AutismKB 2.0

Annotation Detail for LEPR


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Basic Information Top
Gene Symbol:LEPR ( CD295,DKFZp686B1731,OBR )
Gene Full Name: leptin receptor
Band: 1p31.3
Quick LinksEntrez ID:3953; OMIM: 601007; Uniprot ID:LEPR_HUMAN; ENSEMBL ID: ENSG00000116678; HGNC ID: 6554
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04920Adipocytokine signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
No data
Pathway IDPathway Name
200033Signaling events mediated by PTP1B
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
1809HIV infection
1856Obesity
1877Multiple sclerosis
1901Endometriosis
1904Diabetes mellitus
1936Hypercholesterolemia
1944Breast cancer
1961Endometrium cancer
1986Eating disorder
1841Stomach cancer
2006Anorexia nervosa
2038Gastritis
2091Hypertension
2051Leukemia
2053Colon cancer
2064Spinal dysraphism
2069Schizophrenia
2070Cholelithiasis
2094Ulcerative colitis
2122Protein-energy malnutrition
2125Bladder cancer
2169Pituitary tumor
2203Nephrosis
2237Neoplasm metastasis
Desease Name
HEMATOLOGICAL
soluble leptin receptor levels
other metabolic traits
cholesterol, HDL
Overfeeding
C-reactive protein
CARDIOVASCULAR
cholesterol, LDL
leptin
early-onset prostate cancer
CANCER
Weight Gain
body mass index and waist circumference
body mass
bone density
body mass obesity
breast cancer
uric acid
hypertension
lipoprotein
obesity (BMI = 30 kg/m2)
METABOLIC
Insulin in Obese Women with Impaired Glucose Tolerance (IGT)
triglycerides
Diabetes Complications
obesity
insulin
Serum Insulin Levels in obese
Weight Loss
diabetes, type 2
fatty acid
fat mass
Fatty Liver
Diabetes Mellitus, Type 2
Desease Name
Soluble leptin receptor levels
C-reactive protein
Other metabolic traits
Desease Name
Obesity, morbid, with hypogonadism
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of LEPR mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of LEPR mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of LEPR mRNAaffects expression 18648102
C014949 acetylhydrazine acetylhydrazine results in decreased expression of LEPR mRNAdecreases expression 15282401
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LEPR mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of LEPR mRNAdecreases expression 19654921
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of AIFM1 mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of APP mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CAT mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CNTD1 mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX15 mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5A mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5B mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6B1 mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6C mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of FOXO3A mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GNA13 mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GPX3 mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HOXA9 mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of IDH1 mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of ND6 mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA1 mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA5 mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFC2 mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFV2 mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NME2 mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PPP1CB mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PRDX1 mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of RPS2 mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SOD1 mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SPP1 mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TGM2 mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TKT mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UBB mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRB mRNA]decreases reaction|increases expression 16964424
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRC2 mRNA]decreases reaction|increases expression 16964424
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of LEPR mRNAaffects cotreatment|decreases expression 18164116
D002118 Calcium Calcium affects the expression of LEPR mRNAaffects expression 15913539
D002251 Carbon Tetrachloride Drugs, Chinese Herbal inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEPR protein]affects cotreatment|decreases reaction|increases expression 18227024
D002857 Chromium LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of BTC mRNA]affects binding|decreases expression|increases reaction 16940432
D002857 Chromium LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of CIDEA mRNA]affects binding|decreases expression|increases reaction 16940432
D002857 Chromium LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of DDHD1 mRNA]affects binding|decreases expression|increases reaction 16940432
D002857 Chromium LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of NET1 mRNA]affects binding|decreases expression|increases reaction 16940432
D002857 Chromium LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of PCK1 mRNA]affects binding|decreases expression|increases reaction 16940432
D002857 Chromium LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of TTPA mRNA]affects binding|decreases expression|increases reaction 16940432
