AutismKB 2.0

Annotation Detail for LRP1


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Basic Information Top
Gene Symbol:LRP1 ( A2MR,APOER,APR,CD91,FLJ16451,IGFBP3R,LRP,MGC88725,TGFBR5 )
Gene Full Name: low density lipoprotein receptor-related protein 1
Band: 12q13.3
Quick LinksEntrez ID:4035; OMIM: 107770; Uniprot ID:LRP1_HUMAN; ENSEMBL ID: ENSG00000123384; HGNC ID: 6692
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05144Malaria
hsa05010Alzheimer's disease
No data
Pathway IDPathway Name
200127PDGFR-beta signaling pathway
200108amb2 Integrin signaling
Pathway IDPathway Name
P00004Alzheimer disease-presenilin pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1809HIV infection
1918Atherosclerosis
1934Cancer
Desease Name
atherosclerosis, coronary
CARDIOVASCULAR
Alzheimer's disease
CANCER
Lp(a)
breast cancer
NEUROLOGICAL
METABOLIC
thromboembolism, venous
cerebral amyloid angiopathy
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of LRP1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of LRP1 mRNAaffects expression 21346803
C006862 butylphen butylphen results in increased expression of LRP1 proteinincreases expression 15816839
D002927 Cimetidine Cimetidine results in decreased expression of LRP1 proteindecreases expression 11556524
D002995 Clofibric Acid Clofibric Acid affects the expression of LRP1 mRNAaffects expression 17602206
D003300 Copper Copper affects the reaction [LRP1 protein results in increased uptake of PRNP protein]affects reaction|increases uptake 17155929
D016572 Cyclosporine Cyclosporine results in decreased expression of LRP1 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of LRP1 mRNAincreases expression 20435547
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of LRP1 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of LRP1 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of LRP1 mRNAdecreases expression 19638242
D004958 Estradiol Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of LRP1 mRNA]decreases reaction|increases expression 16977382
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of LRP1 mRNAdecreases expression 17108234
D008070 Lipopolysaccharides Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of LRP1 mRNA]decreases reaction|increases expression 16977382
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of LRP1 mRNAincreases expression 16977382
C043062 N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine results in decreased expression of LRP1 proteindecreases expression 11556524
C006253 pirinixic acid pirinixic acid results in decreased expression of LRP1 mRNAdecreases expression 16221962
C075655 Recombivax HB Recombivax HB results in increased expression of LRP1 protein alternative formincreases expression 11527151
D014311 Triprolidine Triprolidine results in decreased expression of LRP1 proteindecreases expression 11556524
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 9.0611850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 9.0618653653
MESH:D000230 Adenocarcinoma Estradiol 4.2211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2214692618
MESH:D000236 Adenoma Diethylnitrosamine 2.856695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.1617162532 19061943 18056438 17620307 16434500 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.1616434500
MESH:D000544 Alzheimer Disease Copper 3.2316410023 16325427 16866297 17119284 16886094 16962711
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 4.3010694572
MESH:D018798 Anemia, Iron-Deficiency Copper 4.8816614410
MESH:D001161 Arteriosclerosis Dietary Fats 9.9515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.1519483382
MESH:D001932 Brain Neoplasms Copper 4.5617079463
MESH:D001943 Breast Neoplasms Copper 2.4015986119 17079463
MESH:D001943 Breast Neoplasms Dietary Fats 2.4020435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.4017474063
MESH:D001943 Breast Neoplasms Estradiol 2.4012948864 19861407 17289903 18497071 17018787 16675129 17261762 14630087
MESH:D001943 Breast Neoplasms N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine 2.4018986763
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4816111702
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.5716705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.5716705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.5720727157 17162532 16569478 10737359 18210153 16830150 19701751 18785209 19919837 19418558 20514400 17173139 20214788 18691550 3084413 16681979 10672840 20084675 16935385 19519916 18971187 17428255 18788625 20432363 19208518 19394651 17055752 16540662 18393292 16698587 16502159 18665156 16878318 20935162 16328049 3581430 19052882 20007298 19539802 16779866 17978847 20524982 17761372 18494052 19171122 18506893 17138121 19335982 20101231 19383236 16807293 11831363 19107877 16288022 19822196 20512989 21159647 18978308 18056438
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.5716924424
MESH:D002294 Carcinoma, Squamous Cell N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine 4.5618986763
MESH:D006332 Cardiomegaly Copper 4.0217327471
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.036135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.0312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.0317174075 21159647 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.0318566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.6919052882
MESH:D002779 Cholestasis Cyclosporine 13.3619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.3617681005 11677210 16105132 17110522 16919318 17333356 15861022
MESH:D002779 Cholestasis pirinixic acid 13.3619176532
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.9418551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1920387270
MESH:D003928 Diabetic Nephropathies Estradiol 3.4119279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.2418551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.2421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.2419107877
MESH:D050171 Dyslipidemias Dietary Fats 3.4518367378
MESH:D004487 Edema Cimetidine 7.4719703484
MESH:D004487 Edema pirinixic acid 7.4712083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2012538720
MESH:D016889 Endometrial Neoplasms Estradiol 2.9811473722 19148513 18566989
MESH:D019446 Endotoxemia Lipopolysaccharides 4.4217637181 15821434 15328337
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1516302075
MESH:D005234 Fatty Liver Cyclosporine 24.7119224547
MESH:D005234 Fatty Liver Dietary Fats 24.7117967931 18296743 19551842 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 24.7120387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.7115345470
MESH:D005234 Fatty Liver pirinixic acid 24.7120131406 19236843
