AutismKB 2.0

Annotation Detail for LFNG


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Basic Information Top
Gene Symbol:LFNG ( SCDO3 )
Gene Full Name: LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Band: 7p22.3
Quick LinksEntrez ID:3955; OMIM: 602576; Uniprot ID:LFNG_HUMAN; ENSEMBL ID: ENSG00000106003; HGNC ID: 6560
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04330Notch signaling pathway
No data
No data
Pathway IDPathway Name
P00045Notch signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1824Bone disease
No data
No data
Desease Name
Spondylocostal dysostosis, autosomal recessive 3
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of LFNG mRNAdecreases expression 19933214
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LFNG mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of LFNG mRNAdecreases expression 20458559
D002117 Calcitriol Calcitriol results in decreased expression of LFNG mRNAdecreases expression 16002434
D009151 Mustard Gas Mustard Gas results in decreased expression of LFNG mRNAdecreases expression 15674843
C105686 SU 5402 SU 5402 affects the expression of LFNG mRNAaffects expression 15298682
D013467 Sulindac Sulindac results in increased expression of LFNG mRNAincreases expression 11906190
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LFNG mRNAdecreases expression 18495758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LFNG mRNAdecreases expression 19933214
C024746 tobacco tar tobacco tar results in decreased expression of LFNG mRNAdecreases expression 19559774
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.8214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1311752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D058186 Acute Kidney Injury Sulindac 4.527897758
MESH:D000230 Adenocarcinoma arsenic trioxide 4.9111798837 19825857
MESH:D000230 Adenocarcinoma Sulindac 4.9111910360
MESH:D000236 Adenoma Sulindac 3.8910223192
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.7915623613 11874996 17611924 11535846 19003578 12394442 16460482
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001249 Asthma Mustard Gas 2.7610378619
MESH:D001768 Blister Mustard Gas 5.4419167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.6616206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.6612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001913 Bowen's Disease Sulindac 5.6711207687
MESH:D001943 Breast Neoplasms Calcitriol 2.0011237771
MESH:D001943 Breast Neoplasms Sulindac 2.0016642371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0020435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.4415286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.2917687719 10378619
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 1.9716217749 11135700 14691202 15073043 15553829
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6711237771
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 4.0819559774
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1812621046 15340226 16354765 8697196 15668235
MESH:D003110 Colonic Neoplasms Sulindac 2.9512902858 12458338
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.8420501625
MESH:D015179 Colorectal Neoplasms Sulindac 2.8410666051 11197048 18059344 11076880
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5210048152 15322242 20055451
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003930 Diabetic Retinopathy Sulindac 5.4212861449 17621415
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema Mustard Gas 7.5311402378 11428631 11428647 9260866
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.5311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.1715138306
MESH:D004715 Endometriosis Sulindac 9.8415652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.8410568697 9294722
MESH:D004890 Erythema Mustard Gas 5.449357497
MESH:D004938 Esophageal Neoplasms arsenic trioxide 5.0012903497
MESH:D004938 Esophageal Neoplasms Sulindac 5.0012235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver arsenic trioxide 3.4915073043
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.7614745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 5.4219069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D005764 Gastroesophageal Reflux Sulindac 5.2511910360
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4310048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1515340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 16354765 15340226 16959395 18606429
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D007249 Inflammation Mustard Gas 9.0311428647 17524151 11402378 8975870 9357497 11428620 11428631 16001271 9260866
MESH:D007249 Inflammation Sulindac 9.033291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.0312878042 12200463
MESH:D007414 Intestinal Neoplasms Sulindac 4.8312584176 12663524 10223192 10213222 12351151 12628509
MESH:D007417 Intestinal Polyps Sulindac 5.2111245490 12394442
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1616467208 16968895 20471514 17050201 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3416330433 19225113 19642359 16966277 11468182 17217047 16823087 15622746 17712046 17869043 9834237 16331271 19075265 15748426 19035177 15336539 17649720 12679006 12712474 11161223 17107899 12018890 15213294 16112521 16891316
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.3412468960
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Sulindac 3.0714986274 16867024
MESH:D008113 Liver Neoplasms arsenic trioxide 4.6614682389
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6616984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.2120377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D008171 Lung Diseases Mustard Gas 3.5818702808 18161513
MESH:D008175 Lung Neoplasms arsenic trioxide 5.0711798837 19825857
MESH:D008175 Lung Neoplasms Mustard Gas 5.078781369 3148597
MESH:D008175 Lung Neoplasms Sulindac 5.0719359593 15713900
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0719555203 11884234
MESH:D008545 Melanoma Sulindac 2.8516642371
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2519549372 14977855 19417148 15949261 11468182
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2516882451 16105982
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2410525206
MESH:D019636 Neurodegenerative Diseases Sulindac 4.4416850258 17266991
MESH:D009503 Neutropenia Mustard Gas 4.197688884 16761898
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4616624393 19769630 12452020
MESH:D010146 Pain Sulindac 3.963291741
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.8315580305
MESH:D010190 Pancreatic Neoplasms Sulindac 5.8316820089 11504793
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D011041 Poisoning Mustard Gas 4.0215727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811399792 11896295 11118676 11222880
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.0615572423
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.3419131511
MESH:D011471 Prostatic Neoplasms Calcitriol 3.3418247401 16289102 16644109 15754350 12479363
MESH:D011537 Pruritus Mustard Gas 4.3818058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9917620002 17894541 17720292 10334151 17266442
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012871 Skin Diseases Mustard Gas 2.7615451306 12880345 16961503
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
OMIM:609813 SPONDYLOCOSTAL DYSOSTOSIS 3, AUTOSOMAL RECESSIVE marker/mechanism
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2419014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5512845720 20435036 11780464 12973940
MESH:D014594 Uterine Neoplasms Sulindac 4.8418645019
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
KEGG:04330 Notch signaling pathway
KEGG:00514 Other types of O-glycan biosynthesis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30336
    • No data
    Releated disease ID Related disease Name
    PA145007205spondylocostal dysostoses (SCDs)
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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