AutismKB 2.0

Annotation Detail for LTBP1


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Basic Information Top
Gene Symbol:LTBP1 ( MGC163161 )
Gene Full Name: latent transforming growth factor beta binding protein 1
Band: 2p22.3
Quick LinksEntrez ID:4052; OMIM: 150390; Uniprot ID:LTBP1_HUMAN; ENSEMBL ID: ENSG00000049323; HGNC ID: 6714
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04350TGF-beta signaling pathway
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1859Ovarian cancer
2018Rheumatic fever
2237Neoplasm metastasis
Desease Name
height
DEVELOPMENTAL
Desease Name
Height
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LTBP1 mRNAaffects cotreatment|increases expression 18164116
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LTBP1 mRNAdecreases expression 20018196
19150397
D002087 Butyrates Butyrates results in increased expression of LTBP1 mRNAincreases expression 14674679
D002945 Cisplatin LTBP1 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LTBP1 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of LTBP1 mRNAincreases expression 19638242
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of LTBP1 mRNAaffects cotreatment|increases expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of LTBP1 mRNAincreases expression 12655037
15576828
D005419 Flavonoids Flavonoids results in increased expression of LTBP1 mRNAincreases expression 18035473
C010176 halofuginone halofuginone results in increased expression of LTBP1 mRNAincreases expression 17180598
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of LTBP1 mRNAincreases expression 16849584
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of LTBP1 mRNAincreases expression 20713471
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of LTBP1 mRNAincreases expression 17616710
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LTBP1 mRNAaffects binding|increases activity|increases expression 19710929
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of LTBP1 mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of LTBP1 mRNAincreases expression 17404688
D020849 Raloxifene Raloxifene affects the expression of LTBP1 mRNAaffects expression 14699072
D018038 Sodium Selenite Sodium Selenite results in decreased expression of LTBP1 mRNAdecreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of LTBP1 mRNAaffects expression 14699072
C004648 testosterone enanthate testosterone enanthate affects the expression of LTBP1 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LTBP1 mRNA]decreases expression|decreases reaction 14728982
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LTBP1 mRNAdecreases expression 14728982
C025643 vinclozolin vinclozolin affects the expression of LTBP1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7615322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8617505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.8817670903 12690470 15814532
MESH:D055371 Acute Lung Injury pirinixic acid 3.0318653653
MESH:D000230 Adenocarcinoma Cisplatin 6.9811798837 17638652
MESH:D000230 Adenocarcinoma Estradiol 6.9811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.9814692618
MESH:D000236 Adenoma beta-Naphthoflavone 11.0319389873
MESH:D000236 Adenoma Diethylnitrosamine 11.036695378 10737359
MESH:D000236 Adenoma Methylcholanthrene 11.036695378 10545420
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.7919052882 19061943 17162532 17620307 16434500 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.7916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.7916835633
MESH:D000419 Albuminuria Raloxifene 4.5117308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5215800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8711748828
MESH:D001008 Anxiety Disorders vinclozolin 3.5719015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6115885639
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4011922910
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.4919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.4912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7115746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.8014601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2617868700
MESH:D001930 Brain Injuries Progesterone 10.6815665606 15380490 15845082
MESH:D001930 Brain Injuries Raloxifene 10.6816580743
MESH:D001943 Breast Neoplasms Cisplatin 4.6719526202 18382427
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.6717474063
MESH:D001943 Breast Neoplasms Estradiol 4.6712948864 17018787 17289903 19861407 16675129 17261762 14630087 18497071
MESH:D001943 Breast Neoplasms Methylcholanthrene 4.6717474063
MESH:D001943 Breast Neoplasms Progesterone 4.6715562024 17614352 16175315
MESH:D001943 Breast Neoplasms Raloxifene 4.6717049068 15572757 17952589 15758505 17595753 16912660 17440819 17893378 17242785 17261762 15775269 16837676
MESH:D001943 Breast Neoplasms Tamoxifen 4.6719288272 19115204 18425577 18629630 17440819 17049068 17242785 18855134 19244106 11161223 20390343 19011961 16873071 15668708 18984771 19189210 20005174 17893378 19066611 19221464 19103187 19189212 16273361 21138602 17261762 19142967 21152245 19155303 19200415 16202921 19059307 19487384 19289846 18351453 18997820 18815881 16818667 20544844 20135344 19410462 20859285 15565566 20065188 19084267 18821012
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.6720435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3816111702
MESH:D002277 Carcinoma Methylcholanthrene 8.0910545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.0916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4219066611
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 6.4917982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.4919701751 20512989 18506893 19822196 17761372 10737359 19171122 3581430 16288022 19418558 18393292 20432363 20524982 20084675 17173139 16830150 20007298 20514400 17978847 19519916 16502159 18665156 16328049 16540662 16569478 18978308 10672840 18785209 18210153 20935162 19052882 16698587 20214788 17162532 16935385 18691550 3084413 21159647 17055752 19107877 19208518 18056438 17138121 17428255 19539802 19335982 19919837 19394651 16878318 19383236 18788625 20101231 20727157 16681979 11831363 18494052 16779866 16807293 18971187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.4916924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.4916924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0116685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.8018337622 6189445 17066447
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.2317572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.2317572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3218850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.3815775269
