AutismKB 2.0

Annotation Detail for LPL


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Basic Information Top
Gene Symbol:LPL ( HDLCQ11,LIPD )
Gene Full Name: lipoprotein lipase
Band: 8p21.3
Quick LinksEntrez ID:4023; OMIM: 609708; Uniprot ID:LIPL_HUMAN; ENSEMBL ID: ENSG00000175445; HGNC ID: 6677
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00561Glycerolipid metabolism
hsa03320PPAR signaling pathway
hsa05010Alzheimer's disease
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
Pathway IDPathway Name
P057262-arachidonoylglycerol biosynthesis
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00154Hyperlipoproteinemia, type I
Inherited disorders of lipid/glycolipid metabolism
Genetic disorders
Desease IDDesease Name
1740Alzheimer's disease
1758Common cold
1889Hyperinsulinism
1904Diabetes mellitus
1918Atherosclerosis
1932Pancreatitis
2091Hypertension
2040Hyperglycemia
2051Leukemia
2066Lung cancer
2068Skin disease
2094Ulcerative colitis
2197Metabolism disease
Desease Name
HDL cholesterol
increased plasma triglyceride and lower high-density lipoprotein cholesterol concentrations
HEMATOLOGICAL
other metabolic traits
cardiovascular disease
cholesterol, HDL
lipid metabolism disorders
atherosclerosis, coronary
Cerebral Infarction
Diabetes Mellitus. Obesity. and Lipaemia
blood pressure, arterial
CARDIOVASCULAR
Pre-Eclampsia
Coronary Artery Disease
atherosclerosis, carotid
blood pressure, arterial hypertension
Adiposity and Abdominal Obesity
plasma HDL cholesterol (HDL-C) levels
prostate cancer
Alzheimer's disease
prostatic hyperplasia
Brain Infarction
lipoproteins
High Triglyceride/ Low HDL Cholesterol Levels
CANCER
PSYCH
fibrinogen
systolic blood pressure
lipids
stroke, myocardial infarction
insulin-resistance syndrome
lower plasma triglyceride levels and increased promoter activity
diabetes, type 2 dyslipidemia heart disease, ischemic
elevated HDL cholesterol levels
nephropathy, diabetic
RENAL
cerebral infarct, atherosclerotic cholesterol, HDL intima media thickness triglycerides
fasting insulin levels
lipoprotein
cardiovascular
lipid levels
NEUROLOGICAL
hyperlipidemia
METABOLIC
adipose tissue lipoprotein lipase activity and lipoprotein lipid and glucose concentrations
Stroke
Myocardial Infarction
triglycerides
decreased blood pressure and plasma triglycerides
plasma HDL-C levels
Albuminuria
coronary heart disease
waist circumference and related phenotypes
REPRODUCTION
diabetes, type 2
Hypertriglyceridemia
premature coronary artery disease
smoking
stable angina of effort
hyperactive-impulsive symptoms
Ischemia
Insulin Resistance
Desease Name
HDL cholesterol
Hyperactive-impulsive symptoms
Hypertriglyceridemia
Metabolic syndrome
Other metabolic traits
Waist circumference and related phenotypes
Triglycerides
Desease Name
Lipoprotein lipase deficiency
High density lipoprotein cholesterol level QTL 11
Combined hyperlipidemia, familial
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C003585 22-hydroxycholesterol 22-hydroxycholesterol results in increased expression of LPL mRNAincreases expression 16142410
C003585 22-hydroxycholesterol [alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of LPL mRNAaffects cotreatment|increases expression 16142410
C007997 25-hydroxycholesterol 25-hydroxycholesterol results in decreased activity of LPL proteindecreases activity 8567968
C007997 25-hydroxycholesterol 25-hydroxycholesterol results in decreased expression of LPL mRNAdecreases expression 8567968
C092561 2-octyl-4H-1,3,2-benzodioxaphosphorin-2-oxide 2-octyl-4H-1,3,2-benzodioxaphosphorin-2-oxide results in decreased activity of LPL proteindecreases activity 16449251
D000082 Acetaminophen Acetaminophen results in decreased expression of LPL mRNAdecreases expression 15030884
D000109 Acetylcholine LPL protein affects the susceptibility to Acetylcholineaffects response to substance 11786490
D000255 Adenosine Triphosphate LPL protein affects the susceptibility to Adenosine Triphosphateaffects response to substance 11786490
C103303 alitretinoin [alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of LPL mRNAaffects cotreatment|increases expression 16142410
C103303 alitretinoin [alitretinoin co-treated with TO-901317] results in increased expression of LPL mRNAaffects cotreatment|increases expression 16142410
C103303 alitretinoin alitretinoin results in increased expression of LPL mRNAincreases expression 16142410
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of LPL mRNAincreases expression 16990341
C040534 alpha-hexachlorocyclohexane alpha-hexachlorocyclohexane results in increased expression of LPL mRNAincreases expression 17785943
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LPL mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of LPL mRNAdecreases expression 19128835
D001554 Benzene Benzene results in increased expression of LPL mRNAincreases expression 15120971
15122651
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LPL mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of LPL mRNAdecreases expression 20106945
C006780 bisphenol A bisphenol A results in increased expression of LPL mRNAincreases expression 20019905
C057368 BRL 37344 BRL 37344 results in increased expression of LPL mRNAincreases expression 9032464
D015124 8-Bromo Cyclic Adenosine Monophosphate 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of LPL mRNAincreases expression 9032464
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of LPL mRNAdecreases expression 15336504
C459604 candoxin candoxin results in decreased expression of LPL mRNAdecreases expression 16309724
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of LPL mRNAaffects expression 17484886
D002251 Carbon Tetrachloride PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of LPL mRNA]increases expression|increases reaction 16006527
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of LPL mRNAincreases expression 17522070
C033394 CGP 12177 CGP 12177 results in increased expression of LPL mRNAincreases expression 9032464
D002725 Chloroform Chloroform results in increased expression of LPL mRNAincreases expression 17522070
D002772 Cholera Toxin Cholera Toxin results in increased expression of LPL mRNAincreases expression 9032464
C011724 cholest-5-en-3 beta,7 alpha-diol cholest-5-en-3 beta,7 alpha-diol results in decreased activity of LPL proteindecreases activity 8567968
C011724 cholest-5-en-3 beta,7 alpha-diol cholest-5-en-3 beta,7 alpha-diol results in decreased expression of LPL mRNAdecreases expression 8567968
D002791 Cholesterol, Dietary [Cholesterol, Dietary co-treated with Cholic Acid] results in increased expression of LPL mRNAaffects cotreatment|increases expression 14684380
D002791 Cholesterol, Dietary Cholesterol, Dietary results in increased expression of LPL mRNAincreases expression 14684380
D008076 Cholesterol, HDL LPL gene polymorphism affects the abundance of Cholesterol, HDLaffects abundance 16030523
D019826 Cholic Acid [Cholesterol, Dietary co-treated with Cholic Acid] results in increased expression of LPL mRNAaffects cotreatment|increases expression 14684380
C019304 ciprofibrate ciprofibrate results in increased expression of LPL mRNAincreases expression 12771043
C014282 cirazoline cirazoline promotes the reaction [Isoproterenol results in increased expression of LPL mRNA]increases expression|increases reaction 9032464
D002994 Clofibrate Clofibrate results in increased expression of LPL mRNAincreases expression 17522070
D003024 Clozapine Clozapine results in decreased expression of LPL mRNAdecreases expression 19682446
D003024 Clozapine Clozapine results in decreased expression of LPL proteindecreases expression 19682446
D003024 Clozapine Clozapine results in increased expression of LPL mRNAincreases expression 17266109
D018119 Stavudine [Stavudine co-treated with Lamivudine] affects the expression of LPL mRNAaffects cotreatment|affects expression 11741158
D018119 Stavudine [Stavudine co-treated with Lamivudine co-treated with Indinavir] affects the expression of LPL mRNAaffects cotreatment|affects expression 11741158
D018119 Stavudine [Stavudine co-treated with Lamivudine co-treated with Nelfinavir] results in decreased expression of LPL mRNAaffects cotreatment|decreases expression 11741158
D003840 Deoxycholic Acid [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of LPL mRNAaffects cotreatment|increases expression 16556975
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LPL mRNAaffects cotreatment|increases expression 16054899
D003907 Dexamethasone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LPL mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D019259 Lamivudine Lamivudine results in decreased expression of LPL mRNAdecreases expression 11741158
D019259 Lamivudine [Stavudine co-treated with Lamivudine] affects the expression of LPL mRNAaffects cotreatment|affects expression 11741158
D019259 Lamivudine [Stavudine co-treated with Lamivudine co-treated with Indinavir] affects the expression of LPL mRNAaffects cotreatment|affects expression 11741158
D019259 Lamivudine [Stavudine co-treated with Lamivudine co-treated with Nelfinavir] results in decreased expression of LPL mRNAaffects cotreatment|decreases expression 11741158
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LPL mRNAaffects cotreatment|decreases expression 11741158
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in decreased expression of LPL mRNAaffects cotreatment|decreases expression 11741158
D004041 Dietary Fats Dietary Fats results in increased expression of LPL mRNAincreases expression 16357043
15238619
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of LPL mRNAincreases expression 12771043
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LPL mRNAaffects cotreatment|increases expression 18164116
D002117 Calcitriol Calcitriol results in decreased expression of LPL mRNAdecreases expression 16368784
D002117 Calcitriol troglitazone inhibits the reaction [Calcitriol results in decreased expression of LPL mRNA]decreases expression|decreases reaction 16368784
D004918 Erythromycin Estolate Erythromycin Estolate results in increased expression of LPL mRNAincreases expression 17522070
D004958 Estradiol Estradiol affects the expression of LPL mRNAaffects expression 14699072
D004958 Estradiol ESR1 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]increases expression|increases reaction 17974624
D004958 Estradiol ESR2 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]increases expression|increases reaction 17974624
D004958 Estradiol Estradiol results in decreased expression of LPL mRNAdecreases expression 16643890
D004958 Estradiol Estradiol results in increased expression of LPL mRNAincreases expression 17974624
D004958 Estradiol fulvestrant inhibits the reaction [ESR1 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]decreases reaction|increases expression|increases reaction 17974624
D004958 Estradiol fulvestrant inhibits the reaction [ESR2 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]decreases reaction|increases expression|increases reaction 17974624
D004958 Estradiol fulvestrant inhibits the reaction [Estradiol results in increased expression of LPL mRNA]decreases reaction|increases expression 17974624
D004958 Estradiol Progesterone inhibits the reaction [ESR1 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]decreases reaction|increases expression|increases reaction 17974624
