AutismKB 2.0

Annotation Detail for LSS


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:LSS ( FLJ25486,FLJ35015,FLJ39450,FLJ46393,OSC )
Gene Full Name: lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
Band: 21q22.3
Quick LinksEntrez ID:4047; OMIM: 600909; Uniprot ID:ERG7_HUMAN; ENSEMBL ID: ENSG00000160285; HGNC ID: 6708
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-341cholesterol biosynthesis I
PWY66-4cholesterol biosynthesis III (via desmosterol)
PWY-6132lanosterol biosynthesis
PWY66-3cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
Pathway IDPathway Name
hsa01100Metabolic pathways
hsa00100Steroid biosynthesis
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
Pathway IDPathway Name
P00014Cholesterol biosynthesis
Pathway IDPathway Name
500825Cholesterol biosynthesis
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C003585 22-hydroxycholesterol 22-hydroxycholesterol results in decreased expression of LSS mRNAdecreases expression 19426978
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of LSS mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of LSS mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of LSS mRNAincreases expression 16788091
D000082 Acetaminophen Acetaminophen results in increased expression of LSS mRNAincreases expression 11264010
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of LSS proteinaffects expression 20106945
D000638 Amiodarone Amiodarone results in increased expression of LSS mRNAincreases expression 15342952
17567588
D000638 Amiodarone Amiodarone results in increased expression of LSS mRNAincreases expression 19224547
D000639 Amitriptyline Amitriptyline results in increased expression of LSS mRNAincreases expression 17567588
15342952
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LSS mRNAaffects expression 16483693
D000965 Antimony Antimony results in decreased expression of LSS mRNAdecreases expression 17547211
D000966 Antimony Potassium Tartrate Antimony Potassium Tartrate results in decreased expression of LSS mRNAdecreases expression 17547211
D016718 Arachidonic Acid Arachidonic Acid results in decreased expression of LSS mRNAdecreases expression 16704987
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of LSS mRNAdecreases expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of LSS mRNAdecreases expression 14729362
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of LSS mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of LSS mRNAdecreases expression 19224547
C084597 chlorcyclizine chlorcyclizine results in increased expression of LSS mRNAincreases expression 15342952
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of LSS mRNAincreases expression 18178546
D002746 Chlorpromazine Chlorpromazine results in increased expression of LSS mRNAincreases expression 15342952
D017291 Clarithromycin Clarithromycin results in decreased expression of LSS mRNAdecreases expression 15342952
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of LSS mRNAaffects cotreatment|affects expression 17602206
D002997 Clomipramine Clomipramine results in increased expression of LSS mRNAincreases expression 15342952
D003024 Clozapine Clozapine results in increased expression of LSS mRNAincreases expression 15342952
D016572 Cyclosporine Cyclosporine results in decreased expression of LSS mRNAdecreases expression 20106945
D003907 Dexamethasone Dexamethasone affects the expression of LSS mRNAaffects expression 15102944
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of LSS mRNAaffects cotreatment|affects expression 17602206
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of LSS mRNAdecreases expression 17547211
D004316 Doxepin Doxepin results in increased expression of LSS mRNAincreases expression 17567588
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of LSS mRNAincreases expression 17351261
D005472 Fluorouracil LSS protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D005473 Fluoxetine Fluoxetine results in increased expression of LSS mRNAincreases expression 15342952
17567588
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of LSS mRNAincreases expression 16849584
D007099 Imipramine Imipramine results in increased expression of LSS mRNAincreases expression 17567588
15342952
D007213 Indomethacin Indomethacin affects the expression of LSS mRNAaffects expression 17546600
D007529 Isoflavones Isoflavones results in increased expression of LSS mRNAincreases expression 17374662
D007654 Ketoconazole Ketoconazole results in increased expression of LSS mRNAincreases expression 17567588
15342952
C099406 L 742694 L 742694 affects the expression of LSS mRNAaffects expression 15102944
D017336 Loratadine Loratadine results in increased expression of LSS mRNAincreases expression 15342952
D008767 Methylmercury Compounds Methylmercury Compounds affects the expression of LSS mRNAaffects expression 16966085
C022838 nickel chloride nickel chloride results in decreased expression of LSS mRNAdecreases expression 17547211
D010419 Pentamidine Pentamidine results in decreased expression of LSS mRNAdecreases expression 15342952
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of LSS mRNAincreases expression 17681415
D010480 Perhexiline Perhexiline results in increased expression of LSS mRNAincreases expression 15342952
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of LSS mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital affects the expression of LSS mRNAaffects expression 19136022
D010634 Phenobarbital Phenobarbital results in increased expression of LSS mRNAincreases expression 19482888
D010795 Phthalic Acids Phthalic Acids results in decreased expression of LSS mRNAdecreases expression 15728792
C006253 pirinixic acid pirinixic acid affects the expression of LSS mRNAaffects expression 19136022
D011374 Progesterone Progesterone results in increased expression of LSS mRNAincreases expression 18070364
D020280 Sertraline Sertraline results in increased expression of LSS mRNAincreases expression 15342952
17567588
D013015 Sotalol Sotalol results in decreased expression of LSS mRNAdecreases expression 15342952
