AutismKB 2.0

Annotation Detail for ARNT


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Basic Information Top
Gene Symbol:ARNT ( HIF-1-beta,HIF-1beta,HIF1-beta,HIF1B,HIF1BETA,TANGO,bHLHe2 )
Gene Full Name: aryl hydrocarbon receptor nuclear translocator
Band: 1q21.3
Quick LinksEntrez ID:405; OMIM: 126110; Uniprot ID:ARNT_HUMAN; ENSEMBL ID: ENSG00000143437; HGNC ID: 700
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05211Renal cell carcinoma
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200030HIF-2-alpha transcription factor network
200122Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
200172HIF-1-alpha transcription factor network
200161Signaling events mediated by VEGFR1 and VEGFR2
200196Notch-mediated HES/HEY network
Pathway IDPathway Name
P00030Hypoxia response via HIF activation
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1901Endometriosis
1904Diabetes mellitus
1944Breast cancer
2051Leukemia
2227Uterine fibroids
2241Infertility
Desease Name
micropenis
No data
Desease Name
Leukemia, acute myeloblastic
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C038890 2,3,4,7,8-pentachlorodibenzofuran 2,3,4,7,8-pentachlorodibenzofuran results in increased activity of [AHR protein binds to ARNT protein]affects binding|increases activity 11294989
C038890 2,3,4,7,8-pentachlorodibenzofuran 2,3,4,7,8-pentachlorodibenzofuran results in increased activity of [AHR protein binds to ARNT protein]affects binding|increases activity 11294989
C014211 2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran results in increased activity of [AHR protein binds to ARNT protein]affects binding|increases activity 11294989
C014211 2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran results in increased activity of [AHR protein binds to ARNT protein]affects binding|increases activity 11294989
C014211 2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran results in decreased expression of ARNT mRNAdecreases expression 16111922
C016392 3,3'-diindolylmethane 3,3'-diindolylmethane promotes the reaction [ARNT protein binds to CYP1A1 promoter]affects binding|increases reaction 16972788
C028451 3,4,3',4'-tetrachlorobiphenyl 3,4,3',4'-tetrachlorobiphenyl results in increased activity of [AHR protein binds to ARNT protein]affects binding|increases activity 11294989
C028451 3,4,3',4'-tetrachlorobiphenyl 3,4,3',4'-tetrachlorobiphenyl promotes the reaction [ARNT protein binds to CYP1A1 promoter]affects binding|increases reaction 16972788
C028451 3,4,3',4'-tetrachlorobiphenyl 3,4,3',4'-tetrachlorobiphenyl results in increased activity of [AHR protein binds to ARNT protein]affects binding|increases activity 11294989
C028451 3,4,3',4'-tetrachlorobiphenyl 3,4,3',4'-tetrachlorobiphenyl results in decreased expression of ARNT mRNAdecreases expression 17291011
C028451 3,4,3',4'-tetrachlorobiphenyl alpha-naphthoflavone affects the reaction [3,4,3',4'-tetrachlorobiphenyl results in decreased expression of ARNT mRNA]affects reaction|decreases expression 17291011
C524042 3,5-bis(2-fluorobenzylidene)piperidin-4-one 3,5-bis(2-fluorobenzylidene)piperidin-4-one results in decreased expression of ARNT proteindecreases expression 18682687
C091768 3'-methoxy-4'-nitroflavone 3'-methoxy-4'-nitroflavone affects the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]affects binding|affects reaction|increases activity 12644593
C091768 3'-methoxy-4'-nitroflavone 3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]affects binding|decreases reaction|increases activity 12644593
C091768 3'-methoxy-4'-nitroflavone ARNT protein promotes the reaction [3'-methoxy-4'-nitroflavone results in increased expression of CYP1A1 protein]increases expression|increases reaction 12859983
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen promotes the reaction [AHR protein binds to ARNT protein]affects binding|increases reaction 19901195
C546607 6,2',4'-trimethoxyflavone 6,2',4'-trimethoxyflavone inhibits the reaction [ARNT protein binds to CYP1A1 promoter]affects binding|decreases reaction 19828881
C054923 6-methyl-1,3,8-trichlorodibenzofuran 6-methyl-1,3,8-trichlorodibenzofuran promotes the reaction [ARNT protein binds to CYP1A1 promoter]affects binding|increases reaction 16972788
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [Curcumin results in increased degradation of ARNT protein]decreases reaction|increases degradation 16880289
D000242 Cyclic AMP Cyclic AMP inhibits the reaction [AHR protein binds to ARNT protein]affects binding|decreases reaction 12859982
C011512 alpha-naphthoflavone alpha-naphthoflavone inhibits the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]affects binding|decreases reaction 11768231
C011512 alpha-naphthoflavone alpha-naphthoflavone inhibits the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]affects binding|decreases reaction|increases expression 11768231
C011512 alpha-naphthoflavone alpha-naphthoflavone affects the reaction [3,4,3',4'-tetrachlorobiphenyl results in decreased expression of ARNT mRNA]affects reaction|decreases expression 17291011
D019324 beta-Naphthoflavone beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]affects binding|increases reaction 19901195
D019324 beta-Naphthoflavone beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]affects binding|increases reaction 17012224
D019324 beta-Naphthoflavone beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]affects binding|increases activity 17012224
D019324 beta-Naphthoflavone kaempferol inhibits the reaction [beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]]affects binding|decreases reaction|increases reaction 17012224
D019324 beta-Naphthoflavone kaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]]affects binding|decreases reaction|increases activity 17012224
D001564 Benzo(a)pyrene Benzo(a)pyrene inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein]]affects binding|decreases reaction|increases reaction 20228066
D001564 Benzo(a)pyrene Benzo(a)pyrene promotes the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]affects binding|increases expression|increases reaction 11768231
D001564 Benzo(a)pyrene Benzo(a)pyrene promotes the reaction [ARNT protein binds to CYP1A1 promoter]affects binding|increases reaction 16972788
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ARNT mRNAincreases expression 18247414
D001564 Benzo(a)pyrene ARNT protein results in increased susceptibility to Benzo(a)pyreneincreases response to substance 19755658
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in increased degradation of ARNT protein]decreases reaction|increases degradation 16880289
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ARNT proteindecreases expression 15899923
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [SP1 protein binds to ARNT promoter]affects binding|increases reaction 14529614
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ARNT mRNAincreases expression 14529614
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde bisindolylmaleimide I inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ARNT mRNA]decreases reaction|increases expression 14529614
C070515 bisindolylmaleimide I bisindolylmaleimide I inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ARNT mRNA]decreases reaction|increases expression 14529614
C006780 bisphenol A bisphenol A results in increased expression of ARNT mRNAincreases expression 16284450
D019328 Buthionine Sulfoximine Buthionine Sulfoximine results in decreased expression of ARNT proteindecreases expression 16880289
