AutismKB 2.0

Annotation Detail for MYO18A


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MYO18A ( DKFZp686L0243,KIAA0216,MYSPDZ,SPR210 )
Gene Full Name: myosin XVIIIA
Band: 17q11.2
Quick LinksEntrez ID:399687; OMIM: 610067; Uniprot ID:MY18A_HUMAN; ENSEMBL ID: ENSG00000196535; HGNC ID: 31104
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
No data
Pathway IDPathway Name
P00044Nicotinic acetylcholine receptor signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of MYO18A mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of MYO18A mRNAaffects expression 17562736
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MYO18A mRNAaffects expression 17484886
C014347 decitabine decitabine results in decreased expression of MYO18A mRNAdecreases expression 19363521
C014347 decitabine TP53 protein affects the reaction [decitabine results in decreased expression of MYO18A mRNA]affects reaction|decreases expression 19363521
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of MYO18A mRNAaffects expression 17555576
C059514 resveratrol resveratrol results in decreased expression of MYO18A mRNAdecreases expression 12569576
D013629 Tamoxifen Tamoxifen affects the expression of MYO18A mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D058186 Acute Kidney Injury resveratrol 4.1316538975
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.333712494
MESH:D000236 Adenoma resveratrol 7.3315688382
MESH:D000544 Alzheimer Disease resveratrol 2.6216162502 16183991
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.8915885639
MESH:D001169 Arthritis, Experimental resveratrol 7.8917115116
MESH:D050197 Atherosclerosis resveratrol 3.4216873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.461440618 11289319
MESH:D002545 Brain Ischemia resveratrol 4.6817600658
MESH:D001943 Breast Neoplasms decitabine 2.0019208741 18320071
MESH:D001943 Breast Neoplasms resveratrol 2.0017651959 17534123 16393696
MESH:D001943 Breast Neoplasms Tamoxifen 2.0019410462 18629630 16273361 18425577 18815881 19142967 20005174 15668708 19059307 19011961 17440819 19084267 16818667 19155303 21152245 19289846 19200415 15565566 17242785 18351453 18984771 16202921 18821012 20135344 19103187 18855134 17261762 20544844 21138602 11161223 17049068 18997820 19189212 17893378 20065188 20390343 16873071 19487384 19244106 19189210 19288272 19221464 19066611 19115204 20859285
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.1415721981 10355542 15673190 16124888 16227642 3786805 15700767 16011737 18705752 16050911 16097048 16192424
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.263581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.263084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.2618788625
MESH:D006528 Carcinoma, Hepatocellular resveratrol 9.2619321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 9.2616924424
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.9916675471
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D002294 Carcinoma, Squamous Cell decitabine 5.1419215824
MESH:D002294 Carcinoma, Squamous Cell resveratrol 5.1416227395
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D002318 Cardiovascular Diseases resveratrol 3.6515458977
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.947505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.549022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.5416919318 17110522 15861022 17681005 11677210 16105132 17333356
MESH:D003092 Colitis resveratrol 4.4916474422
MESH:D003110 Colonic Neoplasms decitabine 4.0917616700
MESH:D003110 Colonic Neoplasms resveratrol 4.0916338953
MESH:D015179 Colorectal Neoplasms decitabine 2.7718981723
MESH:D015179 Colorectal Neoplasms resveratrol 2.7716550006
MESH:D003327 Coronary Disease resveratrol 3.9216507316
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.158156756 8970840 12868966 11298694 2524372 11906362 14531868 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.793621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 4.0016873680
MESH:D003928 Diabetic Nephropathies resveratrol 9.8816286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.8819279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.581440618 18692083 6482804 18289764 11289319 9328219 6679447 8291058 9653073 18648102 9022650 16192314 7440962
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5819420014 14986274 10663392 10774834 11529661 16081117 16485898 19085960 11743745 18071297 19370779 15968718 18713872 19416960 19164858 16177239 14550746 14725611 11739529 17522070 12153990 16781746 2444490 11421492 12392966 11461765 11287661 11834606 15619225 19739265 12540782 12958197 16393943 16227642 19923254 16109766 10915739 12705907 17906064 17562736 12594235
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.5817522070 7179309 21278145 19085960 7440962 6623471 2869522 3732212 15968718 10092053 10915739 16177239 9327722 7120509 4309450 6884620 3786805 15027814 19336974 11566570 15998439 16227642
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004487 Edema resveratrol 3.648985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 17.3612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 17.3617872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 17.3619031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.5619294695
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2117893378 19155303 20544844 16202921
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.2117923197
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.163581430
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.8017595544 12795759 16239168 15959796 19224547 12631006 16045604 61145
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.8015345470
MESH:D005234 Fatty Liver Tamoxifen 14.8014986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005355 Fibrosis Carbon Tetrachloride 3.8118705752
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006258 Head and Neck Neoplasms decitabine 3.6619215824
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 10.346705139
MESH:D006505 Hepatitis Carbon Tetrachloride 10.3419110552 19900420
MESH:D006561 Herpes Simplex resveratrol 4.5716876885
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9316899240
MESH:D006937 Hypercholesterolemia resveratrol 4.2917188708
MESH:D006949 Hyperlipidemias resveratrol 4.3316873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.4515338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.5717488730
