AutismKB 2.0

Annotation Detail for LIPC


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:LIPC ( HDLCQ12,HL,HTGL,LIPH )
Gene Full Name: lipase, hepatic
Band: 15q21.3
Quick LinksEntrez ID:3990; OMIM: 151670; Uniprot ID:LIPC_HUMAN; ENSEMBL ID: ENSG00000166035; HGNC ID: 6619
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
LIPAS-PWYtriacylglycerol degradation
Pathway IDPathway Name
hsa00561Glycerolipid metabolism
hsa01100Metabolic pathways
No data
No data
No data
Pathway IDPathway Name
500796Chylomicron-mediated lipid transport
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1749Transient hypertension of pregnancy
1856Obesity
1904Diabetes mellitus
2097Hyperlipidemia
2236Cardiovascular disease
Desease Name
HDL cholesterol
diabetic nephropathy
increased concentration of HDL-C and decreased promoter activity
cholesterol, HDL
Atherosclerosis
atherosclerosis, coronary
CARDIOVASCULAR
Coronary Artery Disease
blood pressure, arterial hypertension
plasma HDL cholesterol (HDL-C) levels
lower levels of hepatic lipase activity buoyant LDL and higher HDL2 cholesterol
bone density
cardiac death
RENAL
coronary calcification
low hepatic lipase activity
carotid artery stenosis
heritable lipolytic deficiency.
Peripheral Vascular Diseases
Amyotrophic Lateral Sclerosis
NEUROLOGICAL
METABOLIC
high plasma concentrations of high density lipoprotein ch
coronary artery calcium
triglycerides
obesity
hypertension, pregnancy induced preeclampsia
insulin
plasma HDL-C levels
cholesterol, total
coronary heart disease
dyslipidemia
REPRODUCTION
cholesterol, HDL cholesterol, LDL
Cognitive performance
serum metabolites
Diabetes Mellitus, Type 2
lipoprotein subclass profiles
patent ductus arteriosus
Desease Name
HDL cholesterol
Serum metabolites
Cholesterol, total
Triglycerides
Cognitive test performance
Amyotrophic lateral sclerosis
Age-related macular degeneration
Desease Name
Diabetes mellitus, noninsulin-dependent
Hepatic lipase deficiency
High density lipoprotein cholesterol level QTL 12
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of LIPC mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of LIPC mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of LIPC mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of LIPC mRNAdecreases expression 17522070
D000638 Amiodarone Amiodarone affects the expression of LIPC mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LIPC mRNAaffects expression 16483693
C447119 bazedoxifene acetate bazedoxifene acetate results in increased expression of LIPC mRNAincreases expression 15961563
D001553 Benzbromarone Benzbromarone affects the expression of LIPC mRNAaffects expression 19483382
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of LIPC mRNAdecreases expression 15056808
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of LIPC mRNAdecreases expression 17522070
D002713 Chlorine Chlorine results in decreased expression of LIPC mRNAdecreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of LIPC mRNAaffects cotreatment|increases expression 18636392
D002725 Chloroform Chloroform results in decreased expression of LIPC mRNAdecreases expression 17522070
D008076 Cholesterol, HDL Dietary Fats affects the reaction [LIPC promoter SNP affects the abundance of Cholesterol, HDL]affects abundance|affects reaction 12403660
D008076 Cholesterol, HDL LIPC gene polymorphism affects the abundance of Cholesterol, HDLaffects abundance 16030523
D008076 Cholesterol, HDL LIPC promoter SNP affects the abundance of Cholesterol, HDLaffects abundance 12403660
D002994 Clofibrate Clofibrate affects the expression of LIPC mRNAaffects expression 19483382
D002994 Clofibrate Clofibrate results in decreased expression of LIPC mRNAdecreases expression 17522070
D016572 Cyclosporine Cyclosporine results in decreased expression of LIPC mRNAdecreases expression 20106945
D003907 Dexamethasone Dexamethasone results in decreased expression of LIPC mRNAdecreases expression 17522070
D004041 Dietary Fats Dietary Fats affects the reaction [LIPC promoter SNP affects the abundance of Cholesterol, HDL]affects abundance|affects reaction 12403660
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of LIPC mRNAdecreases expression 19638242
D004918 Erythromycin Estolate Erythromycin Estolate results in decreased expression of LIPC mRNAdecreases expression 17522070
D004958 Estradiol Estradiol results in increased expression of LIPC mRNAincreases expression 15961563
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of LIPC mRNAdecreases expression 14976129
D005001 Ethionine Ethionine affects the expression of LIPC mRNAaffects expression 19483382
D005632 Fructose Fructose results in increased expression of and results in increased activity of LIPC proteinincreases activity|increases expression 15504970
D005632 Fructose Fructose results in increased expression of LIPC mRNAincreases expression 15504970
D005632 Fructose rosiglitazone inhibits the reaction [Fructose results in increased expression of and results in increased activity of LIPC protein]decreases reaction|increases activity|increases expression 15504970