D014284 Triiodothyronine Triiodothyronine results in increased expression of LSS mRNAincreases expression 15953391
D013629 Tamoxifen Tamoxifen results in decreased expression of LSS mRNAdecreases expression 15590111
D013629 Tamoxifen Tamoxifen results in increased expression of LSS mRNAincreases expression 15342952
17567588
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LSS mRNAdecreases expression 20106945
D013881 Thioridazine Thioridazine results in increased expression of LSS mRNAincreases expression 15342952
D001371 trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride results in increased expression of LSS mRNAincreases expression 15342952
C034613 triacsin C triacsin C results in decreased expression of LSS mRNAdecreases expression 16704987
D014812 Vitamin K Vitamin K affects the expression of LSS mRNAaffects expression 16844298
C088658 zoledronic acid zoledronic acid results in increased expression of LSS mRNAincreases expression 18325729
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.9514745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 6.386195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.3815322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 2.9818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3517505938
MESH:D058186 Acute Kidney Injury zoledronic acid 3.9519715164
MESH:D055371 Acute Lung Injury pirinixic acid 2.5818653653
MESH:D000210 Acute-Phase Reaction zoledronic acid 4.9020200999
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 11.5320464547 20127859
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 11.5316033868
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 11.5314692618
MESH:D000230 Adenocarcinoma Fluorouracil 11.5317638652
MESH:D000230 Adenocarcinoma Indomethacin 11.5316537180
MESH:D000236 Adenoma Benzo(a)pyrene 13.026695378
MESH:D000236 Adenoma Diethylnitrosamine 13.0210737359 6695378
MESH:D000236 Adenoma Dimethylnitrosamine 13.0219555203
MESH:D000236 Adenoma Indomethacin 13.0211497255
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 20.0919061943 17162532 17620307 16434500 19052882 18056438
MESH:D018248 Adenoma, Liver Cell Phenobarbital 20.0917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.0916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 20.0916835633
MESH:D000380 Agranulocytosis Clozapine 4.4914617031 16160616 12649775
MESH:D017088 AIDS-Related Opportunistic Infections Pentamidine 5.7711806628
OMIM:607154 ALLERGIC RHINITIS Loratadine 5.2216527031
MESH:D000505 Alopecia Isoflavones 4.2517569567
MESH:D016301 Alveolar Bone Loss Indomethacin 4.7817225004
MESH:D000544 Alzheimer Disease Indomethacin 2.5617627676 15579461
MESH:D000740 Anemia Fluorouracil 6.9917963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 6.9911748828
MESH:D000799 Angioedema Acetaminophen 3.2510982225
MESH:D001008 Anxiety Disorders Fluoxetine 8.3318083778
MESH:D001008 Anxiety Disorders Sertraline 8.3318822694
MESH:D001014 Aortic Aneurysm Indomethacin 4.2910231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 9.8219183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 9.8210388637
MESH:D001145 Arrhythmias, Cardiac Amiodarone 8.1018218290 20041841 18057881
MESH:D001145 Arrhythmias, Cardiac Sotalol 8.1018724381
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.9011256880
MESH:D018771 Arthralgia Indomethacin 4.572160914
MESH:D001169 Arthritis, Experimental Dexamethasone 6.1017659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.1015885639
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.6611248219
MESH:D001249 Asthma Loratadine 4.039196086
MESH:D001281 Atrial Fibrillation Amiodarone 3.4619698954 18651412
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 3.9520106747
MESH:D001321 Autistic Disorder Acetaminophen 2.5718445737
MESH:D001321 Autistic Disorder Arachidonic Acid 2.5718582451
MESH:D001321 Autistic Disorder Fluoxetine 2.5718775368 19232924
MESH:D001321 Autistic Disorder Sertraline 2.5718775368
MESH:D001477 Bartter Syndrome Indomethacin 4.4110684365
MESH:D001778 Blood Coagulation Disorders Amiodarone 12.2819483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 12.2819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.2812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3715746008
MESH:D001859 Bone Neoplasms zoledronic acid 4.4219442620 17312309 16121404 11697798 15867366 16778634
MESH:D001862 Bone Resorption zoledronic acid 4.1818496637 8053405 16769263 18404659 11869084 15845617
MESH:D001929 Brain Edema Indomethacin 4.4311481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.7417868700
MESH:D001930 Brain Injuries Progesterone 3.6915665606 15380490 15845082
MESH:D002545 Brain Ischemia Indomethacin 3.8412524144
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.0817474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.0817474063
MESH:D001943 Breast Neoplasms Fluorouracil 4.0819217205 18608205 18357371 16595493 15136595 16110121 16557594
MESH:D001943 Breast Neoplasms Indomethacin 4.0817401462
MESH:D001943 Breast Neoplasms Progesterone 4.0815562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tamoxifen 4.0818629630 18425577 19142967 19059307 19189212 19410462 16818667 19289846 19189210 20544844 18815881 16273361 19084267 19288272 17893378 20859285 19221464 21138602 15668708 19244106 15565566 19487384 17242785 20390343 18351453 17440819 11161223 19103187 16202921 17049068 19011961 16873071 19155303 21152245 19115204 17261762 20135344 19200415 18855134 20005174 19066611 20065188 18997820 18984771 18821012
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.0820435547
MESH:D001943 Breast Neoplasms zoledronic acid 4.0816096432 18695136
MESH:D001991 Bronchitis Antimony 5.548768112
MESH:D002056 Burns Indomethacin 4.1410459503
MESH:D002100 Cachexia Indomethacin 4.4211239499 16537180 15141370 15625704
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.2115673190 3786805 16227642 16192424 15700767 18705752 15721981 16011737 16124888 16097048 16050911 10355542
MESH:D002276 Carcinoid Tumor Fluorouracil 4.0716051944
