AutismKB 2.0

Annotation Detail for LHB


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Basic Information Top
Gene Symbol:LHB ( CGB4,LSH-B,hLHB )
Gene Full Name: luteinizing hormone beta polypeptide
Band: 19q13.3
Quick LinksEntrez ID:3972; OMIM: 152780; Uniprot ID:LSHB_HUMAN; ENSEMBL ID: ENSG00000104826; HGNC ID: 6584
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04912GnRH signaling pathway
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
Hormone biosynthesis
Metabolism of amino acids and derivatives
No data
No data
Pathway IDPathway Name
500769Glycoprotein hormones
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1832Congenital abnormality
1901Endometriosis
2241Infertility
Desease Name
Infertility, Female
prostate cancer
CANCER
REPRODUCTION
No data
Desease Name
Male pseudohermaphroditism due to defective LH
Hypogonadism, hypergonadotropic
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C070379 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Dinoprost inhibits the reaction [LHB protein results in increased secretion of Progesterone]]decreases reaction|increases secretion 17760987
C070379 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [LHB protein results in increased secretion of Progesterone]decreases reaction|increases secretion 17760987
C420062 1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea [1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea co-treated with JNJ-10397049] results in decreased expression of LHB proteinaffects cotreatment|decreases expression 17638707
C014024 2,4,5,2',4',5'-hexachlorobiphenyl 2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [LHB protein results in increased secretion of OXT protein]increases reaction|increases secretion 16780177
C028451 3,4,3',4'-tetrachlorobiphenyl 3,4,3',4'-tetrachlorobiphenyl affects the reaction [LHB protein results in increased secretion of OXT protein]affects reaction|increases secretion 16780177
C028451 3,4,3',4'-tetrachlorobiphenyl 3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [LHB protein results in increased secretion of Progesterone]decreases reaction|increases secretion 16967098
C023035 3,4,5,3',4'-pentachlorobiphenyl 3,4,5,3',4'-pentachlorobiphenyl affects the reaction [LHB protein results in increased secretion of OXT protein]affects reaction|increases secretion 16780177
C023035 3,4,5,3',4'-pentachlorobiphenyl 3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [LHB protein results in increased secretion of Progesterone]decreases reaction|increases secretion 16967098
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of LHB mRNAincreases expression 18648102
C041594 4-nonylphenol 4-nonylphenol affects the expression of LHB proteinaffects expression 15888928
C041594 4-nonylphenol 4-nonylphenol results in decreased expression of and results in decreased secretion of LHB proteindecreases expression|decreases secretion 17033158
C105260 4-tert-octylphenol 4-tert-octylphenol affects the expression of LHB proteinaffects expression 15888928
C105260 4-tert-octylphenol 4-tert-octylphenol results in decreased expression of LHB proteindecreases expression 17033158
C119737 8-prenylnaringenin 8-prenylnaringenin results in decreased expression of LHB mRNAdecreases expression 16522720
C119737 8-prenylnaringenin 8-prenylnaringenin results in decreased expression of LHB proteindecreases expression 16522720
C034632 ABVD protocol ABVD protocol results in increased expression of LHB proteinincreases expression 17965791
D000082 Acetaminophen Acetaminophen affects the expression of LHB mRNAaffects expression 17562736
D053959 Alpha-Amanitin Alpha-Amanitin inhibits the reaction [LHB protein results in increased expression of NR4A1 mRNA]decreases reaction|increases expression 11416027
C069206 alpha helical corticotropin-releasing hormone alpha helical corticotropin-releasing hormone results in decreased secretion of LHB proteindecreases secretion 15486230
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LHB mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of LHB proteindecreases expression 18630931
D001205 Ascorbic Acid Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of LHB protein]decreases expression|decreases reaction 16248992
16298753
17280759
C120841 astressin B astressin B inhibits the reaction [GHRL protein results in decreased expression of LHB protein]decreases expression|decreases reaction 18063681
C120841 astressin B astressin B inhibits the reaction [Lipopolysaccharides results in decreased expression of LHB protein]decreases expression|decreases reaction 17082255
D001280 Atrazine Atrazine results in increased expression of LHB mRNAincreases expression 18461179
D001280 Atrazine NR5A1 protein affects the reaction [Atrazine results in increased expression of LHB mRNA]affects reaction|increases expression 18461179
D001280 Atrazine SGK1 protein affects the reaction [Atrazine results in increased expression of LHB mRNA]affects reaction|increases expression 18461179
D001280 Atrazine Atrazine inhibits the reaction [[estradiol 3-benzoate co-treated with Progesterone] results in increased secretion of LHB protein]affects cotreatment|decreases reaction|increases secretion 15056801
D001280 Atrazine Atrazine inhibits the reaction [estradiol 3-benzoate results in increased secretion of LHB protein]decreases reaction|increases secretion 10696778
D001280 Atrazine Atrazine results in decreased secretion of LHB proteindecreases secretion 15056801
10696778
D001280 Atrazine GNRH1 protein inhibits the reaction [Atrazine results in decreased secretion of LHB protein]decreases reaction|decreases secretion 10696778
C006780 bisphenol A bisphenol A results in increased expression of LHB mRNAincreases expression 20647052
C006780 bisphenol A LHB protein affects the reaction [bisphenol A results in decreased expression of CPLX1 mRNA]affects reaction|decreases expression 17706920
C006780 bisphenol A LHB protein affects the reaction [bisphenol A results in decreased expression of EVX2 mRNA]affects reaction|decreases expression 17706920
C006780 bisphenol A LHB protein affects the reaction [bisphenol A results in decreased expression of GGN mRNA]affects reaction|decreases expression 17706920
C006780 bisphenol A LHB protein affects the reaction [bisphenol A results in decreased expression of MARCKS mRNA]affects reaction|decreases expression 17706920
C006780 bisphenol A LHB protein affects the reaction [bisphenol A results in decreased expression of MS4A6C mRNA]affects reaction|decreases expression 17706920
C006780 bisphenol A LHB protein affects the reaction [bisphenol A results in decreased expression of PPP1R3A mRNA]affects reaction|decreases expression 17706920
C006780 bisphenol A LHB protein affects the reaction [bisphenol A results in decreased expression of SASS6 mRNA]affects reaction|decreases expression 17706920
C006780 bisphenol A LHB protein affects the reaction [bisphenol A results in decreased expression of TPX2 mRNA]affects reaction|decreases expression 17706920
C006780 bisphenol A LHB protein affects the reaction [bisphenol A results in decreased expression of WDR19 mRNA]affects reaction|decreases expression 17706920
C006780 bisphenol A LHB protein affects the reaction [bisphenol A results in decreased expression of WDR51B mRNA]affects reaction|decreases expression 17706920
C006780 bisphenol A LHB protein affects the reaction [bisphenol A results in increased expression of ATP6V1E2 mRNA]affects reaction|increases expression 17706920
C006780 bisphenol A LHB protein affects the reaction [bisphenol A results in increased expression of BBS4 mRNA]affects reaction|increases expression 17706920
C006780 bisphenol A LHB protein affects the reaction [bisphenol A results in increased expression of CYP7A1 mRNA]affects reaction|increases expression 17706920
C006780 bisphenol A LHB protein affects the reaction [bisphenol A results in increased expression of JRK mRNA]affects reaction|increases expression 17706920
C006780 bisphenol A LHB protein affects the reaction [bisphenol A results in increased expression of KLHL18 mRNA]affects reaction|increases expression 17706920