D004958 Estradiol Progesterone inhibits the reaction [ESR2 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]decreases reaction|increases expression|increases reaction 17974624
D004958 Estradiol Progesterone inhibits the reaction [Estradiol results in increased expression of LPL mRNA]decreases reaction|increases expression 17974624
D004958 Estradiol Estradiol results in increased expression of LPL mRNAincreases expression 17522070
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of LPL mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of LPL mRNAdecreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LPL mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of LPL mRNAdecreases expression 17557909
C504648 ethyl(E,E,E)-7-(2-n-propoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-3-yl)-6-fluorp-3-methylocta-2,4,6-trienoate ethyl(E,E,E)-7-(2-n-propoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-3-yl)-6-fluorp-3-methylocta-2,4,6-trienoate results in increased expression of LPL mRNAincreases expression 15997096
C100419 ethyl octylphosphonofluoridate ethyl octylphosphonofluoridate results in decreased activity of LPL proteindecreases activity 16449251
D005227 Fatty Acids LPL protein promotes the reaction [Fatty Acids results in increased uptake of Glucose]increases reaction|increases uptake 20628023
D005230 Fatty Acids, Nonesterified LPL protein affects the abundance of Fatty Acids, Nonesterifiedaffects abundance 11786490
D005231 Fatty Acids, Unsaturated [LPL protein results in increased hydrolysis of very low density lipoprotein triglyceride] which results in increased abundance of Fatty Acids, Unsaturatedincreases abundance|increases hydrolysis 18435438
D011345 Fenofibrate Fenofibrate results in increased expression of LPL mRNAincreases expression 11798191
D005576 Forskolin Forskolin results in increased expression of LPL mRNAincreases expression 9032464
C070081 fulvestrant fulvestrant inhibits the reaction [ESR1 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]decreases reaction|increases expression|increases reaction 17974624
C070081 fulvestrant fulvestrant inhibits the reaction [ESR2 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]decreases reaction|increases expression|increases reaction 17974624
C070081 fulvestrant fulvestrant inhibits the reaction [Estradiol results in increased expression of LPL mRNA]decreases reaction|increases expression 17974624
C070081 fulvestrant fulvestrant results in decreased expression of LPL mRNAdecreases expression 17974624
C056933 fumonisin B1 fumonisin B1 results in increased expression of LPL mRNAincreases expression 16221962
C030691 gluconic acid [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of LPL mRNAaffects cotreatment|increases expression 16556975
D005947 Glucose LPL protein promotes the reaction [Fatty Acids results in increased uptake of Glucose]increases reaction|increases uptake 20628023
C401311 GW 7845 GW 7845 results in increased expression of LPL mRNAincreases expression 20519739
C071909 ICI D7114 ICI D7114 results in increased expression of LPL mRNAincreases expression 9032464
D019469 Indinavir Indinavir results in increased expression of LPL mRNAincreases expression 11741158
D019469 Indinavir [Stavudine co-treated with Lamivudine co-treated with Indinavir] affects the expression of LPL mRNAaffects cotreatment|affects expression 11741158
D019469 Indinavir [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LPL mRNAaffects cotreatment|decreases expression 11741158
D007213 Indomethacin Indomethacin inhibits the reaction [APC gene mutant form results in decreased expression of LPL mRNA]decreases expression|decreases reaction 17546600
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LPL mRNAaffects cotreatment|increases expression 16054899
D015056 1-Methyl-3-isobutylxanthine Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LPL mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D007545 Isoproterenol cirazoline promotes the reaction [Isoproterenol results in increased expression of LPL mRNA]increases expression|increases reaction 9032464
D007545 Isoproterenol Isoproterenol results in increased expression of LPL mRNAincreases expression 9032464
C060893 L 663536 L 663536 inhibits the reaction [mangiferin results in increased activity of LPL protein]decreases reaction|increases activity 15975614
C060893 L 663536 L 663536 inhibits the reaction [mangiferin results in increased expression of LPL mRNA]decreases reaction|increases expression 15975614
C060893 L 663536 L 663536 inhibits the reaction [Plant Extracts results in increased activity of LPL protein]decreases reaction|increases activity 15975614
C060893 L 663536 L 663536 inhibits the reaction [Plant Extracts results in increased expression of LPL mRNA]decreases reaction|increases expression 15975614
D008345 Manganese Manganese results in decreased activity of LPL proteindecreases activity 17040939
C013592 mangiferin L 663536 inhibits the reaction [mangiferin results in increased activity of LPL protein]decreases reaction|increases activity 15975614
C013592 mangiferin L 663536 inhibits the reaction [mangiferin results in increased expression of LPL mRNA]decreases reaction|increases expression 15975614
C013592 mangiferin mangiferin results in increased activity of LPL proteinincreases activity 15975614
C013592 mangiferin mangiferin results in increased expression of LPL mRNAincreases expression 15975614
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in increased expression of LPL mRNAincreases expression 17522070
D019888 Nelfinavir Nelfinavir results in decreased expression of LPL mRNAdecreases expression 11741158
D019888 Nelfinavir [Stavudine co-treated with Lamivudine co-treated with Nelfinavir] results in decreased expression of LPL mRNAaffects cotreatment|decreases expression 11741158
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of LPL mRNAincreases expression 17616710
D009638 Norepinephrine Norepinephrine results in increased expression of LPL mRNAincreases expression 9032464
D009638 Norepinephrine Prazosin inhibits the reaction [Norepinephrine results in increased expression of LPL mRNA]decreases reaction|increases expression 9032464
D009638 Norepinephrine Propranolol inhibits the reaction [Norepinephrine results in increased expression of LPL mRNA]decreases reaction|increases expression 9032464
C055122 orlistat orlistat results in decreased activity of LPL proteindecreases activity 18698144
C055122 orlistat orlistat results in decreased activity of LPL proteindecreases activity 18435438
17517063
D010269 Paraquat Paraquat results in decreased expression of LPL mRNAdecreases expression 17077588
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of LPL mRNAincreases expression 16221955
D010622 Phencyclidine Phencyclidine results in increased expression of LPL mRNAincreases expression 17266109
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of LPL mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital affects the expression of LPL mRNAaffects expression 19136022
D010634 Phenobarbital Phenobarbital results in increased expression of LPL mRNAincreases expression 19482888
C047088 phenylamil phenylamil results in increased expression of LPL mRNAincreases expression 20519739
D010656 Phenylephrine LPL protein affects the susceptibility to Phenylephrineaffects response to substance 11786490
D010852 Picrotoxin Picrotoxin results in decreased expression of LPL mRNAdecreases expression 15170462
C006253 pirinixic acid pirinixic acid affects the expression of LPL mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid results in decreased expression of LPL mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of LPL mRNAincreases expression 15375163
16221962
11798191
17950772
16357043
18301758
20059764
16306350
C006253 pirinixic acid PPARA protein affects the reaction [pirinixic acid results in increased expression of LPL mRNA]affects reaction|increases expression 16221962
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of LPL mRNA]increases expression|increases reaction 17950772
20059764
D010936 Plant Extracts L 663536 inhibits the reaction [Plant Extracts results in increased activity of LPL protein]decreases reaction|increases activity 15975614
D010936 Plant Extracts L 663536 inhibits the reaction [Plant Extracts results in increased expression of LPL mRNA]decreases reaction|increases expression 15975614
D010936 Plant Extracts Plant Extracts results in increased activity of LPL proteinincreases activity 15975614
D010936 Plant Extracts Plant Extracts results in increased expression of LPL mRNAincreases expression 15975614
C025299 polyphenols polyphenols results in decreased expression of LPL mRNAdecreases expression 16293270
D011189 Potassium Chloride LPL protein results in increased susceptibility to Potassium Chlorideincreases response to substance 11786490
D011224 Prazosin Prazosin inhibits the reaction [Norepinephrine results in increased expression of LPL mRNA]decreases reaction|increases expression 9032464
D011374 Progesterone Progesterone affects the expression of LPL mRNAaffects expression 17251523
D011374 Progesterone Progesterone inhibits the reaction [ESR1 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]decreases reaction|increases expression|increases reaction 17974624
D011374 Progesterone Progesterone inhibits the reaction [ESR2 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]decreases reaction|increases expression|increases reaction 17974624
D011374 Progesterone Progesterone inhibits the reaction [Estradiol results in increased expression of LPL mRNA]decreases reaction|increases expression 17974624
D011374 Progesterone Progesterone results in decreased expression of LPL mRNAdecreases expression 17974624
D011433 Propranolol Propranolol inhibits the reaction [Norepinephrine results in increased expression of LPL mRNA]decreases reaction|increases expression 9032464
D020849 Raloxifene [Raloxifene co-treated with ESR1 protein] results in increased expression of LPL mRNAaffects cotreatment|increases expression 19059307
D020849 Raloxifene Raloxifene results in increased expression of LPL mRNAincreases expression 16643890
C009159 rapeseed oil rapeseed oil affects the expression of LPL mRNAaffects expression 16177195
C059514 resveratrol resveratrol results in decreased expression of LPL mRNAdecreases expression 16901463
D019438 Ritonavir Ritonavir affects the expression of LPL mRNAaffects expression 11741158
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LPL mRNAaffects cotreatment|increases expression 16054899
C089730 rosiglitazone rosiglitazone results in increased expression of LPL mRNAincreases expression 15997096
C089730 rosiglitazone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LPL mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D012402 Rotenone Rotenone results in decreased expression of LPL mRNAdecreases expression 19693701
D019258 Saquinavir Saquinavir results in decreased expression of LPL mRNAdecreases expression 11741158
C009277 sodium arsenate sodium arsenate results in decreased expression of LPL mRNAdecreases expression 16882884
C017947 sodium arsenite sodium arsenite affects the expression of LPL mRNAaffects expression 16507464
