AutismKB 2.0

Annotation Detail for CYP4F3


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Basic Information Top
Gene Symbol:CYP4F3 ( CPF3,CYP4F,LTB4H )
Gene Full Name: cytochrome P450, family 4, subfamily F, polypeptide 3
Band: 19p13.12
Quick LinksEntrez ID:4051; OMIM: 601270; Uniprot ID:CP4F3_HUMAN; ENSEMBL ID: ENSG00000186529; HGNC ID: 2646
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00590Arachidonic acid metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Biological oxidations
No data
No data
Pathway IDPathway Name
500201Eicosanoids
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C526219 apple polyphenol extract apple polyphenol extract results in increased expression of CYP4F3 mRNAincreases expression 16369997
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in decreased expression of CYP4F3 mRNAdecreases expression 18687144
D002220 Carbamazepine Carbamazepine results in increased expression of CYP4F3 mRNAincreases expression 17112801
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of CYP4F3 mRNAdecreases expression 15963578
C030984 pyrene pyrene results in decreased expression of CYP4F3 mRNAdecreases expression 15963578
D014212 Tretinoin Tretinoin results in increased expression of CYP4F3 mRNAincreases expression 17218384
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 5.008986270
MESH:D000505 Alopecia Tretinoin 3.8715955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.2516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3216292516
MESH:D001249 Asthma Tretinoin 2.4216456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7816935849
MESH:D001714 Bipolar Disorder Carbamazepine 4.2720046352 17594078
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9316197459 16206674
MESH:D001943 Breast Neoplasms Tretinoin 2.2416873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.0516813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2016050911 16097048 16192424 3786805 15721981 16124888 15673190 16011737 15700767 18705752 16227642 10355542
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6816168501
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1518788625
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.151917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3616051514 16096774
MESH:D002386 Cataract Tretinoin 3.2617460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.0516129372
MESH:D002822 Choriocarcinoma Tretinoin 5.6816461808
MESH:D002972 Cleft Palate Tretinoin 2.789407595
MESH:D003092 Colitis Tretinoin 4.1217035595
MESH:D019465 Craniofacial Abnormalities Carbamazepine 3.149014606
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.149211117 17551590 9142499 10589399 9224671 16925845 14991402 9125849 9664655 8800419
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.8611748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.5816538175 20216337 16538176 15057820
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 4.6017465707
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.607440962 15027814 2869522 7179309 4309450 3732212 19085960 3786805 17522070 6884620 16227642 21278145 16177239 6623471 11566570 10092053 15968718 15998439 9327722 10915739 19336974 7120509
MESH:D004362 Drug Toxicity Carbamazepine 4.6920216337
MESH:D004489 Edema, Cardiac Tretinoin 4.9918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 5.1117654737
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3016569247
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.6418855540 16415921 16538176 20485159 19915237
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 5.6317275665
MESH:D004828 Epilepsies, Partial Carbamazepine 5.4917116037 16628512 15008574
MESH:D004827 Epilepsy Carbamazepine 4.1317178248 20417680 18234410 9014606 7988514 821787 19620853 17465707 19439326 19700373
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 5.777750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 5.5815276670 3659116
MESH:D004916 Erythromelalgia Carbamazepine 6.1819549232
MESH:D005076 Exanthema Carbamazepine 5.9320485159
MESH:D005124 Eye Abnormalities Tretinoin 3.819664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.4961145 12631006 12795759 16239168 16045604 15959796 17595544 19224547
MESH:D005355 Fibrosis Carbon Tetrachloride 10.2318705752
MESH:D005355 Fibrosis Tretinoin 10.2317994277
MESH:D005909 Glioblastoma Tretinoin 3.1917312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.049664655 14991402
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9719900420 19110552
MESH:D006930 Hyperalgesia Tretinoin 3.4616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9916899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9916778211
MESH:D020138 Hyperhomocysteinemia Carbamazepine 5.0110459572
MESH:D006965 Hyperplasia Carbamazepine 5.6318773962
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5015338365
MESH:D007410 Intestinal Diseases Tretinoin 4.1817994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2317551590 15992940
MESH:D007938 Leukemia Tretinoin 2.9017143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0216932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1216294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3417301526 17712046 16935935 9834237 17368321 17649720 16331271 19642359 16140955 16823087 19029980 19035177 17217047 17294898 17506722 17339181 16766008 16788101 12679006 17107899 15748426 16891316 19075265 19225113 17361223
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.539224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9617334410 11903743 21278145 16221502 17174718 17157831 16943688 16239168 11408273
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.5717823541 18166357 18006644 18481824 17714472 20821823 15673190 11481614 17761835 12586293 17922224 14724832 14748882 15893842 15931870 15650968 17869086 16033810 14620537 17900296 12546737 18429990 12666154 17721639 18277467 12958196 18263696 16097048 12609069 15996030 17481882 10355542 16011737 17565644 17708605 18339082 16136751 15362042 12445418 18705752 15818738 15057751 15370692 16116963 12649538 16027843 14512876 17944888 18420326 15123356 14716833 18317297 18395095 12741479 18472094 18205269 15730626 18279442 18472332 16192424 15959796 12667390 15052691 17640975 17976157 18187930 18376398 18210741 16015684 17525996 18054572 12632514 18251166 18395914 15925388 16248980 14716496 18156304 17698563 15876570 12389079 17805973 16638106 17766677 18412020 17631135 12632512 18418968 12898905 15338365 12445421 17557913 13678700
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5716248980 18397230
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1415720792 16246199 17285989 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9914706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.3119294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.7912014681 15583823
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.4417365036
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.6416628512
MESH:D008527 Medulloblastoma Tretinoin 2.8817453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.8416940565
MESH:D008607 Mental Retardation Carbamazepine 3.819014606
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2816166281 18303189 16966607
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2417596541
MESH:D009224 Myotonia Congenita Carbamazepine 5.9320399394
MESH:D009369 Neoplasms Tretinoin 2.5416594593 16946489
MESH:D009421 Nervous System Malformations Carbamazepine 11.4416990009
MESH:D009421 Nervous System Malformations Tretinoin 11.449125849
MESH:D009436 Neural Tube Defects Tretinoin 3.249142499
MESH:D010018 Osteomalacia Carbamazepine 5.9317016548
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4216936753
MESH:D010146 Pain Carbamazepine 8.0915215642
MESH:D010146 Pain Tretinoin 8.0916870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5515976015
MESH:D010267 Parapsoriasis Carbamazepine 6.1216538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 6.3917145499 17679678
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.3110923243
MESH:D011248 Pregnancy Complications Carbamazepine 5.579014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 5.359014606
MESH:D011507 Proteinuria Tretinoin 3.9516636307
MESH:D019310 Pseudolymphoma Carbamazepine 6.129591791 12752131
MESH:D011625 Pterygium Tretinoin 5.2616723453
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1317975199 17365031 17322281 15814490
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4516283617 16116481
MESH:D012640 Seizures Carbamazepine 3.9916938433 16180713 9844417 19414003 9046859 15946322 16876388
MESH:D012878 Skin Neoplasms Tretinoin 2.7316467112
MESH:D012893 Sleep Disorders Carbamazepine 5.5819414003
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.6316415921 18855540 20485159 16538176 15057820 19915237 19694795
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2617045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.0916051514
MESH:D014376 Tuberculosis Tretinoin 3.4116040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9816129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.1316752155
MESH:D014820 Vitiligo Tretinoin 4.4416761959
MESH:D009396 Wilms Tumor Tretinoin 4.2516287080
Pathway ID Pathway Name
KEGG:00590 Arachidonic acid metabolism
REACT:13433 Biological oxidations
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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