AutismKB 2.0

Annotation Detail for LOXL2


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Basic Information Top
Gene Symbol:LOXL2 ( LOR2,WS9-14 )
Gene Full Name: lysyl oxidase-like 2
Band: 8p21.3
Quick LinksEntrez ID:4017; OMIM: 606663; Uniprot ID:LOXL2_HUMAN; ENSEMBL ID: ENSG00000134013; HGNC ID: 6666
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1789Movement disorder
1976Squamous cell cancer
2126Encephalopathies
Desease Name
CARDIOVASCULAR
brain aneurysm
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of LOXL2 mRNAaffects expression 17562736
C095105 bexarotene bexarotene results in increased expression of LOXL2 mRNAincreases expression 17178900
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of LOXL2 mRNAincreases expression 15963989
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of LOXL2 mRNAaffects expression 17484886
D003035 Cobalt [tungsten carbide binds to Cobalt] which results in increased expression of LOXL2 mRNAaffects binding|increases expression 20105288
C018021 cobaltous chloride cobaltous chloride results in increased expression of LOXL2 mRNAincreases expression 20105288
C014347 decitabine decitabine results in increased expression of LOXL2 mRNAincreases expression 19330836
C014347 decitabine trichostatin A promotes the reaction [decitabine results in increased expression of LOXL2 mRNA]increases expression|increases reaction 19330836
D000431 Ethanol Ethanol results in increased expression of LOXL2 mRNAincreases expression 15963989
D011374 Progesterone Progesterone results in decreased expression of LOXL2 mRNAdecreases expression 18070364
D018038 Sodium Selenite Sodium Selenite results in decreased expression of LOXL2 mRNAdecreases expression 18175754
C004648 testosterone enanthate testosterone enanthate affects the expression of LOXL2 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LOXL2 mRNAincreases expression 20106945
D019772 Topotecan LOXL2 protein affects the susceptibility to Topotecanaffects response to substance 16217747
C012589 trichostatin A trichostatin A promotes the reaction [decitabine results in increased expression of LOXL2 mRNA]increases expression|increases reaction 19330836
C002802 tungsten carbide [tungsten carbide binds to Cobalt] which results in increased expression of LOXL2 mRNAaffects binding|increases expression 20105288
C002802 tungsten carbide tungsten carbide results in increased expression of LOXL2 mRNAincreases expression 20105288
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 8.6417676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.6411752688 15322242 14514962
MESH:D000138 Acidosis Ethanol 4.5511192467
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4316835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.3815451039 15451040
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D000853 Anophthalmos Ethanol 4.8615513904
MESH:D001008 Anxiety Disorders Ethanol 4.0311141031
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4017868700
MESH:D001930 Brain Injuries Progesterone 4.3015665606 15845082 15380490
MESH:D001943 Breast Neoplasms marker/mechanism 19330836
MESH:D001943 Breast Neoplasms bexarotene 2.3816344269 16818667
MESH:D001943 Breast Neoplasms Cobalt 2.3815986119
MESH:D001943 Breast Neoplasms decitabine 2.3818320071 19208741
MESH:D001943 Breast Neoplasms Progesterone 2.3816175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3820435547
MESH:D002056 Burns Ethanol 4.6916374292
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8215700767 16011737 15721981 10355542 16227642 16124888 16097048 3786805 15673190 18705752 16050911 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.633084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.6318788625
MESH:D006528 Carcinoma, Hepatocellular Ethanol 4.6318788625 15763234 15289165
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.2316247446
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6019215824
MESH:D006332 Cardiomegaly Ethanol 6.8919332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.8916120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7915894690
MESH:D002971 Cleft Lip Ethanol 3.6015513904
MESH:D002972 Cleft Palate Ethanol 5.9915513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9916354765 15340226 12621046 8697196 15668235
MESH:D003110 Colonic Neoplasms decitabine 2.3417616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0817141729 14669216
MESH:D019465 Craniofacial Abnormalities Ethanol 2.6411873399 15513904 19302082 10194807 15451040 11198716 15451039
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6410048152 15322242 20055451
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 4.0716823706 15059100 11298694
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8016285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.5317187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.1112958197 15619225 11287661 11739529 12705907 11529661 11421492 12153990 16177239 18713872 16485898 10774834 17522070 11743745 18071297 19164858 17562736 14550746 19370779 16393943 16109766 12540782 16781746 10663392 16081117 12392966 14725611 12594235 17906064 19923254 16227642 19420014 11834606 2444490 19085960 19739265 14986274 19416960 15968718 11461765 10915739
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.117179309 2869522 3732212 21278145 9327722 16227642 4309450 15968718 17522070 7440962 3786805 16177239 15998439 10915739 7120509 19085960 10092053 6884620 19336974 11566570 6623471 15027814
MESH:D056486 Drug-Induced Liver Injury Ethanol 12.1111566570
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.1115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.1120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9618230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.8217692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 14.2419294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 14.2419294695
MESH:D004715 Endometriosis Progesterone 9.0216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.0210568697 9294722
MESH:D004938 Esophageal Neoplasms Ethanol 2.7616704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.1315959796 19224547 12795759 17595544 12631006 61145 16045604 16239168
MESH:D005234 Fatty Liver Ethanol 8.1318620774 19236843 16409862
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.7317920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.3516946407 10194807 15451040 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005355 Fibrosis Carbon Tetrachloride 8.7418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.7420067830
MESH:D005756 Gastritis Acetaminophen 11.3416983495
MESH:D005756 Gastritis Ethanol 11.3415046732