D014284 Triiodothyronine Triiodothyronine results in increased expression of LPL mRNAincreases expression 15953391
D013629 Tamoxifen Tamoxifen affects the expression of LPL mRNAaffects expression 14699072
D013629 Tamoxifen [Tamoxifen co-treated with ESR1 protein] results in increased expression of LPL mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen Tamoxifen affects the expression of LPL mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LPL mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of LPL mRNA]affects reaction|increases expression 18827440
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LPL mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LPL mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LPL mRNAdecreases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LPL mRNAincreases expression 16960034
18827440
15800033
16114106
D013752 Tetracycline Tetracycline results in increased expression of LPL mRNAincreases expression 17522070
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of LPL proteinincreases expression 18435438
C423915 TO-901317 [alitretinoin co-treated with TO-901317] results in increased expression of LPL mRNAaffects cotreatment|increases expression 16142410
C423915 TO-901317 TO-901317 results in increased expression of LPL mRNAincreases expression 16142410
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of LPL mRNAdecreases expression 16988111
D014212 Tretinoin Tretinoin results in decreased expression of LPL mRNAdecreases expression 16368784
D014212 Tretinoin troglitazone inhibits the reaction [Tretinoin results in decreased expression of LPL mRNA]decreases expression|decreases reaction 16368784
D014280 Triglycerides LPL protein results in increased abundance of Triglyceridesincreases abundance 18698144
C057693 troglitazone troglitazone inhibits the reaction [Calcitriol results in decreased expression of LPL mRNA]decreases expression|decreases reaction 16368784
C057693 troglitazone troglitazone inhibits the reaction [Tretinoin results in decreased expression of LPL mRNA]decreases expression|decreases reaction 16368784
C081489 valsartan [valsartan co-treated with AGT protein] results in increased activity of LPL proteinaffects cotreatment|increases activity 18640387
C081489 valsartan valsartan results in increased activity of LPL proteinincreases activity 18640387
C030106 very low density lipoprotein triglyceride LPL protein results in increased hydrolysis of very low density lipoprotein triglycerideincreases hydrolysis 18435438
C030106 very low density lipoprotein triglyceride [LPL protein results in increased hydrolysis of very low density lipoprotein triglyceride] which results in increased abundance of Fatty Acids, Unsaturatedincreases abundance|increases hydrolysis 18435438
C025643 vinclozolin vinclozolin affects the expression of LPL mRNAaffects expression 19015723
D015215 Zidovudine Zidovudine affects the expression of LPL mRNAaffects expression 20032539
D015215 Zidovudine Zidovudine results in decreased expression of LPL mRNAdecreases expression 16894629
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LPL mRNAaffects cotreatment|decreases expression 11741158
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in decreased expression of LPL mRNAaffects cotreatment|decreases expression 11741158
D015215 Zidovudine Zidovudine results in decreased expression of LPL mRNAdecreases expression 11741158
D015032 Zinc Zinc affects the expression of LPL mRNAaffects expression 17181878
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.6414745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 5.406195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 5.4014514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 2.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.0417505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 3.969612607
MESH:D000169 Acrodermatitis Zinc 4.5116889938 17190629 17202136
MESH:D058186 Acute Kidney Injury resveratrol 3.0616538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.3018653653
MESH:D000230 Adenocarcinoma arsenic trioxide 9.8911798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.8920127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 9.8911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.8914692618
MESH:D000230 Adenocarcinoma Indomethacin 9.8916537180
MESH:D000236 Adenoma Benzo(a)pyrene 14.716695378
MESH:D000236 Adenoma beta-Naphthoflavone 14.7119389873
MESH:D000236 Adenoma Diethylnitrosamine 14.7110737359 6695378
MESH:D000236 Adenoma Indomethacin 14.7111497255
MESH:D000236 Adenoma resveratrol 14.7115688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.6617620307 16434500 19061943 17162532 18056438 19052882
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.6617620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.6616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.6616835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 3.8015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.0017306315 16712894
MESH:D000380 Agranulocytosis Clozapine 4.1914617031 16160616 12649775
MESH:D000382 Agricultural Workers' Diseases Paraquat 2.9111874814
MESH:D000419 Albuminuria Raloxifene 3.7517308373 17451421
MESH:D000505 Alopecia Tretinoin 2.8815955085
MESH:D016301 Alveolar Bone Loss Indomethacin 4.4717225004
MESH:D000544 Alzheimer Disease Cholesterol, Dietary 14.4720157255
MESH:D000544 Alzheimer Disease Indomethacin 14.4715579461 17627676
MESH:D000544 Alzheimer Disease Plant Extracts 14.4716962711
MESH:D000544 Alzheimer Disease Raloxifene 14.4715800139
MESH:D000544 Alzheimer Disease resveratrol 14.4716162502 16183991
MESH:D000544 Alzheimer Disease rosiglitazone 14.4719621015
MESH:D000544 Alzheimer Disease Zinc 14.4716580781 16325427 16410023 17119284
MESH:D000707 Anaphylaxis mangiferin 4.6014669257 16536907
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.1711748828
MESH:D000741 Anemia, Aplastic Benzene 3.6414761424 17661222 11369114
MESH:D000755 Anemia, Sickle Cell Zinc 4.0516916123
MESH:D000756 Anemia, Sideroblastic Manganese 4.0516910769
MESH:D000799 Angioedema Acetaminophen 2.9410982225
MESH:D001008 Anxiety Disorders vinclozolin 2.9119015723
MESH:D001014 Aortic Aneurysm Indomethacin 4.0010231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 8.8319183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 8.8310388637
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.3317460149
MESH:D001161 Arteriosclerosis Cholesterol, Dietary 12.2215552841
MESH:D001161 Arteriosclerosis Dietary Fats 12.2215238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 12.2211256880
MESH:D018771 Arthralgia Indomethacin 4.272160914
MESH:D001169 Arthritis, Experimental Dexamethasone 16.4517659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 16.4515885639
MESH:D001169 Arthritis, Experimental Plant Extracts 16.4514686799
MESH:D001169 Arthritis, Experimental resveratrol 16.4517115116
MESH:D001169 Arthritis, Experimental Tretinoin 16.4516412693
MESH:D001172 Arthritis, Rheumatoid Indomethacin 3.7111248219
MESH:D001172 Arthritis, Rheumatoid Tretinoin 3.7116292516
MESH:D001249 Asthma Tretinoin 3.8116456186
MESH:D001249 Asthma Zinc 3.8117085522
MESH:D050197 Atherosclerosis mangiferin 5.2018450471
MESH:D050197 Atherosclerosis resveratrol 5.2016873680 17967414
MESH:D001284 Atrophy fulvestrant 4.0011514358
MESH:D001321 Autistic Disorder Acetaminophen 2.2818445737
MESH:D001321 Autistic Disorder Norepinephrine 2.288570775
MESH:D001321 Autistic Disorder Propranolol 2.2818766980
MESH:D001471 Barrett Esophagus Tretinoin 3.5516935849
MESH:D001477 Bartter Syndrome Indomethacin 4.1110684365
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 20.3416206674
MESH:D001778 Blood Coagulation Disorders Clofibrate 20.3419483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 20.3419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 20.3412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 20.3416206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 2.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.1315746008
MESH:D001855 Bone Marrow Diseases Benzene 4.3316183116
MESH:D001862 Bone Resorption bisphenol A 7.2011985600
MESH:D001862 Bone Resorption mangiferin 7.209881647
MESH:D001919 Bradycardia Isoproterenol 12.806740701
MESH:D001919 Bradycardia Phenylephrine 12.8015306635
MESH:D001919 Bradycardia Propranolol 12.806740701
MESH:D001929 Brain Edema Indomethacin 4.1211481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.4317868700
MESH:D001930 Brain Injuries Progesterone 13.4715845082 15380490 15665606
MESH:D001930 Brain Injuries Raloxifene 13.4716580743
MESH:D001930 Brain Injuries Zinc 13.4717109824
MESH:D002545 Brain Ischemia Indomethacin 12.0812524144
MESH:D002545 Brain Ischemia Plant Extracts 12.0816041641
MESH:D002545 Brain Ischemia resveratrol 12.0817600658
MESH:D001943 Breast Neoplasms alitretinoin 12.5716344269
MESH:D001943 Breast Neoplasms Benzene 12.5717162533 11921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 12.5720146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 12.5717123778
MESH:D001943 Breast Neoplasms Calcitriol 12.5711237771
MESH:D001943 Breast Neoplasms Dietary Fats 12.5720435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 12.5717474063
MESH:D001943 Breast Neoplasms Estradiol 12.5717289903 17018787 12948864 14630087 16675129 17261762 19861407 18497071
MESH:D001943 Breast Neoplasms fulvestrant 12.5718984771
MESH:D001943 Breast Neoplasms Indomethacin 12.5717401462
MESH:D001943 Breast Neoplasms Progesterone 12.5715562024 16175315 17614352
MESH:D001943 Breast Neoplasms Raloxifene 12.5717952589 17242785 17440819 15758505 15775269 15572757 17049068 17893378 17261762 16912660 17595753 16837676
MESH:D001943 Breast Neoplasms resveratrol 12.5717651959 17534123 16393696
MESH:D001943 Breast Neoplasms Tamoxifen 12.5718984771 19011961 18821012 20544844 18629630 19221464 19487384 18855134 21152245 17893378 20065188 18815881 19066611 11161223 17440819 18351453 19059307 19155303 19288272 19189210 17049068 19189212 16873071 15668708 21138602 15565566 19289846 20135344 19103187 19084267 19410462 19115204 16818667 19142967 20390343 16202921 20859285 17261762 19244106 19200415 18997820 16273361 20005174 18425577 17242785
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 12.5720435547
MESH:D001943 Breast Neoplasms Tretinoin 12.5716873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.7016813970
MESH:D019121 Burkholderia Infections orlistat 5.7317874328
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.5011589617
MESH:D002056 Burns Indomethacin 3.8410459503
MESH:D002057 Burns, Chemical Plant Extracts 4.439625245
MESH:D002100 Cachexia Indomethacin 4.1215141370 11239499 16537180 15625704
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.5716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 2.9216192424 15673190 18705752 16227642 16124888 15700767 16011737 15721981 3786805 10355542 16050911 16097048