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.5520889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.5517174075 21159647 7505956 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.5518566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 15.5516192471
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.0719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.0716835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.5217333356 16919318 15861022 17681005 11677210 16105132 17110522
MESH:D002779 Cholestasis pirinixic acid 7.5219176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.6615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0716354765 15340226 15668235 8697196 12621046
MESH:D003072 Cognition Disorders Raloxifene 4.5315800139
MESH:D003110 Colonic Neoplasms Butyrates 3.0715936596
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.2514966744
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2819031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.0817474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.7016285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1520387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1517107852
MESH:D003928 Diabetic Nephropathies Estradiol 14.5819279558
MESH:D003928 Diabetic Nephropathies Raloxifene 14.5815920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.5819279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.4117187935
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.0719107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.0715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.0720420201
MESH:D004362 Drug Toxicity Cisplatin 7.9615033597 12649298 12231392 19839026
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.9611462148
MESH:D004487 Edema pirinixic acid 10.9512083418
MESH:D004487 Edema Raloxifene 10.9515860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.9512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 21.2312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 21.2317692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 21.2315845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 21.2319031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.2019148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.2019155303 17893378 20544844 16202921
MESH:D004715 Endometriosis Progesterone 8.6616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.6610568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0416302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2420426865
MESH:D004938 Esophageal Neoplasms Cisplatin 7.2417638652 16481741 15464296 16785472 15173087
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 7.2415150132 15264214 15623463 15878914 15547721 16510608 16704527 15547733 16805852
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9511564622
MESH:D005234 Fatty Liver Diethylnitrosamine 23.7820387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 23.7815345470
MESH:D005234 Fatty Liver pirinixic acid 23.7820131406 19236843
MESH:D005234 Fatty Liver Raloxifene 23.7817473493
MESH:D005234 Fatty Liver Tamoxifen 23.7814986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1019069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.8514633661 10962813
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8620067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.8516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2216417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.6515102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.2219898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.3415464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2811294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.4711110106
MESH:D006333 Heart Failure pirinixic acid 2.4820558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006529 Hepatomegaly pirinixic acid 7.9716221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.9715340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.9515709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.6717440010
MESH:D006689 Hodgkin Disease Cisplatin 3.5216170182 16200630
MESH:D019584 Hot Flashes Estradiol 3.6717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.968697196 18606429 15340226 16354765 16959395
MESH:D006943 Hyperglycemia pirinixic acid 3.1020558911
MESH:D006965 Hyperplasia halofuginone 5.1611874485
MESH:D006973 Hypertension Raloxifene 5.1217577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1218850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7216569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3115869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4617937319
MESH:D007248 Infertility, Male vinclozolin 6.4616467254
MESH:D007249 Inflammation Diethylnitrosamine 15.3818785209
MESH:D007249 Inflammation Flavonoids 15.3817296493
MESH:D007249 Inflammation Progesterone 15.3815869954
MESH:D007249 Inflammation Tamoxifen 15.3819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.3812200463 12878042
MESH:D007333 Insulin Resistance Estradiol 11.9816393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.9816306350
MESH:D007333 Insulin Resistance Sodium Selenite 11.9814714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2516580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.0615464296
MESH:D007674 Kidney Diseases Cisplatin 6.1012231392 19839026 18289764 12649298 15190930
MESH:D007674 Kidney Diseases Estradiol 6.1015618244
MESH:D007680 Kidney Neoplasms Estradiol 7.1415610895
MESH:D007680 Kidney Neoplasms Tamoxifen 7.1418625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.7111231351
MESH:D007889 Leiomyoma Raloxifene 4.4116973256
MESH:D007984 Leydig Cell Tumor vinclozolin 4.6516417039
MESH:D008064 Lipidoses Tamoxifen 3.0917567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.9020032147 19638242 18665156 18407596 18522880
MESH:D008103 Liver Cirrhosis halofuginone 6.9017180598
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.6314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 6.6314739098 11172339 16489207 18458672 12175628
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.6315474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.6318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.6312878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.0817034775
