4.8215268973
MESH:D019446 Endotoxemia Indomethacin 7.8718509659
MESH:D019446 Endotoxemia Lipopolysaccharides 7.8717637181 15821434 15328337
MESH:D004751 Enteritis Indomethacin 3.8916328016 17763956 10567023
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.1617980183
MESH:D004802 Eosinophilia Indomethacin 3.2511298111
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.293659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.023922381 11558140
MESH:D004827 Epilepsy Phenobarbital 5.2420417680
MESH:D004827 Epilepsy Plant Extracts 5.2419700373 19439326
MESH:D004832 Epilepsy, Absence Phenobarbital 2.826401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.437750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.183659116
MESH:D004893 Erythema Nodosum Aspartame 6.069324739
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 7.8617016578
MESH:D004938 Esophageal Neoplasms Ethanol 7.8616704527
MESH:D004938 Esophageal Neoplasms Indomethacin 7.8611005569
MESH:D004938 Esophageal Neoplasms Zinc 7.8616543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.3411564622
MESH:D005141 Eyelid Diseases Aspartame 5.5214996049
MESH:D005218 Fat Necrosis Thioacetamide 4.8616456712
MESH:D005234 Fatty Liver Carbon Tetrachloride 39.8212795759 61145 15959796 19224547 12631006 16045604 17595544 16239168
MESH:D005234 Fatty Liver Dietary Fats 39.8217967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Dietary Sucrose 39.8217967931
MESH:D005234 Fatty Liver Ethanol 39.8219236843 18620774 16409862
MESH:D005234 Fatty Liver Fructose 39.8218395287 18641190 19196556
MESH:D005234 Fatty Liver pirinixic acid 39.8220131406 19236843
MESH:D005234 Fatty Liver Plant Extracts 39.8215975614
MESH:D005234 Fatty Liver rosiglitazone 39.8219196556
MESH:D005234 Fatty Liver Stavudine 39.8218299183
MESH:D005234 Fatty Liver Zidovudine 39.8218299183
MESH:D005235 Fatty Liver, Alcoholic Ethanol 4.8017920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.4516946407 15451040 15513904 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.6311858732
MESH:D005327 Fetal Resorption Vitamin A 4.5116054864
MESH:D005334 Fever Arachidonic Acid 15.6811852909
MESH:D005334 Fever Aspartame 15.689630831
MESH:D005334 Fever Indomethacin 15.6817627676 11852909 10431976
MESH:D005334 Fever Lipopolysaccharides 15.689205823 11852909
MESH:D005354 Fibrosarcoma Indomethacin 9.4110962813
MESH:D005354 Fibrosarcoma Methylnitrosourea 9.4111555667
MESH:D005355 Fibrosis Carbon Tetrachloride 24.0218705752
MESH:D005355 Fibrosis Dietary Fats 24.0218296743
MESH:D005355 Fibrosis Fructose 24.0218504504
MESH:D005355 Fibrosis Indomethacin 24.0217994277
MESH:D005355 Fibrosis Terbutaline 24.0215467267
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 24.0220067830
MESH:D005414 Flatulence orlistat 5.7820002075
MESH:D005499 Folliculitis Indomethacin 4.3111298111
MESH:D005756 Gastritis Acetaminophen 20.3516983495
MESH:D005756 Gastritis Ethanol 20.3515046732
MESH:D005756 Gastritis Indomethacin 20.3515046732
MESH:D005756 Gastritis Zinc 20.3517241300
MESH:D005909 Glioblastoma Genistein 15.8916598420
MESH:D005909 Glioblastoma Indomethacin 15.8912870263
MESH:D005909 Glioblastoma Manganese 15.8917043766
MESH:D005909 Glioblastoma Okadaic Acid 15.8917312396
MESH:D005909 Glioblastoma trichostatin A 15.8918801729
MESH:D005910 Glioma Indomethacin 5.0716487511 18371953
MESH:D005910 Glioma Methylnitrosourea 5.079825942
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.5811849393
MESH:D018149 Glucose Intolerance Fructose 4.5419165636
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.7310696789
MESH:D006073 Gout Indomethacin 4.5111248219
MESH:D006130 Growth Disorders Zinc 3.3617217573
MESH:D006258 Head and Neck Neoplasms decitabine 5.9619215824
MESH:D006258 Head and Neck Neoplasms Indomethacin 5.9615482327
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.1611294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin A 5.1616080930 10992263
MESH:D006333 Heart Failure Dobutamine 28.9217440445
MESH:D006333 Heart Failure Isoproterenol 28.9218097624
MESH:D006333 Heart Failure pirinixic acid 28.9220558911
MESH:D006333 Heart Failure pitavastatin 28.9215502390
MESH:D006333 Heart Failure Plant Extracts 28.9218097624
MESH:D006333 Heart Failure Propranolol 28.9220082655
MESH:D006333 Heart Failure Selenium 28.9217162251
MESH:D006333 Heart Failure Zinc 28.9217162251
MESH:D006335 Heart Injuries Zinc 4.9117074742
MESH:D016481 Helicobacter Infections Zinc 3.7517241300
MESH:D006402 Hematologic Diseases Zidovudine 3.9312579204
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.6316366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.5711000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 8.3915633222