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.0716835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.6319066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.2516168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 22.813084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 22.8115073043 16217749 11135700 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 22.8118788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 22.8120084675 20524982 19519916 20727157 11831363 16328049 18785209 16569478 19394651 19539802 16807293 17761372 17162532 19701751 21159647 3084413 16698587 20214788 17055752 19171122 16779866 17138121 18691550 19052882 20432363 16502159 16540662 10672840 18971187 16878318 19418558 18788625 10737359 19919837 17428255 18393292 18056438 19208518 16830150 20514400 18665156 17173139 20512989 16935385 20101231 16288022 20935162 18506893 19822196 18210153 19383236 17978847 16681979 19335982 3581430 20007298 19107877 18494052 18978308
MESH:D006528 Carcinoma, Hepatocellular Estradiol 22.8116924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 22.8116391822
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 22.8117173139 1701930 6705139 20935162 20007298
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 22.8118834353
MESH:D006528 Carcinoma, Hepatocellular resveratrol 22.8116227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 22.8116507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 22.8116924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 22.811917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.1017123778
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 8.4911053908
MESH:D018827 Carcinoma, Lewis Lung resveratrol 8.4916675471
MESH:D018276 Carcinoma, Medullary Indomethacin 4.4614736730 11352223 18791128
MESH:D002291 Carcinoma, Papillary arsenic trioxide 3.9719014326
MESH:D002292 Carcinoma, Renal Cell Indomethacin 2.8717341418
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.3212490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 19.3920419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 19.3911237771
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 19.3915482327 12636206
MESH:D002294 Carcinoma, Squamous Cell resveratrol 19.3916227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 19.3918572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 19.3918922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 19.3916051514 16096774
MESH:D002294 Carcinoma, Squamous Cell Zinc 19.3916543248
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 6.8817572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 6.8817572228
MESH:D006332 Cardiomegaly Isoproterenol 19.3211179087 7544033
MESH:D006332 Cardiomegaly Norepinephrine 19.3211179087
MESH:D006332 Cardiomegaly Phenylephrine 19.3216170337 15728586 11179087 17124262 11754973 17287366
MESH:D006332 Cardiomegaly Plant Extracts 19.3217645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 19.3218850075 18670907 16120746
MESH:D006332 Cardiomegaly valsartan 19.3219597038
MESH:D009202 Cardiomyopathies valsartan 3.8016247790
MESH:D002318 Cardiovascular Diseases Raloxifene 11.9315775269
MESH:D002318 Cardiovascular Diseases resveratrol 11.9315458977
MESH:D002318 Cardiovascular Diseases valsartan 11.9311230374
MESH:D002318 Cardiovascular Diseases Zinc 11.9316936243
MESH:D002375 Catalepsy Norepinephrine 4.668216760
MESH:D002386 Cataract Acetaminophen 9.0010977129
MESH:D002386 Cataract Adenosine Triphosphate 9.0015003327
MESH:D002386 Cataract Tretinoin 9.0017460283
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 10.611399818
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.612727394 17174075 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.6118566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.6120056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.384080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 3.7016129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 6.7619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 6.7616835633
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 5.3012912871
MESH:D002764 Cholecystitis Indomethacin 4.2711181007
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 9.4616629650 12927374 19486331 7624871 15913567 18590720 15500046 18164287
MESH:D002779 Cholestasis Ethinyl Estradiol 9.4615861022 17681005 17110522 16105132 11677210 16919318 17333356
MESH:D002779 Cholestasis pirinixic acid 9.4619176532
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 4.9510220858 19407337
MESH:D002822 Choriocarcinoma Tretinoin 4.2516461808
MESH:D002916 Chylothorax orlistat 5.7317003701
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.1812621046 8697196 16354765 15340226 15668235
MESH:D002972 Cleft Palate Tretinoin 4.189407595
MESH:D003072 Cognition Disorders Clozapine 8.8017123785
MESH:D003072 Cognition Disorders Raloxifene 8.8015800139
MESH:D003092 Colitis resveratrol 6.7716474422
MESH:D003092 Colitis Tretinoin 6.7717035595
MESH:D003110 Colonic Neoplasms Deoxycholic Acid 8.1816213893
MESH:D003110 Colonic Neoplasms Dexamethasone 8.1815824018
MESH:D003110 Colonic Neoplasms Indomethacin 8.1815786552 11260862 15625704 15637740 15963497 15936596
MESH:D003110 Colonic Neoplasms polyphenols 8.1816293270
MESH:D003110 Colonic Neoplasms resveratrol 8.1816338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.7920501625
MESH:D015179 Colorectal Neoplasms Indomethacin 2.7911197048 12606626 18059344 17054584
MESH:D015179 Colorectal Neoplasms resveratrol 2.7916550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.2917141729 14669216
MESH:D003324 Coronary Artery Disease valsartan 3.4917719468
MESH:D003327 Coronary Disease resveratrol 3.1116507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.3412609071
MESH:D018352 Coronavirus Infections Indomethacin 4.8117302372
MESH:D003384 Coxsackievirus Infections valsartan 4.9520392896
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 9.0210525206
MESH:D019465 Craniofacial Abnormalities Benzene 9.0215643154
MESH:D019465 Craniofacial Abnormalities Dexamethasone 9.0217728286
MESH:D019465 Craniofacial Abnormalities sodium arsenate 9.0210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 9.0210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 9.029142499 17551590 9125849 16925845 9211117 10589399 9664655 8800419 14991402 9224671
MESH:D019465 Craniofacial Abnormalities Zinc 9.0219302082
MESH:D003456 Cryptorchidism vinclozolin 3.4914966744
MESH:D003457 Cryptosporidiosis mangiferin 4.9516547730
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.2715213294
MESH:D003711 Demyelinating Diseases Tamoxifen 3.4919031437
MESH:D003715 Dengue cholest-5-en-3 beta,7 alpha-diol 5.4919427377
MESH:D003865 Depressive Disorder, Major Raloxifene 3.3917474826
MESH:D003872 Dermatitis Benzene 3.9015902427
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 2.6212438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 1.9218249437
MESH:D048909 Diabetes Complications orlistat 4.9419207292
MESH:D003920 Diabetes Mellitus ethyl(E,E,E)-7-(2-n-propoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-3-yl)-6-fluorp-3-methylocta-2,4,6-trienoate 11.3915997096
MESH:D003920 Diabetes Mellitus rosiglitazone 11.3917446233
MESH:D003920 Diabetes Mellitus Zinc 11.3916479319
MESH:D003921 Diabetes Mellitus, Experimental mangiferin 9.9119028559 12093613
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 9.9116873680
MESH:D003921 Diabetes Mellitus, Experimental valsartan 9.9111508273
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 12.8516402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 12.8520387270
MESH:D003924 Diabetes Mellitus, Type 2 mangiferin 12.859881663 11315760
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 12.8512642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 12.8517107852
MESH:D003924 Diabetes Mellitus, Type 2 troglitazone 12.8516023994
MESH:D003925 Diabetic Angiopathies troglitazone 4.7712601628
MESH:D003928 Diabetic Nephropathies Estradiol 30.3519279558
MESH:D003928 Diabetic Nephropathies mangiferin 30.3519960420 19706694
MESH:D003928 Diabetic Nephropathies Plant Extracts 30.3519706694
MESH:D003928 Diabetic Nephropathies Raloxifene 30.3517451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies resveratrol 30.3516286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 30.3519279558
MESH:D003928 Diabetic Nephropathies valsartan 30.3511427623 18630688
MESH:D003929 Diabetic Neuropathies Progesterone 3.6217187935
MESH:D003967 Diarrhea Dexamethasone 8.747237001
MESH:D003967 Diarrhea Indomethacin 8.747237001 7907874
MESH:D003967 Diarrhea orlistat 8.7420002075
MESH:D006970 Disorders of Excessive Somnolence Clozapine 4.6515331141
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 33.8217522070 7624871 20133375 18289764
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 33.8210774834 10915739 12153990 16781746 11743745 14725611 11739529 17906064 17562736 19085960 19923254 15968718 11529661 12958197 14550746 14986274 16393943 11461765 12392966 12705907 12594235 18071297 17522070 16081117 10663392 16227642 18713872 11834606 12540782 16109766 2444490 19416960 19370779 11287661 19164858 19739265 15619225 16177239 19420014 11421492 16485898
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 33.827440962 7120509 16177239 6623471 17522070 3732212 4309450 15027814 19085960 10092053 9327722 7179309 15968718 3786805 10915739 19336974 11566570 6884620 16227642 15998439 21278145 2869522
MESH:D056486 Drug-Induced Liver Injury Chloroform 33.8217522070 6623471 7440962 7120509 2862719 3732212 3104120 6884620
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 33.8219107877
MESH:D056486 Drug-Induced Liver Injury Erythromycin Estolate 33.8217522070 14998559
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 33.8216221962
MESH:D056486 Drug-Induced Liver Injury polyphenols 33.8219370779
MESH:D056486 Drug-Induced Liver Injury Prazosin 33.8218071297
MESH:D056486 Drug-Induced Liver Injury Ritonavir 33.8214986274
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 33.8218186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 33.8220420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 33.8217522070
MESH:D056486 Drug-Induced Liver Injury troglitazone 33.8214986274
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.1919426721
MESH:D004362 Drug Toxicity Lamivudine 13.9815040536
MESH:D004362 Drug Toxicity Stavudine 13.9815040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 13.9811462148
MESH:D004362 Drug Toxicity Zidovudine 13.9815040536
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.2612774134 18043480 16133044 18446180 16326151 17190690
MESH:D004381 Duodenal Ulcer Indomethacin 3.3011535926 11595431 10671773 11595415 17045617 11991626 17329845 17202747 17151854 17351913 16699067
MESH:D050171 Dyslipidemias marker/mechanism 17952847
MESH:D050171 Dyslipidemias Clofibrate 15.0616707586
MESH:D050171 Dyslipidemias Clozapine 15.0616402076
MESH:D050171 Dyslipidemias Dietary Fats 15.0618367378
MESH:D050171 Dyslipidemias Fenofibrate 15.0616707586
MESH:D004421 Dystonia Phenobarbital 3.181851702
MESH:D004485 Eczema Dexamethasone 3.6112438553
MESH:D004487 Edema Dexamethasone 36.8319703484
MESH:D004487 Edema Indomethacin 36.8310653021 7907874 8985016 16100529 19703484 7990266 8273558
MESH:D004487 Edema L 663536 36.837990266
MESH:D004487 Edema perfluorooctanoic acid 36.8312083418 17259670
MESH:D004487 Edema pirinixic acid 36.8312083418
MESH:D004487 Edema Plant Extracts 36.8312787963
MESH:D004487 Edema Raloxifene 36.8315860553
MESH:D004487 Edema resveratrol 36.838985016
MESH:D004487 Edema rosiglitazone 36.8312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 36.8312711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 36.8311698051 7812673 15177302 9599246 16716910 8273558 8113982
