AutismKB 2.0

Annotation Detail for LIMK1


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Basic Information Top
Gene Symbol:LIMK1 ( LIMK )
Gene Full Name: LIM domain kinase 1
Band: 7q11.23
Quick LinksEntrez ID:3984; OMIM: 601329; Uniprot ID:LIMK1_HUMAN; ENSEMBL ID: ENSG00000106683; HGNC ID: 6613
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
hsa04810Regulation of actin cytoskeleton
hsa04666Fc gamma R-mediated phagocytosis
Pathway IDPathway Name
Axon guidance
Pathway IDPathway Name
200007RhoA signaling pathway
200083CXCR4-mediated signaling events
200148Caspase cascade in apoptosis
200190RAC1 signaling pathway
200057CDC42 signaling events
Pathway IDPathway Name
P00016Cytoskeletal regulation by Rho GTPase
Pathway IDPathway Name
500074Sema4D induced cell migration and growth-cone collapse
500076Sema3A PAK dependent Axon repulsion
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1944Breast cancer
Desease Name
CARDIOVASCULAR
brain aneurysm
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of LIMK1 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of LIMK1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LIMK1 mRNAaffects expression 16483693
D001554 Benzene Benzene results in increased expression of LIMK1 mRNAincreases expression 12928149
D001554 Benzene TRP53 protein affects the reaction [Benzene results in increased expression of LIMK1 mRNA]affects reaction|increases expression 12928149
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of LIMK1 mRNAincreases expression 15003993
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of LIMK1 mRNAaffects cotreatment|affects expression 18636392
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of LIMK1 proteindecreases expression 17366564
D020111 Chlorodiphenyl (54% Chlorine) INS1 protein inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of LIMK1 protein]decreases expression|decreases reaction 17366564
D016572 Cyclosporine Cyclosporine results in increased expression of LIMK1 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of LIMK1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of LIMK1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LIMK1 mRNAaffects cotreatment|increases expression 17942748
D005839 Gentamicins Gentamicins results in decreased expression of LIMK1 mRNAdecreases expression 15350274
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of LIMK1 mRNAdecreases expression 12057914
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of LIMK1 mRNAaffects cotreatment|affects expression 18636392
D010269 Paraquat Paraquat results in increased expression of LIMK1 mRNAincreases expression 17077588
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of LIMK1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of LIMK1 mRNAincreases expression 19482888
C017947 sodium arsenite sodium arsenite results in increased expression of LIMK1 mRNAincreases expression 20308225
D013629 Tamoxifen Tamoxifen affects the expression of LIMK1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LIMK1 mRNAincreases expression 12377990
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LIMK1 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5514745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.276195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.2715322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9417505938
MESH:D058186 Acute Kidney Injury Gentamicins 4.5211274264
MESH:D055371 Acute Lung Injury Chlorine 9.4320601635
MESH:D055371 Acute Lung Injury Lipopolysaccharides 9.4311850527 18653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8114692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.743712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.0517620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.0516835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9016712894 17306315
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.7611874814
MESH:D000544 Alzheimer Disease Ozone 2.4315513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D000741 Anemia, Aplastic Benzene 4.3511369114 17661222 14761424
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6515885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5515570426
MESH:D001249 Asthma Ozone 2.6317854713 16373670
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.021440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001855 Bone Marrow Diseases Benzene 5.2316183116
MESH:D001943 Breast Neoplasms Benzene 1.9111921183 17162533
MESH:D001943 Breast Neoplasms Tamoxifen 1.9121138602 19142967 18984771 20135344 17440819 19189210 19289846 19115204 16818667 18351453 18425577 11161223 20005174 19221464 16873071 16202921 18821012 19189212 19084267 20544844 19200415 18815881 19011961 17893378 19066611 15565566 19059307 18629630 17049068 19155303 19103187 18855134 19410462 15668708 17261762 17242785 19244106 18997820 20390343 19288272 20859285 19487384 21152245 16273361 20065188
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9120435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6615516495 17626835 18417511 19059883 18315731 14754758 16777450
MESH:D002100 Cachexia Ozone 4.7316183385
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4919066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.833581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.833084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.8320935162 17173139 20007298 1701930 6705139
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.8317306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.8316924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.667296757
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.3718572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3516120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.5710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.097505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.0912371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.0920056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.244080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.299022650 19486331
MESH:D002779 Cholestasis Cyclosporine 13.2919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.2917333356 15861022 16919318 16105132 17681005 17110522 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.098697196 15668235 15340226 12621046 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0414669216 17141729