MESH:D006501 Hepatic Encephalopathy Thioacetamide 8.3918665440 17276928 15929193
MESH:D006505 Hepatitis Carbon Tetrachloride 15.9719110552 19900420
MESH:D006505 Hepatitis Drugs, Chinese Herbal 15.9718339527
MESH:D006505 Hepatitis Thioacetamide 15.9716456712
MESH:D006505 Hepatitis Zymosan 15.9719110552
MESH:D006509 Hepatitis B Lamivudine 4.3317703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 4.3312044531 16476009 15309715 15631357 15274664
MESH:D019698 Hepatitis C, Chronic Indomethacin 3.8815135802
MESH:D006527 Hepatolenticular Degeneration Zinc 3.8717276780
MESH:D006529 Hepatomegaly Phenobarbital 14.0716109766
MESH:D006529 Hepatomegaly pirinixic acid 14.0718467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Propranolol 14.0716371745
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.0712621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin A 3.2417436238 16292552 16490937 16863852 15707848 16877224
MESH:D006558 Herpes Genitalis Estradiol 4.1715709030
MESH:D006561 Herpes Simplex Plant Extracts 3.7910715843
MESH:D015658 HIV Infections Indinavir 35.3511141242 15388451 11363243
MESH:D015658 HIV Infections Lamivudine 35.3520032539 11141242 9296927 17530837
MESH:D015658 HIV Infections lopinavir 35.3517378895
MESH:D015658 HIV Infections Nelfinavir 35.3515388451 11362904
MESH:D015658 HIV Infections Plant Extracts 35.3512878215
MESH:D015658 HIV Infections Ritonavir 35.3517378895 15388451 11141242 11363243
MESH:D015658 HIV Infections Saquinavir 35.3515388451 11141242
MESH:D015658 HIV Infections Stavudine 35.3511141242
MESH:D015658 HIV Infections Vitamin A 35.3516960176
MESH:D015658 HIV Infections Zidovudine 35.3511141242 17358032 11698656 20032539 11363243
MESH:D006679 HIV Seropositivity Vitamin A 4.7617209195
MESH:D019584 Hot Flashes Estradiol 7.5017088409
MESH:D019584 Hot Flashes Plant Extracts 7.5014716179 16566672 17454163
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.1916959395 18606429 8697196 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 17.2316870215
MESH:D006930 Hyperalgesia Ethanol 17.2318783367
MESH:D006930 Hyperalgesia Freund's Adjuvant 17.2316769263
MESH:D006930 Hyperalgesia Indomethacin 17.2312727271
MESH:D006930 Hyperalgesia rosiglitazone 17.2312083418
MESH:D034321 Hyperamylasemia Indomethacin 4.8617883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.6916899240
MESH:D006937 Hypercholesterolemia 27-hydroxycholesterol 15.7817873880
MESH:D006937 Hypercholesterolemia Cholesterol, Dietary 15.7810876104
MESH:D006937 Hypercholesterolemia Dietary Fats 15.7821332399
MESH:D006937 Hypercholesterolemia Pravastatin 15.7817188708
MESH:D006940 Hyperemia Indomethacin 4.1612524144
MESH:D006943 Hyperglycemia pirinixic acid 2.4420558911
MESH:D020138 Hyperhomocysteinemia Plant Extracts 7.6116484555
MESH:D020138 Hyperhomocysteinemia Superoxides 7.6112615666
MESH:D006946 Hyperinsulinism Fructose 4.1818360027 19008412 18563319 14757778 15752949
MESH:D006948 Hyperkinesis Clozapine 4.0716046005
MESH:D006949 Hyperlipidemias Dietary Fats 20.6121332399
MESH:D006949 Hyperlipidemias Fructose 20.6115752949
MESH:D006949 Hyperlipidemias Indomethacin 20.6117546600
MESH:D006949 Hyperlipidemias orlistat 20.6121332399
MESH:D006949 Hyperlipidemias Plant Extracts 20.6115268973 15975614
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 3.7717604070
MESH:D006973 Hypertension Aspartame 6.5318708962
MESH:D006973 Hypertension Fructose 6.5314573337 14568997 16843071 19008412 14633139
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 6.5318850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.2615338365
MESH:D006976 Hypertension, Pulmonary cyclo(Trp-Asp-Pro-Val-Leu) 4.5516327149
MESH:D015228 Hypertriglyceridemia Fructose 4.3319342510 19799862
MESH:D006984 Hypertrophy Isoproterenol 4.4212791704
MESH:D006985 Hyperventilation Terbutaline 5.2410895896
MESH:D006986 Hypervitaminosis A Vitamin A 5.3116054864
MESH:D007008 Hypokalemia Terbutaline 5.2517292646
MESH:D007022 Hypotension anandamide 11.2614504685
MESH:D007022 Hypotension Isoproterenol 11.266740701
MESH:D007022 Hypotension Propranolol 11.266740701
MESH:D007077 Ileal Diseases Indomethacin 4.1710574470 18306037
MESH:D007079 Ileitis Indomethacin 4.5110647630 10651667 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.5116133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.5815869954
MESH:D007248 Infertility, Male decitabine 5.1717581917
MESH:D007248 Infertility, Male Methylnitrosourea 5.177193160
MESH:D007249 Inflammation Arachidonic Acid 33.569831321 15177302 17371808
MESH:D007249 Inflammation Dietary Fats 33.5620412841
MESH:D007249 Inflammation Fatty Acids, Omega-3 33.5617296493
MESH:D007249 Inflammation Freund's Adjuvant 33.5616793879
MESH:D007249 Inflammation Indomethacin 33.567812673 12568917 3291741