D002857 Chromium LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of UCP1 mRNA]affects binding|decreases expression|increases reaction 16940432
D002857 Chromium LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of ASPH mRNA]affects binding|increases expression|increases reaction 16940432
D002857 Chromium LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of CASQ1 mRNA]affects binding|increases expression|increases reaction 16940432
D002857 Chromium LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of EDNRB mRNA]affects binding|increases expression|increases reaction 16940432
D002857 Chromium LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of ENO3 mRNA]affects binding|increases expression|increases reaction 16940432
D002857 Chromium LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of GARNL1 mRNA]affects binding|increases expression|increases reaction 16940432
D002857 Chromium LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of GPI1 mRNA]affects binding|increases expression|increases reaction 16940432
D002857 Chromium LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of NRAP mRNA]affects binding|increases expression|increases reaction 16940432
D002857 Chromium LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of PI16 mRNA]affects binding|increases expression|increases reaction 16940432
D002857 Chromium LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of SRL mRNA]affects binding|increases expression|increases reaction 16940432
D002857 Chromium LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of TLN1 mRNA]affects binding|increases expression|increases reaction 16940432
D002857 Chromium LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of TPM1 mRNA]affects binding|increases expression|increases reaction 16940432
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of LEPR mRNAaffects cotreatment|affects expression 17602206
D004041 Dietary Fats Dietary Fats results in decreased expression of LEPR mRNAdecreases expression 18721800
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of LEPR mRNAaffects cotreatment|decreases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of LEPR mRNAaffects cotreatment|affects expression 17602206
D004280 Dobutamine LEPR protein affects the susceptibility to Dobutamineaffects response to substance 20175764
D004365 Drugs, Chinese Herbal Drugs, Chinese Herbal inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEPR protein]affects cotreatment|decreases reaction|increases expression 18227024
D004958 Estradiol Estradiol results in decreased expression of LEPR mRNAdecreases expression 14664709
D004958 Estradiol LEPR protein affects the abundance of Estradiolaffects abundance 15093691
D000431 Ethanol Drugs, Chinese Herbal inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEPR protein]affects cotreatment|decreases reaction|increases expression 18227024
D000431 Ethanol Ethanol results in decreased expression of LEPR mRNAdecreases expression 16098508
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of LEPR mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LEPR mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of LEPR mRNAdecreases expression 17351261
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of LEPR geneincreases mutagenesis 16724327
D015525 Fatty Acids, Omega-3 Fatty Acids, Omega-3 results in increased expression of LEPR mRNAincreases expression 15949695
C419708 gefitinib gefitinib results in decreased expression of LEPR mRNAdecreases expression 16685379
C029424 hydrazine hydrazine results in increased expression of LEPR mRNAincreases expression 15370871
D007657 Ketone Bodies Ketone Bodies results in decreased expression of LEPR mRNAdecreases expression 16807920
D008070 Lipopolysaccharides Lipopolysaccharides inhibits the reaction [Thioacetamide results in decreased expression of LEPR mRNA]decreases expression|decreases reaction 17621560
D008628 Mercury Mercury results in decreased expression of LEPR mRNAdecreases expression 16823088
D009020 Morphine Morphine results in increased expression of LEPR mRNAincreases expression 20144693
D009525 Niacin LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of BTC mRNA]affects binding|decreases expression|increases reaction 16940432
D009525 Niacin LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of CIDEA mRNA]affects binding|decreases expression|increases reaction 16940432
D009525 Niacin LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of DDHD1 mRNA]affects binding|decreases expression|increases reaction 16940432
D009525 Niacin LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of NET1 mRNA]affects binding|decreases expression|increases reaction 16940432
D009525 Niacin LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of PCK1 mRNA]affects binding|decreases expression|increases reaction 16940432
D009525 Niacin LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of TTPA mRNA]affects binding|decreases expression|increases reaction 16940432
D009525 Niacin LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of UCP1 mRNA]affects binding|decreases expression|increases reaction 16940432
D009525 Niacin LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of ASPH mRNA]affects binding|increases expression|increases reaction 16940432
D009525 Niacin LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of CASQ1 mRNA]affects binding|increases expression|increases reaction 16940432
D009525 Niacin LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of EDNRB mRNA]affects binding|increases expression|increases reaction 16940432