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 8.9515322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 8.9518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 24.9115138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 24.9112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 24.9117692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 24.9115845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 24.9117872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 24.9119031437
MESH:D016889 Endometrial Neoplasms Estradiol 12.5118566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Fenofibrate 12.5116569247
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.5120544844 17893378 16202921 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 12.5116569247
MESH:D004715 Endometriosis Indomethacin 10.7515652904
MESH:D004715 Endometriosis Progesterone 10.7516134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 10.759294722 10568697
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 4.7815268973
MESH:D019446 Endotoxemia Indomethacin 3.6218509659
MESH:D004751 Enteritis Indomethacin 3.8510567023 17763956 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 9.4917980183
MESH:D020345 Enterocolitis, Necrotizing resveratrol 9.4917923197
MESH:D004802 Eosinophilia Indomethacin 3.2111298111
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.243659116
MESH:D004828 Epilepsies, Partial Phenobarbital 2.983922381 11558140
MESH:D004827 Epilepsy Norepinephrine 8.11821787
MESH:D004827 Epilepsy Phenobarbital 8.1120417680
MESH:D004827 Epilepsy Plant Extracts 8.1119439326 19700373
MESH:D004832 Epilepsy, Absence Phenobarbital 2.786401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.387750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.143659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.2116302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 10.1512903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.1516530937
MESH:D004938 Esophageal Neoplasms Indomethacin 10.1511005569
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 10.1515623463 15878914 15547721 15547733 16704527 15264214 15150132 16510608 16805852
MESH:D004938 Esophageal Neoplasms Zinc 10.1516543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 6.4811564622
MESH:D005124 Eye Abnormalities Tretinoin 6.489664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 65.1615073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 65.1612631006 61145 15959796 16045604 12795759 17595544 16239168 19224547
MESH:D005234 Fatty Liver Clofibrate 65.1619224547
MESH:D005234 Fatty Liver Dietary Fats 65.1619004024 19551842 18296743 17967931
MESH:D005234 Fatty Liver Diethylnitrosamine 65.1621071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 65.1615345470
MESH:D005234 Fatty Liver mangiferin 65.1615975614
MESH:D005234 Fatty Liver pirinixic acid 65.1619236843 20131406
MESH:D005234 Fatty Liver Plant Extracts 65.1615975614
MESH:D005234 Fatty Liver Raloxifene 65.1617473493
MESH:D005234 Fatty Liver rosiglitazone 65.1619196556
MESH:D005234 Fatty Liver Stavudine 65.1618299183
MESH:D005234 Fatty Liver Tamoxifen 65.1619224547 14986274
MESH:D005234 Fatty Liver Tetracycline 65.1619224547 16917069
MESH:D005234 Fatty Liver Zidovudine 65.1618299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.6216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.5911858732
MESH:D005334 Fever Indomethacin 3.3417627676 11852909 10431976
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.6414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.3019069698
MESH:D005354 Fibrosarcoma Indomethacin 4.0110962813
MESH:D005355 Fibrosis Carbon Tetrachloride 23.4718705752
MESH:D005355 Fibrosis Dietary Fats 23.4718296743
MESH:D005355 Fibrosis Indomethacin 23.4717994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 23.4720067830
MESH:D005355 Fibrosis Tretinoin 23.4717994277
MESH:D005355 Fibrosis valsartan 23.4716893502
MESH:D005414 Flatulence orlistat 5.7320002075
MESH:D005499 Folliculitis Indomethacin 4.2711298111
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.4116904648
MESH:D005756 Gastritis Acetaminophen 13.8816983495
MESH:D005756 Gastritis Indomethacin 13.8815046732
MESH:D005756 Gastritis Zinc 13.8817241300
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.0416973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.3916417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 3.7916452187
MESH:D005909 Glioblastoma Indomethacin 8.3112870263
MESH:D005909 Glioblastoma Manganese 8.3117043766
MESH:D005909 Glioblastoma Tretinoin 8.3117312396
MESH:D005910 Glioma Indomethacin 2.7916487511 18371953
MESH:D005911 Gliosis Paraquat 4.2611124998
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 4.6916928621
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.5411849393
MESH:D018149 Glucose Intolerance sodium arsenate 4.2519446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.6910696789
MESH:D006073 Gout Indomethacin 4.4611248219
MESH:D006130 Growth Disorders Zinc 3.3217217573
MESH:D006258 Head and Neck Neoplasms Indomethacin 5.7315482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 5.7316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.2516084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.8320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.8310048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 7.8314991402 9664655
MESH:D006331 Heart Diseases mangiferin 5.9412093613
MESH:D006331 Heart Diseases Raloxifene 5.9411110106
MESH:D006333 Heart Failure Isoproterenol 19.6818097624
MESH:D006333 Heart Failure pirinixic acid 19.6820558911
MESH:D006333 Heart Failure Plant Extracts 19.6818097624
MESH:D006333 Heart Failure Propranolol 19.6820082655
MESH:D006333 Heart Failure valsartan 19.6819027736
MESH:D006333 Heart Failure Zinc 19.6817162251
MESH:D006335 Heart Injuries Zinc 4.8617074742
MESH:D016481 Helicobacter Infections Zinc 3.7117241300
MESH:D006402 Hematologic Diseases Benzene 8.3316183116
MESH:D006402 Hematologic Diseases Zidovudine 8.3312579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.5311000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 3.7615633222
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 6.8618590720
MESH:D006505 Hepatitis Carbon Tetrachloride 6.8619110552 19900420
MESH:D006509 Hepatitis B Lamivudine 4.2917703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 4.2915309715 16476009 15274664 15631357 12044531
MESH:D006526 Hepatitis C therapeutic 17517063
MESH:D019698 Hepatitis C, Chronic Indomethacin 3.8315135802
MESH:D006527 Hepatolenticular Degeneration Zinc 3.8217276780
MESH:D006529 Hepatomegaly fumonisin B1 22.7316221962
MESH:D006529 Hepatomegaly perfluorooctanoic acid 22.733609246
MESH:D006529 Hepatomegaly Phenobarbital 22.7316109766
MESH:D006529 Hepatomegaly pirinixic acid 22.7319772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Propranolol 22.7316371745
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 22.7316120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.677520565
MESH:D006558 Herpes Genitalis Estradiol 4.1315709030
MESH:D006561 Herpes Simplex mangiferin 11.5510715843
MESH:D006561 Herpes Simplex Plant Extracts 11.5510715843
MESH:D006561 Herpes Simplex resveratrol 11.5516876885
MESH:D015658 HIV Infections Indinavir 25.9915388451 11141242 11363243
MESH:D015658 HIV Infections Lamivudine 25.9917530837 11141242 20032539 9296927
MESH:D015658 HIV Infections Nelfinavir 25.9911362904 15388451
MESH:D015658 HIV Infections Plant Extracts 25.9912878215
MESH:D015658 HIV Infections Ritonavir 25.9911363243 15388451 17378895 11141242
MESH:D015658 HIV Infections Saquinavir 25.9911141242 15388451
MESH:D015658 HIV Infections Stavudine 25.9911141242
MESH:D015658 HIV Infections Zidovudine 25.9911141242 20032539 17358032 11698656 11363243
MESH:D006689 Hodgkin Disease sodium arsenite 2.4212676792
MESH:D019584 Hot Flashes Estradiol 7.3617088409
MESH:D019584 Hot Flashes Plant Extracts 7.3617454163 16566672 14716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.1416354765 15340226 18606429 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 21.1016870215
MESH:D006930 Hyperalgesia Indomethacin 21.1012727271
MESH:D006930 Hyperalgesia perfluorooctanoic acid 21.1012083418
MESH:D006930 Hyperalgesia Prazosin 21.1012727271
MESH:D006930 Hyperalgesia rosiglitazone 21.1012083418
MESH:D006930 Hyperalgesia Tretinoin 21.1016870215
MESH:D034321 Hyperamylasemia Indomethacin 4.8117883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.6416899240
MESH:D006937 Hypercholesterolemia Cholesterol, Dietary 10.8910876104
MESH:D006937 Hypercholesterolemia Dietary Fats 10.8921332399
MESH:D006937 Hypercholesterolemia resveratrol 10.8917188708
MESH:D006940 Hyperemia Indomethacin 4.1212524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.7016778211
MESH:D006943 Hyperglycemia pirinixic acid 2.4020558911
MESH:D020138 Hyperhomocysteinemia Plant Extracts 3.7016484555
MESH:D006946 Hyperinsulinism mangiferin 4.249881663 11315760
MESH:D006948 Hyperkinesis Clozapine 4.0316046005
MESH:D006950 Hyperlipidemia, Familial Combined marker/mechanism
MESH:D006949 Hyperlipidemias Dietary Fats 25.2421332399
MESH:D006949 Hyperlipidemias Indomethacin 25.2417546600
MESH:D006949 Hyperlipidemias mangiferin 25.2415975614
MESH:D006949 Hyperlipidemias orlistat 25.2421332399
MESH:D006949 Hyperlipidemias Plant Extracts 25.2415268973 15975614
MESH:D006949 Hyperlipidemias resveratrol 25.2416873680
MESH:D006951 Hyperlipoproteinemias Fatty Acids, Unsaturated 5.3718435438
OMIM:238600 HYPERLIPOPROTEINEMIA, TYPE I marker/mechanism
MESH:D006938 Hyperlipoproteinemia Type II marker/mechanism 16030523
MESH:D006967 Hypersensitivity mangiferin 3.9216536907
MESH:D006973 Hypertension Benzene 14.7617940673
MESH:D006973 Hypertension Dexamethasone 14.7617042910
MESH:D006973 Hypertension Phenylephrine 14.7612717712 8949925
MESH:D006973 Hypertension Raloxifene 14.7615787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 14.7618850075 18670907
MESH:D006973 Hypertension valsartan 14.7620102058 12692753 18344623 16475468 10903974 12850387 18390891 11427623
MESH:D006974 Hypertension, Malignant valsartan 5.5111560862
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.2215338365
MESH:D006976 Hypertension, Pulmonary L 663536 4.4914726295
MESH:D015228 Hypertriglyceridemia marker/mechanism 20657596
MESH:D015228 Hypertriglyceridemia Triglycerides 5.0416238453 16979400
MESH:D006984 Hypertrophy Isoproterenol 8.3112791704
MESH:D006984 Hypertrophy Phenylephrine 8.3118502941 12791704
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.5117488730
MESH:D007021 Hypospadias Ethinyl Estradiol 2.9416945680 16569931
MESH:D007022 Hypotension Isoproterenol 10.926740701
MESH:D007022 Hypotension Norepinephrine 10.926740701
MESH:D007022 Hypotension Propranolol 10.926740701
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 9.7218306037
MESH:D007077 Ileal Diseases Indomethacin 9.7218306037 10574470
MESH:D007079 Ileitis Indomethacin 4.4610651667 10647630 16133968
MESH:D007154 Immune System Diseases mangiferin 4.9516076520
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.4716133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 8.6115869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 8.6117600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.6412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 14.2217937319