MESH:D002277 Carcinoma Dimethylnitrosamine 11.2919555203
MESH:D002277 Carcinoma Fluorouracil 11.2917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 11.2916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.9319066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 23.0116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 23.0116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 23.013084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 23.0121507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 23.0118788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 23.0120727157 17978847 16569478 17138121 17055752 17761372 18210153 19171122 10672840 18494052 20214788 16698587 16935385 18691550 19701751 16681979 18971187 10737359 3084413 20935162 20514400 16288022 19919837 19335982 19208518 19418558 18393292 19383236 16502159 16807293 19052882 18785209 16878318 20524982 18788625 20432363 16328049 20512989 19539802 11831363 16830150 16779866 18506893 18978308 21159647 19107877 16540662 17173139 19394651 18665156 20084675 18056438 19822196 20007298 17162532 3581430 17428255 19519916 20101231
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 23.0118930000 17045692 17971768 16799960 16332177 17088986
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 23.0116391822
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 23.011701930 6705139 17173139 20007298 20935162
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 23.0116924424
MESH:D006528 Carcinoma, Hepatocellular Vitamin K 23.0116328049
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.1411053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.7711352223 14736730 18791128
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 3.3119233551
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 9.1818695887
MESH:D002292 Carcinoma, Renal Cell Indomethacin 9.1817341418
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 9.1818507039
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 9.0920419170
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 9.0916033868
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 9.0916757204 18986760 16280240 17066447
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 9.0915482327 12636206
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.1117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.0218670907 16120746 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 5.5415710769 19225199
MESH:D002311 Cardiomyopathy, Dilated Antimony 5.5410334427
MESH:D002318 Cardiovascular Diseases Isoflavones 3.7417689850
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.5018974383
MESH:D002386 Cataract Acetaminophen 2.2210977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 8.746135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 8.7412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 8.7417174075 21159647 2727394 7505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.684080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.6819052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.6816835633
MESH:D002764 Cholecystitis Indomethacin 4.5711181007
MESH:D002779 Cholestasis Cyclosporine 10.7719486331
MESH:D002779 Cholestasis Ethinyl Estradiol 10.7717681005 11677210 16105132 17110522 16919318 17333356 15861022
MESH:D002779 Cholestasis pirinixic acid 10.7719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.8316354765 15668235 12621046 8697196 15340226
MESH:D003072 Cognition Disorders Clozapine 4.3917123785
MESH:D003110 Colonic Neoplasms Dexamethasone 5.0915824018
MESH:D003110 Colonic Neoplasms Fluorouracil 5.0917016597 15001691 16340194 16510598 17169374 17725105 17018589 18772588 17172411 17287894
MESH:D003110 Colonic Neoplasms Indomethacin 5.0915963497 15637740 15625704 15936596 15786552 11260862
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.2514970324 18383874 17594712 16331619 17016601 16282729 15148649 18802399 18949393 17695437 17401013 20501625 17094418 16524972 17255274 18509181 15289873 16303861 18288408 17454858 16391804 18448328
MESH:D015179 Colorectal Neoplasms Indomethacin 3.2511197048 12606626 17054584 18059344
MESH:D015179 Colorectal Neoplasms Isoflavones 3.2517116718
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.5714669216 17141729
MESH:D018352 Coronavirus Infections Indomethacin 5.1217302372
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.3917728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3910048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.0018551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.0018551238
MESH:D007644 Darier Disease Fluorouracil 4.2116733453
MESH:D016757 Death, Sudden, Cardiac Thioridazine 5.3020210726
MESH:D003704 Dementia Methylmercury Compounds 9.0716140633
MESH:D003704 Dementia Thioridazine 9.0711575062
MESH:D003711 Demyelinating Diseases Tamoxifen 3.7919031437
MESH:D003866 Depressive Disorder Amitriptyline 24.4418083778 15014590
MESH:D003866 Depressive Disorder Clomipramine 24.4418083778
MESH:D003866 Depressive Disorder Doxepin 24.4415014590
MESH:D003866 Depressive Disorder Fluoxetine 24.4415014590
MESH:D003866 Depressive Disorder Imipramine 24.4420305041
MESH:D003866 Depressive Disorder Sertraline 24.4420305041 18822694 15014590
MESH:D003865 Depressive Disorder, Major Sertraline 4.8716968574
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 2.8712438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1318249437
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 6.0916402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.0920387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.0917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 2.9819279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.9217187935
MESH:D003967 Diarrhea Dexamethasone 6.467237001
MESH:D003967 Diarrhea Indomethacin 6.467907874 7237001
MESH:D006970 Disorders of Excessive Somnolence Clozapine 4.9615331141
MESH:D004283 Dog Diseases Antimony 5.0712019027