D005632 Fructose rosiglitazone inhibits the reaction [Fructose results in increased expression of LIPC mRNA]decreases reaction|increases expression 15504970
C029424 hydrazine hydrazine results in decreased expression of LIPC mRNAdecreases expression 15370871
D008727 Methotrexate Methotrexate results in decreased expression of LIPC mRNAdecreases expression 15120968
D009270 Naloxone Naloxone results in decreased expression of LIPC mRNAdecreases expression 17522070
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in decreased expression of LIPC mRNAdecreases expression 17522070
D009853 Omeprazole Omeprazole affects the expression of LIPC mRNAaffects expression 19483382
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of LIPC mRNAaffects cotreatment|increases expression 18636392
D010634 Phenobarbital Phenobarbital results in decreased expression of LIPC mRNAdecreases expression 12807726
D010634 Phenobarbital Phenobarbital results in decreased expression of LIPC mRNAdecreases expression 16510358
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LIPC mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid affects the expression of LIPC mRNAaffects expression 19483382
C025299 polyphenols polyphenols results in decreased expression of LIPC mRNAdecreases expression 16293270
D011441 Propylthiouracil Propylthiouracil affects the expression of LIPC mRNAaffects expression 19483382
D011802 Quinidine Quinidine results in decreased expression of LIPC mRNAdecreases expression 17522070
C089730 rosiglitazone rosiglitazone inhibits the reaction [Fructose results in increased expression of and results in increased activity of LIPC protein]decreases reaction|increases activity|increases expression 15504970
C089730 rosiglitazone rosiglitazone inhibits the reaction [Fructose results in increased expression of LIPC mRNA]decreases reaction|increases expression 15504970
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LIPC mRNAincreases expression 19684285
20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LIPC mRNAdecreases expression 19684285
16960034
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LIPC mRNAdecreases expression 16960034
D013752 Tetracycline Tetracycline results in decreased expression of LIPC mRNAdecreases expression 17522070
D013806 Theophylline Theophylline results in decreased expression of LIPC mRNAdecreases expression 17522070
D013853 Thioacetamide Thioacetamide affects the expression of LIPC mRNAaffects expression 19483382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 12.1012039119
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 12.106195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.1014514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.1818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5517505938
MESH:D055371 Acute Lung Injury Chlorine 7.9920601635
MESH:D055371 Acute Lung Injury pirinixic acid 7.9918653653
MESH:D000230 Adenocarcinoma Estradiol 3.8611473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.8614692618
MESH:D000236 Adenoma Diethylnitrosamine 2.6310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 21.7217620307 19052882 19061943 16434500 18056438 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 21.7217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 21.7216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 21.7216835633
MESH:D000544 Alzheimer Disease Ozone 4.1615513908
MESH:D000544 Alzheimer Disease rosiglitazone 4.1619621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6211748828
MESH:D000799 Angioedema Acetaminophen 3.4610982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 8.4318057881 20041841 18218290
MESH:D001145 Arrhythmias, Cardiac Quinidine 8.4318724381 18057881
MESH:D001161 Arteriosclerosis Dietary Fats 8.6715238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.6711256880
MESH:D001169 Arthritis, Experimental Dexamethasone 6.5817659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.5815885639
MESH:D001172 Arthritis, Rheumatoid Methotrexate 4.6317286800
MESH:D001172 Arthritis, Rheumatoid Ozone 4.6315570426
MESH:D001249 Asthma Ozone 5.0817854713 16373670
MESH:D001249 Asthma Theophylline 5.0812113382 9701106
MESH:D001281 Atrial Fibrillation Amiodarone 3.6218651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4618445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 51.5419483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 51.5419483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 51.5419483382
MESH:D001778 Blood Coagulation Disorders Ethionine 51.5419483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 51.5419483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 51.5419483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 51.5419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 51.5412125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 51.5419483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5215746008