C006780 bisphenol A LHB protein affects the reaction [bisphenol A results in increased expression of PEX2 mRNA]affects reaction|increases expression 17706920
C006780 bisphenol A bisphenol A results in decreased expression of LHB mRNAdecreases expression 14605012
C006780 bisphenol A bisphenol A results in decreased expression of LHB proteindecreases expression 20144698
C025191 bromodichloromethane bromodichloromethane results in decreased secretion of LHB proteindecreases secretion 14657523
17344021
D002118 Calcium Calcium inhibits the reaction [LHB protein results in increased secretion of Progesterone]decreases reaction|increases secretion 17760987
C062876 cetrorelix cetrorelix results in decreased expression of LHB proteindecreases expression 16914592
C062876 cetrorelix cetrorelix results in decreased expression of LHB proteindecreases expression 17638707
D020111 Chlorodiphenyl (54% Chlorine) Ascorbic Acid inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of LHB protein]decreases expression|decreases reaction 17280759
16248992
16298753
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of LHB proteindecreases expression 16248992
16298753
17280759
D020111 Chlorodiphenyl (54% Chlorine) Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of LHB protein]decreases expression|decreases reaction 16298753
17280759
D002994 Clofibrate PPARA protein affects the reaction [Clofibrate results in decreased expression of LHB mRNA]affects reaction|decreases expression 17585979
D003277 Contraceptives, Oral, Combined [LHRH, Ala(6)-Gly(10)-ethylamide- co-treated with Contraceptives, Oral, Combined] results in decreased expression of LHB proteinaffects cotreatment|decreases expression 11228061
D003300 Copper [Copper binds to GNRH1 protein] which results in increased secretion of LHB proteinaffects binding|increases secretion 16892001
D003513 Cycloheximide Cycloheximide promotes the reaction [LHB protein results in increased expression of NR4A1 mRNA]increases expression|increases reaction 11416027
D017373 Cyproterone Acetate [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in decreased expression of LHB proteinaffects cotreatment|decreases expression 16002536
D017135 Desogestrel [Ethinyl Estradiol co-treated with Desogestrel] results in decreased expression of LHB proteinaffects cotreatment|decreases expression 17105841
D017135 Desogestrel Simvastatin promotes the reaction [[Ethinyl Estradiol co-treated with Desogestrel] results in decreased expression of LHB protein]affects cotreatment|decreases expression|increases reaction 17105841
D003907 Dexamethasone Dexamethasone results in decreased expression of LHB mRNAdecreases expression 16675544
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of LHB proteindecreases expression 16400681
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of LHB proteindecreases expression 17213693
16468032
D004054 Diethylstilbestrol Diethylstilbestrol affects the expression of LHB proteinaffects expression 15888928
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of LHB proteinincreases expression 16537657
D011397 Promegestone Promegestone results in decreased expression of LHB mRNAdecreases expression 16675544
C007630 estradiol 17 beta-cypionate estradiol 17 beta-cypionate promotes the reaction [[Tetrachlorodibenzodioxin co-treated with Gonadotropins, Equine] results in increased expression of LHB protein]affects cotreatment|increases expression|increases reaction 12606454
C007630 estradiol 17 beta-cypionate estradiol 17 beta-cypionate promotes the reaction [[Tetrachlorodibenzodioxin co-treated with Gonadotropins, Equine] results in increased secretion of LHB protein]affects cotreatment|increases reaction|increases secretion 12606454
C074283 estradiol 3-benzoate estradiol 3-benzoate results in decreased expression of LHB mRNAdecreases expression 15223135
C074283 estradiol 3-benzoate Atrazine inhibits the reaction [[estradiol 3-benzoate co-treated with Progesterone] results in increased secretion of LHB protein]affects cotreatment|decreases reaction|increases secretion 15056801
C074283 estradiol 3-benzoate Atrazine inhibits the reaction [estradiol 3-benzoate results in increased secretion of LHB protein]decreases reaction|increases secretion 10696778
C074283 estradiol 3-benzoate estradiol 3-benzoate results in decreased expression of LHB mRNAdecreases expression 16614383
C074283 estradiol 3-benzoate estradiol 3-benzoate results in decreased secretion of LHB proteindecreases secretion 16614383
C074283 estradiol 3-benzoate estradiol 3-benzoate results in increased secretion of LHB proteinincreases secretion 17398000
10696778
C074283 estradiol 3-benzoate Raloxifene inhibits the reaction [estradiol 3-benzoate results in increased secretion of LHB protein]decreases reaction|increases secretion 17398000
D004958 Estradiol Estradiol results in increased expression of LHBincreases expression 19456401
D004958 Estradiol Estradiol results in increased expression of LHB mRNAincreases expression 20647052
D004958 Estradiol Estradiol results in decreased secretion of LHB proteindecreases secretion 17629525
D004958 Estradiol Estradiol results in increased expression of LHB proteinincreases expression 15796768
D004958 Estradiol [Estradiol co-treated with Progesterone] results in increased expression of LHB proteinaffects cotreatment|increases expression 17640482
D004958 Estradiol Estradiol results in decreased expression of LHB mRNAdecreases expression 16614383
16522720
D004958 Estradiol Estradiol results in decreased expression of LHB proteindecreases expression 16522720
20144698
D004958 Estradiol Estradiol results in decreased secretion of LHB proteindecreases secretion 16614383
D004958 Estradiol nociceptin (1-13) amide inhibits the reaction [PNOC protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of LHB protein]]affects cotreatment|decreases reaction|increases expression 17640482
D004958 Estradiol PNOC protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of LHB protein]affects cotreatment|decreases reaction|increases expression 17640482
C043090 estradiol-bovine serum albumin estradiol-bovine serum albumin results in decreased secretion of LHB proteindecreases secretion 17629525
C015854 estradiol valerate estradiol valerate results in decreased expression of LHB proteindecreases expression 10843175
D004966 Estrogens, Conjugated (USP) Estrogens, Conjugated (USP) results in decreased expression of LHB proteindecreases expression 10843175
D000431 Ethanol Ethanol results in decreased expression of LHB proteindecreases expression 7592674
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in decreased expression of LHB proteinaffects cotreatment|decreases expression 16002536
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Desogestrel] results in decreased expression of LHB proteinaffects cotreatment|decreases expression 17105841
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of LHB proteinaffects cotreatment|decreases expression 16291413
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of LHB proteindecreases expression 11907703
10843175
D004997 Ethinyl Estradiol Simvastatin promotes the reaction [[Ethinyl Estradiol co-treated with Desogestrel] results in decreased expression of LHB protein]affects cotreatment|decreases expression|increases reaction 17105841
D004997 Ethinyl Estradiol SPP301 affects the reaction [[Ethinyl Estradiol co-treated with Levonorgestrel] affects the expression of LHB protein]affects cotreatment|affects expression|affects reaction 17190377
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of LHB mRNAdecreases expression 16330033
C442659 ethinyl estradiol-desogestrel combination ethinyl estradiol-desogestrel combination results in decreased expression of LHB proteindecreases expression 17105841
C442659 ethinyl estradiol-desogestrel combination Simvastatin promotes the reaction [ethinyl estradiol-desogestrel combination results in decreased expression of LHB protein]decreases expression|increases reaction 17105841