MESH:D005334 Fever Lipopolysaccharides 4.029205823 11852909
MESH:D005355 Fibrosis Cyclosporine 8.7412168785 12639820
MESH:D005355 Fibrosis Dietary Fats 8.7418296743
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D006258 Head and Neck Neoplasms N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine 5.4618986763
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.3916366002
MESH:D006521 Hepatitis, Chronic Copper 5.3117338147
MESH:D006527 Hepatolenticular Degeneration Copper 5.1816607473 17182432 19888908 17109627 17276780
MESH:D006529 Hepatomegaly pirinixic acid 3.0118467677 19176532 16221962 19772884
MESH:D006558 Herpes Genitalis Estradiol 5.0615709030
MESH:D019584 Hot Flashes Estradiol 3.7817088409
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.6221332399
MESH:D006973 Hypertension Cyclosporine 2.1010903974
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4917937319
MESH:D007249 Inflammation Dietary Fats 8.4220412841
MESH:D007249 Inflammation Diethylnitrosamine 8.4218785209
MESH:D007249 Inflammation Lipopolysaccharides 8.4217237260 17255318 12878042 17963957 9205823
MESH:D007333 Insulin Resistance Dietary Fats 12.3011836018 18457598
MESH:D007333 Insulin Resistance Estradiol 12.3016627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 12.3016306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.6417255318
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007674 Kidney Diseases Cyclosporine 5.948314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 5.9415618244
MESH:D007676 Kidney Failure, Chronic Copper 4.9016518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 17.7716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 17.7716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 17.7712371664
MESH:D007680 Kidney Neoplasms Estradiol 17.7715610895
MESH:D007859 Learning Disorders Copper 4.8117134702
MESH:D007970 Leukopenia Lipopolysaccharides 4.7215821434
MESH:D008103 Liver Cirrhosis Dietary Fats 6.6418296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.6418665156 19638242 18407596 20032147 18522880
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.5212878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5215474484
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1017034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.287678174
MESH:D008113 Liver Neoplasms Clofibric Acid 14.2817602206
MESH:D008113 Liver Neoplasms Copper 14.2820302851
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.2821167192 19690152 20501860 18977376 20492335 18644402 2862719 19294768 19551842 15175105 16942905 19090486 19499222 2422723 19850985 19254457 20583210 19426721 19255062 20101389 9163691 18754104 20434301 18648771 19642983 12112319 21071580 20137499 10737359 19812893 19833225 20452335 19073162 12771043 21047994 19996281 21278145 19256749 18978307 15885732 19638242 20118626 20405173 19427195
MESH:D008113 Liver Neoplasms pirinixic acid 14.2820007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.932876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 5.9319009564 17942915 19539802 9362446 16267830 21159647 18775883 18308698 18544905 19004024 18079962 3124819 18164116 18253720 17174075 19126423 17854601 18093689 19519916 2563599 16842330 18282651
MESH:D055370 Lung Injury Lipopolysaccharides 4.0221114838
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620970405 20512841 21163286 6695378
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5611408345 11807958 16891317 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.5119453300
MESH:D007706 Menkes Kinky Hair Syndrome Copper 5.9017109627 17268249
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1419151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.2616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.2616411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.4118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.417678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.573581430 9029167
MESH:D009369 Neoplasms pirinixic acid 1.9517405874
MESH:D009389 Neovascularization, Pathologic Copper 10.4217308104
MESH:D009389 Neovascularization, Pathologic Estradiol 10.4217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2918481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 3.6611399458 16427766
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3420387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1520387270
MESH:D009765 Obesity Dietary Fats 4.4417217161 18457598 21332399 11836018 20132043 19632207 20518802 18674790 16723640
MESH:D009765 Obesity pirinixic acid 4.4420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.9016049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.9016049721
MESH:D010051 Ovarian Neoplasms Estradiol 2.2219401270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4216540662
MESH:D010195 Pancreatitis Cimetidine 5.2910484002
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D011014 Pneumonia Lipopolysaccharides 4.5711605937 12224865
MESH:D011230 Precancerous Conditions Cyclosporine 8.9512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.952563599
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8920887781
MESH:D011471 Prostatic Neoplasms Copper 3.6017079463 17308104
MESH:D011471 Prostatic Neoplasms Estradiol 3.6016740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2316882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.7310835634
MESH:D012559 Schizophrenia Copper 3.0816842975
MESH:D012640 Seizures 2,4-dinitrotoluene 5.8718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.8718551238
MESH:D012772 Shock, Septic Triprolidine 6.2418063050
MESH:D012852 Sinusitis Triprolidine 6.357327846
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.1715821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.987505956
MESH:D013978 Tibial Fractures Estradiol 4.7219048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.0116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.0116049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.0610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.0610091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D014605 Uveitis Cyclosporine 4.011336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5415869587 14671159
MESH:D015430 Weight Gain Dietary Fats 3.7416723640
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:05144 Malaria
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA233
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00025 - Antihemophilic Factor Coagulants;Thrombotic Agents
    DB00031 - Tenecteplase Thrombolytic Agents
    DB00100 - Coagulation Factor IX Coagulants;Thrombotic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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