MESH:D001943 Breast Neoplasms Dietary Fats 2.2020435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D001943 Breast Neoplasms Estradiol 2.2012948864 16675129 17289903 19861407 14630087 17018787 18497071 17261762
MESH:D001943 Breast Neoplasms Methotrexate 2.2016978400
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2020435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3818417511 17626835 15516495 16777450 14754758 19059883 18315731
MESH:D002100 Cachexia Ozone 4.3616183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4116011737 15721981 16050911 16227642 3786805 15700767 18705752 15673190 16097048 10355542 16192424 16124888
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5016835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 18.4716705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 18.4716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 18.473084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 18.471701930
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 18.4718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 18.4718971187 17761372 18785209 3084413 20524982 19539802 18691550 10672840 19107877 19822196 16681979 20214788 19394651 16935385 20084675 17138121 16540662 17173139 19418558 18210153 20935162 19052882 18788625 19171122 10737359 18506893 17428255 20727157 20432363 17978847 20007298 19701751 19519916 16569478 18056438 18393292 16698587 17055752 16830150 19208518 19335982 16288022 16878318 19919837 17162532 16502159 11831363 20514400 21159647 16328049 20512989 3581430 18978308 16779866 19383236 16807293 20101231 18494052 18665156
MESH:D006528 Carcinoma, Hepatocellular Estradiol 18.4716924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 18.4717173139 6705139 20007298 20935162 1701930
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 18.4717997003
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1516120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7615710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7018974383
MESH:D002386 Cataract Acetaminophen 2.3610977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 18.306135515
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 18.301399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 18.3012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 18.3017174075 2727394 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 18.3018566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.884080065
MESH:D002637 Chest Pain Omeprazole 11.2815447763
MESH:D002637 Chest Pain Theophylline 11.2815238202
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 14.2719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 14.2716835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 14.2718291259
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 5.8112912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 16.9612927374 15500046 16629650 15913567 18590720 7624871 19486331 18164287
MESH:D002779 Cholestasis Cyclosporine 16.9619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 16.9616919318 15861022 17681005 17110522 16105132 17333356 11677210
MESH:D002779 Cholestasis pirinixic acid 16.9619176532
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.4719407337 10220858
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9412621046 8697196 16354765 15340226 15668235
MESH:D003110 Colonic Neoplasms Dexamethasone 3.8215824018
MESH:D003110 Colonic Neoplasms polyphenols 3.8216293270
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7417141729 14669216
MESH:D003327 Coronary Disease Fructose 4.2318504504
MESH:D019465 Craniofacial Abnormalities Dexamethasone 3.6617728286
MESH:D019465 Craniofacial Abnormalities Methotrexate 3.6612039119 9562676
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6615322242 10048152 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.6518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.6518551238
MESH:D003550 Cystic Fibrosis Methotrexate 3.9119747007
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.0512438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003882 Dermatomyositis Methotrexate 4.7620191521
MESH:D003920 Diabetes Mellitus rosiglitazone 3.9817446233
MESH:D003921 Diabetes Mellitus, Experimental Fructose 4.1918603373
MESH:D003924 Diabetes Mellitus, Type 2 marker/mechanism
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.4320387270
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 9.4318603373
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 9.4312642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.4317107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.0919279558
MESH:D003967 Diarrhea Dexamethasone 3.347237001
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 38.2720133375 17522070 18289764 7624871
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 38.2721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 38.2718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 38.2711529661 16081117 11739529 11834606 11743745 16177239 12392966 19739265 18713872 14986274 15619225 11421492 12153990 12705907 19923254 18071297 10774834 17906064 19164858 16781746 19420014 16109766 14550746 17522070 10663392 15968718 16485898 12958197 19370779 11287661 17562736 10915739 12594235 19085960 16393943 19416960 2444490 16227642 12540782 11461765 14725611