D002518 Ceramides ARNT protein affects the abundance of Ceramidesaffects abundance 14597763
C043561 chrysin chrysin promotes the reaction [ARNT protein binds to CYP1A1 promoter]affects binding|increases reaction 16972788
C018021 cobaltous chloride Benzo(a)pyrene inhibits the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein]]affects binding|decreases reaction|increases reaction 20228066
C018021 cobaltous chloride cobaltous chloride promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 promoter]affects binding|increases reaction 17599377
C018021 cobaltous chloride cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein]affects binding|increases reaction 20228066
C018021 cobaltous chloride cobaltous chloride promotes the reaction [HIF3A protein binds to ARNT protein]affects binding|increases reaction 14729976
C018021 cobaltous chloride [cobaltous chloride promotes the reaction [HIF3A protein binds to ARNT protein]] which results in increased expression of ALDH1A1 mRNAaffects binding|increases expression|increases reaction 14729976
D003300 Copper Copper results in increased activity of [AHR protein binds to ARNT protein]affects binding|increases activity 16093525
D003300 Copper Copper results in increased activity of [AHR protein binds to ARNT protein]affects binding|increases activity 16093525
D003474 Curcumin Acetylcysteine inhibits the reaction [Curcumin results in increased degradation of ARNT protein]decreases reaction|increases degradation 16880289
D003474 Curcumin benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in increased degradation of ARNT protein]decreases reaction|increases degradation 16880289
D003474 Curcumin Curcumin results in decreased expression of ARNT proteindecreases expression 18682687
D003474 Curcumin Curcumin results in increased degradation of ARNT proteinincreases degradation 19018768
D003474 Curcumin Curcumin results in increased ubiquitination of and results in increased degradation of ARNT proteinincreases degradation|increases ubiquitination 16880289
D003513 Cycloheximide Cycloheximide promotes the reaction [Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]affects binding|increases reaction 20570689
D003513 Cycloheximide Cycloheximide results in increased activity of [AHR protein binds to ARNT protein]affects binding|increases activity 12002481
D003513 Cycloheximide [Cycloheximide results in increased activity of [AHR protein binds to ARNT protein]] which results in increased expression of CYP1A1 mRNAaffects binding|increases activity|increases expression 12002481
C017185 delphinidin delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of ARNT protein]decreases reaction|increases expression 18603805
C121718 dicyclanil [dicyclanil co-treated with Diethylnitrosamine] results in increased expression of ARNT mRNAaffects cotreatment|increases expression 19182440
C121718 dicyclanil Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with dicyclanil] results in increased expression of ARNT mRNA]affects cotreatment|decreases reaction|increases expression 19182440
D004041 Dietary Fats Dietary Fats results in decreased expression of ARNT mRNAdecreases expression 18042831
D004052 Diethylnitrosamine [dicyclanil co-treated with Diethylnitrosamine] results in increased expression of ARNT mRNAaffects cotreatment|increases expression 19182440
D004052 Diethylnitrosamine Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with dicyclanil] results in increased expression of ARNT mRNA]affects cotreatment|decreases reaction|increases expression 19182440
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide promotes the reaction [ARNT protein binds to CAD promoter]affects binding|increases reaction 16675542
D004958 Estradiol Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]]affects binding|increases reaction 16675542
D004958 Estradiol [Tetrachlorodibenzodioxin binds to and results in increased activity of [AHR protein binds to ARNT protein]] inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]affects binding|decreases reaction|increases activity|increases expression 11165043
D004958 Estradiol Estradiol promotes the reaction [ARNT protein binds to FOS promoter]affects binding|increases reaction 17991765
D004958 Estradiol Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [ARNT protein binds to FOS promoter]]affects binding|decreases reaction|increases reaction 17991765
D004958 Estradiol Estradiol promotes the reaction [[ARNT protein binds to VEGFA promoter] which results in increased expression of VEGFA mRNA]affects binding|increases expression|increases reaction 15774498
D000431 Ethanol Ethanol results in decreased expression of ARNT mRNAdecreases expression 15353170
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ARNT mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ARNT mRNAaffects expression 17207528
D005947 Glucose Glucose promotes the reaction [[ARNT protein binds to G6PC promoter] which results in increased expression of G6PC mRNA]affects binding|increases expression|increases reaction 15767253
D005947 Glucose Glucose results in increased activity of ARNT proteinincreases activity 15767253
D006861 Hydrogen Peroxide delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of ARNT protein]decreases reaction|increases expression 18603805
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of ARNT proteindecreases expression 16880289
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of ARNT proteinincreases expression 18603805
C027185 indirubin indirubin results in increased activity of ARNT proteinincreases activity 12972062
C030374 indole indole results in increased activity of [AHR protein binds to ARNT protein]affects binding|increases activity 9407059
C030737 indoleacetic acid indoleacetic acid results in increased activity of [AHR protein binds to ARNT protein]affects binding|increases activity 9407059
C006552 kaempferol kaempferol inhibits the reaction [beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]]affects binding|decreases reaction|increases reaction 17012224
C006552 kaempferol kaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]]affects binding|decreases reaction|increases activity 17012224
D007854 Lead Lead results in increased activity of [AHR protein binds to ARNT protein]affects binding|increases activity 16093525
D007854 Lead Lead results in increased activity of [AHR protein binds to ARNT protein]affects binding|increases activity 16093525
D008628 Mercury Mercury results in increased activity of [AHR protein binds to ARNT protein]affects binding|increases activity 16093525
D008628 Mercury Mercury results in increased activity of [AHR protein binds to ARNT protein]affects binding|increases activity 16093525
D008748 Methylcholanthrene Methylcholanthrene promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]affects binding|increases reaction 11768231
D008748 Methylcholanthrene Methylcholanthrene promotes the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]affects binding|increases expression|increases reaction 11768231
D008748 Methylcholanthrene Cycloheximide promotes the reaction [Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]affects binding|increases reaction 20570689
D008748 Methylcholanthrene Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1A1 enhancer]affects binding|increases reaction 20570689
D010100 Oxygen ARNT protein affects the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]affects reaction|increases expression 19154183
