AutismKB 2.0

Annotation Detail for LHX1


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Basic Information Top
Gene Symbol:LHX1 ( LIM-1,LIM1,MGC126723,MGC138141 )
Gene Full Name: LIM homeobox 1
Band: 17q12
Quick LinksEntrez ID:3975; OMIM: 601999; Uniprot ID:LHX1_HUMAN; ENSEMBL ID: ENSG00000132130; HGNC ID: 6593
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of LHX1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LHX1 mRNAaffects expression 16483693
D002117 Calcitriol Calcitriol results in increased expression of LHX1 mRNAincreases expression 16002434
D005419 Flavonoids Flavonoids results in decreased expression of LHX1 mRNAdecreases expression 18035473
D018038 Sodium Selenite Sodium Selenite results in increased expression of LHX1 mRNAincreases expression 18175754
D014212 Tretinoin Tretinoin results in increased expression of LHX1 mRNAincreases expression 16979153
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D000505 Alopecia Tretinoin 3.8715955085
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.2516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3216292516
MESH:D001249 Asthma Tretinoin 2.4216456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.7816935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9316197459 16206674
MESH:D001943 Breast Neoplasms Calcitriol 2.2811237771
MESH:D001943 Breast Neoplasms Tretinoin 2.2816166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.0516813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6816168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.983084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 2.981917145
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 5.0311237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.0316096774 16051514
MESH:D002386 Cataract Acetaminophen 7.7810977129
MESH:D002386 Cataract Tretinoin 7.7817460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.0516129372
MESH:D002822 Choriocarcinoma Tretinoin 5.6816461808
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1715894690
MESH:D002972 Cleft Palate Tretinoin 2.789407595
MESH:D003092 Colitis Tretinoin 4.1217035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8314991402 16925845 9125849 9224671 9664655 17551590 9142499 10589399 8800419 9211117
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0616285004
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0811421492 2444490 17522070 11743745 15968718 11529661 17906064 19164858 10915739 19420014 12540782 18713872 11461765 16393943 18071297 12153990 16227642 14550746 11834606 11739529 11287661 19923254 19416960 10774834 19739265 12594235 14986274 19370779 12958197 12392966 16177239 17562736 12705907 10663392 19085960 16485898 16081117 15619225 16781746 14725611 16109766
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.0815131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004489 Edema, Cardiac Tretinoin 4.9918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.3115138306
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3016569247
MESH:D005124 Eye Abnormalities Tretinoin 3.819664655 16938888
MESH:D052776 Female Urogenital Diseases marker/mechanism 16002989
MESH:D005355 Fibrosis Tretinoin 3.9317994277
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005909 Glioblastoma Tretinoin 3.1917312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.049664655 14991402
MESH:D006930 Hyperalgesia Acetaminophen 8.4816870215
MESH:D006930 Hyperalgesia Tretinoin 8.4816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9916778211
MESH:D007249 Inflammation Flavonoids 2.7917296493
MESH:D007333 Insulin Resistance Sodium Selenite 3.4714714311
MESH:D007410 Intestinal Diseases Tretinoin 4.1817994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2317551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.3612587719 15629191
MESH:D007938 Leukemia Tretinoin 2.9017143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0216482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1217596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3419029980 17712046 16140955 17361223 15748426 17506722 17107899 12679006 17339181 17294898 17217047 19035177 19225113 16788101 19642359 19075265 16766008 17649720 16935935 9834237 17368321 16891316 16331271 16823087 17301526
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.539224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8116248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6919014921 16610002 19460945 11587558 19784758 12587719 12969438 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.4114737004
MESH:D008527 Medulloblastoma Tretinoin 2.8817453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008591 Meningomyelocele Tretinoin 4.8416940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2417596541
MESH:D009369 Neoplasms Tretinoin 2.5416594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.169125849
MESH:D009436 Neural Tube Defects Tretinoin 3.249142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4216936753
MESH:D010146 Pain Acetaminophen 7.4916870215
MESH:D010146 Pain Tretinoin 7.4916870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5515976015
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.2415572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.3612479363 16289102 16644109 15754350 18247401
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3618760546
MESH:D011507 Proteinuria Tretinoin 3.9516636307
MESH:D011625 Pterygium Tretinoin 5.2616723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4516116481 16283617
MESH:D012878 Skin Neoplasms Tretinoin 2.7316467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2617045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.0916051514
MESH:D014376 Tuberculosis Tretinoin 3.4116040207
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9816129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.1316752155
MESH:D014820 Vitiligo Tretinoin 4.4416761959
MESH:D009396 Wilms Tumor Tretinoin 4.2516287080
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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