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 28.3618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 28.3621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 28.3619164858 19420014 2444490 11461765 14550746 16109766 19923254 16781746 10774834 19416960 12594235 14725611 12153990 11421492 18713872 11287661 12540782 14986274 16393943 19085960 19370779 19739265 17562736 17906064 11529661 16227642 11743745 16081117 11739529 12705907 16485898 17522070 10663392 10915739 12392966 15619225 16177239 15968718 18071297 12958197 11834606
MESH:D056486 Drug-Induced Liver Injury Amiodarone 28.3615265979 18218290
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 28.3615027814 3732212 17522070 7120509 10915739 15998439 2869522 6623471 16227642 3786805 10092053 6884620 16177239 11566570 15968718 19336974 4309450 7179309 21278145 19085960 9327722 7440962
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 28.3617851650
MESH:D056486 Drug-Induced Liver Injury Chlorpromazine 28.3611461765
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 28.3619107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 28.368172417
MESH:D056486 Drug-Induced Liver Injury Ketoconazole 28.3618289764
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 28.3620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3211462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.5618043480 12774134 18446180 17190690 16326151 16133044
MESH:D004381 Duodenal Ulcer Indomethacin 3.5911535926 11595415 17329845 17202747 17151854 10671773 17045617 17351913 11991626 11595431 16699067
MESH:D050171 Dyslipidemias Clozapine 3.7516402076
MESH:D004421 Dystonia Phenobarbital 3.461851702
MESH:D004485 Eczema Dexamethasone 3.9112438553
MESH:D004487 Edema Amitriptyline 38.6512798668
MESH:D004487 Edema Arachidonic Acid 38.6511698051 9831321 7990266 9599246 16716910 15177302
MESH:D004487 Edema Clomipramine 38.6512798668
MESH:D004487 Edema Dexamethasone 38.6519703484
MESH:D004487 Edema Fluoxetine 38.6512798668
MESH:D004487 Edema Imipramine 38.6512798668
MESH:D004487 Edema Indomethacin 38.6516100529 8273558 7907874 8985016 19703484 10653021 7990266
MESH:D004487 Edema perfluorooctanoic acid 38.6517259670 12083418
MESH:D004487 Edema pirinixic acid 38.6512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 38.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3115322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 12.1312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 12.1317692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 12.1319031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 2.6516202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Indomethacin 12.3615652904
MESH:D004715 Endometriosis Progesterone 12.3616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 12.3610568697 9294722
MESH:D019446 Endotoxemia Indomethacin 3.9218509659
MESH:D004751 Enteritis Indomethacin 4.1510567023 17763956 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.4117980183
MESH:D004802 Eosinophilia Indomethacin 3.4911298111
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.543659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.283922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.5720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.056401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.687750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.443659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5216302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 8.8716530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 8.8717016578
MESH:D004938 Esophageal Neoplasms Fluorouracil 8.8716481741 15173087 16785472 16337965 17638652
MESH:D004938 Esophageal Neoplasms Indomethacin 8.8711005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.5711564622
MESH:D005234 Fatty Liver Amiodarone 28.9814986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 28.9817595544 19224547 16239168 61145 16045604 15959796 12795759 12631006
MESH:D005234 Fatty Liver Cyclosporine 28.9819224547
MESH:D005234 Fatty Liver Diethylnitrosamine 28.9820387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.9815345470
MESH:D005234 Fatty Liver pirinixic acid 28.9820131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 28.9814986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.8616709447
MESH:D005264 Femoral Fractures zoledronic acid 5.2416234978
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.8911858732
MESH:D005334 Fever Arachidonic Acid 7.9011852909
MESH:D005334 Fever Indomethacin 7.9010431976 11852909 17627676
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.9414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.6019069698
MESH:D005354 Fibrosarcoma Indomethacin 4.3110962813
MESH:D005355 Fibrosis Carbon Tetrachloride 16.5118705752
MESH:D005355 Fibrosis Cyclosporine 16.5112639820 12168785
MESH:D005355 Fibrosis Indomethacin 16.5117994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.5120067830
MESH:D005499 Folliculitis Indomethacin 4.5711298111
MESH:D005756 Gastritis Acetaminophen 9.1716983495
MESH:D005756 Gastritis Indomethacin 9.1715046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.638708960
MESH:D005909 Glioblastoma Indomethacin 3.1712870263
MESH:D005910 Glioma Fluorouracil 5.3616145905
MESH:D005910 Glioma Indomethacin 5.3618371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.8111849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0010696789
MESH:D006073 Gout Indomethacin 4.7711248219
MESH:D006258 Head and Neck Neoplasms Fluorouracil 6.6315162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Indomethacin 6.6315482327
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.3220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.3211294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.1620558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8111000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.0415633222
MESH:D006505 Hepatitis Carbon Tetrachloride 3.0519900420 19110552
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.1315135802
MESH:D006529 Hepatomegaly Amiodarone 21.1415265979
MESH:D006529 Hepatomegaly perfluorooctanoic acid 21.143609246
