AutismKB 2.0

Annotation Detail for LMX1B


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:LMX1B ( LMX1.2,MGC138325,MGC142051,NPS1 )
Gene Full Name: LIM homeobox transcription factor 1, beta
Band: 9q33.3
Quick LinksEntrez ID:4010; OMIM: 602575; Uniprot ID:LMX1B_HUMAN; ENSEMBL ID: ENSG00000136944; HGNC ID: 6654
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1711Familial Mediterranean fever
1832Congenital abnormality
2032Kidney disease
No data
Desease Name
Body mass index
Desease Name
Nail-patella syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of LMX1B mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LMX1B mRNAaffects expression 16483693
D002330 Carmustine Carmustine results in decreased expression of LMX1B mRNAdecreases expression 15980968
D014212 Tretinoin Tretinoin results in increased expression of LMX1B mRNAincreases expression 15977162
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1918287403
MESH:D000505 Alopecia Tretinoin 3.9415955085
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.3016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.9116935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 4.0316197459 16206674
MESH:D001932 Brain Neoplasms Carmustine 4.7816187019
MESH:D001943 Breast Neoplasms Tretinoin 2.2316873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.2216813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.8816168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.013084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.011917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3716096774 16051514
MESH:D002386 Cataract Acetaminophen 7.9210977129
MESH:D002386 Cataract Tretinoin 7.9217460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.2216129372
MESH:D002822 Choriocarcinoma Tretinoin 5.8816461808
MESH:D002972 Cleft Palate Tretinoin 2.809407595
MESH:D003092 Colitis Tretinoin 4.2617035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.838800419 16925845 9224671 10589399 9664655 17551590 14991402 9211117 9125849 9142499
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6719420014 16227642 19370779 17522070 17562736 11421492 2444490 11461765 19923254 12958197 16109766 19416960 10774834 12540782 15619225 18071297 10663392 16177239 12153990 14725611 16393943 12705907 19164858 15968718 16485898 14550746 12392966 19085960 18713872 16081117 12594235 11834606 11739529 14986274 11529661 19739265 11743745 16781746 11287661 10915739 17906064
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004489 Edema, Cardiac Tretinoin 5.1918230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3516569247
MESH:D005124 Eye Abnormalities Tretinoin 3.879664655 16938888
MESH:D005355 Fibrosis Tretinoin 4.0717994277
MESH:D005756 Gastritis Acetaminophen 4.4016983495
OMIM:137750 GLAUCOMA 1, OPEN ANGLE, A marker/mechanism
MESH:D005909 Glioblastoma Carmustine 8.2716187019
MESH:D005909 Glioblastoma Tretinoin 8.2717312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.8816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0714991402 9664655
MESH:D006930 Hyperalgesia Acetaminophen 8.7216870215
MESH:D006930 Hyperalgesia Tretinoin 8.7216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.1316778211
MESH:D007410 Intestinal Diseases Tretinoin 4.3317994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.3317551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.4015629191 12587719
MESH:D007938 Leukemia Tretinoin 2.9317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.1216482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1217596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3919029980 12679006 19225113 16823087 16331271 17294898 17368321 19035177 16140955 9834237 17107899 19075265 17217047 17361223 17301526 17506722 16935935 17712046 16766008 17649720 15748426 16891316 17339181 19642359 16788101
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.589224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.7012969438 16611625 19014921 11587558 19784758 16610002 19460945 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6317185352 16871587
MESH:D008527 Medulloblastoma Tretinoin 2.9117453147
MESH:D008545 Melanoma Carmustine 3.8212393984
MESH:D008545 Melanoma Tretinoin 3.8216752155
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D008591 Meningomyelocele Tretinoin 4.9916940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2817596541
MESH:D009261 Nail-Patella Syndrome marker/mechanism
MESH:D009369 Neoplasms Tretinoin 2.5716594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.289125849
MESH:D009436 Neural Tube Defects Tretinoin 3.299142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4416936753
MESH:D010146 Pain Acetaminophen 7.7516870215
MESH:D010146 Pain Tretinoin 7.7516870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5715976015
MESH:D011507 Proteinuria Tretinoin 4.0716636307
MESH:D011625 Pterygium Tretinoin 5.4216723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5616283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.7616467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.3317045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.1816051514
MESH:D014376 Tuberculosis Tretinoin 3.4516040207
MESH:D014581 Urticaria Acetaminophen 3.4410982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0716129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.3316752155
MESH:D014820 Vitiligo Tretinoin 4.5616761959
MESH:D009396 Wilms Tumor Tretinoin 4.3416287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30417
    • No data
    Releated disease ID Related disease Name
    PA447199Bipolar Disorder
    PA447216Schizophrenia
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved