AutismKB 2.0

Annotation Detail for LIG1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:LIG1 ( MGC117397,MGC130025 )
Gene Full Name: ligase I, DNA, ATP-dependent
Band: 19q13.33
Quick LinksEntrez ID:3978; OMIM: 126391; Uniprot ID:DNLI1_HUMAN; ENSEMBL ID: ENSG00000105486; HGNC ID: 6598
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03030DNA replication
hsa03420Nucleotide excision repair
hsa03410Base excision repair
hsa03430Mismatch repair
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
Chromosome Maintenance
DNA Repair
No data
No data
Pathway IDPathway Name
500900Processive synthesis on the lagging strand
500945Removal of DNA patch containing abasic residue
500671Processive synthesis on the C-strand of the telomere
500033Resolution of AP sites via the multiple-nucleotide patch replacement pathway
500067Gap-filling DNA repair synthesis and ligation in TC-NER
500052Resolution of D-loop structures through Holliday junction intermediates
500062Gap-filling DNA repair synthesis and ligation in GG-NER
500724Early Phase of HIV Life Cycle
Related Diseases/Disorders Top
Desease IDDesease Name
H00094DNA repair defect
Immune system diseases
Primary immunodeficiency
No data
Desease Name
CANCER
head and neck cancer lung cancer
No data
Desease Name
DNA ligase I deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C031278 2-chloroethyl ethyl sulfide 2-chloroethyl ethyl sulfide results in increased phosphorylation of and results in increased activity of LIG1 proteinincreases activity|increases phosphorylation 16700562
C031278 2-chloroethyl ethyl sulfide N(6),N(6)-dimethyladenine inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of LIG1 protein]decreases reaction|increases phosphorylation 16700562
C031278 2-chloroethyl ethyl sulfide wortmannin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of LIG1 protein]decreases reaction|increases phosphorylation 16700562
D000082 Acetaminophen Acetaminophen results in decreased expression of LIG1 mRNAdecreases expression 17942131
D000082 Acetaminophen Acetaminophen results in increased expression of LIG1 mRNAincreases expression 12540782
D000082 Acetaminophen O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of LIG1 mRNA]decreases reaction|increases expression 12540782
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of LIG1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LIG1 mRNAaffects expression 16483693
C015001 arsenite arsenite results in increased expression of LIG1 mRNAincreases expression 15996700
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of LIG1 mRNAdecreases expression 17942131
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of LIG1 mRNAdecreases expression 17942131
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of LIG1 mRNAdecreases expression 15336504
D002104 Cadmium Cadmium results in decreased activity of LIG1 proteindecreases activity 16677676
D016572 Cyclosporine Cyclosporine results in decreased expression of LIG1 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of LIG1 mRNAdecreases expression 17942131
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of LIG1 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of LIG1 mRNA]decreases reaction|increases expression 17854601
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of LIG1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of LIG1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LIG1 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil LIG1 protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in decreased expression of LIG1 mRNAdecreases expression 12634122
D016685 Mitomycin Mitomycin results in decreased expression of LIG1 mRNAdecreases expression 12760830
D009151 Mustard Gas CASP3 protein affects the reaction [Mustard Gas results in increased phosphorylation of LIG1 protein]affects reaction|increases phosphorylation 16906506
D009151 Mustard Gas Mustard Gas results in increased activity of LIG1 proteinincreases activity 11428624
D009151 Mustard Gas Mustard Gas results in increased phosphorylation of LIG1 proteinincreases phosphorylation 16906506
C001020 N(6),N(6)-dimethyladenine N(6),N(6)-dimethyladenine inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of LIG1 protein]decreases reaction|increases phosphorylation 16700562
C029938 nickel sulfate nickel sulfate results in increased expression of LIG1 mRNAincreases expression 16100012
C107010 O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of LIG1 mRNA]decreases reaction|increases expression 12540782
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of LIG1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of LIG1 mRNAincreases expression 19482888
D011374 Progesterone Progesterone results in decreased expression of LIG1 mRNAdecreases expression 16966611
C017947 sodium arsenite sodium arsenite results in decreased expression of LIG1 mRNAdecreases expression 12760830
C105686 SU 5402 SU 5402 affects the expression of LIG1 mRNAaffects expression 15298682
D013629 Tamoxifen Tamoxifen affects the expression of LIG1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LIG1 mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin results in decreased expression of LIG1 mRNAdecreases expression 16249480
C009687 wortmannin wortmannin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of LIG1 protein]decreases reaction|increases phosphorylation 16700562
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3214745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.536195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.5314514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7117505938
MESH:D055371 Acute Lung Injury nickel sulfate 4.1016100012 12718980 19131640 11954676