MESH:D007249 Inflammation Lipopolysaccharides 33.5617237260 12878042 17255318 17963957 9205823
MESH:D007249 Inflammation Methacholine Chloride 33.5618249437
MESH:D007249 Inflammation Plant Extracts 33.5616366677 12787963 19332304 15997105
MESH:D007249 Inflammation Progesterone 33.5615869954
MESH:D007249 Inflammation rosiglitazone 33.5612083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 33.5612200463 12878042
MESH:D007249 Inflammation Zymosan 33.5611289658 8014878
MESH:D007251 Influenza, Human Selenium 3.3416624496
MESH:D007333 Insulin Resistance bisphenol A 25.5716393666
MESH:D007333 Insulin Resistance Dietary Fats 25.5711836018 18457598
MESH:D007333 Insulin Resistance Estradiol 25.5716627594 16393666
MESH:D007333 Insulin Resistance Fructose 25.5717133782 18563319 19342510 18981581 14757778 14633139 19008412 19586609 19799862 18057795 14573337
MESH:D007333 Insulin Resistance orlistat 25.5717201808
MESH:D007333 Insulin Resistance pirinixic acid 25.5716306350
MESH:D007333 Insulin Resistance rosiglitazone 25.5716306350
MESH:D007410 Intestinal Diseases Indomethacin 7.7815610444 17329856 10210152 11713966 11686837 15831440 11855677 18236018 17994277
MESH:D007410 Intestinal Diseases Superoxides 7.7810210152
MESH:D007414 Intestinal Neoplasms Plant Extracts 3.8712584176 12351151 12628509
MESH:D019586 Intracranial Hypertension Indomethacin 11.3415241188
MESH:D019586 Intracranial Hypertension Vitamin A 11.3415955940
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 3.8417255318
MESH:D043183 Irritable Bowel Syndrome Zymosan 4.9917553498
MESH:D007511 Ischemia Zinc 3.8116584753
MESH:D007569 Jaw Abnormalities Ethanol 7.5715513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 7.5716580747
MESH:D007579 Jejunal Diseases Indomethacin 4.1710574470 18306037 16133968
MESH:D007674 Kidney Diseases Acetaminophen 20.3412587719 15629191
MESH:D007674 Kidney Diseases Aspartame 20.3411409539
MESH:D007674 Kidney Diseases Chromium 20.3417934191
MESH:D007674 Kidney Diseases Estradiol 20.3415618244
MESH:D007674 Kidney Diseases Indomethacin 20.3417190690
MESH:D007674 Kidney Diseases tempol 20.3417640563
MESH:D007674 Kidney Diseases Zinc 20.3416960431
MESH:C531755 Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules orlistat 5.7817185156
MESH:D007676 Kidney Failure, Chronic Selenium 7.5416518626
MESH:D007676 Kidney Failure, Chronic Zinc 7.5416518626
MESH:D007680 Kidney Neoplasms Estradiol 5.3315610895
MESH:D007680 Kidney Neoplasms Zidovudine 5.3312579204
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.1916316344
MESH:D007859 Learning Disorders Ethanol 3.4015451040
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.2012228301 11703811 10320625
MESH:D053609 Lethargy Terbutaline 5.4610895896
MESH:D007938 Leukemia decitabine 4.8418980019 19235587
MESH:D007938 Leukemia Genistein 4.8417468513 18980019
MESH:D004915 Leukemia, Erythroblastic, Acute troglitazone 5.2816085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Drugs, Chinese Herbal 3.4915802533
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Docosahexaenoic Acids 12.2417077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Ritonavir 12.2416174765
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 12.2420370541
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 4.3916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.2616572323 15631656 10785260
MESH:D007951 Leukemia, Myeloid decitabine 3.2417236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.8918704418 19010910 19387464 18460780 18206229 17679729
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 4.8918360721
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.8918206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.6018055864
MESH:D007964 Leukocytosis Indomethacin 4.5116537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 4.8617980183
MESH:D007970 Leukopenia Lipopolysaccharides 3.8615821434
MESH:D017880 Limb Deformities, Congenital Ethanol 10.1917676605
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 10.1915526292
MESH:D017880 Limb Deformities, Congenital Vitamin A 10.1916054864
MESH:D008064 Lipidoses Clozapine 3.3217567588
MESH:D008101 Liver Abscess, Amebic Indomethacin 4.8611479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 27.2516239168 11408273 21278145 16943688 11903743 16221502 17157831 17174718 17334410
MESH:D008103 Liver Cirrhosis Dietary Fats 27.2518296743
MESH:D008103 Liver Cirrhosis Drugs, Chinese Herbal 27.2517163593
MESH:D008103 Liver Cirrhosis Ethanol 27.2515289165
MESH:D008103 Liver Cirrhosis orlistat 27.2517404856
MESH:D008103 Liver Cirrhosis Phenobarbital 27.2521047994
MESH:D008103 Liver Cirrhosis Plant Extracts 27.2517157831
