AutismKB 2.0

Annotation Detail for LRP6


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Basic Information Top
Gene Symbol:LRP6 ( ADCAD2,FLJ90062,FLJ90421 )
Gene Full Name: low density lipoprotein receptor-related protein 6
Band: 12p13.2
Quick LinksEntrez ID:4040; OMIM: 603507; Uniprot ID:LRP6_HUMAN; ENSEMBL ID: ENSG00000070018; HGNC ID: 6698
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04310Wnt signaling pathway
No data
Pathway IDPathway Name
200064Canonical Wnt signaling pathway
200052Presenilin action in Notch and Wnt signaling
200055Wnt signaling network
Pathway IDPathway Name
P00004Alzheimer disease-presenilin pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1840Macular degeneration
1918Atherosclerosis
2042Thrombophlebitis
2120Rabies
Desease Name
CARDIOVASCULAR
Coronary Artery Disease
Dyslipidemias
No data
Desease Name
Coronary artery disease, autosomal dominant, 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001104 Arbutin Arbutin results in decreased expression of LRP6 mRNAdecreases expression 17103032
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of LRP6 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LRP6 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of LRP6 mRNAincreases expression 12414654
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of LRP6 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of LRP6 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of LRP6 mRNAaffects cotreatment|affects expression 17602206
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of LRP6 mRNAincreases expression 12414654
C011890 kojic acid kojic acid results in decreased expression of LRP6 mRNAdecreases expression 16595896
D018021 Lithium Chloride Lithium Chloride results in increased expression of LRP6 mRNAincreases expression 20069066
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LRP6 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of LRP6 mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LRP6 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LRP6 mRNAincreases expression 12377990
D014212 Tretinoin Tretinoin results in increased expression of LRP6 mRNAincreases expression 17064353
C025643 vinclozolin vinclozolin affects the expression of LRP6 mRNAaffects expression 19015723
D024483 Vitamin K 3 Vitamin K 3 results in increased expression of LRP6 mRNAincreases expression 12414654
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9014514962 15322242 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9920127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 6.686695378
MESH:D000236 Adenoma Diethylnitrosamine 6.6810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.5919061943 17162532 19052882 16434500 17620307 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.5916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.5916835633
MESH:D000505 Alopecia Tretinoin 3.6415955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D001008 Anxiety Disorders vinclozolin 3.6619015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1219183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.0916412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2716292516
MESH:D001249 Asthma Tretinoin 2.3516456186
MESH:D001471 Barrett Esophagus Tretinoin 4.4416935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.4519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.4512125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.4516206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9220146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9217474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9216166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6416813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2216168501
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.0519107877 17055752 16540662 19539802 20524982 17978847 20101231 16935385 3581430 18210153 19383236 17761372 18971187 19171122 16328049 17138121 16502159 20514400 21159647 19208518 16779866 16288022 10737359 18393292 19394651 20214788 20432363 17173139 20084675 19919837 18056438 3084413 19418558 19701751 17162532 10672840 16830150 18506893 19519916 19052882 19335982 16569478 19822196 18788625 11831363 16878318 20512989 20727157 17428255 18978308 20007298 16681979 18785209 18665156 16698587 18691550 16807293 18494052 20935162
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.051917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5920419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.5916051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3816120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.5316936243
MESH:D002386 Cataract Tretinoin 3.1117460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.2620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.2612371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.2617174075 21159647 7505956 2727394
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6416129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.4119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.4116835633
MESH:D002779 Cholestasis Cyclosporine 7.8319486331
MESH:D002779 Cholestasis pirinixic acid 7.8319176532
MESH:D002822 Choriocarcinoma Tretinoin 5.2216461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8016354765 8697196 15668235 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 5.809407595
MESH:D003092 Colitis Tretinoin 3.7517035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0817141729 14669216
OMIM:610947 CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT 2 marker/mechanism
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4515322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.4510589399 9224671 17551590 8800419 16925845 9664655 9125849 9211117 14991402 9142499
MESH:D003456 Cryptorchidism vinclozolin 4.3814966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2417107852
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.7519107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D004487 Edema pirinixic acid 6.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.1616714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 12.1618230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1216569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0510568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1816302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.9011564622
MESH:D005124 Eye Abnormalities Tretinoin 8.9016938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 13.2219224547
MESH:D005234 Fatty Liver Diethylnitrosamine 13.2221071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 13.2219236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005355 Fibrosis Cyclosporine 14.9812168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.9820067830
MESH:D005355 Fibrosis Tretinoin 14.9817994277