D009525 Niacin LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of ENO3 mRNA]affects binding|increases expression|increases reaction 16940432
D009525 Niacin LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of GARNL1 mRNA]affects binding|increases expression|increases reaction 16940432
D009525 Niacin LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of GPI1 mRNA]affects binding|increases expression|increases reaction 16940432
D009525 Niacin LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of NRAP mRNA]affects binding|increases expression|increases reaction 16940432
D009525 Niacin LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of PI16 mRNA]affects binding|increases expression|increases reaction 16940432
D009525 Niacin LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of SRL mRNA]affects binding|increases expression|increases reaction 16940432
D009525 Niacin LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of TLN1 mRNA]affects binding|increases expression|increases reaction 16940432
D009525 Niacin LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of TPM1 mRNA]affects binding|increases expression|increases reaction 16940432
C042763 olive oil olive oil analog affects the expression of LEPR mRNAaffects expression 17349074
D010126 Ozone LEPR gene mutant form promotes the reaction [Ozone results in increased expression of CCL11 protein]increases expression|increases reaction 16373670
D010126 Ozone LEPR gene mutant form promotes the reaction [Ozone results in increased expression of CXCL1 protein]increases expression|increases reaction 16373670
D010126 Ozone LEPR gene mutant form promotes the reaction [Ozone results in increased expression of CXCL2 protein]increases expression|increases reaction 16373670
D010126 Ozone LEPR gene mutant form promotes the reaction [Ozone results in increased expression of IL6 protein]increases expression|increases reaction 16373670
D010126 Ozone LEPR gene mutant form results in increased susceptibility to Ozoneincreases response to substance 16373670
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of LEPR mRNAincreases expression 17681415
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LEPR mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of LEPR mRNAincreases expression 18301758
18445702
D013619 Tacrine Tacrine results in increased expression of LEPR mRNAincreases expression 12832660
D013739 Testosterone LEPR protein affects the abundance of Testosteroneaffects abundance 15093691
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LEPR mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LEPR mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of LEPR mRNAaffects expression 15977195
D013853 Thioacetamide Thioacetamide results in increased expression of LEPR mRNAincreases expression 17997003
D013853 Thioacetamide LEPR gene mutant form inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]decreases reaction|increases expression 11984526
D013853 Thioacetamide LEPR protein affects the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]affects reaction|increases expression 11984526
D013853 Thioacetamide Lipopolysaccharides inhibits the reaction [Thioacetamide results in decreased expression of LEPR mRNA]decreases expression|decreases reaction 17621560
D013853 Thioacetamide Thioacetamide results in decreased expression of LEPR mRNAdecreases expression 17621560
D013853 Thioacetamide Thioacetamide results in decreased expression of LEPR proteindecreases expression 17621560
D019772 Topotecan LEPR protein affects the susceptibility to Topotecanaffects response to substance 16217747
D015054 Zymosan LEPR protein affects the susceptibility to Zymosanaffects response to substance 15142272
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 7.1717676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.1714514962 15322242 11752688
MESH:D000038 Abscess Drugs, Chinese Herbal 5.9115043669
MESH:D000138 Acidosis Ammonium Chloride 9.1618287403
MESH:D000138 Acidosis Ethanol 9.1611192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5417505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 7.8418653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 7.8418653653
MESH:D000230 Adenocarcinoma Estradiol 3.8511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.8514692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 14.103712494
MESH:D000236 Adenoma beta-Naphthoflavone 14.1019389873
MESH:D000236 Adenoma Diethylnitrosamine 14.106695378 10737359
MESH:D000236 Adenoma Ethylnitrosourea 14.106695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.9916434500 17620307 18056438 19052882 17162532 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.9916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.9916835633
MESH:D018246 Adrenocortical Adenoma Arsenic 4.8117306315
MESH:D000419 Albuminuria marker/mechanism 20175764
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.9215451039 15451040
MESH:D000544 Alzheimer Disease Ozone 4.5415513908
MESH:D000544 Alzheimer Disease Tacrine 4.5412725862
MESH:D000740 Anemia Drugs, Chinese Herbal 13.0815504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 13.0811748828
MESH:D000740 Anemia Zymosan 13.0818664788
MESH:D000787 Angina Pectoris Drugs, Chinese Herbal 5.0211477813
MESH:D000853 Anophthalmos Ethanol 4.4315513904
MESH:D000987 Antisocial Personality Disorder Testosterone 5.457506515
MESH:D001004 Anus Diseases Drugs, Chinese Herbal 5.5615043669
MESH:D001008 Anxiety Disorders Ethanol 3.7011141031