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 13.8819389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.8819426721 18978307 19499222 20405173 19638242 2422723 15175105 10737359 19690152 19427195 19812893 19256749 12112319 19090486 18648771 19551842 12771043 20434301 20452335 20583210 18977376 19255062 16942905 21071580 20101389 21047994 18754104 21167192 20137499 20492335 21278145 19833225 18644402 15885732 19254457 9163691 19294768 19642983 19850985 20118626 2862719 20501860 19996281 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 13.8820007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 13.8816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.8816984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 13.7118164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.7119004024 18775883 2563599 18544905 17854601 18079962 19519916 19126423 18093689 19539802 19009564 16267830 3124819 18164116 9362446 17174075 18253720 21159647 17942915 18308698 18282651 16842330
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 13.711399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.7112151625
MESH:D008175 Lung Neoplasms Cisplatin 6.4911798837 6189445 17225452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.496695378 20970405 21163286 20512841
MESH:D008175 Lung Neoplasms Methylcholanthrene 6.4920970405 17909032 10545420 21163286 1399818 16271038 7750092 20512841 16337739 6695378 9230183 11893704 15390079
MESH:D008175 Lung Neoplasms Tamoxifen 6.4918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.4919555203 11884234
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.9714737004
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6719428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.6411408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.6417203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.6419196723 11731420 16827153 14580682 19196722
MESH:D020149 Manganese Poisoning Estradiol 12.3819453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.3819453300
MESH:D008545 Melanoma Cisplatin 3.4318332650 16809738 11135225 17761969 16248763 16432458 12374674 18505091 18176117 12393984 12883367 15577323 17023156
MESH:D008545 Melanoma Tamoxifen 3.4319393235 12393984
MESH:D018328 Melanoma, Amelanotic Cisplatin 11.2215990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 11.2215990972
MESH:D008654 Mesothelioma Cisplatin 3.2117638057
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.4715863610
MESH:D009101 Multiple Myeloma Raloxifene 3.3716497877
MESH:D009135 Muscular Diseases pirinixic acid 3.4216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.0216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.0216411023
MESH:D009232 Myxoma Raloxifene 5.4716343187
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.613581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4919410462
MESH:D009369 Neoplasms Cisplatin 4.9616773208
MESH:D009369 Neoplasms pirinixic acid 4.9617405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9219189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6517289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.4115464296
MESH:D009421 Nervous System Malformations Estradiol 9.1816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.1814600291
MESH:D009447 Neuroblastoma Cisplatin 3.408761367
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.2720387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.618761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0420387270
MESH:D009765 Obesity pirinixic acid 1.7920558911
MESH:D010024 Osteoporosis Raloxifene 3.3417882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.1417823083 17893378 15758505 15579764
MESH:D010051 Ovarian Neoplasms Cisplatin 7.8019769630 15464296 17225452 6897625
MESH:D010051 Ovarian Neoplasms Estradiol 7.8019401270
MESH:D010051 Ovarian Neoplasms Progesterone 7.8017393432 16525653
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.3419003803
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3416540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.2215464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.2617638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.472563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.2011118676 11399792 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.2018042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.8518220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8020887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.1016740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.1016220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.1018760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1015067354
MESH:D011472 Prostatitis vinclozolin 4.8518629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.2316919318 15861022
MESH:D011693 Purpura Raloxifene 5.4715770314
MESH:D051437 Renal Insufficiency Cisplatin 4.3215464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.3419058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8318045962
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.3414601052
MESH:D012871 Skin Diseases halofuginone 3.4911874485
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0016192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.2615464296
MESH:D013088 Spermatocele Ethinyl Estradiol 11.2916709447
MESH:D013088 Spermatocele Tamoxifen 11.2916709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.5915862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.5919457130
MESH:D013274 Stomach Neoplasms Cisplatin 3.4617522103 18396642 15958060
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.4618456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 3.4612958204 17575124
MESH:D020521 Stroke Raloxifene 3.7516837676
MESH:D013736 Testicular Neoplasms Cisplatin 4.5517225452 15464296
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms Butyrates 7.3317967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.337505956
MESH:D013978 Tibial Fractures Estradiol 13.4419048282
MESH:D013978 Tibial Fractures Raloxifene 13.4419048282
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 8.2512973940 17225452 15464296
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.2517572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.2516712894 17572228 8653321
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.1316803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2114692618
MESH:D014625 Vaginal Neoplasms Cisplatin 4.5215577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.1316837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4614671159 15869587
MESH:D014839 Vomiting Cisplatin 4.6411897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.4716343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
Pathway ID Pathway Name
KEGG:04350 TGF-beta signaling pathway
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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