AutismKB 2.0

Annotation Detail for LRP4


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Basic Information Top
Gene Symbol:LRP4 ( CLSS,KIAA0816,LRP-4,LRP10,MEGF7 )
Gene Full Name: low density lipoprotein receptor-related protein 4
Band: 11p11.2
Quick LinksEntrez ID:4038; OMIM: 604270; Uniprot ID:LRP4_HUMAN; ENSEMBL ID: ENSG00000134569; HGNC ID: 6696
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00004Alzheimer disease-presenilin pathway
No data
Related Diseases/Disorders Top
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Desease Name
Bone mineral density (hip)
METABOLIC
Desease Name
Bone mineral density (hip)
Desease Name
Cenani-Lenz syndactyly syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of LRP4 mRNAincreases expression 19933214
C026137 3-hydroxyacetanilide 3-hydroxyacetanilide results in decreased expression of LRP4 mRNAdecreases expression 18544908
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of LRP4 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen results in decreased expression of LRP4 mRNAdecreases expression 18544908
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LRP4 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of LRP4 mRNAincreases expression 20458559
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of LRP4 mRNAaffects expression 17484886
D019833 Genistein Genistein results in increased expression of LRP4 mRNAincreases expression 17341692
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of LRP4 mRNAdecreases expression 16221955
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LRP4 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of LRP4 mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of LRP4 mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LRP4 mRNAincreases expression 18796159
19933214
D013752 Tetracycline Tetracycline results in decreased expression of LRP4 mRNAdecreases expression 16917069
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0015322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.6211798837 19825857
MESH:D000230 Adenocarcinoma Genistein 4.6211473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.813712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1911289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.9416206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.9419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.9412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Genistein 2.0716873071 16541309 17200150
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0720435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4511589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9216011737 15721981 16097048 15700767 18705752 15673190 10355542 16192424 16050911 16227642 16124888 3786805
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.047296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.043084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 9.0411135700 16217749 15553829 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.0418788625
MESH:D006528 Carcinoma, Hepatocellular Genistein 9.0416924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0519014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.727296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2212490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Genistein 3.3816332659
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.837505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.1119486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.1119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1412621046 8697196 15668235 15340226 16354765
MESH:D003110 Colonic Neoplasms Genistein 2.3017182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5010048152 20055451 15322242
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2115213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9412868966 2524372 18759878 8970840 8156756 11906362 14531868 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.612952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.4116647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4117107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.3516192314 18289764 9328219 9022650 7440962 18692083 11289319 18648102 6482804 9653073 8291058 1440618 6679447
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.3510663392 16081117 16485898 10915739 11834606 16781746 11743745 11461765 12153990 11287661 19164858 19739265 16227642 14725611 18713872 12705907 14550746 16109766 19420014 11421492 11529661 17522070 2444490 17906064 16393943 15968718 10774834 19416960 12540782 18071297 14986274 12958197 12392966 19085960 15619225 16177239 19923254 19370779 11739529 17562736 12594235
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.3516227642 7120509 7440962 19336974 9327722 3732212 15968718 11566570 2869522 3786805 16177239 6884620 4309450 10092053 19085960 10915739 21278145 15998439 17522070 15027814 6623471 7179309
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.3520420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 12.3517522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema perfluorooctanoic acid 12.1117259670 12083418
MESH:D004487 Edema pirinixic acid 12.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.1111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 15322242 16714409
MESH:D004714 Endometrial Hyperplasia Genistein 4.7416402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4311473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.563581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5612903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver arsenic trioxide 19.7615073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.7612631006 61145 15959796 17595544 12795759 16239168 16045604 19224547
MESH:D005234 Fatty Liver pirinixic acid 19.7620131406 19236843
MESH:D005234 Fatty Liver Tetracycline 19.7619224547 16917069
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.196705139
MESH:D005355 Fibrosis Carbon Tetrachloride 9.0618705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0620067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3916904648
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005909 Glioblastoma Genistein 3.3316598420
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.157505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3811294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.656705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.6519110552 19900420
MESH:D006529 Hepatomegaly perfluorooctanoic acid 15.303609246