MESH:D020261 Arsenic Poisoning Arsenic 2.7512569548 16251483 16835338 18414634
MESH:D001161 Arteriosclerosis Dietary Fats 8.6315238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.6311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7715885639
MESH:D001169 Arthritis, Experimental Zymosan 6.7716872482 17659584 15142272 15188379 15944321
MESH:D015210 Arthritis, Gouty Drugs, Chinese Herbal 5.3619655406
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4615570426
MESH:D001249 Asthma Ozone 2.5117854713 16373670
MESH:D050197 Atherosclerosis Arsenic 6.4912928151 19371607
MESH:D050197 Atherosclerosis olive oil 6.4916216721
MESH:D001289 Attention Deficit Disorder with Hyperactivity Fatty Acids, Omega-3 4.5518448859
MESH:D001321 Autistic Disorder Fatty Acids, Omega-3 2.9016920077
MESH:D001321 Autistic Disorder Mercury 2.9017497416
MESH:D001327 Autoimmune Diseases Mercury 4.4916634805
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.6211289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.3119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.3112125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 13.3119483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5115746008
MESH:D001862 Bone Resorption Drugs, Chinese Herbal 4.479881647
MESH:D001927 Brain Diseases Ethylnitrosourea 4.5414991843
MESH:D002545 Brain Ischemia Morphine 4.7519211983
MESH:D001932 Brain Neoplasms Ethylnitrosourea 3.9516651633 15144691 16436596 16357521 18412241
MESH:D001943 Breast Neoplasms Chromium 2.7515986119
MESH:D001943 Breast Neoplasms Dietary Fats 2.7520435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.7517474063
MESH:D001943 Breast Neoplasms Estradiol 2.7517261762 16675129 17289903 18497071 12948864 19861407 14630087 17018787
MESH:D001943 Breast Neoplasms Testosterone 2.7517261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.7520435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3716777450 19059883 18315731 14754758 15516495 17626835 18417511
MESH:D002056 Burns Ethanol 4.2716374292
MESH:D002100 Cachexia Ozone 4.3516183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4010355542 16227642 16097048 15700767 18705752 15721981 16124888 15673190 16011737 3786805 16050911 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4916835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.3617687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 18.4116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 18.4116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 18.417296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Arsenic 18.4116507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 18.4118788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 18.4116779866 16878318 19822196 18393292 18971187 16935385 17978847 16288022 20007298 18506893 21159647 20101231 20935162 18210153 16830150 19208518 19171122 16328049 17428255 17173139 11831363 19701751 18056438 17761372 17138121 20214788 16540662 17162532 19418558 16569478 16807293 19919837 19539802 19107877 20524982 16502159 18691550 20512989 10737359 18494052 18785209 20514400 20432363 17055752 20084675 19383236 18665156 3084413 19335982 20727157 19394651 19052882 3581430 10672840 16698587 18788625 19519916 18978308 16681979
MESH:D006528 Carcinoma, Hepatocellular Estradiol 18.4116924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 18.4115289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 18.4117997003
MESH:D002289 Carcinoma, Non-Small-Cell Lung gefitinib 3.8116230376 20005069 19233551 15496427 17290066 18347146
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.487296757
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.5718922899 17687452 15504454
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.7418640142
MESH:D006332 Cardiomegaly Ethanol 6.1019332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.1016120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.3110334427
MESH:D002318 Cardiovascular Diseases Arsenic 7.0515738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases olive oil 7.0516216721
MESH:D002340 Carotid Artery Diseases Arsenic 3.9816973168 18022660
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 18.216135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 18.217505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 18.217505956 21159647 2727394 17174075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 18.2118566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 18.2116003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.5817160924
MESH:D002659 Child Development Disorders, Pervasive Testosterone 3.5320678186
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 14.2119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 14.2116835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 14.2118291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 11.689022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 11.6817333356 16105132 15861022 17681005 11677210 16919318 17110522
MESH:D002779 Cholestasis pirinixic acid 11.6819176532
MESH:D002971 Cleft Lip Ethanol 3.3715513904
MESH:D002972 Cleft Palate Ethanol 5.3715513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.3715668235 15340226 12621046 8697196 16354765
MESH:D015179 Colorectal Neoplasms gefitinib 3.2417594712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7317141729 14669216
MESH:D019465 Craniofacial Abnormalities Ethanol 2.5015451039 10194807 19302082 15451040 11873399 15513904 11198716
