AutismKB 2.0

Annotation Detail for ACCN1


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Basic Information Top
Gene Symbol:ACCN1 ( ACCN,ASIC2,ASIC2a,BNC1,BNaC1,MDEG,hBNaC1 )
Gene Full Name: amiloride-sensitive cation channel 1, neuronal
Band: 17q12
Quick LinksEntrez ID:40; OMIM: 601784; Uniprot ID:ACCN1_HUMAN; ENSEMBL ID: ENSG00000108684; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1709Parkinson disease
1860Brain tumor
Desease Name
multiple sclerosis
IMMUNE
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000143 Acids [Acids binds to and affects the activity of ACCN1 protein] which results in increased secretion of Adenosine Triphosphateaffects activity|affects binding|increases secretion 19860742
D000255 Adenosine Triphosphate [Acids binds to and affects the activity of ACCN1 protein] which results in increased secretion of Adenosine Triphosphateaffects activity|affects binding|increases secretion 19860742
D000584 Amiloride Amiloride binds to and results in decreased activity of ACCN1 proteinaffects binding|decreases activity 19860742
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ACCN1 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ACCN1 mRNAdecreases expression 16644059
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ACCN1 mRNAaffects cotreatment|increases expression 16931933
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ACCN1 mRNAaffects cotreatment|increases expression 16931933
D004958 Estradiol Estradiol affects the expression of ACCN1 mRNAaffects expression 15598610
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ACCN1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACCN1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ACCN1 mRNAincreases expression 12075121
D005682 Gadolinium Gadolinium binds to and results in decreased activity of ACCN1 proteinaffects binding|decreases activity 19860742
D019469 Indinavir [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ACCN1 mRNAaffects cotreatment|increases expression 16931933
D010862 Pilocarpine Pilocarpine results in decreased expression of ACCN1 mRNA alternative formdecreases expression 11162239
D019258 Saquinavir [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ACCN1 mRNAaffects cotreatment|increases expression 16931933
D018038 Sodium Selenite Sodium Selenite results in decreased expression of ACCN1 mRNAdecreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACCN1 mRNAaffects cotreatment|increases expression 17942748
C025643 vinclozolin vinclozolin affects the expression of ACCN1 mRNAaffects expression 19015723
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ACCN1 mRNAaffects cotreatment|increases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ACCN1 mRNAaffects cotreatment|increases expression 16931933
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8714514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.849612607
MESH:D000230 Adenocarcinoma Estradiol 4.2211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2214692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4016835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D001008 Anxiety Disorders vinclozolin 3.6419015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D001321 Autistic Disorder marker/mechanism 17376794
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D001943 Breast Neoplasms Estradiol 1.9412948864 17018787 14630087 17261762 17289903 18497071 19861407 16675129
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7916192424 16097048 3786805 16124888 10355542 16011737 15721981 18705752 15700767 16050911 15673190 16227642
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 2.9918788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 2.9916924424
MESH:D002295 Carcinoma, Transitional Cell Amiloride 5.0814644129
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3718850075 18670907 16120746
MESH:D002386 Cataract Adenosine Triphosphate 4.6115003327
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.7718566989
MESH:D002637 Chest Pain Acids 6.4315447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8811677210 15861022 16919318 17333356 17681005 17110522 16105132
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.108697196 15340226 16354765 15668235 12621046
MESH:D003092 Colitis Amiloride 5.1212065299
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 10048152 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.3514966744
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.7816285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4119279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.222869522 7440962 6884620 3786805 15027814 19336974 10092053 7120509 7179309 11566570 21278145 15998439 4309450 16227642 19085960 6623471 15968718 3732212 9327722 16177239 10915739 17522070
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.2215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2220420201
MESH:D004362 Drug Toxicity Lamivudine 13.8915040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 13.8911462148
MESH:D004362 Drug Toxicity Zidovudine 13.8915040536
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9318230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2012538720
MESH:D016889 Endometrial Neoplasms Estradiol 2.9818566989 19148513 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0210568697 9294722
MESH:D004827 Epilepsy Pilocarpine 4.6519700373 11162239 19439326
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.2315959796 16239168 12795759 19224547 17595544 61145 12631006 16045604
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.2315345470
MESH:D005234 Fatty Liver Zidovudine 13.2318299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 8.6418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.6420067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3316417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006130 Growth Disorders Amiloride 4.7519703807