MESH:D006529 Hepatomegaly Phenobarbital 21.1416109766
MESH:D006529 Hepatomegaly pirinixic acid 21.1418467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 21.1415340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.847520565
MESH:D006561 Herpes Simplex Chlorpromazine 4.711682908
MESH:D019584 Hot Flashes Fluoxetine 9.0214716179
MESH:D019584 Hot Flashes Isoflavones 9.0217290160 14716179
MESH:D006816 Huntington Disease Sertraline 5.4518403212
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.458697196 16959395 15340226 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 14.9116870215
MESH:D006930 Hyperalgesia Indomethacin 14.9112727271
MESH:D006930 Hyperalgesia perfluorooctanoic acid 14.9112083418
MESH:D006930 Hyperalgesia zoledronic acid 14.9116769263
MESH:D034321 Hyperamylasemia Indomethacin 5.1217883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.9516899240
MESH:D006934 Hypercalcemia zoledronic acid 4.5219622757 18089816
MESH:D006937 Hypercholesterolemia Amiodarone 3.358137927 9751232
MESH:D006940 Hyperemia Indomethacin 4.4212524144
MESH:D006943 Hyperglycemia pirinixic acid 2.6820558911
MESH:D006948 Hyperkinesis Clozapine 4.3316046005
MESH:D006949 Hyperlipidemias Indomethacin 3.6317546600
MESH:D006973 Hypertension Cyclosporine 7.0710903974
MESH:D006973 Hypertension Dexamethasone 7.0717042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.0718670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.5215338365
MESH:D006996 Hypocalcemia zoledronic acid 5.6012669777
MESH:D007021 Hypospadias Ethinyl Estradiol 9.9116569931 16945680
MESH:D007021 Hypospadias Loratadine 9.9116407038
MESH:D007037 Hypothyroidism Amiodarone 3.9417991464 18020914
MESH:D007077 Ileal Diseases Indomethacin 4.4318306037 10574470
MESH:D007079 Ileitis Indomethacin 4.7710651667 16133968 10647630
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.7816133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.8315869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.0917937319
MESH:D007249 Inflammation Amitriptyline 38.6312798668
MESH:D007249 Inflammation Arachidonic Acid 38.6315177302 17371808 9831321
MESH:D007249 Inflammation Clomipramine 38.6312798668
MESH:D007249 Inflammation Dexamethasone 38.6311099482 8960868
MESH:D007249 Inflammation Diethylnitrosamine 38.6318785209
MESH:D007249 Inflammation Fluoxetine 38.6312798668
MESH:D007249 Inflammation Imipramine 38.6312798668
MESH:D007249 Inflammation Indomethacin 38.637812673 3291741 12568917
MESH:D007249 Inflammation perfluorooctanoic acid 38.6312083418
MESH:D007249 Inflammation Progesterone 38.6315869954
MESH:D007249 Inflammation Tamoxifen 38.6319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 38.6312200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.2416306350
MESH:D007410 Intestinal Diseases Indomethacin 3.7615610444 15831440 18236018 11713966 17994277 11855677 17329856 11686837 10210152
MESH:D019586 Intracranial Hypertension Indomethacin 4.7815241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.8116580747
MESH:D007579 Jejunal Diseases Indomethacin 4.4310574470 16133968 18306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.8515604871
MESH:D007674 Kidney Diseases Acetaminophen 7.9712587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 7.978314463 18776723 10903974
MESH:D007674 Kidney Diseases Indomethacin 7.9717190690
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.2716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.2716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 18.2712371664
MESH:D007680 Kidney Neoplasms Fluorouracil 18.2716985049
MESH:D007680 Kidney Neoplasms Tamoxifen 18.2718625569
MESH:D007896 Leishmaniasis Antimony 8.2910953559 21063981 21182181 15220340 12019027
MESH:D007896 Leishmaniasis Pentamidine 8.2915340016
MESH:D016773 Leishmaniasis, Cutaneous Antimony 16.0811475954 8889330 19141829
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 16.0810320625 12228301 11703811
MESH:D016773 Leishmaniasis, Cutaneous Ketoconazole 16.082166429 8889330 19744259 1311351
MESH:D016773 Leishmaniasis, Cutaneous Pentamidine 16.0810617787 8889330 11806628 12453009
MESH:D007897 Leishmaniasis, Mucocutaneous Antimony 10.317854095 10651420 10881086 11370249 9643325
MESH:D007897 Leishmaniasis, Mucocutaneous Pentamidine 10.3110881086
MESH:D007898 Leishmaniasis, Visceral Antimony 15.061899875 11105143 7875148 8142506 7554475 7854095 20495762
MESH:D007898 Leishmaniasis, Visceral Antimony Potassium Tartrate 15.0612707265
MESH:D007898 Leishmaniasis, Visceral Ketoconazole 15.0611332679
MESH:D007898 Leishmaniasis, Visceral Pentamidine 15.0610467834 7498017 16131481 7715298 12803856 1659303
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 4.2518089816
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.4810785260 16572323 15631656
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.5218360721
MESH:D015473 Leukemia, Promyelocytic, Acute Antimony Potassium Tartrate 4.129834237
MESH:D007964 Leukocytosis Indomethacin 4.7816537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.1217980183
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.658812269
MESH:D008064 Lipidoses marker/mechanism 15342952 16919414
MESH:D008064 Lipidoses Amiodarone 77.9415342952 17567588
MESH:D008064 Lipidoses Amitriptyline 77.9417567588 15342952
MESH:D008064 Lipidoses chlorcyclizine 77.9415342952
MESH:D008064 Lipidoses Chlorpromazine 77.9415342952 17567588
MESH:D008064 Lipidoses Clomipramine 77.9415342952 17567588
MESH:D008064 Lipidoses Clozapine 77.9417567588
MESH:D008064 Lipidoses Fluoxetine 77.9415342952 17567588
MESH:D008064 Lipidoses Imipramine 77.9417567588 15342952
MESH:D008064 Lipidoses Ketoconazole 77.9417567588
MESH:D008064 Lipidoses Loratadine 77.9417567588
MESH:D008064 Lipidoses Perhexiline 77.9415342952 17567588
MESH:D008064 Lipidoses Sertraline 77.9417567588
MESH:D008064 Lipidoses Tamoxifen 77.9417567588 15342952
MESH:D008064 Lipidoses Thioridazine 77.9417567588 15342952
MESH:D008064 Lipidoses trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride 77.9415342952