MESH:D019465 Craniofacial Abnormalities Benzene 2.6715643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6710048152 15322242 20055451
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3519031437
MESH:D003872 Dermatitis Benzene 4.7515902427
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7912868966 11298694 18759878 14531868 8156756 2524372 11906362 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.472952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.4619279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.9418289764 6482804 6679447 9022650 18692083 9653073 7440962 16192314 9328219 11289319 1440618 18648102 8291058
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.9411461765 14725611 19416960 11834606 10663392 16781746 14550746 16227642 12594235 17906064 18713872 16081117 10774834 17522070 12153990 12705907 12540782 11421492 2444490 12958197 19923254 19085960 11743745 11287661 12392966 16109766 16485898 16393943 11529661 10915739 19370779 14986274 15619225 18071297 19164858 15968718 17562736 16177239 19420014 19739265 11739529
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 8.9417851650
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.9420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004362 Drug Toxicity Gentamicins 8.3411033412 15033597
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.3411462148
MESH:D004417 Dyspnea Chlorine 4.6220016425
MESH:D004421 Dystonia Phenobarbital 3.991851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9018230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.8912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.8919031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0316202921 17893378 19155303 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0010568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.3915821434 15328337 17637181
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.093659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.873922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.526401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.247750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.013659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.103581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver Cyclosporine 12.9519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.9515345470
MESH:D005234 Fatty Liver Tamoxifen 12.9519224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005334 Fever Lipopolysaccharides 3.999205823 11852909
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.026705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1719069698
MESH:D005355 Fibrosis Cyclosporine 8.4412168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.4420067830
MESH:D005739 Gas Poisoning Chlorine 5.0120016425
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.6716452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.218708960
MESH:D005911 Gliosis Paraquat 5.1611124998
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.027505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D034381 Hearing Loss Gentamicins 4.8615968427 19130971 17868369 18024279
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3210048152 11294989
MESH:D006402 Hematologic Diseases Benzene 4.6416183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4115720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.3616366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.506705139
MESH:D006529 Hepatomegaly Phenobarbital 8.4016109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.4012621046 15340226 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.1312676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0516959395 15340226 18606429 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.6816870215
MESH:D053565 Hypercalciuria Gentamicins 5.7017652376
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9215034207
MESH:D006973 Hypertension Benzene 8.5717940673
MESH:D006973 Hypertension Cyclosporine 8.5710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.5718850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8016945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.1617937319
MESH:D007248 Infertility, Male Paraquat 11.164850670
MESH:D007248 Infertility, Male sodium arsenite 11.1615346721 12646999
MESH:D007249 Inflammation Lipopolysaccharides 8.2717255318 9205823 17963957 12878042 17237260
MESH:D007249 Inflammation Tamoxifen 8.2719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.2712878042 12200463
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.6117255318
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.029022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4415604871
MESH:D007673 Kidney Cortex Necrosis Gentamicins 5.7318842672
MESH:D007674 Kidney Diseases Acetaminophen 14.3812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 14.388314463 10903974 18776723
MESH:D007674 Kidney Diseases Gentamicins 14.3818289764 17934191 19349640
MESH:D007674 Kidney Diseases sodium arsenite 14.3820008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.276582329
MESH:D007680 Kidney Neoplasms Cyclosporine 12.2712371664
MESH:D007680 Kidney Neoplasms Tamoxifen 12.2718625569
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 5.3811231351
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 4.4410219319
MESH:D007938 Leukemia Benzene 3.3815935818 14694614 17119257 18335105
MESH:D007951 Leukemia, Myeloid Benzene 4.3017506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.6919478238
MESH:D007970 Leukopenia Lipopolysaccharides 4.6915821434
MESH:D008064 Lipidoses Tamoxifen 3.1417567588 15342952
MESH:D008103 Liver Cirrhosis Phenobarbital 2.8821047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.189327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.5012878042
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5012878042
MESH:D008107 Liver Diseases Acetaminophen 3.9119460945 11587558 12969438 12587719 19784758 16611625 19014921 16610002
MESH:D008107 Liver Diseases Phenobarbital 3.9119363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2216871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 10.6419812893 19073162 8742319 21047994 19482888 15975961
MESH:D008113 Liver Neoplasms sodium arsenite 10.6416712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 10.6416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.6416984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.03598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Benzene 14.0312562636