MESH:D056486 Drug-Induced Liver Injury Amiodarone 38.2718218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 38.2716227642 3786805 21278145 15998439 19085960 10092053 7440962 10915739 16177239 7179309 2869522 6623471 15968718 15027814 9327722 7120509 17522070 11566570 4309450 6884620 19336974 3732212
MESH:D056486 Drug-Induced Liver Injury Chloroform 38.2717522070 2862719 7440962 3732212 6884620 3104120 6623471 7120509
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 38.2719107877
MESH:D056486 Drug-Induced Liver Injury Erythromycin Estolate 38.2714998559 17522070
MESH:D056486 Drug-Induced Liver Injury polyphenols 38.2719370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 38.2720420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 38.2717522070
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 38.2712963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4811462148
MESH:D004381 Duodenal Ulcer Omeprazole 3.9715991576 21218061 17151854 16613094
MESH:D050171 Dyslipidemias Clofibrate 7.9116707586
MESH:D050171 Dyslipidemias Dietary Fats 7.9118367378
MESH:D004417 Dyspnea Chlorine 4.2420016425
MESH:D004421 Dystonia Phenobarbital 3.651851702
MESH:D004485 Eczema Dexamethasone 4.1012438553
MESH:D004487 Edema Dexamethasone 13.7019703484
MESH:D004487 Edema pirinixic acid 13.7012083418
MESH:D004487 Edema rosiglitazone 13.7012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5115322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.8312538720
MESH:D016889 Endometrial Neoplasms Estradiol 2.7319148513 11473722 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.6910568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.743659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.493922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.6920417680
MESH:D004832 Epilepsy, Absence Naloxone 8.416254150
MESH:D004832 Epilepsy, Absence Phenobarbital 8.416401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.887750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.643659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7316302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7311564622
MESH:D005218 Fat Necrosis Thioacetamide 5.3316456712
MESH:D005234 Fatty Liver Amiodarone 55.2714986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 55.2712795759 16239168 61145 12631006 17595544 15959796 19224547 16045604
MESH:D005234 Fatty Liver Clofibrate 55.2719224547
MESH:D005234 Fatty Liver Cyclosporine 55.2719224547
MESH:D005234 Fatty Liver Dietary Fats 55.2717967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 55.2721071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 55.2715345470
MESH:D005234 Fatty Liver Fructose 55.2718641190 18395287 19196556
MESH:D005234 Fatty Liver pirinixic acid 55.2719236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 55.2719196556
MESH:D005234 Fatty Liver Tetracycline 55.2716917069 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0811858732
MESH:D005355 Fibrosis Carbon Tetrachloride 23.7918705752
MESH:D005355 Fibrosis Cyclosporine 23.7912639820 12168785
MESH:D005355 Fibrosis Dietary Fats 23.7918296743
MESH:D005355 Fibrosis Fructose 23.7918504504
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 23.7920067830
MESH:D005739 Gas Poisoning Chlorine 4.6220016425
MESH:D005756 Gastritis Acetaminophen 3.2916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.848708960
MESH:D018149 Glucose Intolerance marker/mechanism
MESH:D018149 Glucose Intolerance Fructose 4.9719165636
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2110696789
MESH:D006086 Graft vs Host Disease Methotrexate 4.7816518429
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1311294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.3020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0011000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.2318665440 17276928 15929193
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 13.7918590720
MESH:D006505 Hepatitis Carbon Tetrachloride 13.7919900420 19110552
MESH:D006505 Hepatitis Thioacetamide 13.7916456712
MESH:D006529 Hepatomegaly Amiodarone 17.6215265979
MESH:D006529 Hepatomegaly Phenobarbital 17.6216109766
MESH:D006529 Hepatomegaly pirinixic acid 17.6218467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 17.6212621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.937520565
MESH:D006558 Herpes Genitalis Estradiol 4.6415709030
OMIM:612797 HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 12 marker/mechanism
MESH:D019584 Hot Flashes Estradiol 3.3717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.668697196 16354765 15340226 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 6.8916870215
MESH:D006930 Hyperalgesia rosiglitazone 6.8912083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1516899240