D005485 Flutamide Flutamide results in decreased expression of LHB proteindecreases expression 16735550
D005485 Flutamide [LHRH, Ala(6)-Gly(10)-ethylamide- co-treated with Flutamide] results in decreased expression of LHB proteinaffects cotreatment|decreases expression 11228061
D005485 Flutamide Flutamide affects the expression of LHB proteinaffects expression 15519604
D005485 Flutamide Flutamide inhibits the reaction [Testosterone Propionate results in decreased expression of LHB protein]decreases expression|decreases reaction 11376863
D005485 Flutamide Flutamide results in increased expression of LHB mRNAincreases expression 14967917
D005485 Flutamide Flutamide results in increased expression of LHB proteinincreases expression 16537657
D006064 Gonadotropins, Equine estradiol 17 beta-cypionate promotes the reaction [[Tetrachlorodibenzodioxin co-treated with Gonadotropins, Equine] results in increased expression of LHB protein]affects cotreatment|increases expression|increases reaction 12606454
D006064 Gonadotropins, Equine estradiol 17 beta-cypionate promotes the reaction [[Tetrachlorodibenzodioxin co-treated with Gonadotropins, Equine] results in increased secretion of LHB protein]affects cotreatment|increases reaction|increases secretion 12606454
D006064 Gonadotropins, Equine Mifepristone promotes the reaction [[Tetrachlorodibenzodioxin co-treated with Gonadotropins, Equine] results in increased expression of LHB protein]affects cotreatment|increases expression|increases reaction 12606454
D006064 Gonadotropins, Equine Pentobarbital inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Gonadotropins, Equine] results in increased expression of LHB protein]affects cotreatment|decreases reaction|increases expression 12606454
D006064 Gonadotropins, Equine [Tetrachlorodibenzodioxin co-treated with Gonadotropins, Equine] results in increased expression of LHB proteinaffects cotreatment|increases expression 12606454
C524573 JNJ-10397049 [1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea co-treated with JNJ-10397049] results in decreased expression of LHB proteinaffects cotreatment|decreases expression 17638707
C524573 JNJ-10397049 JNJ-10397049 results in decreased expression of LHB proteindecreases expression 17638707
C067431 letrozole letrozole results in increased expression of LHB proteinincreases expression 16046582
C083781 LHRH, Ala(6)-Gly(10)-ethylamide- [LHRH, Ala(6)-Gly(10)-ethylamide- co-treated with Contraceptives, Oral, Combined] results in decreased expression of LHB proteinaffects cotreatment|decreases expression 11228061
C083781 LHRH, Ala(6)-Gly(10)-ethylamide- [LHRH, Ala(6)-Gly(10)-ethylamide- co-treated with Flutamide] results in decreased expression of LHB proteinaffects cotreatment|decreases expression 11228061
C083781 LHRH, Ala(6)-Gly(10)-ethylamide- LHRH, Ala(6)-Gly(10)-ethylamide- results in decreased expression of LHB proteindecreases expression 11228061
D008070 Lipopolysaccharides astressin B inhibits the reaction [Lipopolysaccharides results in decreased expression of LHB protein]decreases expression|decreases reaction 17082255
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of LHB proteindecreases expression 17082255
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of LHB proteindecreases expression 12207160
C008376 mestanolone mestanolone results in decreased expression of LHB mRNAdecreases expression 16330033
D008714 Methiocarb Methiocarb results in decreased expression of LHB proteindecreases expression 15519604
D008724 Methomyl Methomyl results in increased expression of LHB proteinincreases expression 11516254
C013598 methoxyacetic acid methoxyacetic acid affects the secretion of LHB proteinaffects secretion 1898883
D015741 Metribolone Metribolone results in decreased expression of LHB mRNAdecreases expression 16675544
D015735 Mifepristone Mifepristone promotes the reaction [[Tetrachlorodibenzodioxin co-treated with Gonadotropins, Equine] results in increased expression of LHB protein]affects cotreatment|increases expression|increases reaction 12606454
C009821 molinate molinate affects the secretion of LHB proteinaffects secretion 15601673
C014553 MOPP protocol MOPP protocol affects the expression of LHB proteinaffects expression 14752856
C014553 MOPP protocol MOPP protocol results in increased expression of LHB proteinincreases expression 17981817
17965791
C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased expression of AREG mRNA]decreases reaction|increases expression 15967414
C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased expression of AREG protein]decreases reaction|increases expression 15967414
C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased secretion of Progesterone]decreases reaction|increases secretion 15967414
D009532 Nickel [Nickel binds to GNRH1 protein] which results in increased secretion of LHB proteinaffects binding|increases secretion 16892001
D009583 Nitrofurazone Nitrofurazone inhibits the reaction [GNRH1 protein results in increased secretion of LHB protein]decreases reaction|increases secretion 3126094
D009583 Nitrofurazone Nitrofurazone results in decreased expression of LHB proteindecreases expression 3126094
C439964 nociceptin (1-13) amide nociceptin (1-13) amide inhibits the reaction [PNOC protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of LHB protein]]affects cotreatment|decreases reaction|increases expression 17640482
D016912 Levonorgestrel [Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of LHB proteinaffects cotreatment|decreases expression 16291413
D016912 Levonorgestrel SPP301 affects the reaction [[Ethinyl Estradiol co-treated with Levonorgestrel] affects the expression of LHB protein]affects cotreatment|affects expression|affects reaction 17190377
D010424 Pentobarbital Pentobarbital inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Gonadotropins, Equine] results in increased expression of LHB protein]affects cotreatment|decreases reaction|increases expression 12606454
D010424 Pentobarbital Pentobarbital results in decreased expression of LHB proteindecreases expression 17638707
C045362 prochloraz prochloraz results in increased expression of LHB proteinincreases expression 12377983
C035988 procymidone procymidone results in increased expression of LHB proteinincreases expression 12563111
C035988 procymidone [vinclozolin co-treated with procymidone] results in increased expression of LHB proteinaffects cotreatment|increases expression 12563111
D011374 Progesterone 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Dinoprost inhibits the reaction [LHB protein results in increased secretion of Progesterone]]decreases reaction|increases secretion 17760987
D011374 Progesterone 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [LHB protein results in increased secretion of Progesterone]decreases reaction|increases secretion 17760987
D011374 Progesterone 3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [LHB protein results in increased secretion of Progesterone]decreases reaction|increases secretion 16967098
D011374 Progesterone 3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [LHB protein results in increased secretion of Progesterone]decreases reaction|increases secretion 16967098
D011374 Progesterone Calcium inhibits the reaction [LHB protein results in increased secretion of Progesterone]decreases reaction|increases secretion 17760987
D011374 Progesterone Dinoprost inhibits the reaction [LHB protein results in increased abundance of Progesterone]decreases reaction|increases abundance 15601909
D011374 Progesterone Dinoprost inhibits the reaction [LHB protein results in increased secretion of Progesterone]decreases reaction|increases secretion 17760987
D011374 Progesterone EDN1 protein inhibits the reaction [LHB protein results in increased abundance of Progesterone]decreases reaction|increases abundance 15537863
D011374 Progesterone IGF1 protein inhibits the reaction [LHB protein results in increased abundance of Progesterone]decreases reaction|increases abundance 17154301
