AutismKB 2.0

Annotation Detail for LGALS3BP


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Basic Information Top
Gene Symbol:LGALS3BP ( 90K,BTBD17B,MAC-2-BP )
Gene Full Name: lectin, galactoside-binding, soluble, 3 binding protein
Band: 17q25
Quick LinksEntrez ID:3959; OMIM: 600626; Uniprot ID:LG3BP_HUMAN; ENSEMBL ID: ENSG00000108679; HGNC ID: 6564
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1869Behcet syndrome
1841Stomach cancer
2053Colon cancer
2066Lung cancer
2237Neoplasm metastasis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of LGALS3BP mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of LGALS3BP mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LGALS3BP mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LGALS3BP mRNAaffects cotreatment|increases expression 18164116
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of LGALS3BP mRNAincreases expression 14729362
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of LGALS3BP mRNAdecreases expression 16239168
C019304 ciprofibrate ciprofibrate results in increased expression of LGALS3BP mRNAincreases expression 12771043
C423222 cotylenin A cotylenin A results in increased expression of LGALS3BP mRNAincreases expression 16129123
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of LGALS3BP mRNAincreases expression 17654400
D016572 Cyclosporine Cyclosporine results in decreased expression of LGALS3BP mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of LGALS3BP mRNAdecreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of LGALS3BP mRNAincreases expression 12771043
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LGALS3BP mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of LGALS3BP mRNAincreases expression 19638242
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of LGALS3BP mRNAincreases expression 15289156
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LGALS3BP mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of LGALS3BP mRNAincreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of LGALS3BP mRNAincreases expression 15289156
D004958 Estradiol Estradiol results in decreased expression of LGALS3BP mRNAdecreases expression 20068009
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of LGALS3BP mRNAincreases expression 17557909
D005472 Fluorouracil LGALS3BP protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D019833 Genistein Genistein results in increased expression of LGALS3BP mRNAincreases expression 15289156
C010176 halofuginone halofuginone results in increased expression of LGALS3BP mRNAincreases expression 17180598
C041786 palm oil palm oil results in decreased expression of LGALS3BP mRNAdecreases expression 18042831
D010656 Phenylephrine Phenylephrine results in decreased expression of LGALS3BP mRNAdecreases expression 18158353
D011794 Quercetin Quercetin results in decreased expression of LGALS3BP mRNAdecreases expression 15309432
C488333 Ro 65-7199 Ro 65-7199 affects the expression of LGALS3BP mRNAaffects expression 14610520
C488334 Ro 66-0074 Ro 66-0074 results in increased expression of LGALS3BP mRNAincreases expression 14610520
D013467 Sulindac Sulindac inhibits the reaction [CDKN1A protein results in increased expression of LGALS3BP mRNA]decreases reaction|increases expression 15190207
D013629 Tamoxifen Tamoxifen results in increased expression of LGALS3BP mRNAincreases expression 19155303
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LGALS3BP mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LGALS3BP mRNAincreases expression 19619570
D014212 Tretinoin Tretinoin results in increased expression of LGALS3BP mRNAincreases expression 16129123
C025643 vinclozolin vinclozolin affects the expression of LGALS3BP mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 12.1914745880
MESH:D000008 Abdominal Neoplasms Tamoxifen 12.1914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6115322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6917505938
MESH:D058186 Acute Kidney Injury Sulindac 4.107897758
MESH:D000230 Adenocarcinoma Estradiol 12.8711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.8714692618
MESH:D000230 Adenocarcinoma Fluorouracil 12.8717638652
MESH:D000230 Adenocarcinoma Genistein 12.8711473722
MESH:D000230 Adenocarcinoma Sulindac 12.8711910360
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 14.873712494
MESH:D000236 Adenoma beta-Naphthoflavone 14.8719389873
MESH:D000236 Adenoma Diethylnitrosamine 14.876695378 10737359
MESH:D000236 Adenoma Sulindac 14.8710223192
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.2316434500 19061943 18056438 17620307 17162532 19052882
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.2316835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.3919003578 11874996 11535846 17611924 12394442 16460482 15623613
MESH:D000505 Alopecia Tretinoin 3.4215955085
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2415469931
MESH:D000740 Anemia Fluorouracil 7.9716511603 15504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.9711748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.0217084956
MESH:D000799 Angioedema Acetaminophen 3.5910982225
MESH:D001008 Anxiety Disorders vinclozolin 3.4519015723
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.9017460149
MESH:D001161 Arteriosclerosis Dietary Fats 9.1015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.1011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7115885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Tretinoin 2.2716456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7315336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001327 Autoimmune Diseases Quercetin 4.1719761891