C041786 palm oil palm oil results in decreased expression of ARNT mRNAdecreases expression 18042831
C093973 PD 98059 PD 98059 inhibits the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]affects binding|decreases reaction 15313166
D010936 Plant Extracts Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with dicyclanil] results in increased expression of ARNT mRNA]affects cotreatment|decreases reaction|increases expression 19182440
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls metabolite affects the expression of ARNT mRNAaffects expression 17207528
D011084 Polycyclic Hydrocarbons, Aromatic Polycyclic Hydrocarbons, Aromatic promotes the reaction [AHR protein binds to ARNT protein]affects binding|increases reaction 15832810
C059514 resveratrol resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]affects binding|decreases reaction|increases reaction 19376845
C059514 resveratrol resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]]affects binding|decreases reaction|increases reaction 19376845
C488333 Ro 65-7199 Ro 65-7199 affects the expression of ARNT mRNAaffects expression 14610520
C488334 Ro 66-0074 Ro 66-0074 affects the expression of ARNT mRNAaffects expression 14610520
C005705 sanguinarine sanguinarine promotes the reaction [AHR protein binds to ARNT protein]affects binding|increases reaction 15993743
C417521 SB 216763 ARNT protein promotes the reaction [SB 216763 results in increased expression of CYP1A1 mRNA]increases expression|increases reaction 19448134
D013629 Tamoxifen Tamoxifen affects the expression of ARNT mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin 3'-methoxy-4'-nitroflavone affects the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]affects binding|affects reaction|increases activity 12644593
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]affects binding|increases activity 12644593
D013749 Tetrachlorodibenzodioxin ARNT protein affects the susceptibility to Tetrachlorodibenzodioxinaffects response to substance 16936225
16306231
D013749 Tetrachlorodibenzodioxin ARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A protein]increases expression|increases reaction 16214955
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [AHR2 protein binds to ARNT protein]affects binding|increases reaction 16214955
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [[ARNT protein alternative form binds to AHR2 protein] which binds to CYP1A promoter]affects binding|increases reaction 16306231
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]affects binding|increases reaction 11606800
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]affects binding|increases expression|increases reaction 11606800
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [[AHR1 protein binds to ARNT protein] which binds to CYP1A5 promoter]affects binding|increases reaction 18948129
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]affects binding|increases activity 11294989
D013749 Tetrachlorodibenzodioxin ARNT protein affects the reaction [Tetrachlorodibenzodioxin promotes the reaction [BRCA1 protein binds to CYP1B1 promoter]]affects binding|affects reaction|increases reaction 16567799
D013749 Tetrachlorodibenzodioxin ARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of NPC1 protein]affects reaction|decreases expression 19131362
D013749 Tetrachlorodibenzodioxin ARNT protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]affects reaction|increases expression 19147701
D013749 Tetrachlorodibenzodioxin ARNT protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CTSD mRNA]]decreases reaction|increases expression|increases reaction 11165043
D013749 Tetrachlorodibenzodioxin Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]]affects binding|increases reaction 16675542
D013749 Tetrachlorodibenzodioxin NCOA1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]affects binding|increases activity|increases reaction 12024042
D013749 Tetrachlorodibenzodioxin NCOA2 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]affects binding|increases activity|increases reaction 12024042
D013749 Tetrachlorodibenzodioxin NCOA3 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]affects binding|increases activity|increases reaction 12024042
D013749 Tetrachlorodibenzodioxin resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]affects binding|decreases reaction|increases reaction 19376845
D013749 Tetrachlorodibenzodioxin resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]]affects binding|decreases reaction|increases reaction 19376845
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin binds to and results in increased activity of [AHR protein binds to ARNT protein]affects binding|increases activity 11165043
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to and results in increased activity of [AHR protein binds to ARNT protein]] inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]affects binding|decreases reaction|increases activity|increases expression 11165043
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Tretinoin] results in decreased expression of ARNT mRNAaffects cotreatment|decreases expression 15075337
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]affects binding|increases reaction 17823304
8397410
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CTSD promoter]affects binding|increases reaction 11165043
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]affects binding|increases reaction 15313166
11368516
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 promoter]affects binding|increases reaction 18541696
17599377
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1B1 enhancer]affects binding|increases reaction 12801909
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which results in decreased expression of CTSD mRNA]affects binding|decreases expression|increases reaction 11165043
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]affects binding|increases expression|increases reaction 12024042
11368516
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 enhancer]affects binding|increases reaction 19376845
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 promoter]affects binding|increases reaction 16567799
16972788
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 enhancer]affects binding|increases reaction 19376845
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1B1 promoter]affects binding|increases reaction 16567799
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to UGT1A1 promoter]affects binding|increases reaction 16399344
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ARNT mRNAdecreases expression 15075337
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]affects binding|increases activity 12024042
11294989
11368516
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased activity of ARNT proteinincreases activity 15982688
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ARNT mRNAincreases expression 12727795
D013749 Tetrachlorodibenzodioxin 3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]affects binding|decreases reaction|increases activity 12644593
D013749 Tetrachlorodibenzodioxin ARNT protein affects the susceptibility to Tetrachlorodibenzodioxinaffects response to substance 14530333
D013749 Tetrachlorodibenzodioxin ARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]increases expression|increases reaction 12111005
12859983