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.6920464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.6914692618
MESH:D000230 Adenocarcinoma Fluorouracil 6.6917638652
MESH:D000236 Adenoma Benzo(a)pyrene 6.206695378
MESH:D000236 Adenoma Diethylnitrosamine 6.2010737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.0119061943 17162532 19052882 18056438 17620307 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.0117620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.0116835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6716712894 17306315
MESH:D000505 Alopecia Tretinoin 3.4415955085
MESH:D000740 Anemia Fluorouracil 8.0217963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.0211748828
MESH:D000799 Angioedema Acetaminophen 3.6110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8519183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7415885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Mustard Gas 4.7410378619
MESH:D001249 Asthma Tretinoin 4.7416456186
MESH:D050197 Atherosclerosis Cadmium 3.5115687053
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001471 Barrett Esophagus Tretinoin 4.1816935849
MESH:D001768 Blister Mustard Gas 4.9319167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.2612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.2616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6215746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1117868700
MESH:D001930 Brain Injuries Progesterone 4.0315380490 15845082 15665606
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.6217474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.6217474063
MESH:D001943 Breast Neoplasms Fluorouracil 3.6216595493 16110121 15136595 18357371 19217205 18608205 16557594
MESH:D001943 Breast Neoplasms Progesterone 3.6216175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tamoxifen 3.6219189212 20065188 15668708 21152245 19142967 18821012 20135344 18997820 19084267 19244106 20390343 16818667 19115204 17440819 19221464 20005174 18815881 19066611 15565566 16873071 20544844 20859285 18855134 19487384 19155303 17049068 19189210 17242785 17893378 18984771 18629630 19059307 18351453 19200415 17261762 19289846 16202921 18425577 11161223 19103187 19011961 16273361 19288272 19410462 21138602
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6220435547
MESH:D001943 Breast Neoplasms Tretinoin 3.6216166294 16443354 16873071
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9315286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7517687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3616813970
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4416051944
MESH:D002277 Carcinoma Fluorouracil 7.5917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2819066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9316168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.263084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.2612907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.2618788625 16540662 20727157 20512989 16878318 16779866 3084413 19383236 18393292 17428255 18210153 20101231 17055752 18971187 19539802 16502159 17978847 16681979 17173139 20007298 19171122 19519916 17138121 16807293 19208518 16698587 16288022 19107877 10672840 18665156 16935385 19394651 20214788 18785209 17761372 19418558 19919837 20432363 19701751 18056438 19052882 18978308 18506893 19822196 20514400 10737359 16569478 16328049 16830150 21159647 11831363 18691550 20935162 17162532 20524982 18494052 3581430 19335982 20084675
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 16.2617088986 16332177 18930000 17045692 17971768 16799960
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 16.2617173139 20007298 1701930 20935162 6705139
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 16.2616507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 16.2616924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 16.261917145
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9118695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.2320419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.2316757204 16280240 18986760 17066447
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.2318572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.2316051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2418850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 6.7810977129
MESH:D002386 Cataract Tretinoin 6.7817460283
MESH:D002471 Cell Transformation, Neoplastic Cadmium 19.4817332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 19.4812371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 19.4817174075 21159647 7505956 2727394
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 19.482727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 19.4820056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.034080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3616129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.6919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6916835633
MESH:D002779 Cholestasis Cyclosporine 7.2219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.2217681005 17110522 16919318 17333356 11677210 15861022 16105132
MESH:D002822 Choriocarcinoma Tretinoin 4.9316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4516354765 8697196 12621046 15340226 15668235
MESH:D002972 Cleft Palate Tretinoin 5.459407595
MESH:D003092 Colitis Tretinoin 3.4817035595
MESH:D003110 Colonic Neoplasms arsenite 3.8115037631
MESH:D003110 Colonic Neoplasms Fluorouracil 3.8116510598 17169374 15001691 18772588 17287894 17016597 17725105 17018589 17172411 16340194
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017094418 18802399 18288408 16331619 14970324 17454858 17255274 18509181 18949393 16524972 18448328 17695437 16391804 17401013 17016601 16282729 20501625 15289873 17594712 18383874 15148649 16303861