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3311294989 10048152
MESH:D006402 Hematologic Diseases Zidovudine 4.7212579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6019900420 19110552
MESH:D006509 Hepatitis B Lamivudine 5.1017703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.1016476009 15631357 12044531 15274664 15309715
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9116120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.0615709030
MESH:D015658 HIV Infections Indinavir 15.5415388451 11363243 11141242
MESH:D015658 HIV Infections Lamivudine 15.5411141242 9296927 17530837 20032539
MESH:D015658 HIV Infections Saquinavir 15.5415388451 11141242
MESH:D015658 HIV Infections Zidovudine 15.5417358032 20032539 11141242 11698656 11363243
MESH:D019584 Hot Flashes Estradiol 3.7817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.088697196 18606429 16959395 15340226 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5516899240
MESH:D006973 Hypertension Amiloride 5.6018524855 15174897 19344079
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.6018670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1015338365
MESH:D020514 Hypokalemic Periodic Paralysis Amiloride 5.8719822448
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.6717937319
MESH:D007248 Infertility, Male vinclozolin 6.6716467254
MESH:D007249 Inflammation Amiloride 5.4317237260
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4312878042 12200463
MESH:D007333 Insulin Resistance Estradiol 7.4416393666 16627594
MESH:D007333 Insulin Resistance Sodium Selenite 7.4414714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007674 Kidney Diseases Estradiol 2.5815618244
MESH:D007680 Kidney Neoplasms Estradiol 7.6715610895
MESH:D007680 Kidney Neoplasms Zidovudine 7.6712579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.4220370541
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7516417039
MESH:D056929 Liddle Syndrome Amiloride 5.9819344079
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8111903743 21278145 17157831 16239168 17334410 11408273 17174718 16221502 16943688
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4312632514 12958196 15818738 10355542 15362042 15052691 18251166 16192424 15673190 12632512 17557913 17631135 15123356 16033810 17714472 16097048 12546737 15876570 12741479 17640975 18376398 12445421 12586293 17900296 15730626 12667390 18339082 17525996 18429990 18205269 16027843 13678700 15996030 18187930 17761835 18418968 17805973 18420326 12898905 12609069 17708605 18395095 16248980 18156304 16015684 17976157 16638106 16011737 15931870 14716833 18472094 18263696 12649538 17766677 16116963 15959796 17565644 18279442 12389079 17721639 14748882 14512876 15057751 18395914 18412020 15338365 15925388 18317297 15370692 18166357 12666154 15650968 18006644 18054572 18472332 14620537 18705752 14716496 20821823 17944888 17698563 14724832 18277467 18210741 12445418 17922224 18481824 15893842 17869086 17481882 17823541 11481614 16136751
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4312878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0816246199 15830285 17285989 15720792 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6916899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.4019294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.4016984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.7612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.7612151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5219555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 2.5218800350
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0614737004
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5617203775 11807958 11408345 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.5119453300
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.8717358032
MESH:D009164 Mycobacterium Infections Indinavir 5.4421442799
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2816810080
MESH:D009361 Neoplasm Invasiveness Amiloride 5.3114644129
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7517289903
MESH:D009421 Nervous System Malformations Estradiol 16.6411399458 16427766
MESH:D009421 Nervous System Malformations Pilocarpine 16.6415987249
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.6414600291
MESH:D010051 Ovarian Neoplasms Estradiol 2.2219401270
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.5611896295 11399792 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.5618220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.9518220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8920887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.2616740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.2618760546
MESH:D011472 Prostatitis vinclozolin 4.9518629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012206 Rhabdomyolysis Lamivudine 5.569296927
MESH:D012640 Seizures Pilocarpine 4.4619660546 7750514
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D013226 Status Epilepticus Pilocarpine 6.2915857427 19951488 19570321 11259499 19430551 15987249 19055492
MESH:D013274 Stomach Neoplasms Zidovudine 2.4717696246
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013978 Tibial Fractures Estradiol 4.7219048282
MESH:D014202 Tremor Pilocarpine 5.8317594079
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D014625 Vaginal Neoplasms Zidovudine 4.7712579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5414671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
Pathway ID Pathway Name
KEGG:04742 Taste transduction
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00594 blocker Riva-Amilzide 5/50 mg Sodium channel blockers;Diuretics
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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