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5020055451 15322242 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.6118551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.6118551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 5.9411298694 8156756 11906362 12868966 8970840 18759878 2524372 14531868
MESH:D017449 Dermatitis, Allergic Contact Mercury 5.9416823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.132952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental marker/mechanism 15093691
MESH:D003924 Diabetes Mellitus, Type 2 marker/mechanism 20175764
MESH:D003924 Diabetes Mellitus, Type 2 astaxanthine 6.6616964424
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.6620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.6617107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.0819279558
MESH:D003967 Diarrhea Morphine 4.162540324
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 23.3321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 23.3318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 23.339653073 9328219 7440962 18692083 6482804 18289764 8291058 1440618 16192314 11289319 18648102 9022650 6679447
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 23.336884620 10915739 19085960 9327722 16177239 4309450 15027814 21278145 10092053 2869522 19336974 15968718 3786805 17522070 7120509 16227642 3732212 7440962 7179309 15998439 11566570 6623471
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 23.3319107877
MESH:D056486 Drug-Induced Liver Injury Drugs, Chinese Herbal 23.3315027814
MESH:D056486 Drug-Induced Liver Injury Ethanol 23.3311566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 23.3320420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 23.3312963478
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4711462148
MESH:D050171 Dyslipidemias Dietary Fats 3.1718367378
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.5818357618
MESH:D004487 Edema perfluorooctanoic acid 13.6317259670 12083418
MESH:D004487 Edema pirinixic acid 13.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.6312711302 11000095
MESH:D004487 Edema Zymosan 13.637907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5015322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.8212538720
MESH:D016889 Endometrial Neoplasms Estradiol 2.7211473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.689294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.0015821434 17637181 15328337
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7116302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.263581430
MESH:D004938 Esophageal Neoplasms Ethanol 4.2616704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7211564622
MESH:D005218 Fat Necrosis Thioacetamide 5.3216456712
MESH:D005234 Fatty Liver Carbon Tetrachloride 26.1615959796 19224547 12631006 17595544 12795759 16239168 61145 16045604
MESH:D005234 Fatty Liver Dietary Fats 26.1618296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 26.1621071580 20387270
MESH:D005234 Fatty Liver Ethanol 26.1616409862 18620774 19236843
MESH:D005234 Fatty Liver Ethinyl Estradiol 26.1615345470
MESH:D005234 Fatty Liver pirinixic acid 26.1620131406 19236843
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.2617920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.9015451040 16946407 15513904 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0711858732
MESH:D005334 Fever Lipopolysaccharides 3.679205823 11852909
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.626705139
MESH:D005355 Fibrosis Carbon Tetrachloride 12.5418705752
MESH:D005355 Fibrosis Dietary Fats 12.5418296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.5420067830
MESH:D005391 Firesetting Behavior Testosterone 5.457506515
MESH:D005534 Foot Diseases Arsenic 5.166392382
MESH:D005756 Gastritis Ethanol 4.2915046732
MESH:D005909 Glioblastoma Ethylnitrosourea 6.9416436596
MESH:D005909 Glioblastoma Testosterone 6.9417162496
MESH:D005910 Glioma Ethylnitrosourea 3.3318412241 16651633 16357521
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.677505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1211294989 10048152
MESH:D006333 Heart Failure Dobutamine 6.6417440445
MESH:D006333 Heart Failure pirinixic acid 6.6420558911
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.0416366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9811000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.2218665440 17276928 15929193
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 25.386705139
MESH:D006505 Hepatitis Carbon Tetrachloride 25.3819110552 19900420
MESH:D006505 Hepatitis Drugs, Chinese Herbal 25.3818339527
MESH:D006505 Hepatitis Thioacetamide 25.3816456712
MESH:D006505 Hepatitis Zymosan 25.3819110552
MESH:D006529 Hepatomegaly perfluorooctanoic acid 12.243609246
MESH:D006529 Hepatomegaly pirinixic acid 12.2418467677 19176532 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.2415340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.6315709030
MESH:D006628 Hirsutism Testosterone 5.2517019078
MESH:D019584 Hot Flashes Estradiol 3.3517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6415340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Ethanol 7.2118783367
MESH:D006930 Hyperalgesia perfluorooctanoic acid 7.2112083418
MESH:D017588 Hyperandrogenism Testosterone 4.9117019078
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1416899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.2421332399
MESH:D006943 Hyperglycemia marker/mechanism 15093691 19682441