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3815322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.3810589399 8800419 17551590 9211117 16925845 9224671 14991402 9125849 9664655 9142499
MESH:D007644 Darier Disease Fluorouracil 4.5616733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1419031437
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.4611298694 16823706 16780908
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0320387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0317107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.2919279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2717187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.4514725611 19164858 10915739 12594235 11421492 16177239 16081117 11739529 12705907 15968718 11529661 16485898 18071297 11743745 11834606 19420014 12958197 18713872 11461765 12153990 16227642 19370779 14986274 16393943 17906064 19085960 17522070 17562736 19739265 19923254 11287661 2444490 19416960 10663392 16109766 12392966 16781746 15619225 14550746 10774834 12540782
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.4519107877
MESH:D056486 Drug-Induced Liver Injury O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate 8.4512540782
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.4520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5911462148
MESH:D004421 Dystonia Phenobarbital 3.791851702
MESH:D004487 Edema Mustard Gas 6.1711402378 9260866 11428631 11428647
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.1712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1715322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.1718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.0512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 14.0517692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.0519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.9520544844 19155303 16202921 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 6.9516569247
MESH:D004715 Endometriosis Progesterone 8.2716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.2710568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.883659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.643922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.356401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.037750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.793659116
MESH:D004890 Erythema Mustard Gas 4.939357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8916302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2916530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.2915173087 16785472 16337965 17638652 16481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2811564622
MESH:D005124 Eye Abnormalities Tretinoin 8.2816938888 9664655
MESH:D005234 Fatty Liver arsenite 22.4718296743
MESH:D005234 Fatty Liver Cyclosporine 22.4719224547
MESH:D005234 Fatty Liver Diethylnitrosamine 22.4720387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.4715345470
MESH:D005234 Fatty Liver Tamoxifen 22.4714986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3014745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9519069698
MESH:D005355 Fibrosis arsenite 19.3118296743
MESH:D005355 Fibrosis Cyclosporine 19.3112639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.3120067830
MESH:D005355 Fibrosis Tretinoin 19.3117994277
MESH:D005756 Gastritis Acetaminophen 3.4416983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4516452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.998708960
MESH:D005909 Glioblastoma Tretinoin 2.8617312396
MESH:D005910 Glioma Fluorouracil 2.7816145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.2918337622 15162350 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.2916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9316084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.4020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.4011294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.4014991402 9664655
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006529 Hepatomegaly Phenobarbital 7.7016109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.7012621046 15340226 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 2.9712676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8116959395 15340226 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.0316870215
MESH:D006930 Hyperalgesia Tretinoin 7.0316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3416778211
MESH:D006973 Hypertension Cyclosporine 4.6610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6618670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5816945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1815869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.1417937319
MESH:D007248 Infertility, Male sodium arsenite 6.1412646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 14.6018785209
MESH:D007249 Inflammation Mustard Gas 14.609260866 16001271 8975870 9357497 17524151 11428631 11428620 11402378 11428647
MESH:D007249 Inflammation Progesterone 14.6015869954
MESH:D007249 Inflammation Tamoxifen 14.6019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.6012878042 12200463
MESH:D007410 Intestinal Diseases Tretinoin 3.5417994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2516580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.2515992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2115604871
MESH:D007674 Kidney Diseases Acetaminophen 13.3912587719 15629191
MESH:D007674 Kidney Diseases Cadmium 13.3916962696 16322080 16226777
MESH:D007674 Kidney Diseases Cyclosporine 13.3910903974 8314463 18776723
