AutismKB 2.0

Annotation Detail for LTBP2


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Basic Information Top
Gene Symbol:LTBP2 ( C14orf141,GLC3D,LTBP3,MSTP031 )
Gene Full Name: latent transforming growth factor beta binding protein 2
Band: 14q24.3
Quick LinksEntrez ID:4053; OMIM: 602091; Uniprot ID:LTBP2_HUMAN; ENSEMBL ID: ENSG00000119681; HGNC ID: 6715
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
No data
Desease Name
Height
Desease Name
Glaucoma 3, primary congenital, D
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LTBP2 mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of LTBP2 mRNAdecreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in decreased expression of LTBP2 mRNA]affects reaction|decreases expression 18929588
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LTBP2 mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of LTBP2 mRNAdecreases expression 20064835
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of LTBP2 mRNAincreases expression 15336504
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LTBP2 mRNAaffects cotreatment|increases expression 18164116
D002117 Calcitriol Calcitriol results in increased expression of LTBP2 mRNAincreases expression 16002434
D004317 Doxorubicin LTBP2 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of LTBP2 mRNAincreases expression 12655037
15834898
16174780
D005576 Forskolin Forskolin results in decreased expression of LTBP2 mRNAdecreases expression 15313392
D016685 Mitomycin LTBP2 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D017239 Paclitaxel LTBP2 protein affects the susceptibility to Paclitaxelaffects response to substance 16217747
C017947 sodium arsenite sodium arsenite results in decreased expression of LTBP2 mRNAdecreases expression 16014739
D013629 Tamoxifen Tamoxifen affects the expression of LTBP2 mRNAaffects expression 14699072
D019772 Topotecan LTBP2 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014747 Vinblastine LTBP2 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5814745880
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.0720464547 20127859
MESH:D000230 Adenocarcinoma Doxorubicin 7.0717418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0714692618
MESH:D000236 Adenoma Benzo(a)pyrene 11.226695378
MESH:D000236 Adenoma beta-Naphthoflavone 11.2219389873
MESH:D000236 Adenoma Diethylnitrosamine 11.2210737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.9219061943 19052882 17620307 16434500 18056438 17162532
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9316712894 17306315
MESH:D000419 Albuminuria Doxorubicin 4.5521441931
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.7314601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.5715867366
MESH:D001932 Brain Neoplasms Doxorubicin 3.8117150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9720146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 2.9711237771
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.9717474063
MESH:D001943 Breast Neoplasms Doxorubicin 2.9716826403 16322301 16096432 16935488 18628466 16115903 16264153 15692762 15993339 17426702 18695136 17983394 15136595 11325840 15939500 15567936 19526202 15994142 15668708 16595493 18382427 18234424 15634643 17369602
MESH:D001943 Breast Neoplasms Paclitaxel 2.9716273361 18323546 18223236 15136595 18234424 11325840 16115903 16244791
MESH:D001943 Breast Neoplasms Tamoxifen 2.9719288272 19011961 19289846 15668708 19066611 21138602 18821012 18351453 18425577 18855134 20859285 18629630 16273361 19221464 17242785 11161223 17440819 19410462 19059307 17893378 21152245 19142967 20005174 19155303 18984771 19189210 18997820 20135344 19200415 19115204 19103187 16202921 20065188 15565566 19244106 19487384 16818667 18815881 16873071 19084267 17261762 19189212 20390343 17049068 20544844
MESH:D002276 Carcinoid Tumor Doxorubicin 4.8416051944
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5219066611
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.9017138121 20512989 17055752 19519916 20727157 20084675 17978847 19335982 18210153 18971187 17173139 16681979 19052882 3581430 16569478 17428255 3084413 20101231 19208518 19107877 19701751 18691550 10672840 19394651 16935385 18978308 20214788 19418558 19919837 19383236 16288022 17162532 19539802 20007298 17761372 20524982 16779866 20432363 11831363 16878318 18393292 16540662 21159647 18056438 18506893 18665156 19171122 10737359 16328049 19822196 16502159 18494052 16830150 16698587 16807293 18785209 20514400 18788625 20935162
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.9016234567 17876044 18059187 16023760
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 8.9016313753
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.9017306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.9016924424
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.9616201981 1485588
MESH:D002292 Carcinoma, Renal Cell Vinblastine 6.961485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.8320419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 10.8311237771
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.836189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.8318572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6217572228
MESH:D009202 Cardiomyopathies Doxorubicin 3.5317308081 16278810 16109756 17131338 17382496 16952015 17351982 16612575 15505089 15792986 17519947 17329180 15476868 17007740 18627295 17928571 16269455 17924179 16651473 16455267 16364871 16242529 16731534 15811867 17974986
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9417334414 16243910
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.7821159647 7505956 17174075 2727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.7820056578 19524636
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.6919052882
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8817681005 17110522 16919318 17333356 16105132 15861022 11677210
MESH:D003110 Colonic Neoplasms arsenite 2.5915037631
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.6618259882 18802399
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.6618802399
MESH:D015179 Colorectal Neoplasms Vinblastine 3.6618802399
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3819031437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1920387270
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.4819279558
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.0719107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 4.0717416283
MESH:D004362 Drug Toxicity Doxorubicin 3.6718602426
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 15.4115138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 15.4112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 15.4119031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.5717359293
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.5717893378 19155303 16202921 20544844
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.1918037988
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1516302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6516530937
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.6516481741
MESH:D005234 Fatty Liver arsenite 18.8518296743
MESH:D005234 Fatty Liver Diethylnitrosamine 18.8520387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.8515345470