MESH:D001471 Barrett Esophagus Tretinoin 4.1716935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.7711289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.2112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.2116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D001913 Bowen's Disease Sulindac 5.1011207687
MESH:D001919 Bradycardia Phenylephrine 4.3015306635
MESH:D001943 Breast Neoplasms Dietary Fats 8.0220435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 8.0217474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 8.0217129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 8.0217289903 19861407 12948864 18497071 14630087 17018787 17261762 16675129
MESH:D001943 Breast Neoplasms Fluorouracil 8.0219217205 16595493 15136595 18608205 16557594 16110121 18357371
MESH:D001943 Breast Neoplasms Genistein 8.0216873071 16541309 17200150
MESH:D001943 Breast Neoplasms Quercetin 8.0218628248
MESH:D001943 Breast Neoplasms Sulindac 8.0216642371
MESH:D001943 Breast Neoplasms Tamoxifen 8.0218984771 19084267 20005174 16202921 17261762 19189212 19289846 19142967 19200415 18629630 20859285 16273361 18997820 19189210 17049068 20135344 18821012 18351453 16873071 19155303 20065188 19011961 19059307 18855134 19115204 11161223 19103187 15668708 21152245 19221464 19410462 17893378 19288272 18815881 19487384 21138602 16818667 18425577 17440819 19244106 15565566 19066611 20390343 17242785 20544844
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 8.0220435547
MESH:D001943 Breast Neoplasms Tretinoin 8.0216443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3416813970
MESH:D002105 Cadmium Poisoning Quercetin 5.3016962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.543786805 15721981 10355542 18705752 16011737 15673190 16050911 15700767 16097048 16227642 16192424 16124888
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4216051944
MESH:D002277 Carcinoma Fluorouracil 7.5517121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2619066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9116168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 25.227296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 25.223084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 25.2218788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 25.2218056438 20727157 21159647 16502159 16681979 20512989 19822196 18788625 18691550 3084413 3581430 19208518 19394651 18210153 18665156 20214788 19335982 19052882 20084675 19383236 11831363 19107877 18785209 19171122 20524982 16569478 20432363 19539802 19519916 17761372 10737359 16328049 16779866 16288022 16807293 17055752 19418558 20514400 18971187 16878318 20935162 18393292 20007298 17173139 17428255 17978847 18506893 10672840 17162532 17138121 18494052 16935385 16540662 19919837 16830150 19701751 18978308 20101231 16698587
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 25.2215948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 25.2216924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 25.2216799960 17971768 18930000 16332177 17088986 17045692
MESH:D006528 Carcinoma, Hepatocellular Genistein 25.2216924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 25.2219519916 12508355
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 25.2216924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 25.221917145
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7117234771
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.117296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.1118695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.4818986760 16757204 16280240 17066447
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.4816096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4017572228
MESH:D006332 Cardiomegaly Phenylephrine 10.6911754973 17124262 16170337 15728586 11179087 17287366
MESH:D006332 Cardiomegaly Quercetin 10.6919794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 10.6918670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.1416332659
MESH:D002386 Cataract Acetaminophen 6.7510977129
MESH:D002386 Cataract Tretinoin 6.7517460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 14.637505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.6312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.6317174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.6318566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3416129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.6419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.349022650 19486331
MESH:D002779 Cholestasis Cyclosporine 12.3419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.3415861022 17110522 17681005 11677210 16105132 17333356 16919318
MESH:D002822 Choriocarcinoma Tretinoin 4.9116461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4215668235 8697196 16354765 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 5.429407595
MESH:D003092 Colitis Tretinoin 3.4617035595
MESH:D003110 Colonic Neoplasms Fluorouracil 7.9618772588 15001691 17287894 17725105 16340194 16510598 17172411 17169374 17016597 17018589
MESH:D003110 Colonic Neoplasms Genistein 7.9617182828
MESH:D003110 Colonic Neoplasms Quercetin 7.9619440933 11134977 17148506 17191121 19056647 16640504 15741050
MESH:D003110 Colonic Neoplasms Sulindac 7.9612458338 12902858