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 5.0117600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male decitabine 7.3117581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.3117937319
MESH:D007249 Inflammation resveratrol 5.6816366677
MESH:D007249 Inflammation Tamoxifen 5.6819457130
MESH:D007251 Influenza, Human resveratrol 4.9916624496
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.468074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.3412587719 15629191
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.176582329
MESH:D007680 Kidney Neoplasms Tamoxifen 8.1718625569
MESH:D007938 Leukemia decitabine 3.1919235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.2819117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4118206229 18704418 19387464 17679729 19010910 18460780
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.9118055864
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.7516087638
MESH:D008064 Lipidoses Tamoxifen 3.3515342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9417174718 16943688 11903743 17157831 17334410 16221502 21278145 16239168 11408273
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3515034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.5415057751 12632514 17565644 12741479 18156304 12445418 15876570 14748882 12445421 14716496 18263696 18472094 14716833 17922224 16011737 17805973 15959796 15818738 12958196 15362042 16192424 15931870 16027843 17557913 18420326 16248980 18317297 16638106 17766677 18210741 17944888 17698563 17976157 15925388 16116963 17869086 17640975 15996030 15650968 18472332 18054572 12389079 17525996 14512876 17631135 17481882 12667390 17708605 18418968 18251166 20821823 12666154 18705752 17714472 18166357 15730626 13678700 14620537 16033810 15673190 16097048 17761835 18395095 18376398 11481614 12586293 18481824 18205269 17900296 12546737 12632512 12649538 14724832 15123356 15893842 12898905 18187930 18339082 16015684 18412020 18429990 15338365 12609069 18277467 15052691 15370692 18279442 16136751 10355542 17823541 17721639 18006644 18395914
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.5418564211
MESH:D008107 Liver Diseases Acetaminophen 4.0916611625 19014921 12587719 12969438 16610002 19460945 19784758 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0915720792 15830285 17285989 16246199 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.3116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.3114706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 8.0519294768
MESH:D008113 Liver Neoplasms resveratrol 8.0519073162 19812893 19321006 20405173
MESH:D008113 Liver Neoplasms Tamoxifen 8.0516684651
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.451399818 598648 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.4515583823 12014681
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D008223 Lymphoma decitabine 3.6119470736
MESH:D016393 Lymphoma, B-Cell resveratrol 4.6017088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 4.1014749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 11.3615688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 11.3619428831
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 6.738985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.7319196722 19196723 14580682 16827153 11731420
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma decitabine 5.4216505122 17785578
MESH:D008545 Melanoma resveratrol 5.4217992120
MESH:D008545 Melanoma Tamoxifen 5.4212393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008659 Metabolic Diseases resveratrol 4.6617112576
MESH:D009101 Multiple Myeloma decitabine 8.1618172295
MESH:D009101 Multiple Myeloma resveratrol 8.1616267019 17164350 16490592 14749477 17049120 17935668
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.2717962980
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5218608210 19157545 16882708 19010910
MESH:D009203 Myocardial Infarction resveratrol 3.1216456233 16525036 17125593 17188708 17015251 16317513
MESH:D017202 Myocardial Ischemia resveratrol 4.2317125593 17015251
MESH:D009205 Myocarditis resveratrol 5.1617322642
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.013581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.0119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms decitabine 2.8319470736 19116145 17925555
MESH:D009374 Neoplasms, Experimental resveratrol 4.368985016
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419189210 19200415 19196722
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.086679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.1418514411
MESH:D019636 Neurodegenerative Diseases resveratrol 9.1417652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.7017929310
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.684026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.5617513867
MESH:D010051 Ovarian Neoplasms decitabine 2.7219259094 19331143
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms decitabine 2.8419294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 4.5716679765
MESH:D055728 Primary Myelofibrosis decitabine 5.0917616702
MESH:D011471 Prostatic Neoplasms resveratrol 3.3116731767 17804756 17718901 17675339 17636462 15767336
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.3115067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D051436 Renal Insufficiency, Chronic resveratrol 6.0316325855
MESH:D015427 Reperfusion Injury resveratrol 3.3916314181 17058453 17520802 16317513 15827377
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D012208 Rhabdomyosarcoma decitabine 4.7119155313
MESH:D012878 Skin Neoplasms resveratrol 3.1415837718 8985016
MESH:D013088 Spermatocele Ethinyl Estradiol 13.0916709447
MESH:D013088 Spermatocele Tamoxifen 13.0916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.7516321402
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.956582329 1399818 3712494 7505956 6587162
MESH:D013964 Thyroid Neoplasms decitabine 7.9517967635
MESH:D014062 Tongue Neoplasms resveratrol 4.4816227395
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.898074119
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.8919087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.898653321 17572228 16712894
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.3717473185
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 10.6214692618
MESH:D014594 Uterine Neoplasms resveratrol 10.6217044934
MESH:D014604 Uveal Neoplasms decitabine 5.3617785578
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.6617488730
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved