AutismKB 2.0

Annotation Detail for LPA


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Basic Information Top
Gene Symbol:LPA ( AK38,APOA,LP )
Gene Full Name: lipoprotein, Lp(a)
Band: 6q25.3-q26
Quick LinksEntrez ID:4018; OMIM: 152200; Uniprot ID:APOA_HUMAN; ENSEMBL ID: ENSG00000198670; HGNC ID: 6667
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
Pathway IDPathway Name
200108amb2 Integrin signaling
Pathway IDPathway Name
P00050Plasminogen activating cascade
Pathway IDPathway Name
500798LDL-mediated lipid transport
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1856Obesity
1904Diabetes mellitus
2007Liver tumor
2022Liver cancer
2107Proteinuria
2236Cardiovascular disease
Desease Name
plasma Lp (a) levels
CARDIOVASCULAR
protein quantitative trait loci
Coronary Artery Disease
myocardial infarct
Alzheimer's disease
atherosclerosis, coronary lipoprotein
NEUROLOGICAL
METABOLIC
Desease Name
Protein quantitative trait loci
Plasma Lp (a) levels
Desease Name
LPA deficiency, congenital
Coronary artery disease, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene inhibits the reaction [LPA protein modified form results in decreased expression of PLAT protein]decreases expression|decreases reaction 10856522
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene inhibits the reaction [LPA protein modified form results in increased expression of PLAT protein]decreases reaction|increases expression 10856522
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene inhibits the reaction [LPA protein results in decreased expression of SERPINE1 protein]decreases expression|decreases reaction 10856522
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene inhibits the reaction [LPA protein results in increased expression of SERPINE1 protein]decreases reaction|increases expression 10856522
D002246 Carbon Disulfide Carbon Disulfide results in increased expression of LPA proteinincreases expression 12712689
C004479 pimagedine pimagedine inhibits the reaction [LPA protein modified form results in decreased expression of PLAT protein]decreases expression|decreases reaction 10856522
C004479 pimagedine pimagedine inhibits the reaction [LPA protein modified form results in increased expression of SERPINE1 protein]decreases reaction|increases expression 10856522
D018038 Sodium Selenite Sodium Selenite results in decreased expression of LPA mRNAdecreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D050197 Atherosclerosis marker/mechanism
MESH:D050197 Atherosclerosis Carbon Disulfide 5.1310658303 10367350
MESH:D009202 Cardiomyopathies pimagedine 5.1116612575
MESH:D002386 Cataract pimagedine 4.9817936468 15003327
MESH:D019457 Chromosome Breakage Sodium Selenite 5.3115894690
MESH:D003324 Coronary Artery Disease marker/mechanism 20435227 21378990
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.1516285004
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 2.3615131321
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.9017604070
MESH:D007333 Insulin Resistance Sodium Selenite 3.5214714311
MESH:D007410 Intestinal Diseases pimagedine 6.0111713966
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 3.4618177683
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 2.8711246140 18597497 19359593 19925653 16337739 15390079 11696405
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.5214737004
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 3.981500032
MESH:D009422 Nervous System Diseases Carbon Disulfide 6.1010669001
MESH:D020258 Neurotoxicity Syndromes Carbon Disulfide 5.5615315294
MESH:D020734 Parkinsonian Disorders Carbon Disulfide 6.0315019297
MESH:D011014 Pneumonia Butylated Hydroxytoluene 5.7911893704
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3318760546
MESH:D013276 Stomach Ulcer pimagedine 5.1318209962
MESH:D013927 Thrombosis marker/mechanism
Pathway ID Pathway Name
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:04080 Neuroactive ligand-receptor interaction
KEGG:04810 Regulation of actin cytoskeleton
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30432
    • No data
    Releated disease ID Related disease Name
    PA443797Coronary Disease
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00513 other Aminocaproic Acid Antifibrinolytic Agents
    No data
    No data
    No data

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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