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.4616391804 18383874 17016601 16303861 18288408 17401013 18949393 16282729 17255274 17454858 17094418 18509181 15148649 16331619 14970324 16524972 17594712 20501625 15289873 18802399 18448328 17695437
MESH:D015179 Colorectal Neoplasms Quercetin 3.4618852136 18095365
MESH:D015179 Colorectal Neoplasms Sulindac 3.4618059344 10666051 11197048 11076880
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8517141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3715322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.379224671 9664655 8800419 17551590 9125849 16925845 9211117 10589399 9142499 14991402
MESH:D003456 Cryptorchidism Diethylstilbestrol 10.5916002989 12952375
MESH:D003456 Cryptorchidism vinclozolin 10.5914966744
MESH:D007644 Darier Disease Fluorouracil 4.5416733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1219031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.5718759878 14531868 12868966 11298694 8156756 8970840 2524372 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.263621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.5319496084
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.7320387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.7316647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7317107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.1619279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.1619279558
MESH:D003930 Diabetic Retinopathy Sulindac 4.9417621415 12861449
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 14.271440618 11289319 18692083 9328219 18289764 18648102 9022650 16192314 6679447 6482804 8291058 9653073 7440962
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.2712392966 16177239 10774834 11421492 19370779 10915739 19420014 14986274 14550746 15619225 2444490 16081117 19923254 16227642 18713872 11287661 11739529 19739265 10663392 16109766 16485898 17522070 17562736 16781746 12594235 19416960 19164858 12958197 16393943 14725611 11529661 11834606 12540782 11461765 18071297 15968718 11743745 19085960 12153990 12705907 17906064
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.276884620 16177239 7179309 21278145 11566570 10915739 3786805 9327722 15998439 15968718 6623471 4309450 7440962 17522070 10092053 2869522 7120509 16227642 19085960 3732212 15027814 19336974
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 14.2717654400
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 14.2719107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.2720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2818367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.1711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1116714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.1118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.1712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.1719031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 11.0716402032
MESH:D004714 Endometrial Hyperplasia Genistein 11.0716402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 21.6615700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 21.6611473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 21.6611473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 21.6619155303 20544844 16202921 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 21.6616569247
MESH:D004715 Endometriosis Sulindac 8.4815652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.489294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8716302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.003581430
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.0016785472 15173087 16481741 16337965 17638652
MESH:D004938 Esophageal Neoplasms Sulindac 7.0012235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.249664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 27.8412795759 16045604 12631006 19224547 15959796 61145 17595544 16239168
MESH:D005234 Fatty Liver Cyclosporine 27.8419224547
MESH:D005234 Fatty Liver Dietary Fats 27.8417967931 18296743 19551842 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 27.8421071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.8415345470
MESH:D005234 Fatty Liver Tamoxifen 27.8419224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.7215751030 16513791 16002989 16611131 16534752
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.7216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.776705139
MESH:D018221 Fibromatosis, Abdominal Sulindac 12.1314745880
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 12.1314745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 10.8219069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.8219069698
MESH:D005355 Fibrosis Carbon Tetrachloride 31.3618705752
MESH:D005355 Fibrosis Cyclosporine 31.3612639820 12168785
MESH:D005355 Fibrosis Dietary Fats 31.3618296743
MESH:D005355 Fibrosis Quercetin 31.3619474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 31.3620067830
MESH:D005355 Fibrosis Tretinoin 31.3617994277
MESH:D005756 Gastritis Acetaminophen 3.4316983495
MESH:D005764 Gastroesophageal Reflux Sulindac 4.7811910360
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0516417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7016452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.978708960
MESH:D005909 Glioblastoma Genistein 11.0216598420
MESH:D005909 Glioblastoma Quercetin 11.0219804834
MESH:D005909 Glioblastoma Tretinoin 11.0217312396
MESH:D005910 Glioma Fluorouracil 5.8616145905
MESH:D005910 Glioma Quercetin 5.8617643826