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.1211479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 8.9811903743 16943688 17157831 11408273 17334410 21278145 16221502 16239168 17174718
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 8.9820032147 19638242 18407596 18522880 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 8.9821047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 9.3617481882 18472094 15925388 12741479 14620537 18705752 17698563 17631135 15370692 12958196 14512876 18205269 18006644 16033810 16136751 12445421 12389079 10355542 17869086 17721639 17761835 12609069 18156304 13678700 15818738 12649538 18054572 15893842 18251166 17922224 14748882 15650968 17805973 17525996 12632514 12667390 15338365 14724832 15673190 16638106 12546737 14716833 17714472 17944888 18412020 18317297 18376398 15052691 12666154 16011737 17823541 18420326 16015684 18481824 14716496 18279442 12445418 17640975 18429990 17565644 15730626 15362042 18472332 18395095 16248980 16116963 17708605 15876570 17557913 15123356 12898905 15931870 18277467 16097048 18395914 18263696 18210741 12632512 17766677 18339082 16192424 18187930 12586293 20821823 15959796 11481614 18418968 17900296 15057751 18166357 16027843 17976157 15996030
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 9.3616718785
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 9.3615864749 18567088 15067225 14726149 15086199 18637143 16042886 15577212 15942678 17198567 15763062 15798949 18095165 15339415 15479170 16009107 17465448 17534399 18210741 16570917 16544323 15723089 18364076 17724770 15081153 18239293 15099470 18371158 14659978 15842777 15298665 15369754 14709902 16270385 16169303 15504291 17036385 14643895 17719030 15591649 17348192 15733078 17881167 12918455 17432682 17201889 18672772 14568256 18237412 16627068 17666798 16603200 15138612 15571005 17196135 15366600 15492853 15161499 12925901 18629640 17640959 15744066 15383259 15793283 17203207
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 9.3618194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 9.3615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 9.3618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 9.3612878042
MESH:D008107 Liver Diseases Acetaminophen 10.4711587558 19784758 12587719 12969438 16610002 19460945 19014921 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 10.4716964402 17285989 16246199 15720792 15830285
MESH:D008107 Liver Diseases Chlorpromazine 10.4714986274
MESH:D008107 Liver Diseases Diethylnitrosamine 10.4717034775
MESH:D008107 Liver Diseases Phenobarbital 10.4719363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.5915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 13.3216871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 13.3214706259 16899240
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 13.3217457977
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 40.497678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 40.499163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 40.4920195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 40.4919294768
MESH:D008113 Liver Neoplasms Clofibric Acid 40.4917602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 40.4919294768 19833225 19426721 19642983 2422723 19073162 19690152 10737359 18977376 19638242 19090486 2862719 18644402 20501860 15175105 20583210 19254457 21167192 18754104 9163691 20101389 16942905 18648771 20434301 12771043 19427195 20452335 20405173 19812893 21071580 12112319 19255062 20137499 20492335 19850985 19499222 18978307 19551842 20118626 19256749 15885732 19996281 21047994 21278145
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 40.4915890375 3113478
MESH:D008113 Liver Neoplasms Fluorouracil 40.4918383874 17045692 16603448 15113037
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 40.4914757943 18709148
MESH:D008113 Liver Neoplasms Phenobarbital 40.498742319 19073162 15975961 19812893 19482888 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 40.4920007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 40.4916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 40.4916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 22.356135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 22.358603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 22.3515583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 22.3519539802 21159647 18775883 18253720 16267830 17942915 19009564 17854601 18079962 17174075 18544905 9362446 18164116 19004024 18282651 2563599 16842330 18308698 19126423 18093689 3124819 19519916
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 22.351848544 6150874 15603536
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 22.3517172636 18308698 1399818 6150874 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 22.3512151625
MESH:D008133 Long QT Syndrome Amiodarone 11.4817391786 15350150 11989578
MESH:D008133 Long QT Syndrome Sotalol 11.4811989578 15350150
MESH:D008133 Long QT Syndrome Thioridazine 11.4820210726
MESH:D008171 Lung Diseases Amiodarone 2.9712587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 3.8918516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 13.3914755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 13.3920464547 18569708 20064080 18520028 20869020 18816296 6695378 17053015 20135361
MESH:D008175 Lung Neoplasms Dexamethasone 13.3915824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 13.396695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 13.3916061637 11884234 19555203
MESH:D008175 Lung Neoplasms Fluorouracil 13.3915246190
MESH:D008175 Lung Neoplasms Indomethacin 13.3916537180 11497255 11053908
MESH:D008175 Lung Neoplasms Tamoxifen 13.3918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 13.3919555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.2115086387
MESH:D016778 Malaria, Falciparum Perhexiline 9.8816882315
MESH:D016778 Malaria, Falciparum Thioridazine 9.8816882315
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.1819428831
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 7.8517203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 7.8519196723 19196722 16827153 14580682 11731420