D013749 Tetrachlorodibenzodioxin ARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINE1 mRNA]increases expression|increases reaction 12111005
D013749 Tetrachlorodibenzodioxin ARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINE1 protein]increases expression|increases reaction 12111005
D013749 Tetrachlorodibenzodioxin ARNT protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA]increases expression|increases reaction 12147270
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to [AHR protein binds to ARNT protein]] which results in increased expression of CYP2A5 mRNAaffects binding|increases expression 15657367
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [ARNT protein binds to FOS promoter]]affects binding|decreases reaction|increases reaction 17991765
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]affects binding|increases reaction 12139968
15364539
12237327
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]affects binding|increases reaction 11606800
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP2S1 promoter]affects binding|increases reaction 17277313
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to CYP1A1 5' UTR]affects binding|increases reaction 12917420
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [ARNT protein binds to FMO3 enhancer]affects binding|increases reaction 18765683
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]affects binding|increases activity 12644593
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ARNT mRNAincreases expression 15667827
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased localization of ARNT proteinincreases localization 14761680
D013749 Tetrachlorodibenzodioxin Ursodeoxycholic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of ARNT protein]decreases reaction|increases localization 14761680
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased activity of ARNT protein alternative formincreases activity 8940073
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [[AHR1 protein binds to ARNT protein] which binds to CYP1A5 promoter]affects binding|increases reaction 18948129
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1B1 enhancer]affects binding|increases reaction 12859982
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ARNT proteinincreases expression 12128104
D013752 Tetracycline Tetracycline results in increased expression of ARNT mRNAincreases expression 16917069
D014212 Tretinoin [Tetrachlorodibenzodioxin co-treated with Tretinoin] results in decreased expression of ARNT mRNAaffects cotreatment|decreases expression 15075337
D014580 Ursodeoxycholic Acid Ursodeoxycholic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of ARNT protein]decreases reaction|increases localization 14761680
D014639 Vanadium Vanadium inhibits the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 promoter]affects binding|decreases reaction 18541696
C034028 vanadyl sulfate vanadyl sulfate results in decreased expression of ARNT mRNAdecreases expression 16330358
C499198 WAY-169916 [AHR protein binds to ARNT protein] which affects the susceptibility to WAY-169916affects binding|affects response to substance 19903824
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.9214745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 6.4418926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.4415322242 14514962 11752688
MESH:D000138 Acidosis Ethanol 3.8811192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3117505938
MESH:D058186 Acute Kidney Injury resveratrol 3.3016538975
MESH:D055371 Acute Lung Injury Oxygen 3.9716759491
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 5.8120464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 5.8111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 5.8114692618
MESH:D000236 Adenoma Benzo(a)pyrene 16.916695378
MESH:D000236 Adenoma beta-Naphthoflavone 16.9119389873
MESH:D000236 Adenoma Diethylnitrosamine 16.9110737359 6695378
MESH:D000236 Adenoma Methylcholanthrene 16.9110545420 6695378
MESH:D000236 Adenoma resveratrol 16.9115688382
MESH:D018248 Adenoma, Liver Cell dicyclanil 13.9417162532
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 13.9417162532 19052882 18056438 19061943 17620307 16434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 13.9416835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.6915451039 15451040
MESH:D019973 Alcohol-Related Disorders Curcumin 4.4517887948
MESH:D000505 Alopecia Tretinoin 3.1215955085
MESH:D000544 Alzheimer Disease Copper 7.9816325427 16410023 16962711 17119284 16866297 16886094
MESH:D000544 Alzheimer Disease Curcumin 7.9815590663
MESH:D000544 Alzheimer Disease Plant Extracts 7.9816962711
MESH:D000544 Alzheimer Disease resveratrol 7.9816183991 16162502
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 3.8910694572
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.4111748828
MESH:D018798 Anemia, Iron-Deficiency Copper 4.3416614410
MESH:D000853 Anophthalmos Ethanol 4.2215513904
MESH:D000860 Anoxia Oxygen 4.4420872349
MESH:D001008 Anxiety Disorders Ethanol 3.5111141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.4719183758
MESH:D001161 Arteriosclerosis Dietary Fats 7.9115238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 7.9111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 14.2115885639
MESH:D001169 Arthritis, Experimental Plant Extracts 14.2114686799
MESH:D001169 Arthritis, Experimental resveratrol 14.2117115116
MESH:D001169 Arthritis, Experimental Tretinoin 14.2116412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.1016807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.1016292516
MESH:D001249 Asthma Tretinoin 2.1316456186
MESH:D050197 Atherosclerosis Curcumin 12.4718704882
MESH:D050197 Atherosclerosis Methylcholanthrene 12.4711922910
MESH:D050197 Atherosclerosis Oxygen 12.4716391483
MESH:D050197 Atherosclerosis resveratrol 12.4716873680 17967414
MESH:D001321 Autistic Disorder Mercury 2.8717497416
MESH:D001327 Autoimmune Diseases Curcumin 9.0419761891
MESH:D001327 Autoimmune Diseases Mercury 9.0416634805
MESH:D001471 Barrett Esophagus Tretinoin 3.8116935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.1012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 7.1016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.1615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3415746008
MESH:D001862 Bone Resorption bisphenol A 3.3111985600
MESH:D002545 Brain Ischemia Curcumin 13.5916770732
MESH:D002545 Brain Ischemia Plant Extracts 13.5916041641
MESH:D002545 Brain Ischemia resveratrol 13.5917600658
MESH:D001932 Brain Neoplasms Copper 7.4517079463
MESH:D001932 Brain Neoplasms Curcumin 7.4517596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 12.6717474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 12.6717123778
MESH:D001943 Breast Neoplasms Copper 12.6715986119 17079463
MESH:D001943 Breast Neoplasms Curcumin 12.6716243823 18593918 18462866 19250217
MESH:D001943 Breast Neoplasms Dietary Fats 12.6720435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 12.6717474063
MESH:D001943 Breast Neoplasms Estradiol 12.6716675129 14630087 19861407 12948864 17261762 17289903 17018787 18497071
MESH:D001943 Breast Neoplasms kaempferol 12.6716756079
MESH:D001943 Breast Neoplasms Methylcholanthrene 12.6717474063
MESH:D001943 Breast Neoplasms Oxygen 12.6717263869
MESH:D001943 Breast Neoplasms resveratrol 12.6717651959 17534123 16393696