MESH:D007248 Infertility, Male fulvestrant 14.2211514358
MESH:D007248 Infertility, Male Paraquat 14.224850670
MESH:D007248 Infertility, Male sodium arsenite 14.2212646999 15346721
MESH:D007248 Infertility, Male vinclozolin 14.2216467254
MESH:D007249 Inflammation Dexamethasone 40.158960868 11099482
MESH:D007249 Inflammation Dietary Fats 40.1520412841
MESH:D007249 Inflammation Diethylnitrosamine 40.1518785209
MESH:D007249 Inflammation Indomethacin 40.153291741 7812673 12568917
MESH:D007249 Inflammation mangiferin 40.1515222974
MESH:D007249 Inflammation perfluorooctanoic acid 40.1512083418
MESH:D007249 Inflammation Plant Extracts 40.1516366677 19332304 15997105 12787963
MESH:D007249 Inflammation polyphenols 40.1516366677
MESH:D007249 Inflammation Progesterone 40.1515869954
MESH:D007249 Inflammation resveratrol 40.1516366677
MESH:D007249 Inflammation rosiglitazone 40.1512083418
MESH:D007249 Inflammation Tamoxifen 40.1519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 40.1512878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 40.157562506 8273558 11698051 15177302 7812673
MESH:D007251 Influenza, Human resveratrol 3.6516624496
MESH:D007333 Insulin Resistance bisphenol A 25.0116393666
MESH:D007333 Insulin Resistance Dietary Fats 25.0118457598 11836018
MESH:D007333 Insulin Resistance Estradiol 25.0116393666 16627594
MESH:D007333 Insulin Resistance mangiferin 25.0111315760
MESH:D007333 Insulin Resistance orlistat 25.0117201808
MESH:D007333 Insulin Resistance pirinixic acid 25.0116306350
MESH:D007333 Insulin Resistance rosiglitazone 25.0116306350
MESH:D007410 Intestinal Diseases Indomethacin 7.0218236018 11713966 15610444 17329856 11686837 15831440 10210152 11855677 17994277
MESH:D007410 Intestinal Diseases Tretinoin 7.0217994277
MESH:D007414 Intestinal Neoplasms Plant Extracts 3.8312351151 12584176 12628509
MESH:D019586 Intracranial Hypertension Indomethacin 4.4715241188
MESH:D007511 Ischemia mangiferin 8.3616806951
MESH:D007511 Ischemia Zinc 8.3616584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 7.2416580747
MESH:D007569 Jaw Abnormalities Tretinoin 7.2417551590 15992940
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 9.7218306037
MESH:D007579 Jejunal Diseases Indomethacin 9.7210574470 18306037 16133968
MESH:D017492 Keratosis, Seborrheic alitretinoin 4.7516144296
MESH:D007674 Kidney Diseases Acetaminophen 19.8112587719 15629191
MESH:D007674 Kidney Diseases Estradiol 19.8115618244
MESH:D007674 Kidney Diseases Indomethacin 19.8117190690
MESH:D007674 Kidney Diseases mangiferin 19.8112093613
MESH:D007674 Kidney Diseases sodium arsenite 19.8120008137
MESH:D007674 Kidney Diseases valsartan 19.8112164870 10903974 16893502
MESH:D007674 Kidney Diseases Zinc 19.8116960431
MESH:C531755 Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules orlistat 5.7317185156
MESH:D007676 Kidney Failure, Chronic Zinc 3.6116518626
MESH:D007680 Kidney Neoplasms Estradiol 8.2215610895
MESH:D007680 Kidney Neoplasms Tamoxifen 8.2218625569
MESH:D007680 Kidney Neoplasms Zidovudine 8.2212579204
MESH:D007859 Learning Disorders mangiferin 4.1019182383
MESH:D007889 Leiomyoma Raloxifene 3.6716973256
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.1610320625 12228301 11703811
MESH:D007938 Leukemia arsenic trioxide 7.4115070760
MESH:D007938 Leukemia Benzene 7.4118335105 15935818 14694614 17119257
MESH:D007938 Leukemia Tretinoin 7.4117143497
MESH:D004915 Leukemia, Erythroblastic, Acute troglitazone 5.2416085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 11.8417077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Ritonavir 11.8416174765
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 11.8420370541
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.4216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 10.1514633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 10.1510785260 16572323 15631656
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive mangiferin 10.1515498116
MESH:D007951 Leukemia, Myeloid arsenic trioxide 11.3819077051
MESH:D007951 Leukemia, Myeloid Benzene 11.3817506065
MESH:D007951 Leukemia, Myeloid Tretinoin 11.3816482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.5617050201 19850784 16968895 16467208 20471514
MESH:D015470 Leukemia, Myeloid, Acute Benzene 6.5619478238
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 6.5618360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.5616294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 9.0216891316 12679006 11468182 16331271 19075265 12018890 16823087 17217047 16112521 16330433 9834237 15336539 17649720 15622746 19035177 19225113 15213294 11161223 19642359 17869043 17712046 15748426 12712474 16966277 17107899
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 9.0216087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 9.0217107899 17301526 17339181 17506722 17361223 17217047 16891316 19029980 19035177 17368321 17294898 15748426 16823087 16766008 19225113 16140955 17649720 16935935 16788101 16331271 9834237 12679006 19642359 17712046 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.5016882451
MESH:D007964 Leukocytosis Indomethacin 4.4716537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 4.8117980183
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 9.998812269
MESH:D007984 Leydig Cell Tumor vinclozolin 9.9916417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.639224671
MESH:D008052 Lipid Metabolism, Inborn Errors marker/mechanism
MESH:D008064 Lipidoses Clozapine 5.8017567588
MESH:D008064 Lipidoses Tamoxifen 5.8017567588 15342952
MESH:D008101 Liver Abscess, Amebic Indomethacin 4.8111479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 18.4617334410 11408273 16239168 16943688 11903743 21278145 16221502 17157831 17174718
MESH:D008103 Liver Cirrhosis Dietary Fats 18.4618296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 18.4618522880 18407596 20032147 19638242 18665156
MESH:D008103 Liver Cirrhosis orlistat 18.4617404856
MESH:D008103 Liver Cirrhosis Phenobarbital 18.4621047994
MESH:D008103 Liver Cirrhosis Plant Extracts 18.4617157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 18.2615893842 15925388 15959796 17976157 16116963 18251166 18263696 17823541 18317297 17805973 17565644 17761835 18279442 15370692 16033810 15052691 17640975 16248980 18429990 12898905 15996030 18472332 12958196 17708605 17525996 15730626 17557913 15931870 15876570 12649538 14724832 14512876 14716833 15673190 10355542 15818738 12586293 18395914 18418968 12666154 12667390 12445418 12741479 18472094 12445421 18210741 18481824 16011737 20821823 17481882 11481614 12389079 17766677 14748882 18205269 16015684 15123356 18006644 15057751 15338365 18705752 16638106 18395095 18376398 16027843 17698563 12609069 17869086 17900296 12632514 18187930 14716496 18339082 17714472 17944888 16136751 15362042 17922224 13678700 18054572 18156304 18277467 18420326 12546737 17631135 14620537 16097048 18412020 17721639 16192424 12632512 15650968 18166357
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 18.2616718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 18.2614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 18.2615474484
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 18.2618194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 18.2615474484
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 18.2615479170
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 18.2617347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 18.2618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 18.2612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 18.2618397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental valsartan 18.2616872305 15619341 15504291
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 14.0317184895
MESH:D008107 Liver Diseases Acetaminophen 14.0312587719 12969438 16610002 19460945 11587558 19784758 16611625 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 14.0315830285 16964402 15720792 16246199 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 14.0317034775
MESH:D008107 Liver Diseases Phenobarbital 14.0319363144
MESH:D008107 Liver Diseases Plant Extracts 14.0317034775
MESH:D008107 Liver Diseases polyphenols 14.0316698588
MESH:D017093 Liver Failure Carbon Tetrachloride 8.9615123358
MESH:D017093 Liver Failure Stavudine 8.9618299183
MESH:D017114 Liver Failure, Acute Acetaminophen 6.7817185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 6.7814706259 16899240
MESH:D008113 Liver Neoplasms arsenic trioxide 42.2714682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 42.2720195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 42.2719389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 42.2719294768
MESH:D008113 Liver Neoplasms ciprofibrate 42.2712771043
MESH:D008113 Liver Neoplasms Diethylnitrosamine 42.2720137499 19090486 18977376 20583210 18648771 19551842 12771043 20501860 19638242 20434301 19812893 19073162 19426721 19833225 19294768 19427195 15175105 9163691 18754104 19996281 18644402 21047994 19690152 19256749 20452335 21167192 19254457 19850985 19499222 21071580 20101389 19642983 21278145 18978307 12112319 15885732 10737359 16942905 20492335 19255062 20405173 2422723 20118626 2862719
MESH:D008113 Liver Neoplasms Fenofibrate 42.2718978307
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 42.2718709148 14757943
MESH:D008113 Liver Neoplasms Phenobarbital 42.2719073162 19812893 8742319 19482888 21047994 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 42.2720007298 15890375 16377806
MESH:D008113 Liver Neoplasms Plant Extracts 42.2719168119
MESH:D008113 Liver Neoplasms resveratrol 42.2719812893 20405173 19321006 19073162
MESH:D008113 Liver Neoplasms sodium arsenite 42.2715276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 42.2716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 42.2716984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 26.0720377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 26.0712562636
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 26.0718164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 26.0712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Deoxycholic Acid 26.076150874
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 26.0718775883 16842330 19009564 18282651 18079962 21159647 18253720 19519916 18544905 18093689 16267830 19126423 19539802 17174075 18164116 3124819 17942915 19004024 17854601 18308698 2563599 9362446
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 26.0718775883 18253720
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 26.0718308698 17172636 2563599 1399818 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 26.0712151625
MESH:D008133 Long QT Syndrome arsenic trioxide 2.6415213294
MESH:D008171 Lung Diseases sodium arsenite 2.5319095001
MESH:D017563 Lung Diseases, Interstitial Benzene 3.9114698565
MESH:D008175 Lung Neoplasms alitretinoin 25.1816413115
MESH:D008175 Lung Neoplasms arsenic trioxide 25.1819825857 11798837
MESH:D008175 Lung Neoplasms Benzene 25.1812562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 25.1820464547 17053015 20135361 18520028 18569708 20869020 6695378 20064080 18816296
MESH:D008175 Lung Neoplasms Dexamethasone 25.1815824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 25.1820512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Indomethacin 25.1811053908 16537180 11497255