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 7.8517312309
MESH:D020149 Manganese Poisoning Tamoxifen 3.9519453300
MESH:D008545 Melanoma Tamoxifen 1.7919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.6015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0019513568
MESH:D008569 Memory Disorders Methylmercury Compounds 4.3618436314
MESH:D001523 Mental Disorders Amitriptyline 37.9316856516
MESH:D001523 Mental Disorders Chlorpromazine 37.9316856516
MESH:D001523 Mental Disorders Clomipramine 37.9316856516
MESH:D001523 Mental Disorders Clozapine 37.9316856516
MESH:D001523 Mental Disorders Doxepin 37.9316856516
MESH:D001523 Mental Disorders Fluoxetine 37.9316856516
MESH:D001523 Mental Disorders Imipramine 37.9316856516
MESH:D001523 Mental Disorders Sertraline 37.9316856516
MESH:D001523 Mental Disorders Thioridazine 37.9316856516
MESH:D008654 Mesothelioma zoledronic acid 3.4916675582
MESH:D024821 Metabolic Syndrome X Clozapine 3.9319142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.1916801185
MESH:D008881 Migraine Disorders Amitriptyline 6.8818803445
MESH:D008881 Migraine Disorders Indomethacin 6.8811903285
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 11.7816381670
MESH:D009062 Mouth Neoplasms Fluorouracil 11.7818986760 16757204
MESH:D009062 Mouth Neoplasms Indomethacin 11.7812636206
MESH:D009069 Movement Disorders Methylmercury Compounds 4.7818436314
MESH:D009101 Multiple Myeloma Dexamethasone 6.3715867202 16118317 15744524
MESH:D009101 Multiple Myeloma zoledronic acid 6.3718089719 16996129 19621390
MESH:D009135 Muscular Diseases pirinixic acid 2.9416239165
MESH:D009164 Mycobacterium Infections Clarithromycin 5.7818474467 10063276
MESH:D009175 Mycoplasma Infections Chlorpromazine 5.4010773494
MESH:D009181 Mycoses Amiodarone 4.3117974566 12754197
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.189809623
MESH:D009203 Myocardial Infarction pirinixic acid 1.8819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.5512213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.4916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.8917484760
MESH:D009207 Myoclonus Fluoxetine 5.298041377
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.4118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.4118551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 11.413581430 9029167
MESH:D009362 Neoplasm Metastasis Indomethacin 11.4116537180 11239499 11053908
MESH:D009362 Neoplasm Metastasis Tamoxifen 11.4119393235
MESH:D009362 Neoplasm Metastasis zoledronic acid 11.4115867366 19139120 17312309
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3019410462
MESH:D009369 Neoplasms Benzo(a)pyrene 6.3611141357
MESH:D009369 Neoplasms Fluorouracil 6.3616928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 6.3617405874
MESH:D009374 Neoplasms, Experimental Indomethacin 3.5710663608 15625704
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.4119200415 19196722 19189210
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.8517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.7918481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.6614600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 11.2918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 11.2920387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 11.2912349958
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5220387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.0316436463
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.389802331
MESH:D009765 Obesity Clozapine 4.0918515891 19142110
MESH:D009765 Obesity pirinixic acid 4.0920558911
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 4.9220418887
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.576374098
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.2016049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.2016049721
MESH:D010003 Osteoarthritis Indomethacin 3.297009135
MESH:D010014 Osteolysis zoledronic acid 4.7915867366
MESH:D010018 Osteomalacia Phenobarbital 3.7817016548
MESH:D010024 Osteoporosis Isoflavones 6.6116562857
MESH:D010024 Osteoporosis zoledronic acid 6.6117882678
MESH:D010051 Ovarian Neoplasms Progesterone 2.3217393432 16525653
MESH:D010146 Pain Acetaminophen 24.6716870215
MESH:D010146 Pain Amitriptyline 24.6712798668
MESH:D010146 Pain Clomipramine 24.6712798668
MESH:D010146 Pain Fluoxetine 24.6712798668
MESH:D010146 Pain Imipramine 24.6712798668
MESH:D010146 Pain Indomethacin 24.6717627676 13679232 17440234 3291741
MESH:D010146 Pain zoledronic acid 24.6716475674
MESH:D010149 Pain, Postoperative Indomethacin 4.0912538197 18702446
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 7.1816540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 7.1816500647 16929163 19003803 15113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 7.1816965848
MESH:D010195 Pancreatitis Indomethacin 3.3915028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1511578682
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.1216537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.6112349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.1211903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6512520081
MESH:D010409 Penile Diseases Antimony 5.179643325
MESH:D010437 Peptic Ulcer Indomethacin 4.5611148446
MESH:D010493 Pericarditis Antimony 5.5320465667
MESH:D010518 Periodontitis Indomethacin 4.3217225004
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.438041377
MESH:D011020 Pneumonia, Pneumocystis Pentamidine 6.1215340016
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0018163543
MESH:D011230 Precancerous Conditions Cyclosporine 12.4112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 12.412563599
MESH:D011230 Precancerous Conditions Phenobarbital 12.412563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.1921297632
MESH:D047928 Premature Birth Indomethacin 4.5617000239
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 13.1018436314
