AutismKB 2.0

Annotation Detail for LMO2


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Basic Information Top
Gene Symbol:LMO2 ( RBTN2,RBTNL1,RHOM2,TTG2 )
Gene Full Name: LIM domain only 2 (rhombotin-like 1)
Band: 11p13
Quick LinksEntrez ID:4005; OMIM: 180385; Uniprot ID:RBTN2_HUMAN; ENSEMBL ID: ENSG00000135363; HGNC ID: 6642
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers of haematopoietic and lymphoid tissues
Cancers
H00002Acute lymphoblastic leukemia (ALL) (Precursor T lymphoblastic leukemia)
Desease IDDesease Name
2051Leukemia
Desease Name
CANCER
Hodgkin lymphoma
No data
Desease Name
Leukemia, acute T-cell
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of LMO2 mRNAaffects expression 18648102
C006632 arsenic trioxide arsenic trioxide results in decreased expression of LMO2 mRNAdecreases expression 19128835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of LMO2 mRNAdecreases expression 20064835
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of LMO2 mRNAaffects expression 17484886
D010126 Ozone Ozone results in decreased expression of LMO2 mRNAdecreases expression 12763052
17095637
C467566 pomalidomide pomalidomide results in decreased expression of LMO2 mRNAdecreases expression 15292067
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5719825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5720127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.153712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.156695378
MESH:D000544 Alzheimer Disease Ozone 2.4915513908
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6115570426
MESH:D001249 Asthma Ozone 2.7117854713 16373670
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.541440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.0016206674
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0020146248 17474063
MESH:D016535 Bronchial Hyperreactivity Ozone 3.9318315731 16777450 18417511 19059883 15516495 17626835 14754758
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6811589617
MESH:D002100 Cachexia Ozone 5.2016183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2016227642 16192424 15700767 16050911 16097048 3786805 15673190 10355542 16011737 15721981 16124888 18705752
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.823581430 7296757
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.8215553829 16217749 11135700 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.8218788625
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4019014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4212490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1220419170
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.967505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.3819486331 9022650
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4515213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2111298694 11906362 8970840 14531868 2524372 18759878 12868966 8156756
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.843621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.1318692083 9653073 18648102 9022650 8291058 6482804 11289319 18289764 9328219 1440618 16192314 6679447 7440962
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.137120509 16177239 19336974 7440962 16227642 17522070 3732212 2869522 15998439 4309450 6884620 19085960 15027814 9327722 6623471 15968718 10092053 10915739 3786805 21278145 11566570 7179309
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.613581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.6112903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.6116530937
MESH:D005234 Fatty Liver arsenic trioxide 8.9715073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.9716045604 19224547 12795759 16239168 15959796 17595544 12631006 61145
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D005355 Fibrosis Carbon Tetrachloride 3.8718705752
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.6416904648
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8020471113
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 10.526705139
MESH:D006505 Hepatitis Carbon Tetrachloride 10.5219110552 19900420
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9916899240
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5015338365
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.549022650 8074119
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.236582329
MESH:D007938 Leukemia arsenic trioxide 2.9615070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1816467208 17050201 19850784 16968895 20471514
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4117107899 12679006 16112521 17869043 9834237 15213294 15748426 19225113 16823087 16891316 12712474 15622746 17712046 16966277 19642359 11161223 11468182 16330433 19035177 12018890 19075265 17217047 16331271 15336539 17649720
MESH:D015458 Leukemia, T-Cell marker/mechanism 2034676
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7316882451
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9621278145 16943688 17157831 11408273 17334410 11903743 17174718 16239168 16221502
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7520821823 12898905 14716833 12632514 15876570 17805973 16097048 17922224 10355542 12389079 18418968 15818738 15123356 14620537 11481614 17714472 18481824 15338365 12609069 18412020 12666154 18006644 18705752 16638106 12958196 15925388 12586293 16248980 15959796 18376398 14724832 18251166 18429990 17631135 16116963 18395914 18395095 16192424 18263696 18472094 12445421 12649538 15996030 18210741 17900296 15931870 18187930 15730626 15052691 17869086 17976157 12632512 17525996 14512876 12741479 17481882 17565644 12546737 18279442 15370692 15057751 15673190 18205269 12445418 18317297 17708605 16033810 18054572 17721639 16136751 18156304 17557913 18339082 17761835 15650968 17698563 16027843 18277467 12667390 14748882 17823541 18472332 14716496 18166357 15362042 13678700 17766677 15893842 16015684 17944888 17640975 16011737 18420326
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1417285989 15720792 15830285 16964402 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9916899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 8.0414682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 8.0420195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 8.0419294768
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.95598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.9520377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.9512014681 15583823
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5915213294
MESH:D008171 Lung Diseases Ozone 3.5719066396 8266340
MESH:D055370 Lung Injury Ozone 4.2620417186
MESH:D008175 Lung Neoplasms arsenic trioxide 3.6319825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6320135361 18569708 17053015 20464547 20064080 18816296 20869020 18520028 6695378
MESH:D008175 Lung Neoplasms Ozone 3.638597069 7614698
MESH:D008679 Metaplasia Ozone 5.6310496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3219417148 14977855 11468182 19549372 15949261
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3016882451 16105982
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.3416624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.573581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3011141357
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.906679447
MESH:D009436 Neural Tube Defects arsenic trioxide 7.9010525206
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.724026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4812452020 16624393 19769630
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6115580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010235 Paraganglioma arsenic trioxide 4.5119927285
MESH:D010538 Peritonitis Ozone 4.5516369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D011014 Pneumonia Ozone 4.8618929643 18007984 18381685
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.1119131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1117292933
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.3416646077
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4910029692 19755658
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4317007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4320155912 2093021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.973712494 6582329 6587162 7505956 1399818
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.9719014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.4215213294
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.908074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.9012973940 12845720 20435036 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.9017053015
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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