MESH:D008103 Liver Cirrhosis Vitamin A 27.2516256175
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.2518295389
MESH:D008106 Liver Cirrhosis, Experimental marker/mechanism 12586293 16097051
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 23.6215057751 17922224 16192424 17698563 18166357 17481882 17721639 18472332 18395095 17869086 18429990 12898905 16027843 12632514 15123356 16136751 17900296 12445418 18418968 18054572 17525996 14748882 14716833 12546737 13678700 18472094 17766677 15893842 18279442 18006644 10355542 18277467 16097048 18210741 18420326 17761835 15362042 17708605 18376398 15370692 18156304 12649538 15052691 16015684 17631135 15730626 16011737 17823541 16033810 12389079 18187930 16248980 16116963 15673190 18705752 14620537 12632512 15338365 15876570 15931870 12609069 14512876 15959796 17805973 18481824 12666154 12667390 15925388 18317297 15650968 12741479 14716496 12586293 16638106 11481614 17557913 17944888 18395914 20821823 18251166 18339082 17714472 17565644 18412020 12445421 17640975 15996030 14724832 12958196 17976157 18205269 15818738 18263696
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 23.6215099470 15369754 17719030 14643895 14709902 14568256 15942678 17724770 17196135 15793283 15138612 17465448 15504291 17534399 17640959 15577212 15067225 16570917 15744066 14726149 15086199 18239293 18237412 16169303 15339415 15479170 15864749 15161499 15723089 15571005 18095165 18567088 14659978 16009107 18364076 16627068 17348192 16603200 15081153 15383259 18629640 15798949 15298665 15591649 17036385 18637143 15492853 17203207 15366600 17198567 18371158 17201889 17666798 16544323 18672772 12918455 15842777 15733078 15763062 17881167 12925901 16270385 16042886 17432682 18210741
MESH:D008106 Liver Cirrhosis, Experimental Drugs, Chinese Herbal 23.6215864749 16610055 15818738 15383259 17348192 18567088 17881167 15754396 15849816 15744066 17629604 12632512 17036385 15641146 17666798 15763062 15339415 18606216 18237412 18371158
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 23.6214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 23.6218166357
MESH:D008106 Liver Cirrhosis, Experimental Genistein 23.6217823541
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 23.6218194892
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 23.6212878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 23.6215474484
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 23.6215479170
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 23.6215980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 23.6212878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 23.6212891558 18031379 12085344 17292413 16343077 15078482 18606216 15158331 18263696 18380797 18416461 15474484 15288473 11682029 18615449 16126171 16098781 15095483 12175628 15716488 15465738 16248980 11481614 12531686 18395095 15316131 16511523 17629604 15362042 11172339 17050028 18458672 14739098 18032466 16097051 18295389 12679928 17355460 15288472 15075984 10677585 15334695 17127702 12557150 16489207
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 23.6216248980
MESH:D008107 Liver Diseases Acetaminophen 20.3619784758 16610002 19014921 12587719 19460945 11587558 12969438 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 20.3616246199 16964402 15830285 17285989 15720792
MESH:D008107 Liver Diseases Docosahexaenoic Acids 20.3617056761
MESH:D008107 Liver Diseases Drugs, Chinese Herbal 20.3617207593
MESH:D008107 Liver Diseases Lindane 20.361715830
MESH:D008107 Liver Diseases Phenobarbital 20.3619363144
MESH:D008107 Liver Diseases Plant Extracts 20.3617034775
MESH:D008107 Liver Diseases Thioacetamide 20.3618374380 15158337 16337175
MESH:D008107 Liver Diseases Vitamin A 20.3616175620
MESH:D008108 Liver Diseases, Alcoholic Ethanol 8.8117207112 17347304
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 8.8116762690
MESH:D017093 Liver Failure Carbon Tetrachloride 9.1115123358
MESH:D017093 Liver Failure Stavudine 9.1118299183
MESH:D017114 Liver Failure, Acute Acetaminophen 17.1517185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 17.1514706259 16899240
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 17.1517457977
MESH:D017114 Liver Failure, Acute Thioacetamide 17.1515633222 12479984 15313186 17276928
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 18.5418177683
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 18.5419294768
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 18.543113478 15890375
MESH:D008113 Liver Neoplasms Drugs, Chinese Herbal 18.5418339527
MESH:D008113 Liver Neoplasms Phenobarbital 18.5419073162 19482888 15975961 8742319 19812893 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 18.5420007298 16377806 15890375
