AutismKB 2.0

Annotation Detail for PTPLAD2


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Basic Information Top
Gene Symbol:PTPLAD2 ( DKFZp686F01145,DKFZp686G24132,HACD4 )
Gene Full Name: protein tyrosine phosphatase-like A domain containing 2
Band: 9p21.3
Quick LinksEntrez ID:401494; OMIM: NA; Uniprot ID:HACD4_HUMAN; ENSEMBL ID: ENSG00000188921; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
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Chemical ID Chemical Name Interaction Interaction Action Publication
C015001 arsenite arsenite results in increased expression of PTPLAD2 mRNAincreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in increased expression of PTPLAD2 mRNA]affects reaction|increases expression 18929588
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PTPLAD2 mRNAaffects expression 17484886
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of PTPLAD2 mRNAincreases expression 20713471
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of PTPLAD2 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of PTPLAD2 mRNAincreases expression 19482888
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 4.076195326
MESH:D000236 Adenoma Methylcholanthrene 3.706695378 10545420
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.6017620307
MESH:D050197 Atherosclerosis Methylcholanthrene 3.6611922910
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.8417474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.343786805 16097048 16050911 16227642 16192424 15721981 18705752 15673190 10355542 16124888 16011737 15700767
MESH:D002277 Carcinoma Methylcholanthrene 4.2910545420
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1918788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.1917173139 20935162 20007298 1701930 6705139
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 3.7616192471
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.814080065
MESH:D003110 Colonic Neoplasms arsenite 2.6315037631
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.123732212 4309450 15998439 15968718 6623471 19085960 19336974 16177239 16227642 9327722 7120509 17522070 7440962 10915739 11566570 2869522 15027814 21278145 6884620 3786805 7179309 10092053
MESH:D004421 Dystonia Phenobarbital 4.471851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.673659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.5911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0620417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.916401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.817750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.653659116
MESH:D005234 Fatty Liver arsenite 9.4918296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 9.4961145 15959796 19224547 12795759 17595544 16045604 16239168 12631006
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.5714633661 10962813
MESH:D005355 Fibrosis arsenite 10.9418296743
MESH:D005355 Fibrosis Carbon Tetrachloride 10.9418705752
MESH:D006505 Hepatitis Carbon Tetrachloride 4.1019900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 4.0416109766
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.1616899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.6515338365
MESH:D008103 Liver Cirrhosis arsenite 12.2318296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 12.2316221502 17157831 16239168 16943688 17174718 11408273 17334410 21278145 11903743
MESH:D008103 Liver Cirrhosis Phenobarbital 12.2321047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7517721639 18187930 12649538 18279442 18251166 17823541 17481882 12632512 12546737 16192424 18395914 17631135 12898905 18166357 18210741 17900296 15931870 15052691 15673190 14716496 12632514 16033810 18412020 20821823 16638106 15925388 15730626 14620537 16027843 16097048 17761835 18705752 17805973 15057751 14748882 14724832 18429990 17698563 17714472 12958196 15818738 18054572 18472332 15876570 18472094 13678700 12586293 15893842 18277467 18205269 17557913 18418968 15996030 12666154 15362042 16116963 12741479 12667390 16248980 14512876 16136751 12609069 17869086 18395095 18339082 17525996 15123356 18317297 17922224 18156304 17708605 18420326 18376398 17565644 15338365 17766677 16011737 18481824 17976157 17640975 16015684 15959796 15650968 12445421 18263696 14716833 10355542 12389079 17944888 11481614 15370692 12445418 18006644
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.3617285989 15830285 16964402 15720792 16246199
MESH:D008107 Liver Diseases Phenobarbital 4.3619363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.7315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0816899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 5.0219294768
MESH:D008113 Liver Neoplasms Phenobarbital 5.0219482888 19812893 15975961 21047994 19073162 8742319
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 11.3215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 11.321399818 598648
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 11.326150874 18308698 17172636 1399818 2563599
MESH:D008175 Lung Neoplasms arsenite 2.9916809336
MESH:D008175 Lung Neoplasms Methylcholanthrene 2.9921163286 20970405 6695378 7750092 17909032 1399818 16337739 16271038 11893704 9230183 20512841 15390079 10545420
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.1117484760
MESH:D009389 Neovascularization, Pathologic arsenite 5.0415738583
MESH:D010018 Osteomalacia Phenobarbital 5.0017016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.6016965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.992563599
MESH:D019310 Pseudolymphoma Phenobarbital 5.2212752131
MESH:D012640 Seizures Phenobarbital 2.9516876388 3137016 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.456407741
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.361399818
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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