MESH:D008175 Lung Neoplasms L 663536 25.1815899809
MESH:D008175 Lung Neoplasms mangiferin 25.1818816296 18520028 18569708
MESH:D008175 Lung Neoplasms Plant Extracts 25.1820869020
MESH:D008175 Lung Neoplasms sodium arsenite 25.1816712894 19931552 17306315 15276417 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 25.1818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 25.1819555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 25.1811807781
MESH:D008175 Lung Neoplasms Zidovudine 25.1818800350
MESH:D008207 Lymphatic Metastasis orlistat 5.0318770866 20805790
MESH:D008223 Lymphoma Benzene 3.0717584886 17119257
MESH:D016393 Lymphoma, B-Cell resveratrol 3.4717088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.1314749477
MESH:D015674 Mammary Neoplasms, Animal Benzene 11.7412562636
MESH:D015674 Mammary Neoplasms, Animal resveratrol 11.7415688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 11.7419428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 22.4111921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 22.4111807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 22.4117203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 22.418985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 22.4116827153
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 22.4114580682 16827153 11731420 19196723 19196722
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 22.418985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 22.4112773700
MESH:D020149 Manganese Poisoning Estradiol 17.2019453300
MESH:D020149 Manganese Poisoning Manganese 17.2019453300 16551646 16568477
MESH:D020149 Manganese Poisoning Tamoxifen 17.2019453300
MESH:D008527 Medulloblastoma Tretinoin 2.3417453147
MESH:D008545 Melanoma Glucose 9.0914993021
MESH:D008545 Melanoma orlistat 9.0920805790 18770866
MESH:D008545 Melanoma resveratrol 9.0917992120
MESH:D008545 Melanoma sodium arsenite 9.0919082730 16487513
MESH:D008545 Melanoma Tamoxifen 9.0919393235 12393984
MESH:D008545 Melanoma Tretinoin 9.0916752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.3015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 2.7019513568
MESH:D008569 Memory Disorders mangiferin 4.0919182383
MESH:D008591 Meningomyelocele Tretinoin 3.5516940565
MESH:D001523 Mental Disorders Clozapine 3.1116856516
MESH:D008659 Metabolic Diseases resveratrol 3.5717112576
MESH:D024821 Metabolic Syndrome X Clozapine 7.3719142101
MESH:D024821 Metabolic Syndrome X rosiglitazone 7.3717261469
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 4.9317358032
MESH:D008881 Migraine Disorders Indomethacin 3.0111903285
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 4.6515863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 6.2616381670
MESH:D009062 Mouth Neoplasms Indomethacin 6.2612636206
MESH:D009069 Movement Disorders Manganese 4.1816551646
MESH:D009101 Multiple Myeloma arsenic trioxide 15.4715949261 19417148 14977855 19549372 11468182
MESH:D009101 Multiple Myeloma Benzene 15.4717119195
MESH:D009101 Multiple Myeloma Dexamethasone 15.4715867202 16118317 15744524
MESH:D009101 Multiple Myeloma Raloxifene 15.4716497877
MESH:D009101 Multiple Myeloma resveratrol 15.4717049120 17935668 16490592 16267019 14749477 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 3.9817962980
MESH:D009135 Muscular Diseases orlistat 7.8718430571
MESH:D009135 Muscular Diseases pirinixic acid 7.8716239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.0518186108
MESH:D009164 Mycobacterium Infections Indinavir 13.2821442799
MESH:D009164 Mycobacterium Infections orlistat 13.2821442799
MESH:D009164 Mycobacterium Infections Ritonavir 13.2821442799
MESH:D009182 Mycosis Fungoides arsenic trioxide 3.7718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 8.9216105982 16882451
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 8.929809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 8.9217596541
MESH:D009203 Myocardial Infarction Isoproterenol 9.7215740881 17052832 19595682 16538859 19172585 16697266 16584858
MESH:D009203 Myocardial Infarction mangiferin 9.7216584858 16697266 17052832 16538859 19172585
MESH:D009203 Myocardial Infarction pirinixic acid 9.7219151258
MESH:D009203 Myocardial Infarction resveratrol 9.7216525036 16317513 17188708 17125593 16456233 17015251
MESH:D017202 Myocardial Ischemia resveratrol 6.5617125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 6.5612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 10.1616810080
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 10.1615642760
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 10.1616411023
MESH:D009205 Myocarditis resveratrol 3.8717322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.5917484760
MESH:D009232 Myxoma Raloxifene 4.6516343187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.1216624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 6.843581430 9029167
MESH:D009362 Neoplasm Metastasis Indomethacin 6.8416537180 11239499 11053908
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.8419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.1419410462
MESH:D009369 Neoplasms alitretinoin 12.8816946489
MESH:D009369 Neoplasms Benzo(a)pyrene 12.8811141357
MESH:D009369 Neoplasms orlistat 12.8818710210
MESH:D009369 Neoplasms pirinixic acid 12.8817405874
MESH:D009369 Neoplasms sodium arsenite 12.8811559025
MESH:D009369 Neoplasms Tretinoin 12.8816594593 16946489
MESH:D009374 Neoplasms, Experimental Indomethacin 14.8115625704 10663608
MESH:D009374 Neoplasms, Experimental orlistat 14.8119381703
MESH:D009374 Neoplasms, Experimental resveratrol 14.818985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 14.8120056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.1019189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 7.5717289903
MESH:D009389 Neovascularization, Pathologic orlistat 7.5717012255
MESH:D009395 Nephritis, Interstitial Tetracycline 3.899884423
MESH:D009410 Nerve Degeneration Manganese 14.1916551646
MESH:D009410 Nerve Degeneration mangiferin 14.1917433543
MESH:D009410 Nerve Degeneration Paraquat 14.1916893418
MESH:D009410 Nerve Degeneration Rotenone 14.1918619942 15790535 17356569
MESH:D009421 Nervous System Malformations bisphenol A 16.5411399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 16.5416427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.5414600291
MESH:D009421 Nervous System Malformations Tretinoin 16.549125849
MESH:D009436 Neural Tube Defects arsenic trioxide 15.9710525206
MESH:D009436 Neural Tube Defects Benzene 15.9715643154
MESH:D009436 Neural Tube Defects sodium arsenate 15.9719446573 18186108 11749123 10525206
MESH:D009436 Neural Tube Defects sodium arsenite 15.9712854658
MESH:D009436 Neural Tube Defects Tretinoin 15.979142499
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.3117168769
MESH:D019636 Neurodegenerative Diseases Acetaminophen 13.9718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 13.9720387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 13.9712349958
MESH:D019636 Neurodegenerative Diseases resveratrol 13.9717652729
MESH:D020078 Neurogenic Inflammation resveratrol 3.5717929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.2120387270
MESH:D009503 Neutropenia Ritonavir 4.5517378895
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 9.189802331
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 9.189802331
MESH:C541083 Non-alcoholic Fatty Liver Disease orlistat 4.7517404856
MESH:D009765 Obesity marker/mechanism 18344982
MESH:D009765 Obesity Clozapine 10.5719142110 18515891
MESH:D009765 Obesity Dietary Fats 10.5717217161 20518802 21332399 18457598 19632207 11836018 18674790 16723640 20132043
MESH:D009765 Obesity orlistat 10.5720599501 21442799 18773755 20540997 19207292 21438711 19046740 19461584 20065556 20518802 16938137 20002075
MESH:D009765 Obesity pirinixic acid 10.5720558911
MESH:D009765 Obesity Plant Extracts 10.5720132043 19056576
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.276374098
MESH:D009784 Occupational Diseases Benzene 3.4015612468 17479406 17119257 15913788 15576619 15935809 17178637 15727169 16737584
MESH:D010003 Osteoarthritis Indomethacin 3.067009135
MESH:D010018 Osteomalacia Phenobarbital 3.4817016548
MESH:D010024 Osteoporosis Raloxifene 2.7917882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 7.4617823083 15758505 17893378 15579764
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 7.4617513867
MESH:D010049 Ovarian Diseases bisphenol A 4.1011985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 13.7019769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Benzene 13.7012562636
MESH:D010051 Ovarian Neoplasms Estradiol 13.7019401270
MESH:D010051 Ovarian Neoplasms Progesterone 13.7017393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 13.7017306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 13.7016936753
MESH:D010146 Pain Acetaminophen 7.0216870215
MESH:D010146 Pain Indomethacin 7.0217440234 13679232 3291741 17627676
MESH:D010146 Pain Tretinoin 7.0216870215
MESH:D010149 Pain, Postoperative Indomethacin 3.7818702446 12538197
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 14.8815580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 14.8816540662
MESH:D010190 Pancreatic Neoplasms L 663536 14.8812384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 14.8816965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 14.8815976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 14.8815976015
MESH:D010195 Pancreatitis marker/mechanism 18936103
MESH:D010195 Pancreatitis Fatty Acids, Nonesterified 9.7918983441
MESH:D010195 Pancreatitis Indomethacin 9.7915028970 17883296
MESH:D010195 Pancreatitis orlistat 9.7916938137 20065556
MESH:D016584 Panic Disorder Ethinyl Estradiol 2.8611578682
MESH:D010212 Papilloma Plant Extracts 6.9116517061 15173996
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 6.9112065085 18404319 18922899 8330346
MESH:D010235 Paraganglioma arsenic trioxide 3.3319927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 4.8116537180
MESH:D010300 Parkinson Disease Cholesterol, Dietary 11.6519014385
MESH:D010300 Parkinson Disease Manganese 11.6511181820
MESH:D010300 Parkinson Disease mangiferin 11.6517433543
MESH:D010300 Parkinson Disease Paraquat 11.6511124998 11181820 16510128 11445065 15824117 15451049 16140633 12911755
MESH:D010300 Parkinson Disease Rotenone 11.6519114014 11445065 18191903 15451049 19232380 11535288 16140633 18619942 16412576
MESH:D010302 Parkinson Disease, Secondary Paraquat 3.5716190885
MESH:D020734 Parkinsonian Disorders Indomethacin 10.8412349958
MESH:D020734 Parkinsonian Disorders Manganese 10.8416140633
MESH:D020734 Parkinsonian Disorders Rotenone 10.8415927086 18197244 15574749 15795934
MESH:D051302 Paroxysmal Hemicrania Indomethacin 4.8111903285
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 10.7920133375
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 10.7912520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 4.5311026799
MESH:D010437 Peptic Ulcer Indomethacin 4.2611148446
MESH:D010518 Periodontitis Indomethacin 9.4117225004
MESH:D010518 Periodontitis mangiferin 9.4119026997
MESH:D011014 Pneumonia Paraquat 3.5712504350
MESH:D011085 Polycystic Ovary Syndrome orlistat 4.4817201808
