AutismKB 2.0

Annotation Detail for LLGL2


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Basic Information Top
Gene Symbol:LLGL2 ( HGL,LGL2 )
Gene Full Name: lethal giant larvae homolog 2 (Drosophila)
Band: 17q25.1
Quick LinksEntrez ID:3993; OMIM: NA; Uniprot ID:L2GL2_HUMAN; ENSEMBL ID: ENSG00000073350; HGNC ID: 6629
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2237Neoplasm metastasis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of LLGL2 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of LLGL2 mRNAdecreases expression 20106945
D004958 Estradiol ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA1 protein binds to LLGL2 gene]]affects binding|affects reaction|increases reaction 17962382
D004958 Estradiol ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to LLGL2 gene]]affects binding|affects reaction|increases reaction 17962382
D004958 Estradiol Estradiol promotes the reaction [ESR1 protein binds to LLGL2 gene]affects binding|increases reaction 17962382
C006253 pirinixic acid pirinixic acid results in increased expression of LLGL2 mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D000230 Adenocarcinoma Estradiol 2.1711473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.1116434500
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5719483382
MESH:D001943 Breast Neoplasms Estradiol 2.1017289903 12948864 19861407 17261762 17018787 16675129 18497071 14630087
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0916111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.3416192424 15700767 16124888 18705752 16050911 15721981 3786805 15673190 10355542 16227642 16011737 16097048
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1318788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1316924424
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.4612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.4618566989
MESH:D002779 Cholestasis Cyclosporine 8.7419486331
MESH:D002779 Cholestasis pirinixic acid 8.7419176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D003928 Diabetic Nephropathies Estradiol 3.7819279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.1215998439 4309450 3786805 21278145 16177239 17522070 3732212 7440962 10092053 10915739 19085960 2869522 15968718 7179309 15027814 16227642 19336974 9327722 6623471 6884620 11566570 7120509
MESH:D004487 Edema pirinixic acid 2.9012083418
MESH:D016889 Endometrial Neoplasms Estradiol 3.2218566989 11473722 19148513
MESH:D005234 Fatty Liver Carbon Tetrachloride 15.6412631006 16045604 12795759 61145 16239168 17595544 19224547 15959796
MESH:D005234 Fatty Liver Cyclosporine 15.6419224547
MESH:D005234 Fatty Liver pirinixic acid 15.6419236843 20131406
MESH:D005355 Fibrosis Carbon Tetrachloride 10.6018705752
MESH:D005355 Fibrosis Cyclosporine 10.6012639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.858708960
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.0515720958
MESH:D006505 Hepatitis Carbon Tetrachloride 4.1019110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.5519772884 16221962 19176532 18467677
MESH:D006558 Herpes Genitalis Estradiol 5.7615709030
MESH:D019584 Hot Flashes Estradiol 4.4717088409
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.1616899240
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D006973 Hypertension Cyclosporine 2.2110903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.6515338365
MESH:D007333 Insulin Resistance Estradiol 8.0116393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 8.0116306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.1615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.628314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.6215618244
MESH:D007680 Kidney Neoplasms Cyclosporine 8.4412371664
MESH:D007680 Kidney Neoplasms Estradiol 8.4415610895
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 3.0011903743 16239168 11408273 17174718 16943688 21278145 17157831 17334410 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.6415650968 14716496 15893842 17714472 14716833 17823541 17944888 16136751 18705752 18205269 20821823 12666154 16011737 17805973 14724832 15370692 18187930 14512876 18339082 15673190 18481824 18395914 16033810 17708605 12586293 18472094 15996030 15818738 18156304 17761835 18277467 15931870 17766677 13678700 16027843 16248980 15057751 17698563 15876570 17557913 10355542 12632514 15362042 18210741 12958196 15730626 18429990 15338365 16192424 12389079 18263696 14620537 18420326 18054572 17976157 17869086 18166357 18006644 18395095 15925388 17631135 12546737 12632512 18412020 16097048 12445418 17565644 17922224 17640975 17481882 12741479 12898905 18472332 12649538 17721639 18251166 18317297 18376398 14748882 16638106 12609069 16015684 15052691 16116963 17525996 18418968 12667390 15959796 15123356 12445421 18279442 17900296 11481614
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.6414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6415474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1516246199 17285989 15830285 15720792 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.7315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0816899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.8419294768
MESH:D008113 Liver Neoplasms pirinixic acid 4.8415890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.8415583823 12014681
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7911807958 16891317 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.2119453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.5116801185
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.2916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.2916411023
MESH:D009369 Neoplasms pirinixic acid 2.1117405874
MESH:D009389 Neovascularization, Pathologic Estradiol 4.3617289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6519348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 4.1611399458 16427766
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010051 Ovarian Neoplasms Estradiol 2.3119401270
MESH:D011230 Precancerous Conditions Cyclosporine 3.5912371664
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.3120887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0216740699
MESH:D011565 Psoriasis Cyclosporine 2.3316882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D013978 Tibial Fractures Estradiol 5.4119048282
MESH:D014605 Uveitis Cyclosporine 4.711336536
MESH:D014985 Xerophthalmia Cyclosporine 5.1617120751
Pathway ID Pathway Name
KEGG:04530 Tight junction
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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