AutismKB 2.0

Annotation Detail for LRPAP1


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Basic Information Top
Gene Symbol:LRPAP1 ( A2MRAP,A2RAP,HBP44,MGC138272,MRAP,RAP )
Gene Full Name: low density lipoprotein receptor-related protein associated protein 1
Band: 4p16.3
Quick LinksEntrez ID:4043; OMIM: 104225; Uniprot ID:AMRP_HUMAN; ENSEMBL ID: ENSG00000163956; HGNC ID: 6701
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
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Pathway IDPathway Name
200144Signaling events mediated by the Hedgehog family
200114Lissencephaly gene (LIS1) in neuronal migration and development
200051Reelin signaling pathway
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1858Hemorrhagic disorder
2070Cholelithiasis
2136Hypothyroidism
Desease Name
CARDIOVASCULAR
myocardial infarct
Alzheimer's disease
NEUROLOGICAL
METABOLIC
Myocardial Infarction
gallstones
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of LRPAP1 mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LRPAP1 mRNAaffects expression 16483693
D001194 Asbestos Asbestos affects the expression of LRPAP1 mRNAaffects expression 17297452
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of LRPAP1 mRNAincreases expression 20382639
D019256 Cadmium Chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of LRPAP1 mRNAaffects cotreatment|increases expression 12634122
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of LRPAP1 mRNAaffects expression 17484886
C023600 chromium oxide [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of LRPAP1 mRNAaffects cotreatment|increases expression 12634122
C017133 chromous chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of LRPAP1 mRNAaffects cotreatment|increases expression 12634122
C008261 lead acetate [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of LRPAP1 mRNAaffects cotreatment|increases expression 12634122
D012402 Rotenone Rotenone results in decreased expression of LRPAP1 mRNAdecreases expression 19013527
C017947 sodium arsenite [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of LRPAP1 mRNAaffects cotreatment|increases expression 12634122
C017947 sodium arsenite sodium arsenite results in increased expression of LRPAP1 mRNAincreases expression 12634122
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.833712494
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1217306315 16712894
MESH:D050197 Atherosclerosis Asbestos 4.3018795166
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2411289319 1440618
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.953786805 16227642 10355542 15673190 16124888 15721981 16192424 15700767 16050911 16011737 16097048 18705752
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.713581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7118788625
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.7116507464 15276417 17306315
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.737296757
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4118572023
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.757505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.7520889678
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.7519524636 20056578
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.2519486331 9022650
MESH:D019465 Craniofacial Abnormalities lead acetate 3.1519769572
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9718759878 11906362 8156756 8970840 12868966 14531868 2524372 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.643621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.0018289764 9328219 18692083 9022650 8291058 6679447 18648102 7440962 16192314 9653073 6482804 11289319 1440618
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.002869522 19085960 3786805 4309450 6623471 16177239 11566570 10915739 7120509 7440962 3732212 15968718 6884620 17522070 21278145 16227642 7179309 9327722 10092053 19336974 15027814 15998439
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.493581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4920426865
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.3116045604 12631006 19224547 15959796 17595544 12795759 16239168 61145
MESH:D005317 Fetal Growth Retardation lead acetate 5.5419769572
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005355 Fibrosis Carbon Tetrachloride 3.6318705752
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8716452187
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.776705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.7719900420 19110552
MESH:D006689 Hodgkin Disease sodium arsenite 3.2712676792
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007248 Infertility, Male sodium arsenite 3.0815346721 12646999
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.249022650 8074119
MESH:D007674 Kidney Diseases Cadmium Chloride 6.6816962696
MESH:D007674 Kidney Diseases sodium arsenite 6.6820008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.086582329
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8811408273 17174718 16943688 16239168 17157831 16221502 17334410 21278145 11903743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7516027843 18054572 17944888 18251166 15362042 16136751 18187930 12898905 12667390 15052691 18339082 14620537 18418968 17761835 12586293 12632514 17900296 15338365 11481614 18395914 10355542 15370692 15650968 17922224 18420326 15818738 17721639 12666154 12741479 15931870 18395095 18412020 17525996 18263696 12958196 14716496 20821823 17557913 15996030 18472094 15876570 14748882 12609069 16248980 15893842 12445418 18705752 18006644 14724832 15673190 15057751 12389079 18429990 16015684 15730626 14512876 18156304 12649538 18481824 17708605 18166357 18210741 17640975 17698563 12445421 15925388 17631135 16638106 12632512 18376398 16192424 17481882 16097048 17714472 14716833 17823541 12546737 18277467 16033810 18472332 13678700 17805973 18279442 17869086 18205269 18317297 15123356 16011737 17766677 16116963 17565644 15959796 17976157
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1116964402 16246199 17285989 15720792 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8216899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.7919294768
MESH:D008113 Liver Neoplasms sodium arsenite 4.7915276417 16712894
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.19598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1912014681 15583823
MESH:D008171 Lung Diseases sodium arsenite 3.2619095001
MESH:D008175 Lung Neoplasms Asbestos 3.0512111688
MESH:D008175 Lung Neoplasms sodium arsenite 3.0517077188 19931552 16712894 15276417 17306315
MESH:D008545 Melanoma sodium arsenite 2.0519082730 16487513
MESH:D008654 Mesothelioma Asbestos 4.1318709470 16564556 18310086 16319530 16919927
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.523581430
MESH:D009369 Neoplasms sodium arsenite 2.5611559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8420056578
MESH:D009410 Nerve Degeneration Rotenone 3.9917356569 15790535 18619942
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.556679447
MESH:D009436 Neural Tube Defects sodium arsenite 7.5512854658
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.556482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4717306315 15276417
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010300 Parkinson Disease Rotenone 3.0215451049 18191903 11445065 16140633 19114014 19232380 11535288 16412576 18619942
MESH:D020734 Parkinsonian Disorders Rotenone 4.2118197244 15795934 15574749 15927086
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2816039940
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012878 Skin Neoplasms sodium arsenite 2.7518572023 19524636
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9012854658
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.996582329 7505956 6587162 1399818 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.258074119
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.2516452187 16712894 11723127 17306315
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9011813266
MESH:D014652 Vascular Diseases sodium arsenite 4.6217056641
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30458
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA152241909PP2
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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