MESH:D007674 Kidney Diseases sodium arsenite 13.3920008137
MESH:D007680 Kidney Neoplasms Cyclosporine 11.3512371664
MESH:D007680 Kidney Neoplasms Fluorouracil 11.3516985049
MESH:D007680 Kidney Neoplasms Tamoxifen 11.3518625569
MESH:D007938 Leukemia Tretinoin 2.6617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4916482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0419850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0115748426 16891316 19225113 9834237 16766008 17339181 16140955 17107899 16331271 19075265 17301526 19035177 19642359 17361223 16935935 17294898 17217047 17649720 17368321 17712046 19029980 16788101 12679006 16823087 17506722
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.159224671
MESH:D008064 Lipidoses Tamoxifen 2.9917567588 15342952
MESH:D008103 Liver Cirrhosis arsenite 10.3818296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.3819638242 20032147 18522880 18665156 18407596
MESH:D008103 Liver Cirrhosis Phenobarbital 10.3821047994
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.2918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.2912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.2918397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 6.1219014921 16611625 19460945 12587719 19784758 16610002 12969438 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 6.1217034775
MESH:D008107 Liver Diseases Phenobarbital 6.1219363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0416871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 28.4615890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 28.4620195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 28.4619812893 19256749 12112319 20434301 19254457 19073162 18977376 19551842 19690152 19996281 18648771 15885732 18754104 21047994 12771043 20501860 20137499 19427195 19638242 16942905 20101389 19833225 19499222 20118626 18644402 9163691 15175105 20492335 21278145 19642983 20452335 21071580 19426721 10737359 20405173 19090486 2862719 18978307 19850985 19255062 19294768 2422723 21167192 20583210
MESH:D008113 Liver Neoplasms Fluorouracil 28.4617045692 15113037 18383874 16603448
MESH:D008113 Liver Neoplasms Mitomycin 28.4615113037
MESH:D008113 Liver Neoplasms Phenobarbital 28.4615975961 21047994 19812893 19073162 8742319 19482888
MESH:D008113 Liver Neoplasms sodium arsenite 28.4616712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 28.4616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 28.4616984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 12.958603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 12.9518775883 17854601 18079962 18164116 18544905 17942915 18093689 17174075 16267830 19126423 19539802 2563599 19009564 18308698 18253720 18282651 19519916 3124819 21159647 9362446 16842330 19004024
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 12.9518308698 1399818 17172636 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.9512151625
MESH:D008171 Lung Diseases 2-chloroethyl ethyl sulfide 11.7018675330 16252256 12815614
MESH:D008171 Lung Diseases Mustard Gas 11.7018702808 18161513
MESH:D008171 Lung Diseases sodium arsenite 11.7019095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 14.8514755239
MESH:D008175 Lung Neoplasms arsenite 14.8516809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 14.8518816296 20064080 20464547 20135361 18569708 6695378 18520028 17053015 20869020
MESH:D008175 Lung Neoplasms Diethylnitrosamine 14.8520970405 20512841 21163286 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 14.8515246190
MESH:D008175 Lung Neoplasms Mustard Gas 14.853148597 8781369
MESH:D008175 Lung Neoplasms sodium arsenite 14.8519931552 16712894 17077188 17306315 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 14.8518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 14.8511884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5615086387
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5319428831
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 5.6011408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.6011731420 19196723 14580682 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.3219453300
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma sodium arsenite 4.8516487513 19082730
MESH:D008545 Melanoma Tamoxifen 4.8512393984 19393235
MESH:D008545 Melanoma Tretinoin 4.8516752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9515990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3419513568
MESH:D008591 Meningomyelocele Tretinoin 4.2016940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5616801185
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.6617671175
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.9516381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.9516757204 18986760
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9517596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8412213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2517484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.433581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.4319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4419410462
MESH:D009369 Neoplasms Benzo(a)pyrene 10.9411141357
MESH:D009369 Neoplasms Fluorouracil 10.9416928823 18600527 18239605
MESH:D009369 Neoplasms sodium arsenite 10.9411559025
MESH:D009369 Neoplasms Tretinoin 10.9416946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.4420056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7719196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic arsenite 4.1815738583
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0918481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.7814600291