MESH:D006529 Hepatomegaly pirinixic acid 15.3016221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.3015340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2215340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 8.1516870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 8.1512083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0815034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D007249 Inflammation perfluorooctanoic acid 5.3212083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3212200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.199022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2612587719 15629191
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.066582329
MESH:D007938 Leukemia arsenic trioxide 6.6015070760
MESH:D007938 Leukemia Genistein 6.6017468513 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9017077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.8719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1516467208 16968895 17050201 20471514 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2815213294 11468182 16891316 17869043 19075265 16331271 17712046 15336539 17107899 11161223 17649720 12018890 12712474 16966277 16823087 15622746 19642359 19035177 9834237 16112521 17217047 12679006 15748426 16330433 19225113
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4816882451
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.388812269
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8616943688 17174718 11408273 17157831 17334410 16239168 16221502 11903743 21278145
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2615034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.0315876570 16015684 17976157 16638106 15996030 15931870 12958196 12546737 13678700 18420326 16011737 15730626 15057751 18395914 18705752 18054572 16116963 15673190 17525996 12898905 17631135 18210741 16192424 16248980 12632512 15370692 18418968 17922224 15052691 16033810 12667390 14620537 18317297 18395095 17944888 17900296 18187930 14716496 18339082 12389079 15362042 12609069 15338365 17761835 18412020 14716833 18263696 18251166 17766677 12632514 15123356 18277467 12445421 18006644 18429990 18376398 18279442 14748882 18156304 12649538 18166357 17481882 18481824 12445418 10355542 17698563 12741479 17869086 18205269 12666154 15893842 15925388 12586293 17823541 15650968 17708605 15959796 18472094 17640975 16136751 17565644 14512876 17805973 15818738 17721639 17714472 16027843 18472332 14724832 17557913 20821823 16097048 11481614
MESH:D008106 Liver Cirrhosis, Experimental Genistein 5.0317823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0312878042
MESH:D008107 Liver Diseases Acetaminophen 3.9811587558 16611625 19014921 12969438 19460945 12587719 19784758 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9815830285 17285989 16964402 15720792 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.7616871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.7616899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 14.6614682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.6619294768
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 14.6614757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 14.6616377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.6616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.67598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.6720377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.6712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.6712151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4315213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.3211798837 19825857
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3211884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0114578162 12929590
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1819417148 15949261 14977855 11468182 19549372
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2016882451 16105982
MESH:D009203 Myocardial Infarction Genistein 5.8217141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.8219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.6717141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.6716411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0916624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.513581430
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D009395 Nephritis, Interstitial Tetracycline 4.969884423
MESH:D009421 Nervous System Malformations Genistein 10.0316427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.0314600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.486679447
MESH:D009436 Neural Tube Defects arsenic trioxide 7.4810525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 5.099802331
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.526482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.193988306
MESH:D010024 Osteoporosis Genistein 3.3219401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.2016169203
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.0719769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Genistein 5.0719005980
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5615580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.627296757
MESH:D010235 Paraganglioma arsenic trioxide 4.2819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.6111026799
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.646228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 10.1917132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.1911118676 11896295 11222880 11399792
MESH:D017096 Prion Diseases Tetracycline 5.5710903871
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.3319131511
MESH:D011471 Prostatic Neoplasms Genistein 3.3315256057 16925846 15378649
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.463692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0916646077
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013576 Syndactyly marker/mechanism 16207730
MESH:C538150 Syndactyly Cenani Lenz type marker/mechanism
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.441399818 6582329 3712494 7505956 6587162
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.4419014326
MESH:D014071 Tooth Abnormalities marker/mechanism 16207730
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1115213294
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.218074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.2111780464 20435036 12973940 12845720
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30454
    • No data
    Releated disease ID Related disease Name
    PA445190Osteoporosis
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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