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 14.0318308698 17172636 6150874 1399818 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.0312151625
MESH:D008171 Lung Diseases Ozone 7.4719066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 7.4719095001
MESH:D017563 Lung Diseases, Interstitial Benzene 4.8114698565
MESH:D055370 Lung Injury Lipopolysaccharides 9.1921114838
MESH:D055370 Lung Injury Ozone 9.1920417186
MESH:D008175 Lung Neoplasms Benzene 6.5712562636
MESH:D008175 Lung Neoplasms Ozone 6.578597069 7614698
MESH:D008175 Lung Neoplasms sodium arsenite 6.5715276417 16712894 17077188 19931552 17306315
MESH:D008175 Lung Neoplasms Tamoxifen 6.5718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5719555203 11884234
MESH:D008223 Lymphoma Benzene 3.7217584886 17119257
MESH:D015674 Mammary Neoplasms, Animal Benzene 10.0512562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 10.0519428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 6.2011921183
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.2019196722 11731420 16827153 14580682 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.5519453300
MESH:D008545 Melanoma sodium arsenite 3.3119082730 16487513
MESH:D008545 Melanoma Tamoxifen 3.3119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7916801185
MESH:D008679 Metaplasia Ozone 5.1110496685
MESH:D009101 Multiple Myeloma Benzene 3.6517119195
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 6.2818694830
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.4717484760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.673581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.6719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5119410462
MESH:D009369 Neoplasms sodium arsenite 2.4911559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6520056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0019200415 19189210 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2718481113 19348381
MESH:D009410 Nerve Degeneration Paraquat 3.7016893418
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2014600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 12.136679447
MESH:D009436 Neural Tube Defects Benzene 12.1315643154
MESH:D009436 Neural Tube Defects sodium arsenite 12.1312854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8518514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.104026338 6482804
MESH:D009784 Occupational Diseases Benzene 9.1015612468 17178637 15935809 17479406 16737584 15576619 15727169 17119257 15913788
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.023988306
MESH:D010018 Osteomalacia Phenobarbital 4.3617016548
MESH:D010051 Ovarian Neoplasms Benzene 5.0912562636
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.0917306315 15276417
MESH:D010146 Pain Acetaminophen 2.3716870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.4816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.477296757
MESH:D010300 Parkinson Disease Paraquat 2.8015451049 11181820 12911755 16510128 16140633 11445065 15824117 11124998
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.4216190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010538 Peritonitis Ozone 4.1216369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.476228378
MESH:D011014 Pneumonia Lipopolysaccharides 18.5412224865 11605937
MESH:D011014 Pneumonia Ozone 18.5418007984 18929643 18381685
MESH:D011014 Pneumonia Paraquat 18.5412504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.9112371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.912563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1811118676 11896295 11399792 11222880
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2616039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2615067354
MESH:D011507 Proteinuria Gentamicins 4.7015033597
MESH:D011537 Pruritus Ethinyl Estradiol 3.3016919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.5012752131
MESH:D011565 Psoriasis Cyclosporine 2.2216882103
MESH:D011658 Pulmonary Fibrosis Paraquat 2.9017997886 16324872
MESH:D051437 Renal Insufficiency Gentamicins 4.9815728788 17132701
MESH:D012120 Respiration Disorders Chlorine 5.2118579056
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.8911700416
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.7210835634
MESH:D012135 Respiratory Sounds Paraquat 4.0411874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.863692021
MESH:D012162 Retinal Degeneration Paraquat 8.8616458197
MESH:D012173 Retinitis Gentamicins 6.2818644591
MESH:D012640 Seizures Phenobarbital 2.6816876388 3137016 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.816407741
MESH:D012878 Skin Neoplasms sodium arsenite 9.3919524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.398532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.3916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.5616709447
MESH:D013088 Spermatocele Tamoxifen 11.5616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0319457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7812854658
MESH:D013274 Stomach Neoplasms Benzene 2.4212562636
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.1515821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1315669648
MESH:D013953 Thymus Neoplasms Benzene 4.9510850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.091399818 6582329 6587162 7505956 3712494
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.091399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.278074119
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.2711723127 17306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.278653321 16712894 17572228
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.7511813266
MESH:D014594 Uterine Neoplasms Benzene 9.5212562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.5214692618
MESH:D014605 Uveitis Cyclosporine 3.981336536
MESH:D014652 Vascular Diseases sodium arsenite 4.4217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5214671159 15869587
MESH:D015837 Vestibular Diseases Gentamicins 5.5018776599
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4417120751
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04360 Axon guidance
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:04810 Regulation of actin cytoskeleton
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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