MESH:D009421 Nervous System Malformations Tretinoin 8.789125849
MESH:D009436 Neural Tube Defects sodium arsenite 6.8212854658
MESH:D009436 Neural Tube Defects Tretinoin 6.829142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.5718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.5720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8920387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2916436463
MESH:D009503 Neutropenia Mustard Gas 3.767688884 16761898
MESH:D009765 Obesity 2-chloroethyl ethyl sulfide 3.7716289378
MESH:D010018 Osteomalacia Phenobarbital 4.1317016548
MESH:D010051 Ovarian Neoplasms Progesterone 7.4916525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.4917306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 7.4916936753
MESH:D010146 Pain Acetaminophen 5.9816870215
MESH:D010146 Pain Tretinoin 5.9816870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 15.4516540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 15.4516929163 15113037 19003803 16500647
MESH:D010190 Pancreatic Neoplasms Mitomycin 15.4515113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 15.4516965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 15.4515976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.1515687053
MESH:D011041 Poisoning Mustard Gas 3.5915727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.1612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.162563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.162563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9611399792 11222880 11118676 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms Cadmium 1.8917075824
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8919082440 18626508
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8916039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011507 Proteinuria Tretinoin 3.3916636307
MESH:D011537 Pruritus Ethinyl Estradiol 8.7615861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.7618058305
MESH:D019310 Pseudolymphoma Phenobarbital 4.2612752131
MESH:D011565 Psoriasis Cyclosporine 2.1516882103
MESH:D011625 Pterygium Tretinoin 4.5616723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8417720292 10334151 17620002 17266442 17894541
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8215538739 18722050 16160472 18286688
MESH:D012128 Respiratory Distress Syndrome, Adult 2-chloroethyl ethyl sulfide 4.8916292752 18257742 12210543
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8916283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7818045962
MESH:D012640 Seizures Phenobarbital 2.553137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.596407741
MESH:D012871 Skin Diseases Mustard Gas 2.6615451306 12880345 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 16.7810029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 16.7818572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 16.788532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.7816192470
MESH:D012878 Skin Neoplasms Tretinoin 16.7816467112
MESH:D013088 Spermatocele Ethinyl Estradiol 10.7916709447
MESH:D013088 Spermatocele Tamoxifen 10.7916709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.1116503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.1119457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6212854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.522093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.5218456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.5216951190 17522103 18567086 18396642 15786421 16424979 17498489 19084572 17172411 19015929
MESH:D013274 Stomach Neoplasms Tretinoin 4.5217261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9615669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.987505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 10.981399818
MESH:D013964 Thyroid Neoplasms Tretinoin 10.9816026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 9.1716280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.1716051514
MESH:D014376 Tuberculosis Tretinoin 3.0916040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.7817053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.7816712894 17306315 11723127 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.7816712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 2.7710982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 14.7116803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.7111813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.7116129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0814692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3816752155
MESH:D014605 Uveitis Cyclosporine 3.751336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2017056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3314671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.8416761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
MESH:D009396 Wilms Tumor Tretinoin 3.7816287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2117120751
Pathway ID Pathway Name
KEGG:03410 Base excision repair
REACT:152 Cell Cycle, Mitotic
REACT:22172 Chromosome Maintenance
REACT:216 DNA Repair
REACT:383 DNA Replication
KEGG:03030 DNA replication
KEGG:03430 Mismatch repair
KEGG:03420 Nucleotide excision repair
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30372
    • No data
    Releated disease ID Related disease Name
    PA446969Venous Thrombosis
    PA445742Stomach Neoplasms
    Releated drug ID Related drug Name
    PA451644thalidomide
    PA449957ibuprofen
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00290 inhibitor Bleomycin Antimetabolites;Antibiotics, Antineoplastic
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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