D011374 Progesterone LHB protein results in increased abundance of Progesteroneincreases abundance 17154301
16740971
D011374 Progesterone LHB protein results in increased secretion of Progesteroneincreases secretion 17760987
16303614
D011374 Progesterone PRKCE protein promotes the reaction [Dinoprost inhibits the reaction [LHB protein results in increased secretion of Progesterone]]decreases reaction|increases reaction|increases secretion 17760987
D011374 Progesterone Protein Kinase Inhibitors inhibits the reaction [Dinoprost inhibits the reaction [LHB protein results in increased abundance of Progesterone]]decreases reaction|increases abundance 15601909
D011374 Progesterone LHB protein results in increased secretion of Progesteroneincreases secretion 15525572
15967414
D011374 Progesterone N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased secretion of Progesterone]decreases reaction|increases secretion 15967414
D011374 Progesterone LHB protein results in increased secretion of Progesteroneincreases secretion 17379658
17991618
D011374 Progesterone Atrazine inhibits the reaction [[estradiol 3-benzoate co-treated with Progesterone] results in increased secretion of LHB protein]affects cotreatment|decreases reaction|increases secretion 15056801
D011374 Progesterone [Estradiol co-treated with Progesterone] results in increased expression of LHB proteinaffects cotreatment|increases expression 17640482
D011374 Progesterone nociceptin (1-13) amide inhibits the reaction [PNOC protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of LHB protein]]affects cotreatment|decreases reaction|increases expression 17640482
D011374 Progesterone PNOC protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of LHB protein]affects cotreatment|decreases reaction|increases expression 17640482
D015237 Dinoprost 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Dinoprost inhibits the reaction [LHB protein results in increased secretion of Progesterone]]decreases reaction|increases secretion 17760987
D015237 Dinoprost Dinoprost inhibits the reaction [LHB protein results in increased abundance of Progesterone]decreases reaction|increases abundance 15601909
D015237 Dinoprost Dinoprost inhibits the reaction [LHB protein results in increased secretion of Progesterone]decreases reaction|increases secretion 17760987
D015237 Dinoprost PRKCE protein promotes the reaction [Dinoprost inhibits the reaction [LHB protein results in increased secretion of Progesterone]]decreases reaction|increases reaction|increases secretion 17760987
D015237 Dinoprost Protein Kinase Inhibitors inhibits the reaction [Dinoprost inhibits the reaction [LHB protein results in increased abundance of Progesterone]]decreases reaction|increases abundance 15601909
D011458 Prostaglandins E LHB protein results in increased secretion of Prostaglandins Eincreases secretion 17991618
D047428 Protein Kinase Inhibitors Protein Kinase Inhibitors inhibits the reaction [Dinoprost inhibits the reaction [LHB protein results in increased abundance of Progesterone]]decreases reaction|increases abundance 15601909
D020849 Raloxifene Raloxifene inhibits the reaction [estradiol 3-benzoate results in increased secretion of LHB protein]decreases reaction|increases secretion 17398000
D019821 Simvastatin Simvastatin promotes the reaction [[Ethinyl Estradiol co-treated with Desogestrel] results in decreased expression of LHB protein]affects cotreatment|decreases expression|increases reaction 17105841
D019821 Simvastatin Simvastatin promotes the reaction [ethinyl estradiol-desogestrel combination results in decreased expression of LHB protein]decreases expression|increases reaction 17105841
C484919 SPP301 SPP301 affects the reaction [[Ethinyl Estradiol co-treated with Levonorgestrel] affects the expression of LHB protein]affects cotreatment|affects expression|affects reaction 17190377
C484919 SPP301 SPP301 results in increased expression of LHB proteinincreases expression 17190377
D013629 Tamoxifen Tamoxifen results in decreased expression of LHB mRNAdecreases expression 20647052
D013629 Tamoxifen Tamoxifen results in decreased expression of LHB mRNAdecreases expression 19152838
D013629 Tamoxifen Tamoxifen results in increased expression of LHB mRNAincreases expression 16330033
D043343 Testosterone Propionate Flutamide inhibits the reaction [Testosterone Propionate results in decreased expression of LHB protein]decreases expression|decreases reaction 11376863
D043343 Testosterone Propionate Testosterone Propionate results in decreased expression of LHB proteindecreases expression 11376863
D013749 Tetrachlorodibenzodioxin estradiol 17 beta-cypionate promotes the reaction [[Tetrachlorodibenzodioxin co-treated with Gonadotropins, Equine] results in increased expression of LHB protein]affects cotreatment|increases expression|increases reaction 12606454
D013749 Tetrachlorodibenzodioxin estradiol 17 beta-cypionate promotes the reaction [[Tetrachlorodibenzodioxin co-treated with Gonadotropins, Equine] results in increased secretion of LHB protein]affects cotreatment|increases reaction|increases secretion 12606454
D013749 Tetrachlorodibenzodioxin Mifepristone promotes the reaction [[Tetrachlorodibenzodioxin co-treated with Gonadotropins, Equine] results in increased expression of LHB protein]affects cotreatment|increases expression|increases reaction 12606454
D013749 Tetrachlorodibenzodioxin Pentobarbital inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Gonadotropins, Equine] results in increased expression of LHB protein]affects cotreatment|decreases reaction|increases expression 12606454
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Gonadotropins, Equine] results in increased expression of LHB proteinaffects cotreatment|increases expression 12606454
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of [FSHB protein results in increased expression of LHB mRNA]decreases expression|increases expression 15746889
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of [IGF1 protein results in increased stability of LHB mRNA]decreases expression|increases stability 15746889
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LHB mRNAdecreases expression 19490992
19276399
16254025
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LHB proteindecreases expression 16254025
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LHB proteinincreases expression 16141434
D014260 Triclosan Triclosan results in decreased expression of LHB proteindecreases expression 19118620
D014425 Turpentine Turpentine results in decreased expression of LHB proteindecreases expression 12207160
C101044 tyrphostin AG 1478 tyrphostin AG 1478 inhibits the reaction [LHB protein results in increased expression of HAS2 mRNA]decreases reaction|increases expression 15459120
C101044 tyrphostin AG 1478 tyrphostin AG 1478 inhibits the reaction [LHB protein results in increased expression of PTGS2 mRNA]decreases reaction|increases expression 15459120
C101044 tyrphostin AG 1478 tyrphostin AG 1478 inhibits the reaction [LHB protein results in increased expression of TNFAIP6 mRNA]decreases reaction|increases expression 15459120
C101044 tyrphostin AG 1478 tyrphostin AG 1478 inhibits the reaction [LHB protein results in increased phosphorylation of EGFR protein]decreases reaction|increases phosphorylation 15459120
C025643 vinclozolin [vinclozolin co-treated with procymidone] results in increased expression of LHB proteinaffects cotreatment|increases expression 12563111
C025643 vinclozolin vinclozolin results in increased expression of LHB mRNAincreases expression 14967917
17980475
C025643 vinclozolin vinclozolin results in increased expression of LHB proteinincreases expression 12563111
17980475
14967917
D014810 Vitamin E Vitamin E inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of LHB protein]decreases expression|decreases reaction 17280759
16298753
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.7814745880
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 14.386734493
MESH:D000014 Abnormalities, Drug-Induced Ethanol 14.3818926900 17676605
