AutismKB 2.0

Annotation Detail for CHCHD10


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Basic Information Top
Gene Symbol:CHCHD10 ( C22orf16,MGC70831,N27C7-4 )
Gene Full Name: coiled-coil-helix-coiled-coil-helix domain containing 10
Band: 22q11.23
Quick LinksEntrez ID:400916; OMIM: NA; Uniprot ID:CHC10_HUMAN; ENSEMBL ID: ENSG00000241579,ENSG00000242131; HGNC ID: 15559
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000968 Antimycin A Antimycin A results in increased expression of CHCHD10 mRNAincreases expression 19304788
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CHCHD10 mRNAdecreases expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of CHCHD10 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of CHCHD10 mRNAincreases expression 20106945
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of CHCHD10 mRNAaffects cotreatment|increases expression 17183730
C006253 pirinixic acid pirinixic acid results in increased expression of CHCHD10 mRNAincreases expression 18301758
D011374 Progesterone Progesterone affects the expression of CHCHD10 mRNAaffects expression 17251523
D012402 Rotenone Rotenone results in increased expression of CHCHD10 mRNAincreases expression 19304788
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of CHCHD10 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.778875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1319490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000550 Amblyopia Valproic Acid 5.5517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.7417497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001321 Autistic Disorder Valproic Acid 1.9918316065 18985861 17157402 19460635 18940202 19232924 18177632 18396377 17688650 20603192 18775368 15238991 16609825 18558336 17507914
MESH:D001714 Bipolar Disorder Valproic Acid 3.1720046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.528888407
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6617868700
MESH:D001930 Brain Injuries Progesterone 4.5215845082 15380490 15665606
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1517474063 20146248
MESH:D001943 Breast Neoplasms Progesterone 2.1515562024 16175315 17614352
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0415700767 16011737 15721981 16124888 15673190 16192424 16050911 3786805 16227642 10355542 16097048 18705752
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8518788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6612371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7720734317
MESH:D002779 Cholestasis Cyclosporine 8.2619486331
MESH:D002779 Cholestasis pirinixic acid 8.2619176532
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.908888407 16575769 17688650
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003929 Diabetic Neuropathies Progesterone 4.7517187935
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.1321278145 16177239 7179309 17522070 6884620 19336974 10915739 19085960 6623471 11566570 7120509 7440962 10092053 9327722 15998439 16227642 3786805 2869522 15027814 15968718 3732212 4309450
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.1319641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.271851702
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.0217692515
MESH:D004715 Endometriosis Progesterone 3.9616134523
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.413659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.2316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0318234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.777562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.353659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0516530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.5512795759 16239168 16045604 15959796 17595544 12631006 19224547 61145
MESH:D005234 Fatty Liver Cyclosporine 20.5519224547
MESH:D005234 Fatty Liver pirinixic acid 20.5519236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 20.5519224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.2016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.378888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 9.5418705752
MESH:D005355 Fibrosis Cyclosporine 9.5412168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8319900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.2519772884 16221962 18467677 19176532
MESH:D006849 Hydrocephalus Valproic Acid 5.1517688650
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8816612254
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6615869954
MESH:D007249 Inflammation Progesterone 2.6915869954
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.448314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9012371664
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1816294345 17596541
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9117174718 11903743 21278145 16943688 11408273 17157831 17334410 16221502 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3712586293 17922224 16192424 17481882 15673190 18054572 18156304 17805973 15893842 18412020 18481824 15931870 18339082 16136751 15876570 18376398 17766677 18251166 16027843 16638106 15996030 12445418 14724832 16015684 18205269 17714472 12898905 15338365 20821823 15370692 15730626 14512876 17944888 17698563 12632512 18472094 18429990 12389079 16248980 12649538 18210741 17708605 17721639 18006644 17557913 14620537 18187930 15925388 18317297 17761835 15123356 15818738 12667390 17869086 12741479 18395095 15362042 18472332 18395914 14716496 18705752 12609069 12632514 14748882 17631135 15052691 17640975 16011737 11481614 14716833 12445421 18420326 15057751 17900296 15650968 12666154 17525996 15959796 13678700 16097048 12546737 18277467 10355542 17976157 17565644 18263696 18279442 16033810 16116963 17823541 18418968 18166357 12958196
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3715474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1217285989 15720792 15830285 16964402 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8814706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7820195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.7819294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.7816377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.7315583823 12014681
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5817228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.566695378 20064080 18816296 20869020 18569708 18520028 20464547 17053015 20135361
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.9917203775 11408345
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D008881 Migraine Disorders Valproic Acid 3.3318803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.238888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2617596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1311141357
MESH:D009369 Neoplasms pirinixic acid 5.1317405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009410 Nerve Degeneration Rotenone 4.0418619942 17356569 15790535
MESH:D009436 Neural Tube Defects Valproic Acid 3.258888407 16359493
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010051 Ovarian Neoplasms Progesterone 2.5817393432 16525653
MESH:D010300 Parkinson Disease Rotenone 3.0411445065 18619942 15451049 16412576 11535288 19232380 16140633 18191903 19114014
MESH:D020734 Parkinsonian Disorders Rotenone 4.2715927086 15574749 15795934 18197244
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.1120603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9417292933
MESH:D019310 Pseudolymphoma Valproic Acid 4.8611422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4019155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8714763951 17978042 1511512 11738929 11044598 15475178 3137016 16876388
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4519755658 10029692
MESH:D013119 Spinal Cord Injuries Progesterone 4.5615862959 16503802
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8612833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D014178 Translocation, Genetic Valproic Acid 5.5517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.813119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2417053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.908888407
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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