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.817505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.2518337622 15162350 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.2516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9116084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1110048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.1114991402 9664655
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.446705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.4419110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6515340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.7815709030
MESH:D019584 Hot Flashes Estradiol 3.5017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.808697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 6.9916870215
MESH:D006930 Hyperalgesia Tretinoin 6.9916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2816899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3721332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3316778211
MESH:D006943 Hyperglycemia Quercetin 3.8218262572 11834736
MESH:D006949 Hyperlipidemias Dietary Fats 3.3921332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 17.0815034207
MESH:D006965 Hyperplasia Diethylstilbestrol 17.0812960047 14722030
MESH:D006965 Hyperplasia halofuginone 17.0811874485
MESH:D006973 Hypertension Cyclosporine 11.6110903974
MESH:D006973 Hypertension Phenylephrine 11.618949925 12717712
MESH:D006973 Hypertension Quercetin 11.6118356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.6118850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8515338365
MESH:D006984 Hypertrophy Phenylephrine 4.3318502941 12791704
MESH:D007021 Hypospadias Diethylstilbestrol 10.4416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.4416945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.1215036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.1217937319
MESH:D007248 Infertility, Male vinclozolin 6.1216467254
MESH:D007249 Inflammation Dietary Fats 14.5120412841
MESH:D007249 Inflammation Diethylnitrosamine 14.5118785209
MESH:D007249 Inflammation Sulindac 14.513291741
MESH:D007249 Inflammation Tamoxifen 14.5119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.5112878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.2616624496
MESH:D007333 Insulin Resistance Dietary Fats 6.8411836018 18457598
MESH:D007333 Insulin Resistance Estradiol 6.8416393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 3.5317994277
MESH:D007414 Intestinal Neoplasms Sulindac 4.4210213222 12584176 12351151 12663524 10223192 12628509
MESH:D007417 Intestinal Polyps Sulindac 4.7612394442 11245490
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.778074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.2015992940 17551590
MESH:D007627 Keloid Quercetin 4.7117086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1915604871
MESH:D007674 Kidney Diseases Acetaminophen 13.2715629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 13.278314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 13.2715618244
MESH:D007674 Kidney Diseases Quercetin 13.2716962696
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 26.526582329
MESH:D007680 Kidney Neoplasms Cyclosporine 26.5212371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 26.5215003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 26.5215610895
MESH:D007680 Kidney Neoplasms Fluorouracil 26.5216985049
MESH:D007680 Kidney Neoplasms Tamoxifen 26.5218625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8217184923
MESH:D007938 Leukemia Genistein 9.8317468513 18980019
MESH:D007938 Leukemia Quercetin 9.8317468513
MESH:D007938 Leukemia Tretinoin 9.8317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4816482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0419850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9916823087 9834237 17368321 19035177 19029980 17339181 17294898 17107899 19225113 16788101 16140955 17712046 16766008 16891316 17217047 17361223 16935935 19075265 17301526 19642359 15748426 17649720 16331271 12679006 17506722
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4816417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.139224671
MESH:D008064 Lipidoses Tamoxifen 2.9817567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 14.7011408273 17334410 16943688 16239168 16221502 21278145 11903743 17174718 17157831
MESH:D008103 Liver Cirrhosis Dietary Fats 14.7018296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 14.7020032147 18407596 18665156 19638242 18522880
MESH:D008103 Liver Cirrhosis halofuginone 14.7017180598
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 8.0015034207 9327722
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 8.0012468960
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 12.6915650968 10355542 18156304 18205269 15052691 12586293 17565644 17721639 12632512 12741479 16192424 15996030 17631135 18279442 18418968 18251166 16097048 17714472 18166357 18412020 18263696 14748882 17900296 16015684 16011737 14716496 16116963 12445418 18705752 18210741 15057751 18472332 15362042 17481882 18317297 15338365 17944888 14512876 12667390 15818738 18339082 18376398 18187930 12546737 17525996 12649538 17766677 17869086 18395095 15730626 15123356 14620537 17922224 17698563 17640975 17823541 20821823 12389079 12445421 15931870 16033810 16027843 15959796 15370692 18420326 12666154 11481614 17557913 13678700 18054572 14716833 17805973 12609069 18429990 17976157 17761835 12958196 18006644 14724832 16248980 16638106 15925388 15893842 17708605 15876570 16136751 18481824 18472094 18395914 12898905 18277467 15673190 12632514
