AutismKB 2.0

Annotation Detail for LIFR


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:LIFR ( CD118,FLJ98106,FLJ99923,LIF-R,SJS2,STWS,SWS )
Gene Full Name: leukemia inhibitory factor receptor alpha
Band: 5p13.1
Quick LinksEntrez ID:3977; OMIM: 151443; Uniprot ID:LIFR_HUMAN; ENSEMBL ID: ENSG00000113594; HGNC ID: 6597
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2106Pancreas cancer
No data
No data
Desease Name
Stuve-Wiedemann syndrome/Schwartz-Jampel type 2 syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C049325 1,2-dithiol-3-thione 1,2-dithiol-3-thione results in decreased expression of LIFR mRNAdecreases expression 15302862
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of LIFR mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of LIFR mRNAdecreases expression 16788091
C520164 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased expression of LIFR mRNAincreases expression 17321000
C430898 AGN 194204 AGN 194204 results in decreased expression of LIFR mRNAdecreases expression 15302862
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LIFR mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of LIFR mRNAdecreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in decreased expression of LIFR mRNA]affects reaction|decreases expression 18929588
D001194 Asbestos Asbestos affects the expression of LIFR mRNAaffects expression 17297452
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LIFR mRNAdecreases expression 19150397
20018196
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of LIFR mRNAincreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of LIFR mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of LIFR mRNAdecreases expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of LIFR mRNAaffects expression 12734012
D016572 Cyclosporine Cyclosporine results in decreased expression of LIFR mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of LIFR mRNAdecreases expression 15238619
D004958 Estradiol Estradiol results in increased expression of LIFR mRNAincreases expression 12469912
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of LIFR mRNAaffects expression 14976129
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of LIFR mRNAincreases expression 12072388
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LIFR mRNAaffects cotreatment|increases expression 17942748
D011345 Fenofibrate Fenofibrate results in decreased expression of LIFR mRNAdecreases expression 11798191
C056933 fumonisin B1 fumonisin B1 results in decreased expression of LIFR mRNAdecreases expression 16221962
C056507 gemcitabine gemcitabine results in increased expression of LIFR mRNAincreases expression 17039268
D005839 Gentamicins Gentamicins results in decreased degradation of LIFR mRNA alternative formdecreases degradation 19603067
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of LIFR mRNAincreases expression 17321000
D009151 Mustard Gas Mustard Gas affects the expression of LIFR mRNAaffects expression 15651846
C006253 pirinixic acid pirinixic acid results in decreased expression of LIFR mRNAdecreases expression 17321000
15302862
16221962
20059764
11798191
C006253 pirinixic acid PPARA protein affects the reaction [pirinixic acid results in decreased expression of LIFR mRNA]affects reaction|decreases expression 16221962
17321000
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of LIFR mRNA]decreases expression|increases reaction 20059764
C009166 retinol acetate retinol acetate results in increased expression of LIFR mRNAincreases expression 16772331
C116926 rofecoxib rofecoxib results in decreased expression of LIFR mRNAdecreases expression 17070997
C089730 rosiglitazone rosiglitazone results in increased expression of LIFR mRNAincreases expression 17321000
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LIFR mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LIFR mRNAaffects cotreatment|increases expression 17942748
C423915 TO-901317 TO-901317 results in decreased expression of LIFR mRNAdecreases expression 15302862
D014212 Tretinoin Tretinoin results in decreased expression of LIFR mRNAdecreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6115322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6917505938
MESH:D058186 Acute Kidney Injury Gentamicins 4.3311274264
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.2811850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 8.2818653653
MESH:D000230 Adenocarcinoma Estradiol 4.0011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.0014692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.0816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.0816835633
MESH:D000505 Alopecia Tretinoin 3.4215955085
MESH:D000544 Alzheimer Disease rosiglitazone 2.8019621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7311748828
MESH:D001161 Arteriosclerosis Dietary Fats 9.1015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.1011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.5215885639
MESH:D001169 Arthritis, Experimental rofecoxib 11.5216690336
MESH:D001169 Arthritis, Experimental Tretinoin 11.5216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Mustard Gas 4.7210378619
MESH:D001249 Asthma Tretinoin 4.7216456186
MESH:D050197 Atherosclerosis Asbestos 4.0818795166
MESH:D001471 Barrett Esophagus Tretinoin 4.1716935849
MESH:D001768 Blister Mustard Gas 4.9119167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.9919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.9912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.9916206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D001943 Breast Neoplasms Dietary Fats 2.2620435547