MESH:D006943 Hyperglycemia pirinixic acid 2.8420558911
MESH:D006946 Hyperinsulinism marker/mechanism 15093691
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.1117050553
MESH:D006949 Hyperlipidemias Dietary Fats 3.2621332399
MESH:D006963 Hyperphagia marker/mechanism 15093691
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.5515034207
MESH:D006973 Hypertension Arsenic 4.7016076760 9931084 11953799
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7018850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7015338365
MESH:D006976 Hypertension, Pulmonary gefitinib 4.4118424623
MESH:D017380 Hypertrophy, Right Ventricular gefitinib 5.8418424623
MESH:D006987 Hypesthesia Arsenic 5.1616093927
MESH:D007006 Hypogonadism marker/mechanism
MESH:D007006 Hypogonadism Testosterone 4.3112002444
MESH:D007018 Hypopituitarism Testosterone 5.8017426086
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4216945680 16569931
MESH:D007174 Impulse Control Disorders Testosterone 5.457506515
MESH:D007246 Infertility marker/mechanism 15093691
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.2317937319
MESH:D007249 Inflammation Dietary Fats 20.9820412841
MESH:D007249 Inflammation Diethylnitrosamine 20.9818785209
MESH:D007249 Inflammation Fatty Acids, Omega-3 20.9817296493
MESH:D007249 Inflammation Lipopolysaccharides 20.989205823 12878042 17963957 17237260 17255318
MESH:D007249 Inflammation perfluorooctanoic acid 20.9812083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 20.9812878042 12200463
MESH:D007249 Inflammation Zymosan 20.988014878 11289658
MESH:D007333 Insulin Resistance Dietary Fats 10.7811836018 18457598
MESH:D007333 Insulin Resistance Estradiol 10.7816393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 10.7816306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.2717255318
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.4417553498
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.629022650 8074119
MESH:D007569 Jaw Abnormalities Ethanol 8.9515513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.9516580747
MESH:D007642 Keratosis Arsenic 4.6016930632 12749816
MESH:D007674 Kidney Diseases Chromium 9.0217934191
MESH:D007674 Kidney Diseases Estradiol 9.0215618244
MESH:D007674 Kidney Diseases Mercury 9.0217934191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 24.9816705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 24.9816705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 24.986582329
MESH:D007680 Kidney Neoplasms Estradiol 24.9815610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 24.9817379185
MESH:D007680 Kidney Neoplasms gefitinib 24.9818625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.6416316344
MESH:D007859 Learning Disorders Ethanol 3.8315451040
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Drugs, Chinese Herbal 3.7515802533
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.2917339181
MESH:D007970 Leukopenia Lipopolysaccharides 4.3015821434
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.838812269
MESH:D017880 Limb Deformities, Congenital Ethanol 3.5317676605
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 18.3811903743 16239168 16943688 17334410 11408273 17174718 17157831 21278145 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 18.3818296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 18.3820032147 18407596 18522880 19638242 18665156
MESH:D008103 Liver Cirrhosis Drugs, Chinese Herbal 18.3817163593
MESH:D008103 Liver Cirrhosis Ethanol 18.3815289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.7018295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.959327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 12.2118376398 18317297 17698563 16097048 14512876 16136751 18277467 18705752 16638106 15057751 18472094 16116963 17721639 18156304 15338365 14724832 15931870 18395095 17922224 12958196 18205269 15996030 15818738 15893842 12666154 15650968 18006644 11481614 15925388 14716833 12649538 18420326 17823541 17481882 18054572 14748882 10355542 12741479 16248980 18187930 18210741 12586293 18472332 20821823 14716496 15876570 18412020 17900296 12445418 18263696 17557913 12445421 15370692 17640975 15673190 17766677 12546737 16033810 16015684 12667390 17869086 18166357 12389079 15052691 17714472 13678700 15730626 16011737 12898905 17525996 18279442 17976157 17805973 18481824 17708605 12609069 18395914 17631135 12632514 16192424 18251166 12632512 14620537 18418968 17761835 15959796 15362042 17565644 18429990 17944888 16027843 15123356 18339082
MESH:D008106 Liver Cirrhosis, Experimental Drugs, Chinese Herbal 12.2117348192 15383259 15339415 18606216 17666798 18237412 15818738 18567088 15864749 16610055 18371158 15744066 15849816 12632512 17036385 15754396 17881167 15763062 15641146 17629604
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 12.2114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 12.2118166357
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 12.2112878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 12.2115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 12.2112878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 12.2111481614 17292413 15075984 18295389 15288473 17355460 17127702 18458672 12085344 17629604 15474484 16343077 12531686 11172339 15334695 18031379 18263696 15716488 17050028 15078482 12891558 18380797 16098781 16489207 18416461 16248980 10677585 15288472 18395095 15095483 15465738 16126171 11682029 15158331 12679928 15316131 16097051 18032466 14739098 18615449 18606216 15362042 12557150 16511523 12175628