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 12.6914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 12.6917823541
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 12.6914739098 18458672 16489207 12175628 11172339
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 12.6912741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 12.6918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 12.6912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 12.6918397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 8.8612969438 16611625 19460945 12587719 19014921 16610002 19784758 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.8616964402 17285989 15720792 15830285 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 8.8617034775
MESH:D008107 Liver Diseases Sulindac 8.8614986274 16867024
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.7016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.7016899240 14706259
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 28.3121295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 28.3119294768
MESH:D008113 Liver Neoplasms ciprofibrate 28.3112771043
MESH:D008113 Liver Neoplasms Diethylnitrosamine 28.3119638242 19073162 19254457 10737359 19690152 20492335 20137499 20405173 20434301 21278145 20452335 19426721 19812893 2422723 18644402 18978307 20101389 21047994 18648771 16942905 12112319 21167192 19850985 20118626 12771043 21071580 19294768 19642983 18754104 19256749 15175105 19427195 19499222 19833225 18977376 20501860 15885732 19551842 20583210 9163691 19255062 2862719 19996281 19090486
MESH:D008113 Liver Neoplasms Diethylstilbestrol 28.3116712894 15890375
MESH:D008113 Liver Neoplasms Fluorouracil 28.3115113037 16603448 18383874 17045692
MESH:D008113 Liver Neoplasms Quercetin 28.3118980244
MESH:D008113 Liver Neoplasms Tamoxifen 28.3116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 28.3116984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 21.40598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 21.4018164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 21.4012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 21.4019004024 19009564 16842330 21159647 17942915 18079962 18164116 18544905 3124819 17854601 19519916 18775883 18308698 16267830 17174075 19539802 19126423 18282651 2563599 18093689 18253720 9362446
MESH:D008114 Liver Neoplasms, Experimental Quercetin 21.4019519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 21.4012151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.1420512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Fluorouracil 8.1415246190
MESH:D008175 Lung Neoplasms Quercetin 8.1416280456
MESH:D008175 Lung Neoplasms Sulindac 8.1415713900 19359593
MESH:D008175 Lung Neoplasms Tamoxifen 8.1418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.1411884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5415086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9015166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.3015700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2716002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5119428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.0711807958 17203775 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.0714578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.0719196723 19196722 16827153 14580682 11731420
MESH:D020149 Manganese Poisoning Estradiol 11.8119453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.8119453300
MESH:D008527 Medulloblastoma Tretinoin 2.6917453147
MESH:D008545 Melanoma Sulindac 4.9316642371
MESH:D008545 Melanoma Tamoxifen 4.9312393984 19393235
MESH:D008545 Melanoma Tretinoin 4.9316752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3319513568
MESH:D008591 Meningomyelocele Tretinoin 4.1816940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5416801185
MESH:D009062 Mouth Neoplasms Fluorouracil 3.4518986760 16757204
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9417596541
MESH:D009203 Myocardial Infarction Genistein 5.6517141266
MESH:D009203 Myocardial Infarction Quercetin 5.6519595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.2116810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.2117141266
MESH:D015428 Myocardial Reperfusion Injury Quercetin 13.2119207477
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 8.883581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.889029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.8819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4419410462
MESH:D009369 Neoplasms Diethylstilbestrol 10.9115313581
MESH:D009369 Neoplasms Fluorouracil 10.9118239605 18600527 16928823
MESH:D009369 Neoplasms Quercetin 10.9115185748
MESH:D009369 Neoplasms Tretinoin 10.9116946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7519200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0819348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 28.2311399458
MESH:D009421 Nervous System Malformations Estradiol 28.2316427766 11399458
MESH:D009421 Nervous System Malformations Genistein 28.2316427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 28.2314600291
MESH:D009421 Nervous System Malformations Tretinoin 28.239125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 6.706679447
MESH:D009436 Neural Tube Defects Tretinoin 6.709142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 12.9718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 12.9720387270
MESH:D019636 Neurodegenerative Diseases Sulindac 12.9717266991 16850258