MESH:D001943 Breast Neoplasms Estradiol 2.2617018787 17289903 16675129 19861407 12948864 18497071 17261762 14630087
MESH:D001943 Breast Neoplasms gemcitabine 2.2617039268 18382427
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2620435547
MESH:D001943 Breast Neoplasms Tretinoin 2.2616166294 16443354 16873071
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7317687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3416813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5416097048 15673190 16192424 15721981 16124888 18705752 3786805 15700767 10355542 16227642 16011737 16050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6116835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9116168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.2316705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.2318788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.2316924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.231917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2216051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2318850075 18670907 16120746
MESH:D002386 Cataract Tretinoin 2.9517460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 14.626135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 14.6220889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.6212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.6218566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3416129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D002779 Cholestasis Cyclosporine 12.3019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.3016919318 17110522 17681005 17333356 16105132 11677210 15861022
MESH:D002779 Cholestasis pirinixic acid 12.3019176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9116461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4216354765 8697196 15668235 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 5.429407595
MESH:D003092 Colitis Tretinoin 3.4617035595
MESH:D003110 Colonic Neoplasms arsenite 4.1915037631
MESH:D003110 Colonic Neoplasms rofecoxib 4.1912902858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8517141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3715322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.3717551590 9664655 10589399 9125849 16925845 8800419 14991402 9224671 9142499 9211117
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.7818551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3118249437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.0917446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.2812642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2119279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.3818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.383786805 16227642 19336974 9327722 10092053 7179309 3732212 2869522 16177239 17522070 6623471 7440962 19085960 10915739 11566570 4309450 7120509 21278145 15027814 6884620 15968718 15998439
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 8.3816221962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.3820420201
MESH:D004362 Drug Toxicity Gentamicins 7.8011033412 15033597
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.8011462148
MESH:D050171 Dyslipidemias Dietary Fats 8.3718367378
MESH:D050171 Dyslipidemias Fenofibrate 8.3716707586
MESH:D004487 Edema Mustard Gas 14.6611428631 9260866 11428647 11402378
MESH:D004487 Edema pirinixic acid 14.6612083418
MESH:D004487 Edema rosiglitazone 14.6612083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.6612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1115322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.1118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9512538720
MESH:D016889 Endometrial Neoplasms Estradiol 11.6511473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Fenofibrate 11.6516569247
MESH:D016889 Endometrial Neoplasms Tretinoin 11.6516569247
MESH:D004715 Endometriosis rofecoxib 8.6215652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.629294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.1517637181 15328337 15821434
MESH:D004890 Erythema Mustard Gas 4.919357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0120426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.2416938888 9664655
MESH:D005234 Fatty Liver arsenite 33.5818296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 33.5812631006 15959796 12795759 61145 16045604 17595544 16239168 19224547
MESH:D005234 Fatty Liver Cyclosporine 33.5819224547
MESH:D005234 Fatty Liver Dietary Fats 33.5817967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 33.5815345470
MESH:D005234 Fatty Liver pirinixic acid 33.5820131406 19236843
MESH:D005234 Fatty Liver rosiglitazone 33.5819196556
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D005334 Fever Lipopolysaccharides 3.8011852909 9205823
MESH:D005355 Fibrosis arsenite 31.3618296743
MESH:D005355 Fibrosis Carbon Tetrachloride 31.3618705752
MESH:D005355 Fibrosis Cyclosporine 31.3612639820 12168785
MESH:D005355 Fibrosis Dietary Fats 31.3618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 31.3620067830
MESH:D005355 Fibrosis Tretinoin 31.3617994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.978708960
MESH:D005909 Glioblastoma Tretinoin 2.8517312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0216096774
MESH:D034381 Hearing Loss Gentamicins 4.6817868369 19130971 15968427 18024279
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9116084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1111294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.1114991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.3920558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1715720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1716366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3619110552 19900420