MESH:D008107 Liver Diseases Arsenic 11.3211134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 11.3215830285 17285989 15720792 16246199 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 11.3217034775
MESH:D008107 Liver Diseases Drugs, Chinese Herbal 11.3217207593
MESH:D008107 Liver Diseases Thioacetamide 11.3215158337 16337175 18374380
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.2717347304 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.6716899240 14706259
MESH:D017114 Liver Failure, Acute Thioacetamide 8.6715633222 12479984 15313186 17276928
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 30.917678174
MESH:D008113 Liver Neoplasms Arsenic 30.9116368122
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 30.9119389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 30.9119294768
MESH:D008113 Liver Neoplasms Clofibric Acid 30.9117602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 30.9120137499 19073162 19294768 19090486 15885732 20492335 15175105 10737359 12771043 20583210 18754104 16942905 18648771 2422723 19254457 19256749 20452335 19996281 19638242 20501860 19426721 9163691 18644402 19833225 19690152 19255062 21278145 19551842 20101389 19642983 18977376 21071580 19499222 12112319 19812893 2862719 20434301 21047994 19850985 18978307 21167192 19427195 20118626 20405173
MESH:D008113 Liver Neoplasms Drugs, Chinese Herbal 30.9118339527
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 30.9114757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 30.9115890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 30.9116984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 20.122876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 20.12598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 20.1218164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 20.1212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 20.1218093689 18079962 18282651 16267830 18164116 19009564 19519916 18775883 2563599 21159647 17174075 19539802 3124819 18544905 9362446 18308698 19126423 17854601 17942915 16842330 19004024 18253720
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 20.1212151625
MESH:D008133 Long QT Syndrome Dobutamine 4.4419353679
MESH:D008171 Lung Diseases Dobutamine 7.1316638327
MESH:D008171 Lung Diseases Ozone 7.138266340 19066396
MESH:D055370 Lung Injury Lipopolysaccharides 7.9721114838
MESH:D055370 Lung Injury Ozone 7.9720417186
MESH:D008175 Lung Neoplasms Arsenic 7.8217306315 19168569 17976673
MESH:D008175 Lung Neoplasms Diethylnitrosamine 7.8220970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Drugs, Chinese Herbal 7.8218339527
MESH:D008175 Lung Neoplasms Ethylnitrosourea 7.826695378 16271038 17703301 16019985
MESH:D008175 Lung Neoplasms Ozone 7.828597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.8219555203 11884234
MESH:D008223 Lymphoma Ethylnitrosourea 3.6615790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.6615375218
MESH:D008325 Mammary Neoplasms, Experimental Drugs, Chinese Herbal 12.3214758024
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.3216891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 12.3210767621 10838139 18041768
MESH:D008325 Mammary Neoplasms, Experimental gefitinib 12.3218375820
MESH:D020149 Manganese Poisoning Estradiol 4.0819453300
MESH:D008569 Memory Disorders Ethanol 3.8218411066 15451040
MESH:D008579 Meningioma Ethylnitrosourea 5.5817943659
MESH:D008679 Metaplasia Ozone 4.7010496685
MESH:D009102 Multiple Organ Failure Zymosan 4.8510890648 18160304 15259001 10479408 15213630 15241586 17724436 12130978 12879239 15834315
MESH:D009135 Muscular Diseases pirinixic acid 3.1216239165
MESH:D009203 Myocardial Infarction pirinixic acid 1.9719151258
MESH:D017202 Myocardial Ischemia Arsenic 13.6415371236
MESH:D017202 Myocardial Ischemia Dobutamine 13.6412447174
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 13.6412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.2516810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.2516411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.0418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.047678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.143581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.143581430 9029167
MESH:D009369 Neoplasms pirinixic acid 1.7617405874
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.0216707424
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3417289903
MESH:D009421 Nervous System Malformations Estradiol 8.2216427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.2214600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 6.516679447
MESH:D009436 Neural Tube Defects Arsenic 6.5116620997
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.0217160924 16003739 16651423
MESH:D009447 Neuroblastoma Topotecan 3.6415176712
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.0220387270
MESH:D020078 Neurogenic Inflammation Arsenic 4.0117056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7120387270
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.579802331
MESH:D009765 Obesity Dietary Fats 4.0619632207 21332399 16723640 20132043 18457598 17217161 18674790 11836018 20518802
MESH:D009765 Obesity pirinixic acid 4.0620558911
MESH:D009767 Obesity, Morbid marker/mechanism
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 13.0916049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 13.0916049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 13.094026338 6482804