MESH:D020078 Neurogenic Inflammation Quercetin 4.1317929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8720387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2716436463
MESH:D009765 Obesity Dietary Fats 2.2321332399 20518802 11836018 18457598 17217161 16723640 20132043 18674790 19632207
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.216482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.773988306
MESH:D010024 Osteoporosis Genistein 3.1019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.3816169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 9.3819495926
MESH:D010051 Ovarian Neoplasms Estradiol 10.6519401270
MESH:D010051 Ovarian Neoplasms Genistein 10.6519005980
MESH:D010051 Ovarian Neoplasms Quercetin 10.6519005980
MESH:D010051 Ovarian Neoplasms Tretinoin 10.6516936753
MESH:D010146 Pain Acetaminophen 10.1716870215
MESH:D010146 Pain Sulindac 10.173291741
MESH:D010146 Pain Tretinoin 10.1716870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 15.3816540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 15.3815113037 16929163 19003803 16500647
MESH:D010190 Pancreatic Neoplasms Quercetin 15.3816965848
MESH:D010190 Pancreatic Neoplasms Sulindac 15.3811504793 16820089
MESH:D010190 Pancreatic Neoplasms Tretinoin 15.3815976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4611578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.247296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.226228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9214722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4315687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.1312371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.132563599
MESH:D011230 Precancerous Conditions Quercetin 14.1319056647
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 14.8417184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.8411118676 11222880 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 14.8418042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.6918220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6620887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.8815846301 15046698 17136230
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8819082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 1.8815256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Quercetin 1.8817292933 14715546
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8815067354
MESH:D011472 Prostatitis vinclozolin 4.6918629315
MESH:D011507 Proteinuria Tretinoin 3.3816636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0715861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011625 Pterygium Tretinoin 4.5516723453
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8015538739 18722050 16160472 18286688
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.193692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8716283617 16116481
MESH:D012554 Schistosomiasis japonica Quercetin 5.3016862918
MESH:D012852 Sinusitis Phenylephrine 4.467327846
MESH:D012871 Skin Diseases halofuginone 3.4511874485
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 8.758532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.7516192470
MESH:D012878 Skin Neoplasms Tretinoin 8.7516467112
MESH:D013088 Spermatocele Diethylstilbestrol 18.6816709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 18.6816709447
MESH:D013088 Spermatocele Tamoxifen 18.6816709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7919457130
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2518456281
MESH:D013274 Stomach Neoplasms Fluorouracil 3.2517498489 16424979 19015929 17522103 17172411 18396642 15786421 16951190 18567086 19084572
MESH:D013274 Stomach Neoplasms Tretinoin 3.2517261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 10.886587162 6582329 3712494 7505956 1399818
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.887505956
MESH:D013964 Thyroid Neoplasms Tretinoin 10.8816026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.4419048282
MESH:D014062 Tongue Neoplasms Fluorouracil 9.1216280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.1216051514
MESH:D014376 Tuberculosis Tretinoin 3.0816040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.158074119
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 11.1517306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Quercetin 11.1516720314
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.1517572228 8653321 16712894
MESH:D014581 Urticaria Acetaminophen 2.7510982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 14.6616175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 14.6616803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.6616129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.9214652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 14.7715809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 14.7714692618
MESH:D014594 Uterine Neoplasms Sulindac 14.7718645019
MESH:D014604 Uveal Neoplasms Tretinoin 4.3616752155
MESH:D014605 Uveitis Cyclosporine 3.731336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1916002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3214671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.8216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
MESH:D015430 Weight Gain Dietary Fats 3.5316723640
MESH:D009396 Wilms Tumor Tretinoin 3.7616287080
MESH:D014985 Xerophthalmia Cyclosporine 4.1917120751
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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