MESH:D001943 Breast Neoplasms Tamoxifen 12.6717440819 20544844 19244106 15668708 20390343 15565566 19410462 19155303 19221464 18629630 16873071 20135344 19189212 18351453 17261762 19115204 20065188 11161223 17049068 19142967 19189210 16273361 18821012 17242785 17893378 19059307 19084267 19103187 19288272 20005174 16818667 18984771 21138602 19289846 19066611 18425577 19487384 16202921 18997820 18855134 18815881 21152245 19200415 19011961 20859285
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 12.6720435547
MESH:D001943 Breast Neoplasms Tretinoin 12.6716873071 16443354 16166294
MESH:D001943 Breast Neoplasms Vanadium 12.6715565634
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.9716813970
MESH:D002056 Burns Ethanol 4.0516374292
MESH:D002057 Burns, Chemical Plant Extracts 4.719625245
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.8516111702
MESH:D002277 Carcinoma Curcumin 11.1518593918
MESH:D002277 Carcinoma Methylcholanthrene 11.1510545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 11.1516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.9019066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.5316168501
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 17.0917162532
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 17.0918971187 16830150 21159647 19171122 20512989 18978308 19418558 16328049 10737359 17138121 18665156 16288022 19822196 18788625 20007298 16569478 19335982 20727157 19383236 19539802 3581430 17173139 19107877 16935385 20101231 10672840 17162532 17978847 18691550 17055752 16681979 16698587 16779866 16878318 11831363 20214788 18056438 16502159 20432363 16540662 18494052 20514400 18393292 19919837 19394651 19208518 19519916 19052882 17761372 20084675 17428255 18506893 18785209 3084413 16807293 20524982 18210153 20935162 19701751
MESH:D006528 Carcinoma, Hepatocellular Estradiol 17.0916924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 17.0915763234 18788625 15289165
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 17.0918834353
MESH:D006528 Carcinoma, Hepatocellular resveratrol 17.0916227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 17.0916924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 17.091917145
MESH:D006528 Carcinoma, Hepatocellular Vanadium 17.0916830150 16878318
MESH:D002278 Carcinoma in Situ bisphenol A 4.3717123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 3.9816675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.7318414057
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 11.9117015178
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 11.9120419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 11.9118462866
MESH:D002294 Carcinoma, Squamous Cell resveratrol 11.9116227395
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 11.9116096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.0817572228
MESH:D006332 Cardiomegaly Copper 13.3117327471
MESH:D006332 Cardiomegaly Ethanol 13.3119332462
MESH:D006332 Cardiomegaly Plant Extracts 13.3117645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 13.3118670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.2110334427
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 9.8216936243
MESH:D002318 Cardiovascular Diseases kaempferol 9.8216756079
MESH:D002318 Cardiovascular Diseases resveratrol 9.8215458977
MESH:D002386 Cataract Tretinoin 2.7017460283
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 16.4518226522
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.457505956 17174075 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.4518566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 16.4516192471
MESH:D002471 Cell Transformation, Neoplastic Vanadium 16.4517174075
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 3.9716129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.5819052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.5816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.0117333356 17681005 17110522 11677210 16105132 16919318 15861022
MESH:D002779 Cholestasis Ursodeoxycholic Acid 7.0116487557
MESH:D002780 Cholestasis, Intrahepatic Ursodeoxycholic Acid 5.9914728856
MESH:D002822 Choriocarcinoma Tretinoin 4.5316461808
MESH:D002971 Cleft Lip Ethanol 3.2315513904
MESH:D002972 Cleft Palate Ethanol 8.0915513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.0915668235 12621046 16354765 15340226 8697196
MESH:D002972 Cleft Palate Tretinoin 8.099407595
MESH:D003092 Colitis Curcumin 12.6318200517 16804969 16782535
MESH:D003092 Colitis resveratrol 12.6316474422
MESH:D003092 Colitis Tretinoin 12.6317035595
MESH:D003103 Coloboma Curcumin 3.9918809619
MESH:D003110 Colonic Neoplasms Curcumin 5.2016340194 19359593
MESH:D003110 Colonic Neoplasms resveratrol 5.2016338953
MESH:D003110 Colonic Neoplasms Vanadium 5.2018155637
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.7615531428
MESH:D015179 Colorectal Neoplasms resveratrol 2.7616550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.5417141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.2918497527
MESH:D003327 Coronary Disease resveratrol 3.3316507316
MESH:D019465 Craniofacial Abnormalities Ethanol 4.7011198716 11873399 10194807 15451040 19302082 15513904 15451039
MESH:D019465 Craniofacial Abnormalities Lead 4.7019769572
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.7015322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.7014991402 17551590 9664655 16925845 9125849 8800419 9142499 10589399 9224671 9211117
MESH:D003550 Cystic Fibrosis Acetylcysteine 3.8419747007
MESH:D003704 Dementia Lead 8.7416140633
MESH:D003704 Dementia Polychlorinated Biphenyls 8.7416140633
MESH:D003711 Demyelinating Diseases Tamoxifen 3.7619031437
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 5.7011298694 15059100 16823706
MESH:D017449 Dermatitis, Allergic Contact Mercury 5.7016823706
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 7.1016873680
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 7.1016684804
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 5.9718403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 5.9720387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 5.9717107852
MESH:D003928 Diabetic Nephropathies Curcumin 22.5318204486
MESH:D003928 Diabetic Nephropathies Estradiol 22.5319279558
MESH:D003928 Diabetic Nephropathies Plant Extracts 22.5319706694
MESH:D003928 Diabetic Nephropathies resveratrol 22.5316286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 22.5319279558
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 12.2611287661
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.2619107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 12.2611566570
MESH:D056486 Drug-Induced Liver Injury indoleacetic acid 12.2619107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.2620420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 12.2617522070
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.2911462148
MESH:D004381 Duodenal Ulcer Curcumin 3.4717351913
MESH:D050171 Dyslipidemias Dietary Fats 2.9918367378
MESH:D004417 Dyspnea Oxygen 4.2120016425
MESH:D004487 Edema bisindolylmaleimide I 12.088273558
MESH:D004487 Edema Plant Extracts 12.0812787963
MESH:D004487 Edema resveratrol 12.088985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.0812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 9.8515322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 9.8518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 11.9812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 11.9817872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 11.9819031437