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.5817160924
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.623988306
MESH:D010024 Osteoporosis Calcium 3.5417882678
MESH:D015663 Osteoporosis, Postmenopausal Drugs, Chinese Herbal 4.6216548355
MESH:D010051 Ovarian Neoplasms Arsenic 4.5017306315
MESH:D010051 Ovarian Neoplasms Estradiol 4.5019401270
MESH:D010146 Pain Morphine 3.8815275824 15215642 18699797 6776300 20225289 16273134
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 4.9316540662
MESH:D010190 Pancreatic Neoplasms Ethanol 4.9312384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3211578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.107296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8512520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.8116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.606392382 15371236 16905509
MESH:D010538 Peritonitis Ozone 9.1316369182
MESH:D010538 Peritonitis Zymosan 9.1315259001 18760300 19088179 15979727 17826846 11985352 18557954 18977430 19641140 14761945 17371808
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.076228378
MESH:D011014 Pneumonia Lipopolysaccharides 9.7911605937 12224865
MESH:D011014 Pneumonia Ozone 9.7918381685 18929643 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1818163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.222563599
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 8.3617132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.3611118676 11896295 11222880 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.6920887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 9.6920887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.9316140617
MESH:D011471 Prostatic Neoplasms Estradiol 2.9316740699
MESH:D011471 Prostatic Neoplasms gefitinib 2.9317914592 15651060 16685379
MESH:D011507 Proteinuria Arsenic 3.6421343184
MESH:D011537 Pruritus Ethinyl Estradiol 2.9215861022 16919318
MESH:D011658 Pulmonary Fibrosis Drugs, Chinese Herbal 6.0216987627
MESH:D011658 Pulmonary Fibrosis gefitinib 6.0218424623
MESH:D012003 Rectal Fistula Drugs, Chinese Herbal 5.5615043669
MESH:D015427 Reperfusion Injury Morphine 6.2219211983
MESH:D015427 Reperfusion Injury pirinixic acid 6.2219058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.4710835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4618990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.083692021
MESH:D012221 Rhinitis, Allergic, Perennial Drugs, Chinese Herbal 4.8715015336
MESH:D012640 Seizures 2,4-dinitrotoluene 8.3118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 8.3118551238
MESH:D012640 Seizures Ethanol 8.319754883
MESH:D018805 Sepsis Zymosan 4.3311441115
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.8016631401
MESH:D012871 Skin Diseases Arsenic 2.6419834688 17050553 18709164 17453740 16353154 17548696 15952646 6392382 16759981 16702368 17938729
MESH:D012878 Skin Neoplasms Arsenic 5.0617050553 15504454 17029826 19538983 17976673 16251483
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.0616192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5416709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3418456281
MESH:D013274 Stomach Neoplasms Drugs, Chinese Herbal 3.3418339527
MESH:D013274 Stomach Neoplasms Ethanol 3.3418456281
MESH:D013276 Stomach Ulcer Ethanol 6.789211565 17918041 17189318 11906479 9562338 16755016
MESH:D013276 Stomach Ulcer olive oil 6.7816252198 12498302
MESH:D013345 Subarachnoid Hemorrhage Drugs, Chinese Herbal 5.3617634840
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.919754883
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.8215821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8215669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.7715790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 10.421399818 6582329 6587162 7505956 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.427505956
MESH:D013964 Thyroid Neoplasms gefitinib 10.4216940797
MESH:D013978 Tibial Fractures Estradiol 4.2819048282
MESH:D016171 Torsades de Pointes Dobutamine 4.9619353679
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 10.5616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 10.5616049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 10.568074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 10.5617976673 19429237 11144890 17306315 19322015 15987713 18640142
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.6710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.6710091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9314692618
MESH:D014605 Uveitis Zymosan 5.0011006244
MESH:D014652 Vascular Diseases Arsenic 4.3417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1914671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8515886252
MESH:D015430 Weight Gain Dietary Fats 3.4116723640
MESH:D014947 Wounds and Injuries Drugs, Chinese Herbal 4.2216313111
Pathway ID Pathway Name
KEGG:04920 Adipocytokine signaling pathway
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04630 Jak-STAT signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA229
    • No data
    Releated disease ID Related disease Name
    PA447054Stroke
    PA443886Diabetes Mellitus
    PA447159Metabolic Syndrome X
    PA445019Myocardial Infarction
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA133950441hmg coa reductase inhibitors
    PA451257risperidone
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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