MESH:D000014 Abnormalities, Drug-Induced methoxyacetic acid 14.3815959878 12805644 1761404 3652986 1761407
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 14.3814514962 15322242 11752688
MESH:D000022 Abortion, Spontaneous bromodichloromethane 6.1214691210 12970577
MESH:D000138 Acidosis Ammonium Chloride 7.9818287403
MESH:D000138 Acidosis Ethanol 7.9811192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.1817505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 7.2711850527 18653653
MESH:D055371 Acute Lung Injury Nickel 7.2716166738
MESH:D000210 Acute-Phase Reaction Turpentine 5.4216044259
MESH:D000230 Adenocarcinoma arsenic trioxide 5.4819825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 5.4811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 5.4814692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.283712494
MESH:D018248 Adenoma, Liver Cell 3,4,5,3',4'-pentachlorobiphenyl 8.0616628245
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.0616835633
MESH:D000382 Agricultural Workers' Diseases Atrazine 3.5011874814
MESH:D000419 Albuminuria Raloxifene 3.8817308373 17451421
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.5515451039 15451040
MESH:D000505 Alopecia astressin B 5.2721359208
MESH:D000544 Alzheimer Disease Copper 3.8716325427 16410023 17119284 16962711 16886094 16866297
MESH:D000544 Alzheimer Disease Raloxifene 3.8715800139
MESH:D000686 Amyloidosis Diethylstilbestrol 3.7615469931
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 3.7810694572
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.2911748828
MESH:D018798 Anemia, Iron-Deficiency Copper 4.2116614410
MESH:D000799 Angioedema Acetaminophen 3.0810982225
MESH:D000853 Anophthalmos Ethanol 4.0815513904
MESH:D001008 Anxiety Disorders Ethanol 11.4511141031
MESH:D001008 Anxiety Disorders Pentobarbital 11.4511141031 18313124
MESH:D001008 Anxiety Disorders vinclozolin 11.4519015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.7311256880
MESH:D001169 Arthritis, Experimental Dexamethasone 5.6617659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 5.6615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.5518445737
MESH:D053713 Azoospermia ABVD protocol 10.5617965791
MESH:D053713 Azoospermia MOPP protocol 10.5617965791
MESH:D001649 Bile Duct Diseases bromodichloromethane 6.468717228
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.2511289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 11.5016206674
MESH:D001778 Blood Coagulation Disorders Clofibrate 11.5019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 11.5012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.0315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.2415746008
MESH:D001862 Bone Resorption bisphenol A 3.1911985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.5717868700
MESH:D001930 Brain Injuries Progesterone 8.5315665606 15380490 15845082
MESH:D001930 Brain Injuries Raloxifene 8.5316580743
MESH:D001932 Brain Neoplasms Copper 3.9017079463
MESH:D001943 Breast Neoplasms Ascorbic Acid 6.7316443354
MESH:D001943 Breast Neoplasms bisphenol A 6.7317123778
MESH:D001943 Breast Neoplasms Copper 6.7315986119 17079463
MESH:D001943 Breast Neoplasms Diethylstilbestrol 6.7317129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 6.7312948864 18497071 17289903 17018787 14630087 19861407 17261762 16675129
MESH:D001943 Breast Neoplasms letrozole 6.7316002280 17892469
MESH:D001943 Breast Neoplasms Nickel 6.7315986119
MESH:D001943 Breast Neoplasms Progesterone 6.7315562024 16175315 17614352
MESH:D001943 Breast Neoplasms Raloxifene 6.7316912660 17893378 17049068 15758505 17242785 15572757 17440819 16837676 17952589 15775269 17595753 17261762
MESH:D001943 Breast Neoplasms Tamoxifen 6.7321138602 19155303 16873071 19142967 20859285 18351453 19487384 11161223 17440819 19084267 15565566 19115204 16273361 17242785 19410462 18855134 19288272 20135344 19103187 19189212 19289846 19221464 17261762 19011961 21152245 19189210 19200415 20544844 15668708 20065188 17049068 18815881 20390343 18629630 19244106 16202921 18425577 17893378 19059307 20005174 18821012 19066611 18984771 16818667 18997820
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.7320435547
MESH:D016535 Bronchial Hyperreactivity tyrphostin AG 1478 4.2812794006
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.6311589617
MESH:D002056 Burns Ethanol 3.9216374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.7116111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.2016050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.1916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.7719066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.203581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.203084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.2015073043 16217749 11135700 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 11.2015948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.2016924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 11.2015289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 11.2016924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.2317123778
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.1119014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.277296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.4512490120
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 7.3017572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 7.3017572228
MESH:D006332 Cardiomegaly Copper 8.7917327471
MESH:D006332 Cardiomegaly Ethanol 8.7919332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 8.7916120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Raloxifene 2.9015775269
MESH:D002386 Cataract Acetaminophen 6.1410977129
MESH:D002386 Cataract Simvastatin 6.1412518039
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.617505956
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 11.611399818
MESH:D002471 Cell Transformation, Neoplastic Dinoprost 11.6116192471
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.6118566989
MESH:D014355 Chagas Disease Nitrofurazone 6.4111354658
MESH:D018281 Cholangiocarcinoma 3,4,5,3',4'-pentachlorobiphenyl 7.6616628245
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.6616835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 10.2719486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 10.2717681005 15861022 17110522 16105132 17333356 16919318 11677210
MESH:D002779 Cholestasis Levonorgestrel 10.2715861022
MESH:D002971 Cleft Lip Ethanol 3.1315513904
MESH:D002972 Cleft Palate Ethanol 4.6715513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.6712621046 15340226 16354765 8697196 15668235
MESH:D003072 Cognition Disorders Raloxifene 3.8815800139
MESH:D003110 Colonic Neoplasms bromodichloromethane 3.9614668109
MESH:D003110 Colonic Neoplasms Dexamethasone 3.9615824018
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D003139 Common Cold Ascorbic Acid 4.7117323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 7.4014669216 17141729
MESH:D000013 Congenital Abnormalities Triclosan 7.4019283420
MESH:D023903 Coronary Restenosis arsenic trioxide 3.4712609071
MESH:D019465 Craniofacial Abnormalities 3,4,5,3',4'-pentachlorobiphenyl 7.7117686920
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 7.7110525206
MESH:D019465 Craniofacial Abnormalities Dexamethasone 7.7117728286
MESH:D019465 Craniofacial Abnormalities Ethanol 7.7115513904 15451039 11873399 19302082 15451040 11198716 10194807
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 7.7120055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 7.7119769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 8.9912952375 16002989
MESH:D003456 Cryptorchidism vinclozolin 8.9914966744
MESH:D003550 Cystic Fibrosis Simvastatin 4.2919747007
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.4015213294
MESH:D003711 Demyelinating Diseases Tamoxifen 3.6319031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.5117474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 7.5818759878 8970840 8156756 11298694 12868966 14531868 2524372 11906362
