AutismKB 2.0

Annotation Detail for ARL1


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Basic Information Top
Gene Symbol:ARL1 ( ARFL1 )
Gene Full Name: ADP-ribosylation factor-like 1
Band: 12q23.2
Quick LinksEntrez ID:400; OMIM: 603425; Uniprot ID:ARL1_HUMAN; ENSEMBL ID: ENSG00000120805; HGNC ID: 692
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00029Huntington disease
P00034Integrin signalling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ARL1 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ARL1 mRNAdecreases expression 20018196
D016572 Cyclosporine Cyclosporine results in increased expression of ARL1 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ARL1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARL1 mRNAaffects cotreatment|increases expression 17942748
D020849 Raloxifene Raloxifene affects the expression of ARL1 mRNAaffects expression 16079270
D012402 Rotenone Rotenone results in decreased expression of ARL1 mRNAdecreases expression 19013527
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARL1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ARL1 mRNAincreases expression 18796159
C066340 tolcapone tolcapone binds to ARL1 proteinaffects binding 19783845
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1811752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.6711080934
MESH:D000419 Albuminuria Raloxifene 4.8817451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 4.8415800139
MESH:D000544 Alzheimer Disease tolcapone 4.8420150427
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001930 Brain Injuries Raloxifene 4.7816580743
MESH:D001943 Breast Neoplasms Raloxifene 2.1116912660 15775269 16837676 15572757 17595753 17049068 15758505 17261762 17242785 17893378 17952589 17440819
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1120435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.3017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4916120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6015775269
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0912371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Cyclosporine 8.3719486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.3717110522 16919318 15861022 17681005 17333356 11677210 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1916354765 8697196 12621046 15668235 15340226
MESH:D003072 Cognition Disorders Raloxifene 4.9215800139
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003866 Depressive Disorder tolcapone 4.477768276 11224284
MESH:D003865 Depressive Disorder, Major Raloxifene 10.9717474826
MESH:D003865 Depressive Disorder, Major tolcapone 10.9710440460
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Raloxifene 4.1517308373 17451421 15920148
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.3620420201
MESH:D056486 Drug-Induced Liver Injury tolcapone 4.3619783845 16604736
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.7711455177
MESH:D004487 Edema Raloxifene 7.6715860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.6712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2816714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.0715845917
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1220426865
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 6.3219578428
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Cyclosporine 14.5719224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.5715345470
MESH:D005234 Fatty Liver Raloxifene 14.5717473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Cyclosporine 9.5212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.5220067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.6911110106
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2016120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.428697196 18606429 16959395 15340226 16354765
MESH:D006973 Hypertension Cyclosporine 9.0410903974
MESH:D006973 Hypertension Raloxifene 9.0417577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 9.0418670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.468314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D007889 Leiomyoma Raloxifene 4.7616973256
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2412151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.9315863610
MESH:D009101 Multiple Myeloma Raloxifene 3.6016497877
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009232 Myxoma Raloxifene 5.9316343187
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5018481113 19348381
MESH:D009410 Nerve Degeneration Rotenone 4.0617356569 18619942 15790535
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D010024 Osteoporosis Raloxifene 3.5317882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4917823083 17893378 15758505 15579764
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010300 Parkinson Disease Rotenone 6.1211535288 15451049 11445065 16140633 16412576 18191903 18619942 19114014 19232380
MESH:D010300 Parkinson Disease tolcapone 6.1211746615 20216409 17089403 7566641 10651109 9754991 11432539 9708959 8739811 11586115 19783845 20334432 11793426 9305320 9333106 8635184 19578428 16758261 9591521 1977408 18328768
MESH:D020734 Parkinsonian Disorders Rotenone 4.3015795934 15927086 18197244 15574749
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311896295 11399792 11222880 11118676
MESH:D011471 Prostatic Neoplasms Raloxifene 3.5715731164 16536755 16220300
MESH:D011537 Pruritus Ethinyl Estradiol 3.6515861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011693 Purpura Raloxifene 5.9315770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D020521 Stroke Raloxifene 4.0116837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013978 Tibial Fractures Raloxifene 5.5819048282
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 6.3219578428
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 2.8917572228
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.5816837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D014820 Vitiligo tolcapone 5.4710573327
MESH:D014846 Vulvar Neoplasms Raloxifene 5.9316343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB04315 - Guanosine-5'-Diphosphate
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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