MESH:D006529 Hepatomegaly fumonisin B1 13.0916221962
MESH:D006529 Hepatomegaly pirinixic acid 13.0916221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.0915340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.7815709030
MESH:D019584 Hot Flashes Estradiol 3.5017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8015340226 18606429 16354765 16959395 8697196
MESH:D006930 Hyperalgesia rosiglitazone 7.4412083418
MESH:D006930 Hyperalgesia Tretinoin 7.4416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2816899240
MESH:D053565 Hypercalciuria Gentamicins 5.4617652376
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3721332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3316778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9720558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.3921332399
MESH:D006973 Hypertension Cyclosporine 4.6310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6318670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3317937319
MESH:D007249 Inflammation Dietary Fats 14.5220412841
MESH:D007249 Inflammation Lipopolysaccharides 14.5212878042 17963957 17255318 17237260 9205823
MESH:D007249 Inflammation Mustard Gas 14.5211428620 11428631 9260866 9357497 8975870 16001271 17524151 11402378 11428647
MESH:D007249 Inflammation rosiglitazone 14.5212083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.5212200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 16.3618457598 11836018
MESH:D007333 Insulin Resistance Estradiol 16.3616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 16.3616306350
MESH:D007333 Insulin Resistance rosiglitazone 16.3616306350
MESH:D007410 Intestinal Diseases rofecoxib 9.3415831440
MESH:D007410 Intestinal Diseases Tretinoin 9.3417994277
MESH:D007417 Intestinal Polyps rofecoxib 5.1411245490
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4017255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.2015992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1915604871
MESH:D007673 Kidney Cortex Necrosis Gentamicins 5.4818842672
MESH:D007674 Kidney Diseases Cyclosporine 9.3810903974 18776723 8314463
MESH:D007674 Kidney Diseases Estradiol 9.3815618244
MESH:D007674 Kidney Diseases Gentamicins 9.3819349640 18289764 17934191
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.2216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.2212371664
MESH:D007680 Kidney Neoplasms Estradiol 11.2215610895
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 5.1311231351
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 4.2610219319
MESH:D007938 Leukemia Tretinoin 2.6517143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4816932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0419850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9916891316 17107899 19029980 16766008 17301526 16823087 16140955 17339181 12679006 17361223 16935935 16331271 17506722 16788101 19225113 17294898 17217047 15748426 17368321 17712046 17649720 19075265 19035177 19642359 9834237
MESH:D007970 Leukopenia Lipopolysaccharides 4.4515821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.139224671
MESH:D008103 Liver Cirrhosis arsenite 10.3218296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.3217174718 11903743 16239168 11408273 17334410 16943688 17157831 16221502 21278145
MESH:D008103 Liver Cirrhosis Dietary Fats 10.3218296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 15.0815057751 17714472 16027843 18472094 16011737 17557913 18317297 18205269 16033810 15370692 12586293 14512876 18187930 17823541 15996030 12666154 18418968 12546737 14748882 17708605 17565644 15818738 11481614 15338365 15123356 15931870 15959796 12898905 15362042 16136751 18420326 17761835 18277467 18395914 18156304 17698563 16116963 12389079 18481824 15730626 17631135 14620537 15893842 18006644 12445421 18210741 14724832 18054572 18429990 18412020 12609069 17869086 20821823 15925388 18395095 12445418 17944888 15673190 12741479 12649538 15052691 12632514 17525996 17922224 18263696 16248980 17721639 17481882 18705752 18251166 15650968 16638106 14716833 18376398 17900296 13678700 12632512 14716496 18339082 17805973 18472332 16015684 17640975 10355542 12667390 17766677 18279442 18166357 16097048 16192424 15876570 17976157 12958196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 15.0814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 15.0815474484
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 15.0812878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 15.0815474484
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 15.0817565644
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 15.0817347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 15.0812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 15.0818397230 16248980
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0317285989 16246199 15720792 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4816899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.237678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.2319294768
MESH:D008113 Liver Neoplasms Fenofibrate 13.2318978307
MESH:D008113 Liver Neoplasms pirinixic acid 13.2316377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.2316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 12.902876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 12.9012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 12.9018253720 18775883