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 13.1017132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.1011222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8919082440 18626508
MESH:D011471 Prostatic Neoplasms Isoflavones 1.8916365062 17374662 17219775 17571952
MESH:D011471 Prostatic Neoplasms Ketoconazole 1.8917404083
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011471 Prostatic Neoplasms zoledronic acid 1.8912438248 19103299
MESH:D011507 Proteinuria Indomethacin 3.6311849393
MESH:D011537 Pruritus Ethinyl Estradiol 2.7415861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 3.9012752131
MESH:D011565 Psoriasis Cyclosporine 2.0016882103
MESH:D011618 Psychotic Disorders Clozapine 8.0815331141
MESH:D011618 Psychotic Disorders Thioridazine 8.0816882315
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.6011597910 12490602 12832656
MESH:D012004 Rectal Neoplasms Fluorouracil 3.5118286688 15538739 16160472 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.0719058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.4818379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.2818990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6218045962
MESH:D012512 Sarcoma, Ewing's zoledronic acid 4.3816121404
MESH:D012559 Schizophrenia Clozapine 2.6520580759 16141801 11763009 20168265 20521326 17667964 20452607 11151749 20107430 19369910 18855531 17123785 18806925 20521320 17726453
MESH:D012640 Seizures 2,4-dinitrotoluene 7.4318551238
MESH:D012640 Seizures 2,6-dinitrotoluene 7.4318551238
MESH:D012640 Seizures Phenobarbital 7.433137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.246407741
MESH:D020230 Serotonin Syndrome Fluoxetine 5.308704074
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.5018724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 7.6010029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 7.608532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 7.6016192470
MESH:D012892 Sleep Deprivation Imipramine 5.6119798453
MESH:D007319 Sleep Initiation and Maintenance Disorders Amitriptyline 9.1215341891
MESH:D007319 Sleep Initiation and Maintenance Disorders Doxepin 9.1215341891
MESH:D013088 Spermatocele Ethinyl Estradiol 9.5816709447
MESH:D013088 Spermatocele Tamoxifen 9.5816709447
MESH:D013119 Spinal Cord Injuries Progesterone 8.9416503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 8.9419457130
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.6712587719
MESH:D013272 Stomach Diseases Dexamethasone 8.4415472012
MESH:D013272 Stomach Diseases Indomethacin 8.4418209964 17207306 16184426 16113693 18545984 15038085 16280098 10215738 17160473 10486359 10192188 15472012 17638125
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 5.5320155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 5.5318456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 5.5316033868
MESH:D013274 Stomach Neoplasms Fluorouracil 5.5317522103 18396642 15786421 16424979 17172411 18567086 16951190 17498489 19015929 19084572
MESH:D013274 Stomach Neoplasms Indomethacin 5.5315609394
MESH:D013276 Stomach Ulcer Amiodarone 9.1818087811
MESH:D013276 Stomach Ulcer Dexamethasone 9.1815138204
MESH:D013276 Stomach Ulcer Indomethacin 9.1816631530 12498302 17977527 17657623 1323529 18237397 17895592 11595431 16150113 18193104 10878458 18543354 17918041 18726076 15104355 17135157 15138204 18299717 12077510 16252198 10423059 16169175 11906479 14567935 16397915 11729361 16934674 12787963 18181030 17654042 16755016 11595415 17627676 11145282 18431645 15255614 10750652 12467913 11523592 18209962 12500499 18087811
MESH:D013610 Tachycardia Amiodarone 3.7411238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 9.0619225199
MESH:D017180 Tachycardia, Ventricular Thioridazine 9.0620210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.0811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6615669648
MESH:D013959 Thyroid Diseases Amiodarone 10.0719731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.0712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 9.437505956
MESH:D013964 Thyroid Neoplasms Indomethacin 9.4311352223 14736730 18791128
MESH:D013964 Thyroid Neoplasms Phenobarbital 9.431399818
MESH:D013971 Thyrotoxicosis Amiodarone 4.2919584973 18020914
MESH:D014062 Tongue Neoplasms Fluorouracil 3.4816280240
MESH:D016171 Torsades de Pointes Amiodarone 9.1717467628 11989578
MESH:D016171 Torsades de Pointes Sotalol 9.1711989578 17467628
MESH:D014352 Trypanosomiasis Antimony 11.9215220340
MESH:D014352 Trypanosomiasis Pentamidine 11.9215340016
MESH:D014456 Ulcer Indomethacin 4.3110574470 17380554
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 9.6916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 9.6916049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 9.6917053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 9.6916712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.0510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.0510091137
MESH:D014581 Urticaria Acetaminophen 7.4710982225
MESH:D014581 Urticaria Loratadine 7.472568013
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.3716803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.7514692618
MESH:D014605 Uveitis Cyclosporine 9.791336536
MESH:D014605 Uveitis Dexamethasone 9.791336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0012125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0114671159 15869587
MESH:D014839 Vomiting Indomethacin 4.1511897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6515886252
MESH:D015430 Weight Gain Clozapine 3.9717502770 20521320 16402076 16141801 20564506 20107430
MESH:D015431 Weight Loss Clozapine 4.4917933447
MESH:D014985 Xerophthalmia Cyclosporine 3.8517120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:00100 Steroid biosynthesis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30473
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02016 - R048-8071
    DB03122 - B-Octylglucoside Detergents
    DB03563 - Tetradecane
    DB03696 - Lanosterol
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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