AutismKB 2.0

Annotation Detail for FADS3


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Basic Information Top
Gene Symbol:FADS3 ( CYB5RP,LLCDL3 )
Gene Full Name: fatty acid desaturase 3
Band: 11q12.2
Quick LinksEntrez ID:3995; OMIM: 606150; Uniprot ID:FADS3_HUMAN; ENSEMBL ID: ENSG00000221968; HGNC ID: 3576
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5996oleate biosynthesis II (animals)
No data
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
HDL cholesterol
sphingolipid concentrations
METABOLIC
LDL cholesterol
triglycerides
cholesterol, total
Desease Name
Sphingolipid concentrations
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of FADS3 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of FADS3 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of FADS3 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of FADS3 mRNAincreases expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of FADS3 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of FADS3 mRNAdecreases expression 18042831
D004958 Estradiol Estradiol results in increased expression of FADS3 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FADS3 mRNAaffects cotreatment|increases expression 17942748
C041786 palm oil palm oil results in decreased expression of FADS3 mRNAdecreases expression 18042831
D010656 Phenylephrine Phenylephrine results in increased expression of FADS3 mRNAincreases expression 18158353
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FADS3 mRNAaffects binding|decreases expression|increases activity 19710929
D012643 Selenium Selenium results in increased expression of FADS3 mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FADS3 mRNAaffects cotreatment|increases expression 17942748
D014635 Valproic Acid Valproic Acid results in increased expression of FADS3 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.5911752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.598875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9819490988
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.0820127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.0811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0814692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.686695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.1816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.1816835633
MESH:D000550 Amblyopia Valproic Acid 5.3317688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6217497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.1617460149
MESH:D001161 Arteriosclerosis Dietary Fats 10.1515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.1511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8515238991 18558336 20603192 18985861 17507914 18940202 18316065 16609825 19460635 18177632 17157402 18775368 19232924 17688650 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 3.1017594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.9519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.9512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.1315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.138888407
MESH:D001919 Bradycardia Phenylephrine 4.6315306635
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9220146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 1.9220435547
MESH:D001943 Breast Neoplasms Estradiol 1.9219861407 17289903 17261762 18497071 12948864 17018787 14630087 16675129
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.583084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.5821507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5816924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0620419170
MESH:D006332 Cardiomegaly Phenylephrine 6.9815728586 17287366 17124262 16170337 11179087 11754973
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.9818850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.7012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.7018566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis Cyclosporine 13.5819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.5817681005 17110522 16105132 15861022 16919318 17333356 11677210
MESH:D002779 Cholestasis pirinixic acid 13.5819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1212621046 8697196 16354765 15668235 15340226
MESH:D003092 Colitis Selenium 3.8517936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4915322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.4917688650 16575769 8888407
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.0916485898 12594235 19923254 12958197 10774834 15968718 12153990 16227642 11743745 11461765 15619225 18071297 11529661 17906064 12540782 11287661 11739529 14986274 12392966 19739265 16393943 19164858 19370779 19420014 14550746 17522070 2444490 11834606 17562736 11421492 12705907 16109766 16781746 16081117 18713872 19416960 14725611 16177239 10663392 10915739 19085960
MESH:D056486 Drug-Induced Liver Injury Selenium 9.0915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.0920420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.0919641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4918367378
MESH:D004421 Dystonia Valproic Acid 4.111851702
MESH:D004487 Edema pirinixic acid 6.7212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0015322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2512538720
MESH:D016889 Endometrial Neoplasms Estradiol 3.0118566989 19148513 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0710568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.233659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.0116628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9618234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.636426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.377750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.153659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Cyclosporine 25.2719224547
MESH:D005234 Fatty Liver Dietary Fats 25.2718296743 19004024 17967931 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.2715345470
MESH:D005234 Fatty Liver pirinixic acid 25.2720131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 25.2719224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005315 Fetal Diseases Valproic Acid 4.9816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.198888407 18558336
MESH:D005355 Fibrosis Cyclosporine 15.1612168785 12639820
MESH:D005355 Fibrosis Dietary Fats 15.1618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.1620067830
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 7.0620558911
MESH:D006333 Heart Failure Selenium 7.0617162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly pirinixic acid 8.5019772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.5012621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D019584 Hot Flashes Estradiol 3.8517088409
MESH:D006849 Hydrocephalus Valproic Acid 4.9517688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1416354765 16959395 8697196 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6521332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.6721332399
MESH:D006973 Hypertension Cyclosporine 8.7210903974
MESH:D006973 Hypertension Phenylephrine 8.728949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.7218850075 18670907
MESH:D006984 Hypertrophy Phenylephrine 4.6118502941 12791704
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5217937319
MESH:D007249 Inflammation Dietary Fats 5.0020412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0012878042 12200463
MESH:D007251 Influenza, Human Selenium 4.2916624496
MESH:D007333 Insulin Resistance Dietary Fats 12.4911836018 18457598
MESH:D007333 Insulin Resistance Estradiol 12.4916393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 12.4916306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Acetaminophen 10.1515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.1518776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 10.1515618244
MESH:D007676 Kidney Failure, Chronic Selenium 3.9416518626
MESH:D007680 Kidney Neoplasms Cyclosporine 7.4212371664
MESH:D007680 Kidney Neoplasms Estradiol 7.4215610895
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1617596541 16294345
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9018296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4112878042
MESH:D008107 Liver Diseases Acetaminophen 1.6412969438 16611625 19014921 19460945 19784758 12587719 16610002 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2917185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 10.839163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.8321137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 10.8320007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.8316984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.918603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9112151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3617228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.3914755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3920135361 17053015 6695378 20869020 18520028 20064080 18569708 18816296 20464547
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3919555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.1311807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.1315318939
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008654 Mesothelioma Selenium 2.8115107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D008881 Migraine Disorders Valproic Acid 3.2318765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.088888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1817596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.3916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.3916411023
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9011141357
MESH:D009369 Neoplasms pirinixic acid 4.9017405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8117289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3318481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 9.6811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.6814600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.1616359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D009765 Obesity Dietary Fats 4.4711836018 21332399 18457598 20132043 19632207 17217161 18674790 20518802 16723640
MESH:D009765 Obesity pirinixic acid 4.4720558911
MESH:D010051 Ovarian Neoplasms Estradiol 2.2319401270
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.7411222880 11896295 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.7420603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9420887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1017292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.1016740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.3915861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.6412752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2319155313
MESH:D012559 Schizophrenia Valproic Acid 2.0715737665 19110320
MESH:D012640 Seizures Valproic Acid 2.771511512 16876388 14763951 11738929 3137016 15475178 11044598 17978042
MESH:D012852 Sinusitis Phenylephrine 4.787327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5510029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8219490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6412833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013978 Tibial Fractures Estradiol 4.7819048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.3317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.603119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2017053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.718888407
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5914671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D015430 Weight Gain Dietary Fats 3.7916723640
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27975
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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