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.9012151625
MESH:D008171 Lung Diseases Mustard Gas 3.2918702808 18161513
MESH:D055370 Lung Injury Lipopolysaccharides 3.7721114838
MESH:D008175 Lung Neoplasms arsenite 4.7016809336
MESH:D008175 Lung Neoplasms Asbestos 4.7012111688
MESH:D008175 Lung Neoplasms Mustard Gas 4.703148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7011884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.7411807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 5.7416827153
MESH:D020149 Manganese Poisoning Estradiol 4.2319453300
MESH:D008527 Medulloblastoma Tretinoin 2.6917453147
MESH:D008545 Melanoma Tretinoin 1.9116752155
MESH:D008591 Meningomyelocele Tretinoin 4.1816940565
MESH:D008654 Mesothelioma Asbestos 3.9918709470 16564556 16919927 18310086 16319530
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.1817261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5416801185
MESH:D009135 Muscular Diseases pirinixic acid 3.2716239165
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 6.0318694830
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9417596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.6316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.6316411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.627678174 18551238
MESH:D009369 Neoplasms pirinixic acid 4.5117405874
MESH:D009369 Neoplasms Tretinoin 4.5116594593 16946489
MESH:D009389 Neovascularization, Pathologic arsenite 9.3315738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.3317289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0818481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 14.9711399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.9714600291
MESH:D009421 Nervous System Malformations Tretinoin 14.979125849
MESH:D009436 Neural Tube Defects Tretinoin 2.909142499
MESH:D009503 Neutropenia Mustard Gas 3.747688884 16761898
MESH:D009765 Obesity Dietary Fats 4.2221332399 18457598 20132043 19632207 17217161 18674790 11836018 20518802 16723640
MESH:D009765 Obesity pirinixic acid 4.2220558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.2216049721
MESH:D010003 Osteoarthritis rofecoxib 4.2316690336
MESH:D010051 Ovarian Neoplasms Estradiol 4.5419401270
MESH:D010051 Ovarian Neoplasms Tretinoin 4.5416936753
MESH:D010146 Pain Tretinoin 2.7116870215
MESH:D010149 Pain, Postoperative rofecoxib 5.1416678543 18165598
MESH:D010190 Pancreatic Neoplasms gemcitabine 5.3616929163 11504793 18383843 17440100 18992248
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.3615976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4611578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D011014 Pneumonia Lipopolysaccharides 4.3111605937 12224865
MESH:D011041 Poisoning Mustard Gas 3.5715727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9511896295 11222880 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6620887781
MESH:D011471 Prostatic Neoplasms AGN 194204 3.6816000583
MESH:D011471 Prostatic Neoplasms Estradiol 3.6816740699
MESH:D011507 Proteinuria Gentamicins 8.7815033597
MESH:D011507 Proteinuria Tretinoin 8.7816636307
MESH:D011537 Pruritus Ethinyl Estradiol 8.7015861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.7018058305
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011625 Pterygium Tretinoin 4.5516723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8317620002 17894541 10334151 17266442 17720292
MESH:D051437 Renal Insufficiency Gentamicins 4.7515728788 17132701
MESH:D015427 Reperfusion Injury pirinixic acid 2.2719058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5710835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012173 Retinitis Gentamicins 6.0318644591
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8716116481 16283617
MESH:D012640 Seizures 2,6-dinitrotoluene 2.3818551238
MESH:D012871 Skin Diseases Mustard Gas 2.6515451306 12880345 16961503
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 8.758532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.7516192470
MESH:D012878 Skin Neoplasms Tretinoin 8.7516467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6916709447
MESH:D013274 Stomach Neoplasms Tretinoin 1.7917261132
MESH:C537502 Stuve-Wiedemann syndrome marker/mechanism 19603067
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9515821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6512697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.8416026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.4419048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.5716051514
MESH:D014376 Tuberculosis Tretinoin 3.0816040207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.2016049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.0710091137
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4616129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3616752155
MESH:D014605 Uveitis Cyclosporine 3.731336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3214671159 15869587
MESH:D015837 Vestibular Diseases Gentamicins 5.2818776599
MESH:D014820 Vitiligo Tretinoin 3.8216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
MESH:D015430 Weight Gain Dietary Fats 3.5316723640
MESH:D009396 Wilms Tumor Tretinoin 3.7616287080
MESH:D014985 Xerophthalmia Cyclosporine 4.1917120751
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04630 Jak-STAT signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30371
    • No data
    Releated disease ID Related disease Name
    PA152238068Cold-Induced Sweating Syndrome
    PA152238067Crisponi Syndrome
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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