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9816973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3616417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D005909 Glioblastoma Tretinoin 3.0217312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2216084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.1720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.1710048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 11.179664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.5520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly pirinixic acid 8.4019772884 19176532 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.4016120746 12621046 15340226
MESH:D006869 Hydronephrosis Lithium Chloride 13.2419797860
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 13.2416354765 15340226 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.2316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6116778211
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006973 Hypertension Cyclosporine 4.9810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9818670907 18850075
MESH:D007248 Infertility, Male vinclozolin 3.0616467254
MESH:D007249 Inflammation Diethylnitrosamine 4.9418785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9412878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.6516306350
MESH:D007410 Intestinal Diseases Tretinoin 3.8117994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.0316580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.0315992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Cyclosporine 2.358314463 10903974 18776723
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.3016518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7612371664
MESH:D007938 Leukemia Tretinoin 2.7817143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7316482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0819850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1719642359 17339181 16766008 17712046 19225113 17107899 19035177 16891316 16140955 17361223 16331271 16823087 17301526 12679006 16935935 9834237 17217047 17294898 17368321 16788101 15748426 17649720 19029980 19075265 17506722
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7816417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.339224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8420032147 19638242 18665156 18522880 18407596
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.4116248980 18397230
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1117034775
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.3520195826 21137059
MESH:D008113 Liver Neoplasms Clofibric Acid 14.3517602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.3512112319 19256749 19254457 19073162 19812893 10737359 18977376 21071580 18754104 2422723 20452335 19294768 19690152 2862719 18644402 15885732 20137499 21047994 20101389 20434301 19638242 21167192 19499222 19551842 15175105 19833225 18648771 20492335 21278145 18978307 19426721 20118626 12771043 20405173 20501860 9163691 19642983 19996281 19090486 19850985 20583210 19427195 19255062 16942905
MESH:D008113 Liver Neoplasms pirinixic acid 14.3520007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.3516984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.993124819 18079962 21159647 18544905 18164116 18093689 19519916 18775883 9362446 19009564 17174075 19539802 18282651 16267830 19126423 17854601 18308698 2563599 17942915 16842330 19004024 18253720
MESH:D008114 Liver Neoplasms, Experimental kojic acid 9.9918544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.9912151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3620135361 18816296 20064080 20464547 6695378 18569708 18520028 17053015 20869020
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.3620970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3619555203 11884234
MESH:D008527 Medulloblastoma Tretinoin 2.7917453147
MESH:D008545 Melanoma Tretinoin 3.7816752155
MESH:D008545 Melanoma Vitamin K 3 3.7819082730
MESH:D008591 Meningomyelocele Tretinoin 4.4716940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2116381670
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0917596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9716411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.589029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 8.2711141357
MESH:D009369 Neoplasms pirinixic acid 8.2717405874
MESH:D009369 Neoplasms Tretinoin 8.2716594593 16946489
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3118481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.6314600291
MESH:D009421 Nervous System Malformations Tretinoin 9.639125849
MESH:D009436 Neural Tube Defects Tretinoin 3.079142499
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1820387270
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3516936753
MESH:D010146 Pain Tretinoin 2.9216870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.2816540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.2815976015
MESH:D010212 Papilloma Hydrogen Peroxide 4.1312065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D011141 Polyuria Lithium Chloride 6.0519692487
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.0312371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.032563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.6611896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.6618042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.9818220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9717292933
MESH:D011472 Prostatitis vinclozolin 4.9818629315
MESH:D011507 Proteinuria Tretinoin 3.6416636307
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011625 Pterygium Tretinoin 4.8416723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1316283617 16116481
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 18.0619755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 18.0612065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 18.068532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 18.0616192470
MESH:D012878 Skin Neoplasms Tretinoin 18.0616467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.3420155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3418456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.3417261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.247505956
MESH:D013964 Thyroid Neoplasms Tretinoin 7.2417045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.8116051514
MESH:D014376 Tuberculosis Tretinoin 3.2416040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.1917053015
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7016129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.6716752155
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D014820 Vitiligo Tretinoin 4.0916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D009396 Wilms Tumor Tretinoin 3.9916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
Pathway ID Pathway Name
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30456
    • No data
    Releated disease ID Related disease Name
    PA443796Coronary Artery Disease
    PA443842Death
    PA443886Diabetes Mellitus
    PA444528Hyperlipidemias
    PA444552Hypertension
    PA447159Metabolic Syndrome X
    PA445190Osteoporosis
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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