MESH:D008113 Liver Neoplasms Plant Extracts 18.5419168119
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.5416984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 15.7912014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 15.791848544 6150874 15603536
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 15.791399818 6150874 17172636 18308698 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.7912151625
MESH:D008114 Liver Neoplasms, Experimental Vanadium 15.7917174075
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 15.7917113696
MESH:D008133 Long QT Syndrome Dobutamine 4.0719353679
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 4.6416080182
MESH:D008171 Lung Diseases Dobutamine 9.0816638327
MESH:D008171 Lung Diseases Ozone 9.088266340 19066396
MESH:D008171 Lung Diseases Vitamin A 9.0816863852
MESH:D055370 Lung Injury Lipopolysaccharides 10.7121114838
MESH:D055370 Lung Injury Oleic Acid 10.7115090967
MESH:D055370 Lung Injury Ozone 10.7120417186
MESH:D008175 Lung Neoplasms Acetaldehyde 13.8917372256
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 13.8916337739 18597497 11246140 19925653 15390079 11696405 19359593
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 13.8916061637 11884234 19555203
MESH:D008175 Lung Neoplasms Drugs, Chinese Herbal 13.8918339527
MESH:D008175 Lung Neoplasms Indomethacin 13.8911053908 11497255 16537180
MESH:D008175 Lung Neoplasms Methylnitrosourea 13.8918062963
MESH:D008175 Lung Neoplasms Ozone 13.898597069 7614698
MESH:D008175 Lung Neoplasms Plant Extracts 13.8920869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 13.8911884234 19555203
MESH:D008175 Lung Neoplasms Zidovudine 13.8918800350
MESH:D008207 Lymphatic Metastasis orlistat 5.0818770866 20805790
MESH:D008223 Lymphoma decitabine 5.7819470736
MESH:D008223 Lymphoma Methylnitrosourea 5.7816257854 11418001
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 3.9914633661
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 26.871500032
MESH:D008325 Mammary Neoplasms, Experimental Drugs, Chinese Herbal 26.8714758024
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 26.8716891317 11408345 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 26.8714578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 26.8715113128 12931682 16619500 17131329 11807958 14999141 19196723 14633655 16051031 17020996 15313902 10838139 10767621 16944150 11751437 15688392 16827153
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 26.8717203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 26.8716827153
MESH:D008325 Mammary Neoplasms, Experimental Selenium 26.8715318939
MESH:D008325 Mammary Neoplasms, Experimental Zinc 26.8712773700
MESH:D020149 Manganese Poisoning Estradiol 10.1619453300
MESH:D020149 Manganese Poisoning Manganese 10.1616568477 19453300 16551646
MESH:D008545 Melanoma Cerulenin 7.3220805790
MESH:D008545 Melanoma decitabine 7.3217785578 16505122
MESH:D008545 Melanoma Glucose 7.3214993021
MESH:D008545 Melanoma orlistat 7.3218770866 20805790
MESH:D008545 Melanoma trichostatin A 7.3216505122
MESH:D008546 Melanoma, Experimental Acetaminophen 2.7419513568
MESH:D008569 Memory Disorders Ethanol 3.3918411066 15451040
MESH:D001523 Mental Disorders Clozapine 6.0116856516
MESH:D001523 Mental Disorders Phosphates 6.0112686366
MESH:D008654 Mesothelioma Selenium 2.3815107826
MESH:D024821 Metabolic Syndrome X marker/mechanism 18515891 16793964
MESH:D024821 Metabolic Syndrome X Clozapine 12.0119142101
MESH:D024821 Metabolic Syndrome X Fructose 12.0117098227 18497449 16815490 17261469 19165636
MESH:D024821 Metabolic Syndrome X rosiglitazone 12.0117261469
MESH:D008679 Metaplasia Ozone 4.2510496685
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 4.9817358032
MESH:D008881 Migraine Disorders Aspartame 6.2010792367 18627677
MESH:D008881 Migraine Disorders Indomethacin 6.2011903285
MESH:D009062 Mouth Neoplasms Indomethacin 3.3112636206
MESH:D009069 Movement Disorders Manganese 4.2216551646
MESH:D009101 Multiple Myeloma decitabine 8.6318172295
MESH:D009101 Multiple Myeloma trichostatin A 8.6318172295
MESH:D009101 Multiple Myeloma Vitamin A 8.6316374440
MESH:D009102 Multiple Organ Failure Zymosan 4.4315241586 17724436 18160304 15259001 10479408 10890648 12130978 15834315 12879239 15213630
MESH:D009135 Muscular Diseases orlistat 8.0218430571
MESH:D009135 Muscular Diseases pirinixic acid 8.0216239165
MESH:D009164 Mycobacterium Infections Indinavir 18.8921442799
MESH:D009164 Mycobacterium Infections lopinavir 18.8921442799
MESH:D009164 Mycobacterium Infections orlistat 18.8921442799
MESH:D009164 Mycobacterium Infections Ritonavir 18.8921442799
MESH:D009190 Myelodysplastic Syndromes decitabine 2.8319010910 16882708 18608210 19157545