MESH:D006937 Hypercholesterolemia Amiodarone 8.048137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 8.0421332399
MESH:D006943 Hyperglycemia pirinixic acid 2.8520558911
MESH:D006946 Hyperinsulinism Fructose 4.5815752949 14757778 18360027 19008412 18563319
MESH:D006949 Hyperlipidemias Dietary Fats 8.3921332399
MESH:D006949 Hyperlipidemias Fructose 8.3915752949
MESH:D006938 Hyperlipoproteinemia Type II marker/mechanism 16030523
MESH:D006973 Hypertension Cyclosporine 11.1410903974
MESH:D006973 Hypertension Dexamethasone 11.1417042910
MESH:D006973 Hypertension Fructose 11.1414568997 14633139 19008412 14573337 16843071
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.1418670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7215338365
MESH:D015228 Hypertriglyceridemia Fructose 4.7519342510 19799862
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4416569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 10.3717991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 10.3718031379 8137927
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.3217937319
MESH:D007248 Infertility, Male Theophylline 6.3216988215
MESH:D007249 Inflammation Dexamethasone 17.3011099482 8960868
MESH:D007249 Inflammation Dietary Fats 17.3020412841
MESH:D007249 Inflammation Diethylnitrosamine 17.3018785209
MESH:D007249 Inflammation polyphenols 17.3016366677
MESH:D007249 Inflammation rosiglitazone 17.3012083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 17.3012878042 12200463
MESH:D007333 Insulin Resistance marker/mechanism 15504970
MESH:D007333 Insulin Resistance Dietary Fats 20.5418457598 11836018
MESH:D007333 Insulin Resistance Estradiol 20.5416393666 16627594
MESH:D007333 Insulin Resistance Fructose 20.5414573337 17133782 19342510 18563319 18057795 14633139 18981581 19799862 14757778 19008412 19586609
MESH:D007333 Insulin Resistance pirinixic acid 20.5416306350
MESH:D007333 Insulin Resistance rosiglitazone 20.5416306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0515604871
MESH:D007674 Kidney Diseases Acetaminophen 8.6712587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 8.6718776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 8.6715618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 15.2116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 15.2116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 15.2112371664
MESH:D007680 Kidney Neoplasms Estradiol 15.2115610895
MESH:D007805 Language Development Disorders Methotrexate 4.759562676
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.7919248655
MESH:D008052 Lipid Metabolism, Inborn Errors marker/mechanism
MESH:D008064 Lipidoses Amiodarone 3.2415342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 18.4617174718 17157831 16943688 11903743 11408273 17334410 16239168 21278145 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 18.4618296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 18.4620032147 19638242 18665156 18407596 18522880
MESH:D008103 Liver Cirrhosis Methotrexate 18.4614986274
MESH:D008103 Liver Cirrhosis Phenobarbital 18.4621047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.0616638106 13678700 18376398 18205269 15931870 12445421 15370692 12741479 14512876 17525996 18251166 11481614 17823541 18705752 12666154 12609069 15730626 16027843 16015684 15876570 12445418 17631135 18210741 18187930 17714472 18412020 17976157 18263696 16011737 18339082 18472332 20821823 15673190 10355542 18054572 18156304 17761835 14716833 15338365 15893842 12649538 18166357 14748882 17640975 12389079 15996030 17922224 12667390 17869086 16097048 16136751 18429990 17698563 17766677 16248980 18481824 15925388 16033810 18277467 18279442 18006644 15052691 12632514 17721639 18420326 12958196 18472094 12586293 14620537 15123356 17708605 17900296 14716496 18317297 17481882 15057751 17805973 15959796 12898905 16192424 12546737 17944888 15818738 12632512 18418968 14724832 15650968 17557913 18395095 16116963 18395914 15362042 17565644
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 10.0616718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.0614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.0615474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 10.0617347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.0612878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 10.0612175628 16126171 15288473 18032466 15075984 15716488 16097051 18458672 18615449 18295389 15465738 17629604 16489207 15095483 15362042 11682029 18606216 18380797 18416461 15474484 11481614 15316131 17050028 18395095 12891558 16248980 18263696 17355460 15334695 18031379 17127702 17292413 10677585 15078482 12531686 11172339 16511523 15288472 12085344 16343077 12679928 15158331 12557150 16098781 14739098
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 17.6917184895
MESH:D008107 Liver Diseases Acetaminophen 17.6916610002 19014921 12587719 12969438 16611625 19784758 11587558 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 17.6915720792 16246199 17285989 15830285 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 17.6917034775