MESH:D018159 Endolymphatic Hydrops Dimethyl Sulfoxide 5.9320641076
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 14.3119148513
MESH:D016889 Endometrial Neoplasms Estradiol 14.3119148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 14.3116202921 17893378 19155303 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 14.3116569247
MESH:D004715 Endometriosis 2,3,4,7,8-pentachlorodibenzofuran 7.889294722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.8810568697 9294722
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.0515268973
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.2517923197
MESH:D004827 Epilepsy Plant Extracts 3.3819439326 19700373
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.4916302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 3.9316530937
MESH:D004938 Esophageal Neoplasms Ethanol 3.9316704527
MESH:D020329 Essential Tremor Lead 5.3114594619 18007985
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.2611564622
MESH:D005124 Eye Abnormalities Tretinoin 7.2616938888 9664655
MESH:D005234 Fatty Liver Curcumin 33.6419297423
MESH:D005234 Fatty Liver Dietary Fats 33.6417967931 18296743 19551842 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 33.6421071580 20387270
MESH:D005234 Fatty Liver Ethanol 33.6419236843 18620774 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 33.6415345470
MESH:D005234 Fatty Liver Plant Extracts 33.6415975614
MESH:D005234 Fatty Liver Tamoxifen 33.6414986274 19224547
MESH:D005234 Fatty Liver Tetracycline 33.6416917069 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.0317920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.8316709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.6810194807 16946407 15451040 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.8611858732
MESH:D005317 Fetal Growth Retardation Lead 4.9519769572
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.9114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.5719069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.3210962813 14633661
MESH:D005355 Fibrosis Curcumin 16.2618705752
MESH:D005355 Fibrosis Dietary Fats 16.2618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.2620067830
MESH:D005355 Fibrosis Tretinoin 16.2617994277
MESH:D005739 Gas Poisoning Oxygen 4.5920016425
MESH:D005756 Gastritis Ethanol 4.0715046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.0918462866
MESH:D005909 Glioblastoma Curcumin 5.8717596214
MESH:D005909 Glioblastoma Tretinoin 5.8717312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.9610696789
MESH:D006258 Head and Neck Neoplasms Curcumin 6.4318462866 18829502
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.4316096774
MESH:D034381 Hearing Loss Dimethyl Sulfoxide 4.6420641076
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.5316084493
MESH:D006330 Heart Defects, Congenital 2,3,4,7,8-pentachlorodibenzofuran 21.6411294989
MESH:D006330 Heart Defects, Congenital 2,3,7,8-tetrachlorodibenzofuran 21.6411294989
MESH:D006330 Heart Defects, Congenital 3,4,3',4'-tetrachlorobiphenyl 21.6411294989
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 21.6420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 21.6411294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 21.6414991402 9664655
MESH:D006333 Heart Failure Plant Extracts 3.4718097624
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.7811000095
MESH:D006521 Hepatitis, Chronic Copper 4.6517338147
MESH:D006527 Hepatolenticular Degeneration Copper 4.5717276780 16607473 17109627 17182432 19888908
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.3015340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.4417701891
MESH:D006558 Herpes Genitalis Estradiol 4.4015709030
MESH:D006561 Herpes Simplex Plant Extracts 8.0810715843
MESH:D006561 Herpes Simplex resveratrol 8.0816876885
MESH:D015658 HIV Infections Plant Extracts 3.3312878215
MESH:D019584 Hot Flashes Estradiol 8.2517088409
MESH:D019584 Hot Flashes Plant Extracts 8.2516566672 17454163 14716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.4216959395 16354765 8697196 15340226 18606429
MESH:D006930 Hyperalgesia Ethanol 6.3618783367
MESH:D006930 Hyperalgesia Tretinoin 6.3616870215
MESH:D006937 Hypercholesterolemia Curcumin 12.1718704882
MESH:D006937 Hypercholesterolemia Dietary Fats 12.1721332399
MESH:D006937 Hypercholesterolemia resveratrol 12.1717188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.9616778211
MESH:D006943 Hyperglycemia kaempferol 4.4618262572
MESH:D020138 Hyperhomocysteinemia Plant Extracts 3.9416484555
MESH:D006949 Hyperlipidemias Dietary Fats 12.2621332399
MESH:D006949 Hyperlipidemias Plant Extracts 12.2615268973 15975614
MESH:D006949 Hyperlipidemias resveratrol 12.2616873680
MESH:D006968 Hypersensitivity, Delayed indirubin 5.3111275354
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.6518850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.7617488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.2116945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.0417600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.8912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.7217937319
MESH:D007248 Infertility, Male Lead 5.7216780224
MESH:D007249 Inflammation bisindolylmaleimide I 22.348273558
MESH:D007249 Inflammation Curcumin 22.3416956363 17151092 18403477
MESH:D007249 Inflammation Dietary Fats 22.3420412841
MESH:D007249 Inflammation Diethylnitrosamine 22.3418785209
MESH:D007249 Inflammation Plant Extracts 22.3415997105 16366677 19332304 12787963
MESH:D007249 Inflammation resveratrol 22.3416366677
MESH:D007249 Inflammation Tamoxifen 22.3419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 22.3412878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.9318596194 18200517
MESH:D007251 Influenza, Human resveratrol 3.9216624496
MESH:D007333 Insulin Resistance bisphenol A 9.9016393666
MESH:D007333 Insulin Resistance Dietary Fats 9.9018457598 11836018
MESH:D007333 Insulin Resistance Estradiol 9.9016627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.1717994277
MESH:D007414 Intestinal Neoplasms Curcumin 8.3210783313
MESH:D007414 Intestinal Neoplasms Plant Extracts 8.3212628509 12584176 12351151
MESH:D007569 Jaw Abnormalities Ethanol 13.9715513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 13.9716580747
MESH:D007569 Jaw Abnormalities Tretinoin 13.9717551590 15992940
MESH:D007674 Kidney Diseases Estradiol 5.1115618244
MESH:D007674 Kidney Diseases Mercury 5.1117934191
MESH:D007676 Kidney Failure, Chronic Copper 8.5516518626
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 8.5516518626
MESH:D007680 Kidney Neoplasms Estradiol 5.7115610895
MESH:D007680 Kidney Neoplasms Tamoxifen 5.7118625569
MESH:D007855 Lead Poisoning Lead 5.3116700817
MESH:D007859 Learning Disorders Copper 12.9217134702
MESH:D007859 Learning Disorders Ethanol 12.9215451040
MESH:D007859 Learning Disorders Lead 12.9216384672
MESH:D007889 Leiomyoma Curcumin 4.0018555241
MESH:D007938 Leukemia Curcumin 8.6918462866
MESH:D007938 Leukemia kaempferol 8.6917468513
MESH:D007938 Leukemia Tretinoin 8.6917143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.6516106398
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 4.6116972261
MESH:D007951 Leukemia, Myeloid Tretinoin 3.1516932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 1.9517596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 6.3416087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.3416140955 16935935 17339181 17301526 17368321 19225113 19642359 16331271 17217047 16766008 17107899 19029980 17712046 19075265 17649720 12679006 16823087 17506722 17294898 15748426 19035177 16788101 17361223 9834237 16891316