MESH:D009203 Myocardial Infarction Genistein 9.9917141266
MESH:D009203 Myocardial Infarction Isoproterenol 9.9915740881 16697266 19172585 17052832 19595682 16538859 16584858
MESH:D009203 Myocardial Infarction pirinixic acid 9.9919151258
MESH:D009203 Myocardial Infarction Pravastatin 9.9917188708
MESH:D017202 Myocardial Ischemia Dobutamine 7.0712447174
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.0712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 10.2316810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 10.2317141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 10.2316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.6317484760
MESH:D009362 Neoplasm Metastasis Indomethacin 2.7611239499 16537180 11053908
MESH:D009369 Neoplasms Aspartame 13.3216507461
MESH:D009369 Neoplasms decitabine 13.3217925555 19116145 19470736
MESH:D009369 Neoplasms Lindane 13.3212807735 16818664
MESH:D009369 Neoplasms Methylnitrosourea 13.3215533788
MESH:D009369 Neoplasms orlistat 13.3218710210
MESH:D009369 Neoplasms pirinixic acid 13.3217405874
MESH:D009374 Neoplasms, Experimental Indomethacin 10.9010663608 15625704
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 10.9012696579
MESH:D009374 Neoplasms, Experimental orlistat 10.9019381703
MESH:D009389 Neovascularization, Pathologic Estradiol 7.7117289903
MESH:D009389 Neovascularization, Pathologic orlistat 7.7117012255
MESH:D009410 Nerve Degeneration Manganese 3.6016551646
MESH:D009421 Nervous System Malformations bisphenol A 16.9016427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 16.9011399458 16427766
MESH:D009421 Nervous System Malformations Genistein 16.9016427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.9014600291
MESH:D009436 Neural Tube Defects Vitamin A 3.4717400914
MESH:D009442 Neurilemmoma Methylnitrosourea 4.6411555667
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.3617168769
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.0418514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 6.0412349958
MESH:D009503 Neutropenia lopinavir 8.0117378895
MESH:D009503 Neutropenia Ritonavir 8.0117378895
MESH:C541083 Non-alcoholic Fatty Liver Disease orlistat 4.7917404856
MESH:D009765 Obesity marker/mechanism 18515891
MESH:D009765 Obesity Clozapine 13.7819142110 18515891
MESH:D009765 Obesity Dietary Fats 13.7817217161 20132043 19632207 18457598 21332399 20518802 16723640 18674790 11836018
MESH:D009765 Obesity Fructose 13.7818585860 17707055
MESH:D009765 Obesity orlistat 13.7820002075 20599501 19207292 21438711 19046740 20065556 16938137 20518802 18773755 21442799 19461584 20540997
MESH:D009765 Obesity pirinixic acid 13.7820558911
MESH:D009765 Obesity Plant Extracts 13.7819056576 20132043
MESH:D007752 Obstetric Labor, Premature Indomethacin 10.636374098
MESH:D007752 Obstetric Labor, Premature Terbutaline 10.6314998686
MESH:D019226 Oral Ulcer therapeutic 16391412
MESH:D010003 Osteoarthritis Aspartame 6.399630831
MESH:D010003 Osteoarthritis Indomethacin 6.397009135
MESH:D010018 Osteomalacia Phenobarbital 3.5217016548
MESH:D010024 Osteoporosis Calcium 5.5317882678
MESH:D010024 Osteoporosis Genistein 5.5319401787
MESH:D015663 Osteoporosis, Postmenopausal Drugs, Chinese Herbal 7.8216548355
MESH:D015663 Osteoporosis, Postmenopausal Genistein 7.8216169203
MESH:D010049 Ovarian Diseases bisphenol A 4.1411985600
MESH:D010051 Ovarian Neoplasms decitabine 11.0619259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 11.0619401270
MESH:D010051 Ovarian Neoplasms Genistein 11.0619005980
MESH:D010051 Ovarian Neoplasms Progesterone 11.0617393432 16525653
MESH:D010051 Ovarian Neoplasms trichostatin A 11.0619331143
MESH:D010146 Pain Acetaminophen 7.4816870215
MESH:D010146 Pain Aspartame 7.489630831
MESH:D010146 Pain Indomethacin 7.4813679232 3291741 17440234 17627676
MESH:D010149 Pain, Postoperative Indomethacin 3.8312538197 18702446
MESH:D010190 Pancreatic Neoplasms decitabine 12.0519294695
MESH:D010190 Pancreatic Neoplasms Ethanol 12.0512384795
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 12.0516965848
MESH:D010190 Pancreatic Neoplasms Phenobarbital 12.0516965848
MESH:D010190 Pancreatic Neoplasms trichostatin A 12.0519294695
MESH:D010195 Pancreatitis Indomethacin 6.5015028970 17883296
MESH:D010195 Pancreatitis orlistat 6.5020065556 16938137
MESH:D010212 Papilloma Plant Extracts 3.6815173996 16517061
MESH:D010257 Paraneoplastic Syndromes Indomethacin 4.8616537180
MESH:D010300 Parkinson Disease Cholesterol, Dietary 4.8719014385
MESH:D010300 Parkinson Disease Manganese 4.8711181820
MESH:D020734 Parkinsonian Disorders Indomethacin 7.0412349958
MESH:D020734 Parkinsonian Disorders Manganese 7.0416140633
MESH:D051302 Paroxysmal Hemicrania Indomethacin 4.8611903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.3912520081