MESH:D017499 Porokeratosis alitretinoin 5.1016144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.7118163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 6.532563599
MESH:D011230 Precancerous Conditions Phenobarbital 6.532563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 2.9721297632
MESH:D011225 Pre-Eclampsia Zinc 3.4517114810
MESH:D047928 Premature Birth Indomethacin 4.2617000239
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 21.2210548101
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 21.2217132714
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 21.2216679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 21.2211222880 11399792 11118676 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 21.2218042343 18220299 19015723
MESH:D017096 Prion Diseases Tetracycline 4.5210903871
MESH:D011469 Prostatic Diseases vinclozolin 4.0418220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 3.8915572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 7.8620887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 7.8620887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 15386377
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.3119131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3117292933
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3116740699
MESH:D011471 Prostatic Neoplasms Calcitriol 3.3118247401 16289102 15754350 12479363 16644109
MESH:D011471 Prostatic Neoplasms Estradiol 3.3116740699
MESH:D011471 Prostatic Neoplasms Plant Extracts 3.3114666653 17804756
MESH:D011471 Prostatic Neoplasms Raloxifene 3.3115731164 16220300 16536755
MESH:D011471 Prostatic Neoplasms resveratrol 3.3117718901 17636462 16731767 17804756 15767336 17675339
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3116039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.3115067354
MESH:D011471 Prostatic Neoplasms Zinc 3.3116517595 16606632 12429649 16700911
MESH:D011472 Prostatitis vinclozolin 4.0418629315
MESH:D011507 Proteinuria Indomethacin 10.8711849393
MESH:D011507 Proteinuria Tretinoin 10.8716636307
MESH:D011507 Proteinuria valsartan 10.8717664856 18344623 12164870
MESH:D011537 Pruritus Ethinyl Estradiol 7.1816919318 15861022
MESH:D011537 Pruritus L 663536 7.1817827870
MESH:D019310 Pseudolymphoma Phenobarbital 3.5912752131
MESH:D011618 Psychotic Disorders Clozapine 3.4915331141
MESH:D011625 Pterygium Tretinoin 3.9016723453
MESH:D011629 Puberty, Precocious bisphenol A 3.9010548101
MESH:D011654 Pulmonary Edema Isoproterenol 4.3510903255
MESH:D011658 Pulmonary Fibrosis Paraquat 6.9717997886 16324872
MESH:D011658 Pulmonary Fibrosis troglitazone 6.9718162602
MESH:D011658 Pulmonary Fibrosis valsartan 6.9717241526
MESH:D011693 Purpura Raloxifene 4.6515770314
MESH:D011833 Radiation Injuries, Experimental mangiferin 5.5015830843
MESH:D012035 Refsum Disease orlistat 5.1820871815
MESH:D051436 Renal Insufficiency, Chronic resveratrol 4.6816325855
MESH:D015427 Reperfusion Injury pirinixic acid 4.7919058328
MESH:D015427 Reperfusion Injury resveratrol 4.7915827377 16314181 17520802 17058453 16317513
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 6.5311700416 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 6.5311700416
MESH:D012130 Respiratory Hypersensitivity Acetylcholine 3.609413022
MESH:D012135 Respiratory Sounds Paraquat 3.2011874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 2.9918990726
MESH:D012162 Retinal Degeneration Paraquat 6.8316458197
MESH:D012162 Retinal Degeneration Zinc 6.8316584753
MESH:D012206 Rhabdomyolysis Lamivudine 4.659296927
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.2716283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.4518045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.1216646077
MESH:D012559 Schizophrenia Clozapine 2.5920452607 11151749 18855531 19369910 11763009 18806925 20168265 17123785 17726453 20521320 20580759 17667964 20107430 16141801 20521326
MESH:D012640 Seizures Phenobarbital 4.3411442880 3137016 16876388 4039156
MESH:D012640 Seizures Picrotoxin 4.348954991 8635557
MESH:D003294 Seizures, Febrile Phenobarbital 3.936407741
MESH:D012772 Shock, Septic mangiferin 4.3615177305
MESH:D012852 Sinusitis Phenylephrine 3.827327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 26.7410029692 19755658
MESH:D012878 Skin Neoplasms Glucose 26.7414993021
MESH:D012878 Skin Neoplasms Plant Extracts 26.7415173996 16517061
MESH:D012878 Skin Neoplasms resveratrol 26.748985016 15837718
MESH:D012878 Skin Neoplasms sodium arsenite 26.7418572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 26.748532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 26.7416192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 26.7418404319 8985016 8330346 12065085 11807781
MESH:D012878 Skin Neoplasms Tretinoin 26.7416467112
MESH:D013088 Spermatocele Ethinyl Estradiol 8.5716709447
MESH:D013088 Spermatocele Tamoxifen 8.5716709447
MESH:D013119 Spinal Cord Injuries Progesterone 7.9416503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 7.9419457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.0712854658
MESH:D013272 Stomach Diseases Dexamethasone 7.4415472012
MESH:D013272 Stomach Diseases Indomethacin 7.4415038085 18209964 10486359 16113693 17160473 17638125 10215738 10192188 17207306 16184426 16280098 18545984 15472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 13.6417007042
MESH:D013274 Stomach Neoplasms Benzene 13.6412562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 13.642093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 13.6418456281
MESH:D013274 Stomach Neoplasms Indomethacin 13.6415609394
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 13.6417575124 12958204
MESH:D013274 Stomach Neoplasms orlistat 13.6419381703
MESH:D013274 Stomach Neoplasms Tretinoin 13.6417261132
MESH:D013274 Stomach Neoplasms troglitazone 13.6415930296
MESH:D013274 Stomach Neoplasms Zidovudine 13.6417696246
MESH:D013276 Stomach Ulcer Dexamethasone 10.8015138204
MESH:D013276 Stomach Ulcer Indomethacin 10.8011906479 18193104 17627676 16252198 16631530 14567935 11595415 16169175 15104355 18209962 17135157 12787963 17918041 12467913 10878458 17654042 16755016 18726076 10750652 11729361 10423059 18299717 17895592 11595431 18543354 18237397 15138204 18181030 12077510 11523592 18431645 12498302 16150113 17657623 1323529 16934674 17977527 18087811 16397915 11145282 15255614 12500499
MESH:D013276 Stomach Ulcer mangiferin 10.8017918041
MESH:D013276 Stomach Ulcer Plant Extracts 10.8017135157 12787963 18237397 18193104 15255614
MESH:D020521 Stroke Raloxifene 3.0916837676
OMIM:601367 STROKE, ISCHEMIC resveratrol 3.6816321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.1116684133 16045194
MESH:D013610 Tachycardia Norepinephrine 4.593261545
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 10.2817997062
MESH:D013705 Temporomandibular Joint Disorders polyphenols 10.2817997062
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 3.9720133375
MESH:D019851 Thrombophilia Ethinyl Estradiol 2.7911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.3915669648
MESH:D013953 Thymus Neoplasms Benzene 4.0710850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.0012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 14.9719014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 14.977505956
MESH:D013964 Thyroid Neoplasms Indomethacin 14.9714736730 18791128 11352223
MESH:D013964 Thyroid Neoplasms Phenobarbital 14.971399818
MESH:D013964 Thyroid Neoplasms Tretinoin 14.9716026305 17045167
MESH:D013978 Tibial Fractures Estradiol 10.7219048282
MESH:D013978 Tibial Fractures Raloxifene 10.7219048282
MESH:D014062 Tongue Neoplasms resveratrol 12.0816227395
MESH:D014062 Tongue Neoplasms Tretinoin 12.0816051514
MESH:D014062 Tongue Neoplasms Zinc 12.0816543248
MESH:D016171 Torsades de Pointes arsenic trioxide 3.0815213294
MESH:D014235 Trichinellosis mangiferin 5.1614669257
MESH:D014376 Tuberculosis Tretinoin 2.6116040207
MESH:D014456 Ulcer Indomethacin 4.0117380554 10574470
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 10.9220435036 12845720 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 10.9217053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 10.9217572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 10.9216712894 11723127 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 10.9216712894 8653321 17572228
MESH:D014581 Urticaria Acetaminophen 2.1710982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 11.3417473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 11.3411813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 11.3416129372
MESH:D014591 Uterine Diseases bisphenol A 4.1014652134
MESH:D014594 Uterine Neoplasms Benzene 11.2412562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 11.2414692618
MESH:D014594 Uterine Neoplasms resveratrol 11.2417044934
MESH:D014604 Uveal Neoplasms Tretinoin 3.7116752155
MESH:D014605 Uveitis Dexamethasone 3.921336536
MESH:D014625 Vaginal Neoplasms Zidovudine 3.8912579204
MESH:D014652 Vascular Diseases sodium arsenite 3.5417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.6912125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.3016837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.7314671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 12.3818097624
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 12.3818097624
MESH:D018487 Ventricular Dysfunction, Left resveratrol 12.3817488730
MESH:D020257 Ventricular Remodeling Isoproterenol 16.2418097624
MESH:D020257 Ventricular Remodeling Plant Extracts 16.2418097624
MESH:D020257 Ventricular Remodeling valsartan 16.2419027736
MESH:D014820 Vitiligo Tretinoin 3.2116761959
MESH:D014839 Vomiting Indomethacin 3.8511897121
MESH:D014846 Vulvar Neoplasms Raloxifene 4.6516343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.3415886252
MESH:D015430 Weight Gain Clozapine 7.2620564506 17502770 20521320 20107430 16402076 16141801
MESH:D015430 Weight Gain Dietary Fats 7.2616723640
MESH:D015431 Weight Loss Clozapine 4.1917933447
MESH:D009396 Wilms Tumor Tretinoin 3.1916287080
MESH:D014947 Wounds and Injuries Plant Extracts 3.5120213670 19894650
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
REACT:15380 Diabetes pathways
KEGG:00561 Glycerolipid metabolism
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:03320 PPAR signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA232
    • Releated gene ID Related gene Name
    PA232LPL
    Releated disease ID Related disease Name
    PA444785Lipodystrophy
    PA443635Cardiovascular Diseases
    PA447216Schizophrenia
    PA443796Coronary Artery Disease
    PA445131Obesity
    PA446120Hypertriglyceridemia
    PA444528Hyperlipidemias
    PA443890Diabetes Mellitus, Type 2
    PA446414Carotid Stenosis
    Releated drug ID Related drug Name
    PA449905hydrocortisone
    PA450970pioglitazone
    PA451283rosiglitazone
    PA452631thiazolidinediones
    PA451776triglycerides
    PA451799troglitazone
    PA450952phospholipids
    PA449688fluvastatin
    PA133950441hmg coa reductase inhibitors
    PA449061clozapine
    PA450688olanzapine
    PA449594fenofibrate
    PA450970pioglitazone
    PA450480metoprolol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB06439 antagonist Tyloxapol Surface-Active Agents;Detergents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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