MESH:D015458 Leukemia, T-Cell Curcumin 4.1716106398
MESH:D017880 Limb Deformities, Congenital Ethanol 6.7917676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 6.799224671
MESH:D008064 Lipidoses Tamoxifen 2.7017567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 12.7418296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 12.7418665156 20032147 18407596 18522880 19638242
MESH:D008103 Liver Cirrhosis Ethanol 12.7415289165
MESH:D008103 Liver Cirrhosis Plant Extracts 12.7417157831
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.4818295389
MESH:D008105 Liver Cirrhosis, Biliary Ursodeoxycholic Acid 4.7312468960
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 11.2818006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental Dimethyl Sulfoxide 11.2811682029
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 11.2814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 11.2818166357
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 11.2815479170
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 11.2818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 11.2812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 11.2818397230 16248980
MESH:D008107 Liver Diseases Curcumin 5.5316956363
MESH:D008107 Liver Diseases Diethylnitrosamine 5.5317034775
MESH:D008107 Liver Diseases Plant Extracts 5.5317034775
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.0517207112 17347304
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 24.5520195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 24.5519389873 21295105
MESH:D008113 Liver Neoplasms Copper 24.5520302851
MESH:D008113 Liver Neoplasms dicyclanil 24.5520118626
MESH:D008113 Liver Neoplasms Diethylnitrosamine 24.5519255062 19090486 20583210 21047994 19642983 2422723 21278145 19551842 18648771 19850985 19690152 20434301 21167192 16942905 12112319 18978307 19254457 20118626 19996281 19427195 18977376 19833225 20137499 20501860 12771043 19073162 19426721 15885732 2862719 18644402 21071580 20405173 20101389 19812893 15175105 20452335 19294768 19638242 19499222 19256749 18754104 20492335 9163691 10737359
MESH:D008113 Liver Neoplasms Plant Extracts 24.5519168119
MESH:D008113 Liver Neoplasms resveratrol 24.5520405173 19073162 19321006 19812893
MESH:D008113 Liver Neoplasms Tamoxifen 24.5516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.5516984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 18.0618164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 18.0619009564 17942915 19519916 18079962 18308698 18253720 16267830 18164116 19539802 18775883 16842330 18544905 9362446 3124819 18282651 2563599 19126423 17854601 21159647 17174075 19004024 18093689
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 18.061399818 598648
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 18.061423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.0612151625
MESH:D008114 Liver Neoplasms, Experimental Vanadium 18.0617174075
MESH:D008171 Lung Diseases Acetylcysteine 3.6212815614
MESH:D055370 Lung Injury Oxygen 3.9218339021
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 11.0518816296 17053015 18569708 6695378 20464547 18520028 20135361 20869020 20064080
MESH:D008175 Lung Neoplasms Curcumin 11.0516243823 19359593 18462866
MESH:D008175 Lung Neoplasms Diethylnitrosamine 11.0520512841 20970405 21163286 6695378
MESH:D008175 Lung Neoplasms Methylcholanthrene 11.0520970405 17909032 7750092 20512841 16271038 11893704 1399818 10545420 9230183 16337739 15390079 6695378 21163286
MESH:D008175 Lung Neoplasms Plant Extracts 11.0520869020
MESH:D008175 Lung Neoplasms Polycyclic Hydrocarbons, Aromatic 11.0510814675
MESH:D008175 Lung Neoplasms Tamoxifen 11.0518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 11.0511884234 19555203
MESH:D008223 Lymphoma Curcumin 3.1418462866
MESH:D016393 Lymphoma, B-Cell resveratrol 3.7317088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.3614749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.0916173963
MESH:D015674 Mammary Neoplasms, Animal resveratrol 7.9615688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 7.9619428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 7.5717203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 7.578985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 7.5719196722 16827153 11731420 19196723 14580682
MESH:D020149 Manganese Poisoning Estradiol 10.5619453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.5619453300
MESH:D008527 Medulloblastoma Tretinoin 2.5017453147
MESH:D008545 Melanoma Curcumin 8.1918462866 17885582
MESH:D008545 Melanoma Glucose 8.1914993021
MESH:D008545 Melanoma resveratrol 8.1917992120
MESH:D008545 Melanoma Tamoxifen 8.1912393984 19393235
MESH:D008545 Melanoma Tretinoin 8.1916752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.5715990972
MESH:D008569 Memory Disorders Curcumin 12.7917263510
MESH:D008569 Memory Disorders Ethanol 12.7918411066 15451040
MESH:D008569 Memory Disorders Lead 12.7917263510 16384672
MESH:D008591 Meningomyelocele Tretinoin 3.8216940565
MESH:D007706 Menkes Kinky Hair Syndrome Copper 5.2617109627 17268249
MESH:D008659 Metabolic Diseases resveratrol 3.8217112576
MESH:D020326 Migraine without Aura Cyclic AMP 4.5711304026
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.7116381670
MESH:D009101 Multiple Myeloma Curcumin 6.0619372569
MESH:D009101 Multiple Myeloma resveratrol 6.0617164350 16267019 14749477 16490592 17049120 17935668
MESH:D009134 Muscular Atrophy, Spinal Curcumin 10.3617962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 10.3617962980
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.7017596541
MESH:D009203 Myocardial Infarction resveratrol 5.6917125593 16317513 17015251 16456233 16525036 17188708
MESH:D009203 Myocardial Infarction SB 216763 5.6916288908
MESH:D017202 Myocardial Ischemia resveratrol 7.3517015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.3512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.7216810080
MESH:D015428 Myocardial Reperfusion Injury WAY-169916 7.7216810080
MESH:D009205 Myocarditis resveratrol 4.1417322642
MESH:D009361 Neoplasm Invasiveness Curcumin 3.7818495463
MESH:D009362 Neoplasm Metastasis Acetylcysteine 7.9114720322
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 7.913581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 7.9119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.2819410462
MESH:D009369 Neoplasms Benzo(a)pyrene 3.8811141357
MESH:D009369 Neoplasms Tretinoin 3.8816594593 16946489
MESH:D009374 Neoplasms, Experimental resveratrol 3.418985016
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 8.7512497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 8.7519189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Copper 8.3117308104
MESH:D009389 Neovascularization, Pathologic Estradiol 8.3117289903
MESH:D009395 Nephritis, Interstitial Tetracycline 4.169884423
MESH:D009421 Nervous System Malformations bisphenol A 18.6416427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 18.6416427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 18.6414600291
MESH:D009421 Nervous System Malformations Tretinoin 18.649125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.0018462866
MESH:D009436 Neural Tube Defects Acetylcysteine 6.2219446573
MESH:D009436 Neural Tube Defects Tretinoin 6.229142499