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 7.5812438553
MESH:D017449 Dermatitis, Allergic Contact Nickel 7.5817100760 19470301 17244072
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 3.6416882537
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 7.233621924 2952479
MESH:D003877 Dermatitis, Contact Nickel 7.232952479
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 3.7016506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.7017107852
MESH:D003928 Diabetic Nephropathies Estradiol 11.2919279558
MESH:D003928 Diabetic Nephropathies Raloxifene 11.2917451421 15920148 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 11.2919279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.7617187935
MESH:D003967 Diarrhea Dexamethasone 3.017237001
MESH:D012734 Disorders of Sex Development marker/mechanism
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.8118692083 18289764 6679447 7440962 9328219 6482804 11289319 9022650 18648102 9653073 8291058 16192314 1440618
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.812444490 16781746 19416960 16109766 12153990 14725611 11461765 16177239 12540782 19085960 18071297 12705907 14550746 14986274 11743745 16081117 17562736 17906064 18713872 19739265 10774834 11287661 16485898 17522070 12594235 11834606 10663392 11421492 19923254 12958197 16393943 16227642 19164858 15968718 11739529 15619225 11529661 10915739 19370779 19420014 12392966
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 8.8117851650
MESH:D056486 Drug-Induced Liver Injury Ethanol 8.8111566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.8120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.3319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.1811462148
MESH:D050171 Dyslipidemias Clofibrate 3.4916707586
MESH:C538011 Eales disease Ascorbic Acid 10.539068938
MESH:C538011 Eales disease Vitamin E 10.539068938
MESH:D004485 Eczema Dexamethasone 3.7412438553
MESH:D004487 Edema Dexamethasone 7.7019703484
MESH:D004487 Edema Raloxifene 7.7015860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.7012711302 11000095
MESH:D004489 Edema, Cardiac 3,4,5,3',4'-pentachlorobiphenyl 9.8817686920
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 9.8815322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 16.0912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 16.0917692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 16.0915845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 16.0919031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 3.9416402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 9.3716804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 9.3719148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 9.3720544844 16202921 17893378 19155303
MESH:D004715 Endometriosis Mifepristone 11.5016134523
MESH:D004715 Endometriosis Progesterone 11.5016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 11.5010568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 3.6517637181 15328337 15821434
MESH:D007172 Erectile Dysfunction estradiol valerate 5.1014972507
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 5.733581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 5.7312903497
MESH:D004938 Esophageal Neoplasms Ethanol 5.7316704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.4211564622
MESH:D005234 Fatty Liver arsenic trioxide 22.0215073043
MESH:D005234 Fatty Liver Clofibrate 22.0219224547
MESH:D005234 Fatty Liver Ethanol 22.0218620774 19236843 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.0215345470
MESH:D005234 Fatty Liver Raloxifene 22.0217473493
MESH:D005234 Fatty Liver Tamoxifen 22.0219224547 14986274
MESH:D005235 Fatty Liver, Alcoholic Ethanol 4.9017920746
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 6.5116611131 15751030 16513791 16002989 16534752
MESH:D052776 Female Urogenital Diseases Tamoxifen 6.5116709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.5516946407 15513904 10194807 15451040
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.7211858732
MESH:D005334 Fever Dinoprost 7.6711852909
MESH:D005334 Fever Lipopolysaccharides 7.6711852909 9205823
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.256705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.7714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.4319069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.2320067830
MESH:D005532 Foot Deformities, Congenital methoxyacetic acid 5.003652986
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.5416904648
MESH:D005756 Gastritis Acetaminophen 8.5916983495
MESH:D005756 Gastritis Ethanol 8.5915046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.1816973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.5316417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.1916452187
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.347505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.8310696789
MESH:D006330 Heart Defects, Congenital 3,4,3',4'-tetrachlorobiphenyl 16.2511294989
MESH:D006330 Heart Defects, Congenital 3,4,5,3',4'-pentachlorobiphenyl 16.2517686920 20471113
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 16.2516080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 16.2510048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 16.2516080930
MESH:D006331 Heart Diseases Raloxifene 2.9911110106
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.7216366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.6511000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 2.806705139
MESH:D006521 Hepatitis, Chronic Copper 4.5117338147
MESH:D006527 Hepatolenticular Degeneration Copper 4.4316607473 17276780 19888908 17182432 17109627
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.1815340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 7.7116490937 16863852
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 7.717520565
MESH:D006548 Hernia, Diaphragmatic Vitamin E 7.7116863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.2615709030
MESH:D006628 Hirsutism LHRH, Ala(6)-Gly(10)-ethylamide- 6.6011228061
MESH:D015658 HIV Infections Nickel 3.3817263646
MESH:D006689 Hodgkin Disease ABVD protocol 6.9517065142 15837968 10798542 16135485 12907440 16794504 17673811 15621842 17168361 16640815 15453925 17606976 14565654 14657226 17646666 15183480 15315964 15941081 17954296 17420510 17726078 17713864 12586796 14752856 16264800 18024389 14760121 18072259 18180244 12805333 16314615 17459049 17846017 15199092 18154127 15465201 17562619 18209012 16172458 17515571 16879607 12162096 17562247 17071938 17085663
MESH:D006689 Hodgkin Disease MOPP protocol 6.9517726078 17981817 15183480 17562247 12805333 15170884 16966260 14760121 17515571 14752856
MESH:D019584 Hot Flashes 8-prenylnaringenin 12.9017088409
MESH:D019584 Hot Flashes Estradiol 12.9017088409
MESH:D019584 Hot Flashes Vitamin E 12.9014716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.2818606429 15340226 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 5.7816870215
MESH:D006930 Hyperalgesia Ethanol 5.7818783367
MESH:D017588 Hyperandrogenism Flutamide 4.7015356085
MESH:D006938 Hyperlipoproteinemia Type II Simvastatin 4.6016238680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 8.4015034207
MESH:D006965 Hyperplasia Diethylstilbestrol 8.4012960047 14722030
MESH:D006973 Hypertension Dexamethasone 6.5917042910
MESH:D006973 Hypertension Raloxifene 6.5915787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 6.5918670907 18850075
MESH:D007006 Hypogonadism marker/mechanism 18449926
MESH:D007021 Hypospadias Diethylstilbestrol 8.8016002989
MESH:D007021 Hypospadias Ethinyl Estradiol 8.8016945680 16569931
MESH:D007057 Ichthyosis ABVD protocol 6.1512162096
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.6715869954
MESH:D007246 Infertility marker/mechanism
MESH:D007246 Infertility Diethylstilbestrol 3.6415036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.7612013081
MESH:D007248 Infertility, Male Atrazine 15.4512948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 15.4517937319