MESH:D010437 Peptic Ulcer Indomethacin 4.3011148446
MESH:D010518 Periodontitis Indomethacin 4.0617225004
MESH:D010538 Peritonitis Ozone 7.6916369182
MESH:D010538 Peritonitis Zymosan 7.6919088179 17371808 15259001 11985352 19641140 18977430 17826846 14761945 15979727 18760300 18557954
MESH:D010954 Plasmacytoma Selenium 4.0315087411
MESH:D011014 Pneumonia Butylated Hydroxytoluene 13.8311893704
MESH:D011014 Pneumonia Lipopolysaccharides 13.8312224865 11605937
MESH:D011014 Pneumonia Ozone 13.8318381685 18929643 18007984
MESH:D011085 Polycystic Ovary Syndrome orlistat 4.5317201808
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.7518163543
MESH:D011230 Precancerous Conditions Phenobarbital 2.902563599
MESH:D011225 Pre-Eclampsia Zinc 3.4917114810
MESH:D047928 Premature Birth Indomethacin 4.3017000239
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 6.7310548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 6.7311118676 11222880 11399792 11896295
MESH:D055728 Primary Myelofibrosis decitabine 9.6917616702
MESH:D055728 Primary Myelofibrosis trichostatin A 9.6917616702
MESH:D011470 Prostatic Hyperplasia Calcitriol 3.9415572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.0020887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.0020887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 15042602
MESH:D011471 Prostatic Neoplasms Apigenin 2.8617132221
MESH:D011471 Prostatic Neoplasms bisphenol A 2.8616740699
MESH:D011471 Prostatic Neoplasms Calcitriol 2.8616289102 16644109 18247401 12479363 15754350
MESH:D011471 Prostatic Neoplasms Estradiol 2.8616740699
MESH:D011471 Prostatic Neoplasms Genistein 2.8615256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Lindane 2.8614688026 12661182
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.8615682402 12376480
MESH:D011471 Prostatic Neoplasms Plant Extracts 2.8617804756 14666653
MESH:D011471 Prostatic Neoplasms trichostatin A 2.8618798265 19789329
MESH:D011471 Prostatic Neoplasms Zinc 2.8616700911 16517595 16606632 12429649
MESH:D011507 Proteinuria Indomethacin 3.3911849393
MESH:D019310 Pseudolymphoma Phenobarbital 3.6412752131
MESH:D011618 Psychotic Disorders Clozapine 3.5315331141
MESH:D011629 Puberty, Precocious bisphenol A 3.9410548101
MESH:D011649 Pulmonary Alveolar Proteinosis 27-hydroxycholesterol 5.5315466366
MESH:D011654 Pulmonary Edema Isoproterenol 13.5210903255
MESH:D011654 Pulmonary Edema Oleic Acid 13.5215090967
MESH:D011654 Pulmonary Edema Terbutaline 13.5210903255
MESH:D011658 Pulmonary Fibrosis Drugs, Chinese Herbal 5.1216987627
MESH:D011658 Pulmonary Fibrosis troglitazone 5.1218162602
MESH:D012003 Rectal Fistula Drugs, Chinese Herbal 5.1115043669
MESH:D012035 Refsum Disease orlistat 5.2320871815
MESH:D015427 Reperfusion Injury pirinixic acid 5.3619058328
MESH:D015427 Reperfusion Injury Superoxides 5.3618460982
MESH:D012128 Respiratory Distress Syndrome, Adult Oleic Acid 7.5918549715
MESH:D012128 Respiratory Distress Syndrome, Adult Terbutaline 7.592878809
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 4.9616877224
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.1210835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.0318990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 7.1618155124 18172121
MESH:D012162 Retinal Degeneration Zinc 7.1616584753
MESH:D012175 Retinoblastoma Methylnitrosourea 4.6411555667
MESH:D012206 Rhabdomyolysis Lamivudine 4.699296927
MESH:D012208 Rhabdomyosarcoma decitabine 3.6219155313
MESH:D012220 Rhinitis Acetaldehyde 4.0117050345
MESH:D012221 Rhinitis, Allergic, Perennial Drugs, Chinese Herbal 4.4215015336
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.4818045962
MESH:D012512 Sarcoma, Ewing's Dactinomycin 4.2814601052
MESH:D012559 Schizophrenia Clozapine 2.5920580759 20168265 17726453 20452607 11763009 20521320 20107430 19369910 20521326 18806925 18855531 17667964 16141801 17123785 11151749
MESH:D012640 Seizures Ethanol 6.489754883
MESH:D012640 Seizures Lindane 6.487539098 12842176 15475178
MESH:D012640 Seizures Phenobarbital 6.484039156 16876388 11442880 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 3.986407741
MESH:D018805 Sepsis Zymosan 3.9411441115
MESH:D012772 Shock, Septic Terbutaline 4.663431524
MESH:D012859 Sjogren's Syndrome Aspartame 5.7216800424
MESH:D012871 Skin Diseases Vitamin A 3.0718709164
MESH:D012878 Skin Neoplasms Glucose 9.7214993021
MESH:D012878 Skin Neoplasms Okadaic Acid 9.7212628509
MESH:D012878 Skin Neoplasms Plant Extracts 9.7215173996 16517061
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.7216192470
MESH:D019082 Smith-Lemli-Opitz Syndrome 27-hydroxycholesterol 5.1811254748