MESH:D005909 Glioblastoma trichostatin A 3.8518801729
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.5019215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3411294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6319900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9312621046 15340226 16120746
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8117440010
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.118697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 7.8816870215
MESH:D006930 Hyperalgesia Ethanol 7.8818783367
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5816899240
MESH:D006973 Hypertension Cobalt 5.6417039479
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.6418670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1315338365
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4415869954
MESH:D007248 Infertility, Male decitabine 3.2217581917
MESH:D007249 Inflammation Progesterone 5.0215869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0212878042 12200463
MESH:D007333 Insulin Resistance Sodium Selenite 3.2914714311
MESH:D007569 Jaw Abnormalities Ethanol 10.2215513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.2216580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2115629191 12587719
MESH:D007859 Learning Disorders Ethanol 4.2515451040
MESH:D007938 Leukemia decitabine 3.0818980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.0318454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.2919387464 18460780 18704418 19010910 18206229 17679729
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.2918206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.5218055864
MESH:D017880 Limb Deformities, Congenital Ethanol 3.8317676605
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.8616943688 16239168 11408273 17157831 11903743 17174718 17334410 16221502 21278145
MESH:D008103 Liver Cirrhosis Ethanol 6.8615289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.1518295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5317823541 12586293 12632514 17944888 18210741 10355542 15818738 15996030 16015684 17565644 14512876 15057751 17481882 18166357 15673190 16116963 12445418 15052691 17869086 17900296 18472332 14620537 14748882 20821823 18412020 11481614 12666154 16033810 16248980 18705752 15931870 15893842 12649538 16097048 12546737 15925388 17922224 18205269 17557913 13678700 16136751 18339082 16638106 18420326 18376398 18006644 15730626 15362042 18054572 18481824 15370692 18395095 18395914 12609069 17714472 12389079 14716496 15650968 17805973 15123356 17761835 18429990 18277467 17976157 18251166 14724832 18187930 16011737 12898905 18263696 15338365 14716833 18472094 16027843 17698563 18317297 12958196 15959796 17708605 18279442 12667390 12741479 17631135 17721639 17640975 12632512 12445421 17766677 16192424 18418968 17525996 15876570 18156304
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.5318166357
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008107 Liver Diseases Acetaminophen 3.9219014921 12587719 19460945 11587558 19784758 16610002 12969438 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9215830285 15720792 16246199 16964402 17285989
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.6917347304 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.5016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.5016899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.4319294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.4316984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.8112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.8112151625
MESH:D008173 Lung Diseases, Obstructive Cobalt 5.906434250
MESH:D008175 Lung Neoplasms bexarotene 2.5417849452
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5419555203 11884234
MESH:D008223 Lymphoma decitabine 3.4419470736
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0914737004
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.1911161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 6.4319196723 19196722 15591091
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.4311408345 17203775
MESH:D008545 Melanoma decitabine 3.7417785578 16505122
MESH:D008545 Melanoma trichostatin A 3.7416505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008569 Memory Disorders Ethanol 4.2218411066 15451040
MESH:D009101 Multiple Myeloma decitabine 7.7218172295
MESH:D009101 Multiple Myeloma trichostatin A 7.7218172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4016882708 19010910 18608210 19157545
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D009369 Neoplasms decitabine 2.7217925555 19116145 19470736
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.8519196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2514600291
MESH:D009447 Neuroblastoma Topotecan 3.8615176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D010051 Ovarian Neoplasms decitabine 8.1119331143 19259094
MESH:D010051 Ovarian Neoplasms Progesterone 8.1117393432 16525653
MESH:D010051 Ovarian Neoplasms trichostatin A 8.1119331143
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D010190 Pancreatic Neoplasms decitabine 8.8919294695
MESH:D010190 Pancreatic Neoplasms Ethanol 8.8912384795
MESH:D010190 Pancreatic Neoplasms trichostatin A 8.8919294695
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2411118676 11222880 11896295 11399792
MESH:D055728 Primary Myelofibrosis decitabine 12.5717616702
MESH:D055728 Primary Myelofibrosis trichostatin A 12.5717616702
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.6118760546
MESH:D011471 Prostatic Neoplasms trichostatin A 3.6119789329 18798265
MESH:D011658 Pulmonary Fibrosis Cobalt 4.016434250
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.4319155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8618045962
MESH:D012640 Seizures Ethanol 3.199754883
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.638532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6316192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.3316503802 15862959
MESH:D013274 Stomach Neoplasms decitabine 2.7419037991
MESH:D013274 Stomach Neoplasms Ethanol 2.7418456281
MESH:D013276 Stomach Ulcer Ethanol 3.5617189318 9211565 9562338 17918041 11906479 16755016
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.289754883
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013964 Thyroid Neoplasms decitabine 3.3517967635
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.7319087683 17616700
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D014604 Uveal Neoplasms decitabine 4.9817785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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