MESH:D008107 Liver Diseases Phenobarbital 17.6919363144
MESH:D008107 Liver Diseases polyphenols 17.6916698588
MESH:D008107 Liver Diseases Thioacetamide 17.6915158337 18374380 16337175
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 14.3516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 14.3516899240 14706259
MESH:D017114 Liver Failure, Acute Thioacetamide 14.3515633222 15313186 12479984 17276928
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 15.957678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 15.9519294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 15.9518644402 20583210 20137499 19256749 19294768 10737359 18754104 20434301 19426721 2862719 12112319 19833225 18977376 20118626 20101389 20405173 21278145 9163691 19638242 20501860 19690152 19996281 18648771 19255062 20452335 19642983 19254457 21071580 15175105 20492335 19499222 18978307 12771043 21167192 19812893 2422723 19850985 16942905 15885732 19551842 21047994 19073162 19090486 19427195
MESH:D008113 Liver Neoplasms Phenobarbital 15.9519812893 8742319 19482888 19073162 21047994 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 15.9520007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.9516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 16.082876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 16.0812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 16.0817174075 18544905 9362446 18775883 18282651 18079962 18253720 19004024 19126423 19539802 17854601 3124819 16842330 17942915 18164116 19009564 18308698 18093689 19519916 16267830 21159647 2563599
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 16.086150874 17172636 18308698 1399818 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.0812151625
MESH:D008133 Long QT Syndrome Amiodarone 7.8217391786 15350150 11989578
MESH:D008133 Long QT Syndrome Quinidine 7.8215350150 11989578
MESH:D008171 Lung Diseases Amiodarone 6.7312587719
MESH:D008171 Lung Diseases Ozone 6.738266340 19066396
MESH:D017563 Lung Diseases, Interstitial Amiodarone 10.2518516814
MESH:D017563 Lung Diseases, Interstitial Methotrexate 10.2518516814
MESH:D055370 Lung Injury Ozone 3.4820417186
MESH:D008175 Lung Neoplasms Dexamethasone 4.4411195469 15824018
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.4420970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Ozone 4.448597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.4419555203 11884234
MESH:D008223 Lymphoma Methotrexate 3.6817352296
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.4416891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 5.4416827153
MESH:D020149 Manganese Poisoning Estradiol 4.0919453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2019513568
MESH:D024821 Metabolic Syndrome X Fructose 9.0118497449 19165636 17098227 17261469 16815490
MESH:D024821 Metabolic Syndrome X rosiglitazone 9.0117261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4016801185
MESH:D008679 Metaplasia Ozone 4.7210496685
MESH:D052016 Mucositis Methotrexate 4.9017488658
MESH:D009101 Multiple Myeloma Dexamethasone 3.2416118317 15867202 15744524
MESH:D009135 Muscular Diseases pirinixic acid 3.1416239165
MESH:D009181 Mycoses Amiodarone 4.5117974566 12754197
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.329809623
MESH:D009203 Myocardial Infarction pirinixic acid 1.9819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.2816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.2816411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0917484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.0818551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.087678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.419029167 3581430
MESH:D009369 Neoplasms pirinixic acid 1.7717405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3517289903
MESH:D009395 Nephritis, Interstitial Tetracycline 4.409884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9718481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 8.2616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.2614600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.1618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.1620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7320387270
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.579802331
MESH:D009765 Obesity Dietary Fats 6.9020518802 17217161 11836018 21332399 16723640 19632207 18457598 18674790 20132043
MESH:D009765 Obesity Fructose 6.9017707055 18585860
MESH:D009765 Obesity pirinixic acid 6.9020558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.7912819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.7916049721
MESH:D010018 Osteomalacia Phenobarbital 3.9817016548
MESH:D010051 Ovarian Neoplasms Estradiol 2.1019401270
MESH:D010146 Pain Acetaminophen 2.1016870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 4.7716540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 4.7716965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3411578682