OMIM:270800 SPASTIC PARAPLEGIA 5A, AUTOSOMAL RECESSIVE 27-hydroxycholesterol 5.5319812052
MESH:D013119 Spinal Cord Injuries Progesterone 3.4415862959 16503802
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.4112587719
MESH:D013272 Stomach Diseases Indomethacin 8.2015472012 18209964 17207306 15038085 10486359 16184426 17160473 17638125 10215738 16280098 16113693 18545984 10192188
MESH:D013272 Stomach Diseases phosphoramidon 8.2016280098
MESH:D013274 Stomach Neoplasms decitabine 13.9719037991
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 13.9716033868
MESH:D013274 Stomach Neoplasms Docosahexaenoic Acids 13.9719015929
MESH:D013274 Stomach Neoplasms Drugs, Chinese Herbal 13.9718339527
MESH:D013274 Stomach Neoplasms Ethanol 13.9718456281
MESH:D013274 Stomach Neoplasms Indomethacin 13.9715609394
MESH:D013274 Stomach Neoplasms Methylnitrosourea 13.9716257854 18593901 15930296
MESH:D013274 Stomach Neoplasms orlistat 13.9719381703
MESH:D013274 Stomach Neoplasms troglitazone 13.9715930296
MESH:D013274 Stomach Neoplasms Zidovudine 13.9717696246
MESH:D013276 Stomach Ulcer therapeutic 18181030
MESH:D013276 Stomach Ulcer Ethanol 11.1816755016 9562338 17918041 9211565 11906479 17189318
MESH:D013276 Stomach Ulcer Indomethacin 11.1817654042 16397915 12498302 10750652 16934674 16150113 18087811 15104355 18299717 17627676 18237397 16252198 16169175 10423059 11729361 11145282 18181030 11906479 11595415 18431645 17657623 1323529 18726076 18543354 17977527 17135157 11523592 16755016 11595431 12077510 14567935 17918041 16631530 12500499 18209962 15138204 12467913 17895592 15255614 10878458 18193104 12787963
MESH:D013276 Stomach Ulcer phosphoramidon 11.1811145282
MESH:D013276 Stomach Ulcer Plant Extracts 11.1812787963 17135157 15255614 18237397 18193104
MESH:D013345 Subarachnoid Hemorrhage Drugs, Chinese Herbal 4.9017634840
MESH:D019966 Substance-Related Disorders bisphenol A 3.1516684133 16045194
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.519754883
MESH:D013610 Tachycardia Terbutaline 4.7010895896
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 4.6217997062
MESH:D013921 Thrombocytopenia Aspartame 7.8317534100
MESH:D013921 Thrombocytopenia Lipopolysaccharides 7.8315821434
MESH:D013953 Thymus Neoplasms Methylnitrosourea 4.3911418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.0412697716
MESH:D013964 Thyroid Neoplasms decitabine 11.6817967635
MESH:D013964 Thyroid Neoplasms Indomethacin 11.6811352223 18791128 14736730
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 11.687505956 3078959
MESH:D013964 Thyroid Neoplasms Phenobarbital 11.681399818
MESH:D013978 Tibial Fractures Estradiol 3.8319048282
MESH:D014062 Tongue Neoplasms Zinc 3.6516543248
MESH:D016171 Torsades de Pointes Dobutamine 4.5119353679
MESH:D014456 Ulcer Indomethacin 4.0517380554 10574470
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.3417616700 19087683
MESH:D014581 Urticaria Acetaminophen 2.2110982225
MESH:D014591 Uterine Diseases bisphenol A 4.1514652134
MESH:D014604 Uveal Neoplasms decitabine 4.0517785578
MESH:D014605 Uveitis Zymosan 4.5411006244
MESH:D014625 Vaginal Neoplasms Zidovudine 3.9412579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.7312125929
MESH:D018487 Ventricular Dysfunction, Left Dietary Sucrose 12.8518551017
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 12.8518097624
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 12.8518097624
MESH:D020257 Ventricular Remodeling Isoproterenol 10.0718097624
MESH:D020257 Ventricular Remodeling Plant Extracts 10.0718097624
MESH:D014802 Vitamin A Deficiency Vitamin A 4.4916146918 16960172 16175781
MESH:D014839 Vomiting Indomethacin 3.8911897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.3915886252
MESH:D015430 Weight Gain marker/mechanism 17502770
MESH:D015430 Weight Gain Clozapine 7.3920107430 20521320 17502770 20564506 16141801 16402076
MESH:D015430 Weight Gain Dietary Fats 7.3916723640
MESH:D015431 Weight Loss Clozapine 4.2417933447
MESH:D014947 Wounds and Injuries Drugs, Chinese Herbal 6.7716313111
MESH:D014947 Wounds and Injuries Plant Extracts 6.7719894650 20213670
Pathway ID Pathway Name
KEGG:04920 Adipocytokine signaling pathway
KEGG:04060 Cytokine-cytokine receptor interaction
REACT:15380 Diabetes pathways
KEGG:04630 Jak-STAT signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA228
    • Releated gene ID Related gene Name
    PA228LEP
    Releated disease ID Related disease Name
    PA446969Venous Thrombosis
    PA447216Schizophrenia
    PA443309Alcoholism
    Releated drug ID Related drug Name
    PA451257risperidone
    PA451644thalidomide
    PA450688olanzapine
    PA448073ethanol
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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