MESH:D007248 Infertility, Male MOPP protocol 15.4514752856
MESH:D007248 Infertility, Male Triclosan 15.4520821571
MESH:D007248 Infertility, Male vinclozolin 15.4516467254
MESH:D007249 Inflammation Dexamethasone 17.318960868 11099482
MESH:D007249 Inflammation Lipopolysaccharides 17.3117963957 17237260 17255318 12878042 9205823
MESH:D007249 Inflammation Nickel 17.3116166738
MESH:D007249 Inflammation Progesterone 17.3115869954
MESH:D007249 Inflammation Tamoxifen 17.3119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 17.3112878042 12200463
MESH:D007249 Inflammation Triclosan 17.319584910 20507366
MESH:D007251 Influenza, Human Vitamin E 3.4516624496
MESH:D007333 Insulin Resistance bisphenol A 5.6616393666
MESH:D007333 Insulin Resistance Estradiol 5.6616393666 16627594
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 3.9317255318
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.259022650 8074119
MESH:D007569 Jaw Abnormalities Ethanol 7.8515513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 7.8516580747
MESH:D007674 Kidney Diseases Acetaminophen 7.2215629191 12587719
MESH:D007674 Kidney Diseases Estradiol 7.2215618244
MESH:D007674 Kidney Diseases Vitamin E 7.2212488133
MESH:D007676 Kidney Failure, Chronic Copper 4.2216518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.666582329
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 12.6615003126 16762066 14681315
MESH:D007680 Kidney Neoplasms Estradiol 12.6615610895
MESH:D007680 Kidney Neoplasms Tamoxifen 12.6618625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.2816316344
MESH:D007859 Learning Disorders Copper 12.0217134702
MESH:D007859 Learning Disorders Diethylstilbestrol 12.0217184923
MESH:D007859 Learning Disorders Ethanol 12.0215451040
MESH:D007889 Leiomyoma Raloxifene 3.8016973256
MESH:D007938 Leukemia arsenic trioxide 2.4115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.1212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.5616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 2.8514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.0819077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.1116467208 16968895 19850784 17050201 20471514
MESH:D015470 Leukemia, Myeloid, Acute MOPP protocol 4.1112100147
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 2.6817869043 16891316 19225113 17107899 17217047 17712046 16966277 16112521 15748426 19075265 16331271 16823087 15336539 9834237 11161223 11468182 12018890 15213294 15622746 19035177 12679006 17649720 16330433 19642359 12712474
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.6316882451
MESH:D007970 Leukopenia Lipopolysaccharides 3.9515821434
MESH:D007984 Leydig Cell Tumor vinclozolin 3.9816417039
MESH:D017880 Limb Deformities, Congenital Ethanol 6.9417676605
MESH:D017880 Limb Deformities, Congenital methoxyacetic acid 6.9412805644 15959878
MESH:D008064 Lipidoses Tamoxifen 2.5917567588 15342952
MESH:D008103 Liver Cirrhosis Ethanol 2.9115289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.3418295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.689327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 8.6316718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.6314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 8.6318166357
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 8.6312878042
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.6318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.6312878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 8.6316169303
MESH:D008107 Liver Diseases Acetaminophen 1.4219784758 12587719 19014921 16611625 12969438 16610002 19460945 11587558
MESH:D008108 Liver Diseases, Alcoholic Ethanol 3.9217207112 17347304
MESH:D017114 Liver Failure, Acute Acetaminophen 2.5716871587 17185352
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 16.3618644402 16835634
MESH:D008113 Liver Neoplasms arsenic trioxide 16.3614682389
MESH:D008113 Liver Neoplasms Copper 16.3620302851
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 16.3611940454
MESH:D008113 Liver Neoplasms Diethylstilbestrol 16.3615890375 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 16.3616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.3616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.92598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.9220377131
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 9.9218544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.9212151625
MESH:D008133 Long QT Syndrome arsenic trioxide 2.7615213294
MESH:D008171 Lung Diseases Ascorbic Acid 5.9216863852
MESH:D008171 Lung Diseases Vitamin E 5.9216863852
MESH:D055370 Lung Injury Lipopolysaccharides 3.2921114838
MESH:D008175 Lung Neoplasms arsenic trioxide 6.6819825857 11798837
MESH:D008175 Lung Neoplasms Ascorbic Acid 6.6816401635
MESH:D008175 Lung Neoplasms Dexamethasone 6.6811195469 15824018
MESH:D008175 Lung Neoplasms Tamoxifen 6.6818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.6819555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 6.6811062179
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.4015166399
MESH:D008223 Lymphoma Diethylstilbestrol 2.9115700306
MESH:D016483 Lymphoma, AIDS-Related ABVD protocol 6.1512176798 17378895 17296568
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.7516002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.0219428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.3011408345 17203775 16891317 11807958
MESH:D008325 Mammary Neoplasms, Experimental estradiol 3-benzoate 13.3015375486
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 13.3017203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 13.3019196723 19196722 16827153 11731420 14580682
MESH:D008325 Mammary Neoplasms, Experimental Triclosan 13.3015358634
MESH:D020149 Manganese Poisoning Estradiol 10.1019453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.1019453300
MESH:D008545 Melanoma Tamoxifen 1.7719393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.4315990972
MESH:D008546 Melanoma, Experimental Acetaminophen 2.8319513568
MESH:D008569 Memory Disorders Ethanol 3.4818411066 15451040
MESH:D007706 Menkes Kinky Hair Syndrome Copper 5.1317268249 17109627
MESH:D008654 Mesothelioma Atrazine 3.171916698
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 4.7915863610
MESH:D009101 Multiple Myeloma arsenic trioxide 8.9015949261 19417148 14977855 19549372 11468182
MESH:D009101 Multiple Myeloma Dexamethasone 8.9015744524 15867202 16118317
MESH:D009101 Multiple Myeloma Raloxifene 8.9016497877
MESH:D009182 Mycosis Fungoides arsenic trioxide 3.9118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 5.9416105982 16882451
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 5.949809623
MESH:D009203 Myocardial Infarction ABVD protocol 4.5517284715
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.4012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.6816810080
MESH:D009232 Myxoma Raloxifene 4.7916343187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.2516624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 4.453581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 4.4519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.2119410462
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 6.278820588
MESH:D009369 Neoplasms Diethylstilbestrol 6.2715313581
MESH:D009369 Neoplasms Nitrofurazone 6.2715488632
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.2419196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Copper 7.8617308104
MESH:D009389 Neovascularization, Pathologic Estradiol 7.8617289903
MESH:D009402 Nephrosis, Lipoid ABVD protocol 6.3617954296
MESH:D009421 Nervous System Malformations bisphenol A 17.6111399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 17.6111399458
MESH:D009421 Nervous System Malformations Estradiol 17.6116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 17.6114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 5.476679447
MESH:D009436 Neural Tube Defects arsenic trioxide 5.4710525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.2518514411