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 12.4920133375
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 12.4912520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.0411026799
MESH:D010538 Peritonitis Ozone 3.7616369182
MESH:D011014 Pneumonia Ozone 4.0118929643 18381685 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2018163543
MESH:D011230 Precancerous Conditions Cyclosporine 13.4312371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 13.432563599
MESH:D011230 Precancerous Conditions Phenobarbital 13.432563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3321297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8111399792 11896295 11118676 11222880
MESH:D017096 Prion Diseases Tetracycline 5.0310903871
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5420887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.2116740699
MESH:D011537 Pruritus Ethinyl Estradiol 8.7615861022 16919318
MESH:D011537 Pruritus Naloxone 8.7615861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.1112752131
MESH:D011565 Psoriasis Cyclosporine 5.4316882103
MESH:D011565 Psoriasis Methotrexate 5.4317410198
MESH:D029424 Pulmonary Disease, Chronic Obstructive Theophylline 4.8418983928
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7011597910 12490602 12832656
MESH:D051437 Renal Insufficiency Methotrexate 4.3417352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.2019058328
MESH:D012120 Respiration Disorders Chlorine 4.8218579056
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.6711700416 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4718990726
MESH:D012640 Seizures 2,4-dinitrotoluene 8.3018551238
MESH:D012640 Seizures 2,6-dinitrotoluene 8.3018551238
MESH:D012640 Seizures Phenobarbital 8.303137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.446407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7018724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.8616192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5516709447
MESH:D013272 Stomach Diseases Dexamethasone 9.1715472012
MESH:D013272 Stomach Diseases Omeprazole 9.1718545984
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013276 Stomach Ulcer Amiodarone 10.2518087811
MESH:D013276 Stomach Ulcer Dexamethasone 10.2515138204
MESH:D013276 Stomach Ulcer Omeprazole 10.2518237397 11906479 16755016 17977527 10750652 15991576
MESH:D013576 Syndactyly Methotrexate 4.679562676
MESH:D013610 Tachycardia Amiodarone 3.9311238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8319225199
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.8617997062
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.4220133375
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8315669648
MESH:D013959 Thyroid Diseases Amiodarone 10.7619731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.7612697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.397505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 10.391399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 10.3915710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.4918020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.3019048282
MESH:D016171 Torsades de Pointes Amiodarone 3.8111989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 4.4916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.4916049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.7210091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.7210091137
MESH:D014581 Urticaria Acetaminophen 2.6310982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9414692618
MESH:D014605 Uveitis Cyclosporine 10.471336536
MESH:D014605 Uveitis Dexamethasone 10.471336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2015869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8615886252
MESH:D015430 Weight Gain Dietary Fats 3.4216723640
MESH:D014985 Xerophthalmia Cyclosporine 4.0517120751
Pathway ID Pathway Name
KEGG:00561 Glycerolipid metabolism
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA230
    • No data
    Releated disease ID Related disease Name
    PA443421Arrhythmias, Cardiac
    PA443459Atrial Fibrillation
    PA159018367Brugada syndrome
    PA443633Cardiomyopathy, Hypertrophic
    PA443797Coronary Disease
    PA446379Death, Sudden, Cardiac
    PA444368Heart Diseases
    PA444807Long QT Syndrome
    PA445769Sudden Infant Death
    PA445848Thromboembolism
    PA446294Torsades de Pointes
    PA446028Ventricular Fibrillation
    PA447054Stroke
    PA445019Myocardial Infarction
    PA443425Arteriosclerosis
    PA444528Hyperlipidemias
    PA446120Hypertriglyceridemia
    PA443635Cardiovascular Diseases
    PA444516Hypercholesterolemia
    PA443886Diabetes Mellitus
    PA443796Coronary Artery Disease
    PA446414Carotid Stenosis
    Releated drug ID Related drug Name
    PA164712547Beta blocking agents, selective
    PA451906warfarin
    PA133950441hmg coa reductase inhibitors
    PA449688fluvastatin
    PA449096colestipol
    PA450480metoprolol
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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