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.5817168769
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.8320387270
MESH:D019636 Neurodegenerative Diseases resveratrol 6.8317652729
MESH:D020078 Neurogenic Inflammation resveratrol 3.8317929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.4920387270
MESH:D009765 Obesity Curcumin 6.4419297423
MESH:D009765 Obesity Dietary Fats 6.4417217161 18457598 20518802 16723640 21332399 11836018 19632207 18674790 20132043
MESH:D009765 Obesity Plant Extracts 6.4419056576 20132043
MESH:D010024 Osteoporosis Curcumin 6.4118719352
MESH:D010024 Osteoporosis kaempferol 6.4116756079
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.6917513867
MESH:D010049 Ovarian Diseases bisphenol A 4.3711985600
MESH:D010051 Ovarian Neoplasms Curcumin 6.5218462866 19020741
MESH:D010051 Ovarian Neoplasms Estradiol 6.5219401270
MESH:D010051 Ovarian Neoplasms Tretinoin 6.5216936753
MESH:D010146 Pain Tretinoin 2.4216870215
MESH:D010190 Pancreatic Neoplasms Curcumin 10.1517440100 19401701 19196508
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 10.1516540662
MESH:D010190 Pancreatic Neoplasms Ethanol 10.1512384795
MESH:D010190 Pancreatic Neoplasms Tretinoin 10.1515976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1111578682
MESH:D010212 Papilloma Hydrogen Peroxide 7.7012065085
MESH:D010212 Papilloma Plant Extracts 7.7015173996 16517061
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.1416702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6212520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 4.8011026799
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.9718163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.032563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 18.2910548101
MESH:D011297 Prenatal Exposure Delayed Effects Lead 18.2916384672
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 18.2916679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 18.2911118676 11896295 11399792 11222880
MESH:D017096 Prion Diseases Tetracycline 4.7910903871
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.7020887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.7020887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6417292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.6416740699
MESH:D011471 Prostatic Neoplasms Copper 2.6417308104 17079463
MESH:D011471 Prostatic Neoplasms Curcumin 2.6418156803 12497104 15129424 18769126 11398177 10851300 18226269
MESH:D011471 Prostatic Neoplasms Estradiol 2.6416740699
MESH:D011471 Prostatic Neoplasms Plant Extracts 2.6414666653 17804756
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.6415721890
MESH:D011471 Prostatic Neoplasms resveratrol 2.6417804756 17718901 17636462 16731767 17675339 15767336
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6415067354
MESH:D011507 Proteinuria Tretinoin 3.0416636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.7015861022 16919318
MESH:D011625 Pterygium Tretinoin 4.1716723453
MESH:D011629 Puberty, Precocious bisphenol A 4.1710548101
MESH:D011656 Pulmonary Emphysema Curcumin 3.9819168576
MESH:D051436 Renal Insufficiency, Chronic resveratrol 4.9516325855
MESH:D015427 Reperfusion Injury resveratrol 2.9415827377 17058453 17520802 16317513 16314181
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 12.1212210543
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 12.1210666014 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 12.1217627322 18339021
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.2518990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.5316283617 16116481
MESH:D012509 Sarcoma Curcumin 3.5818462866
MESH:D012559 Schizophrenia Copper 2.9916842975
MESH:D012640 Seizures Ethanol 2.769754883
MESH:D018805 Sepsis Curcumin 3.5618389075
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 22.1410029692 19755658
MESH:D012878 Skin Neoplasms Glucose 22.1414993021
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 22.1412065085
MESH:D012878 Skin Neoplasms Plant Extracts 22.1416517061 15173996
MESH:D012878 Skin Neoplasms resveratrol 22.1415837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 22.1416192470
MESH:D012878 Skin Neoplasms Tretinoin 22.1416467112
MESH:D013088 Spermatocele Ethinyl Estradiol 9.4716709447
MESH:D013088 Spermatocele Tamoxifen 9.4716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.4219457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.0220155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.0218456281
MESH:D013274 Stomach Neoplasms Ethanol 4.0218456281
MESH:D013274 Stomach Neoplasms Tretinoin 4.0217261132
MESH:D013276 Stomach Ulcer Acetylcysteine 12.7817918041
MESH:D013276 Stomach Ulcer Curcumin 12.7819188055 16631530
MESH:D013276 Stomach Ulcer Ethanol 12.789562338 11906479 9211565 17918041 17189318 16755016
MESH:D013276 Stomach Ulcer Plant Extracts 12.7812787963 17135157 18237397 15255614 18193104
OMIM:601367 STROKE, ISCHEMIC resveratrol 3.9416321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.3716684133 16045194
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.719754883
MESH:D013398 Sudden Infant Death Oxygen 4.9312563064
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 4.8517997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.0511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.2712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 5.587505956
MESH:D013964 Thyroid Neoplasms Tretinoin 5.5816026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.0619048282
MESH:D014062 Tongue Neoplasms resveratrol 8.1116227395
MESH:D014062 Tongue Neoplasms Tretinoin 8.1116051514
MESH:D014202 Tremor Lead 4.8721145352
MESH:D014376 Tuberculosis Tretinoin 2.8216040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 6.6917053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 6.6918593936
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 6.6916712894 8653321 17572228
MESH:D014565 Urogenital Neoplasms Curcumin 4.6518462866
MESH:D002583 Uterine Cervical Neoplasms resveratrol 7.7417473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 7.7416129372
MESH:D014591 Uterine Diseases bisphenol A 4.3814652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.5614692618
MESH:D014594 Uterine Neoplasms resveratrol 7.5617044934
MESH:D014604 Uveal Neoplasms Tretinoin 3.9816752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.9612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.9814671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 8.5418097624
MESH:D018487 Ventricular Dysfunction, Left resveratrol 8.5417488730
MESH:D020257 Ventricular Remodeling Plant Extracts 4.7018097624
MESH:D014820 Vitiligo Tretinoin 3.4716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6215886252
MESH:D015430 Weight Gain Dietary Fats 3.2116723640
MESH:D009396 Wilms Tumor Tretinoin 3.4416287080
MESH:D014947 Wounds and Injuries Plant Extracts 3.7520213670 19894650
Pathway ID Pathway Name
KEGG:05200 Pathways in cancer
KEGG:05211 Renal cell carcinoma
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24994
    • No data
    Releated disease ID Related disease Name
    PA443890Diabetes Mellitus, Type 2
    PA446108Colorectal Neoplasms
    Releated drug ID Related drug Name
    PA164743471adenosine triphosphate
    PA449773glucose
    PA164778686pyruvic acid
    PA164747225l-citrulline
    PA452604xenobiotics
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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