MESH:D009503 Neutropenia ABVD protocol 5.2317071938 16690524
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.209802331
MESH:D009765 Obesity Ascorbic Acid 2.9117217161
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 2.764026338 6482804
MESH:D009845 Oligospermia ABVD protocol 9.6917965791
MESH:D009845 Oligospermia MOPP protocol 9.6917965791
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.253988306
MESH:D010024 Osteoporosis Calcium 9.2217882678
MESH:D010024 Osteoporosis Levonorgestrel 9.2212665316
MESH:D010024 Osteoporosis Raloxifene 9.2215775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.5317823083 15758505 17893378 15579764
MESH:D010049 Ovarian Diseases bisphenol A 4.2311985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 11.6619769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 11.6619401270
MESH:D010051 Ovarian Neoplasms Mifepristone 11.6616525653
MESH:D010051 Ovarian Neoplasms Nitrofurazone 11.6611026599
MESH:D010051 Ovarian Neoplasms Progesterone 11.6616525653 17393432
MESH:D010146 Pain Acetaminophen 1.8016870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 4.3415580305
MESH:D010190 Pancreatic Neoplasms Ethanol 4.3412384795
MESH:D010195 Pancreatitis Methomyl 4.6816258382 15767733
MESH:D016584 Panic Disorder Ethinyl Estradiol 2.9911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 2.767296757
MESH:D010235 Paraganglioma arsenic trioxide 3.4619927285
MESH:D010300 Parkinson Disease Atrazine 2.9517218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.4812520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.706228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.4014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 3.9315687265 16977796
MESH:D011014 Pneumonia Lipopolysaccharides 3.8112224865 11605937
MESH:D011041 Poisoning Methomyl 4.7511800311
MESH:D011085 Polycystic Ovary Syndrome ethinyl estradiol-desogestrel combination 13.3117105841
MESH:D011085 Polycystic Ovary Syndrome Flutamide 13.3115356085
MESH:D011085 Polycystic Ovary Syndrome Simvastatin 13.3117105841
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.8418163543
MESH:D011230 Precancerous Conditions bromodichloromethane 5.0214668109
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.0721297632
MESH:D011248 Pregnancy Complications bromodichloromethane 5.3612970577 17344021 14657523
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 17.1410548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 17.1417184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.1411896295 11118676 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 17.1418042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.1818220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.2820887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.2820887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5219131511
MESH:D011471 Prostatic Neoplasms bisphenol A 2.5216740699
MESH:D011471 Prostatic Neoplasms Copper 2.5217079463 17308104
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.5215046698 15846301 17136230
MESH:D011471 Prostatic Neoplasms Estradiol 2.5216740699
MESH:D011471 Prostatic Neoplasms Flutamide 2.523169114
MESH:D011471 Prostatic Neoplasms Raloxifene 2.5216220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5215067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5215084515
MESH:D011472 Prostatitis vinclozolin 4.1818629315
MESH:D011537 Pruritus Ethinyl Estradiol 7.5216919318 15861022
MESH:D011537 Pruritus Levonorgestrel 7.5215861022
MESH:D011629 Puberty, Precocious astressin B 11.0620002962
MESH:D011629 Puberty, Precocious bisphenol A 11.0610548101
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 4.5714606601
MESH:D011693 Purpura Raloxifene 4.7915770314
MESH:D012004 Rectal Neoplasms bromodichloromethane 5.2317535441
MESH:D012021 Reflex, Abnormal Pentobarbital 5.2710930210
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.3318379247 11700416
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.2010835634
MESH:D012135 Respiratory Sounds Atrazine 3.7911874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.1218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 2.793692021
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.0416849425
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.5318045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.2516646077
MESH:D012559 Schizophrenia Copper 2.9616842975
MESH:D012640 Seizures Ethanol 7.209754883
MESH:D012640 Seizures Methomyl 7.2012660363 11218047
MESH:D012640 Seizures Pentobarbital 7.209754883 10087439
MESH:D012871 Skin Diseases Ascorbic Acid 4.3118709164
MESH:D012871 Skin Diseases Vitamin E 4.3118709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.6516192470
MESH:D013088 Spermatocele Diethylstilbestrol 15.7216002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 15.7216709447
MESH:D013088 Spermatocele Tamoxifen 15.7216709447
MESH:D013119 Spinal Cord Injuries Progesterone 8.3816503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 8.3819457130
MESH:D013272 Stomach Diseases Dexamethasone 3.5815472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.3917007042
MESH:D013274 Stomach Neoplasms Ethanol 2.3918456281
MESH:D013276 Stomach Ulcer Ascorbic Acid 8.3818726076
MESH:D013276 Stomach Ulcer Dexamethasone 8.3815138204
MESH:D013276 Stomach Ulcer Ethanol 8.3817189318 16755016 9211565 17918041 9562338 11906479
MESH:D020521 Stroke Ascorbic Acid 10.9516403987 16517955
MESH:D020521 Stroke Raloxifene 10.9516837676
MESH:D020521 Stroke Vitamin E 10.9516517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.2416684133 16045194
MESH:D013375 Substance Withdrawal Syndrome Ethanol 8.059754883
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 8.0511529278 9754883
MESH:D013576 Syndactyly methoxyacetic acid 4.911761407 1761404
MESH:D013733 Testicular Diseases methoxyacetic acid 4.5818486176 6499806
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.5015821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 8.7911994571
MESH:D019851 Thrombophilia ethinyl estradiol-desogestrel combination 8.7911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.5115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 9.9612697716
MESH:D013959 Thyroid Diseases Triclosan 9.9619910387
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 5.196582329 1399818 3712494 6587162 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 5.1919014326
MESH:D013978 Tibial Fractures Estradiol 11.1719048282
MESH:D013978 Tibial Fractures Raloxifene 11.1719048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.2215213294
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.878074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.8711780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 11.8716452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 11.8717572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.8716712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 2.2910982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.3716175088
MESH:D014591 Uterine Diseases bisphenol A 11.2714652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 11.2714652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 7.1015809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.1014692618
MESH:D014605 Uveitis Dexamethasone 4.051336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.7016002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.8312125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.4416837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 14.0014671159 15869587
MESH:D020246 Venous Thrombosis ethinyl estradiol-desogestrel combination 14.0015869587
MESH:D020246 Venous Thrombosis Levonorgestrel 14.0015869587
MESH:D014846 Vulvar Neoplasms Raloxifene 4.7916343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.4815886252
MESH:D014947 Wounds and Injuries Nitrofurazone 4.7818440737 18222664
Pathway ID Pathway Name
KEGG:04912 GnRH signaling pathway
REACT:15314 Hormone biosynthesis
REACT:13 Metabolism of amino acids and derivatives
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018