MESH:D005234 Fatty Liver Tamoxifen 18.8514986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2416709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5514745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 11.5119069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 11.5119069698
MESH:D005355 Fibrosis arsenite 4.0818296743
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7016452187
OMIM:613086 GLAUCOMA 3, PRIMARY CONGENITAL, D marker/mechanism
MESH:D005909 Glioblastoma Doxorubicin 3.3517150277
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.5315692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6620471113
MESH:D006331 Heart Diseases Doxorubicin 3.4817875725 16879835 16495754 16244371 18006777 16144979 16244372 16707910 12587719 18674790 14766674 17888722 16330681
MESH:D006333 Heart Failure Doxorubicin 3.3417481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.9015692506
MESH:D006689 Hodgkin Disease Doxorubicin 12.4217606976 15147373 18501091
MESH:D006689 Hodgkin Disease sodium arsenite 12.4212676792
MESH:D006689 Hodgkin Disease Vinblastine 12.4218501091 18180244
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.6517937319
MESH:D007248 Infertility, Male sodium arsenite 6.6512646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 5.0818785209
MESH:D007249 Inflammation Tamoxifen 5.0819457130
MESH:D007674 Kidney Diseases Doxorubicin 6.2815699352 15369732 16775033
MESH:D007674 Kidney Diseases sodium arsenite 6.2820008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.1616707910
MESH:D007680 Kidney Neoplasms Tamoxifen 3.0418625569
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.1916085563
MESH:D008064 Lipidoses Tamoxifen 3.1615342952 17567588
MESH:D008080 Liposarcoma Paclitaxel 4.8317353645
MESH:D008103 Liver Cirrhosis arsenite 6.8418296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.8418407596 18522880 19638242 20032147 18665156
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.6216439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.6218564211
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1017034775
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.0221137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 18.0219389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.0219073162 19090486 19499222 19996281 18754104 9163691 19426721 21167192 19690152 19427195 18644402 15885732 12771043 19833225 19254457 10737359 15175105 2422723 21278145 21071580 12112319 20118626 19294768 2862719 20137499 20583210 18648771 20501860 19812893 19256749 19638242 20492335 20101389 20405173 20452335 19551842 18977376 18978307 20434301 19642983 16942905 19850985 19255062 21047994
MESH:D008113 Liver Neoplasms Mitomycin 18.0215113037
MESH:D008113 Liver Neoplasms sodium arsenite 18.0216712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 18.0216684651
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.0018164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.003124819 18775883 18282651 18544905 18253720 18079962 17942915 18093689 19004024 19519916 21159647 9362446 16842330 17174075 18308698 2563599 19009564 16267830 19126423 19539802 18164116 17854601
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 10.0017085340 16842330
MESH:D008171 Lung Diseases sodium arsenite 3.1719095001
MESH:D008175 Lung Neoplasms arsenite 8.5716809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.5718816296 20064080 18569708 20135361 20464547 20869020 18520028 17053015 6695378
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.5720970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Doxorubicin 8.5717418594 6189445
MESH:D008175 Lung Neoplasms sodium arsenite 8.5717306315 19931552 17077188 15276417 16712894
MESH:D008175 Lung Neoplasms Tamoxifen 8.5718625569
MESH:D008223 Lymphoma Doxorubicin 3.4616098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 8.9717654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 8.9714749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.5815621674
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7819428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.1515458769
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.1516827153 11731420 19196723 14580682 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.5819453300
MESH:D008545 Melanoma Doxorubicin 9.8416827129
MESH:D008545 Melanoma Paclitaxel 9.8416342250 12025231 12040289
MESH:D008545 Melanoma sodium arsenite 9.8419082730 16487513
MESH:D008545 Melanoma Tamoxifen 9.8412393984 19393235
MESH:D008545 Melanoma Vinblastine 9.8416432458 18332650 18505091 17761969 16809738 15577320 16248763 18176117 15577323 12374674
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2015990972
MESH:D008654 Mesothelioma Doxorubicin 3.0617638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.5015792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1916381670
MESH:D052016 Mucositis Doxorubicin 4.8117415656
MESH:D009101 Multiple Myeloma Paclitaxel 3.6914749477
MESH:D009203 Myocardial Infarction Doxorubicin 2.9519429709 15857846
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 13.649029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 13.6418259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 13.6415867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 13.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009369 Neoplasms Benzo(a)pyrene 5.0311141357
MESH:D009369 Neoplasms sodium arsenite 5.0311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6820056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0319196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic arsenite 4.4315738583
MESH:D009401 Nephrosis Doxorubicin 4.7816899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.0016889571 15640375
MESH:D009436 Neural Tube Defects sodium arsenite 3.1412854658
MESH:D009447 Neuroblastoma Doxorubicin 7.3015555623
MESH:D009447 Neuroblastoma Topotecan 7.3015176712
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3420387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1520387270
MESH:D009503 Neutropenia Vinblastine 4.5817378895
MESH:D010014 Osteolysis Paclitaxel 5.0015867366
MESH:D012516 Osteosarcoma Doxorubicin 4.1115930896
MESH:D010051 Ovarian Neoplasms Paclitaxel 5.1211161223
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.1215276417 17306315
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.6216540662
MESH:D010190 Pancreatic Neoplasms Mitomycin 5.6215113037
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D003557 Phyllodes Tumor Doxorubicin 5.1917983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.1917638057
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.552563599
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.8015572423
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms Calcitriol 1.8916289102 18247401 15754350 12479363 16644109
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8916888761 15897917 15749863 18437689 16868541 16729912
MESH:D011471 Prostatic Neoplasms Paclitaxel 1.8916356831 17172428 17136230 16729912
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8916039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.3315861022 16919318
MESH:D051437 Renal Insufficiency Doxorubicin 4.2317922066
MESH:D012509 Sarcoma Doxorubicin 3.9917710206 16767912 15675481 15625365 17203757 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.2514601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.8117846226
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.6119755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 13.6115692506
MESH:D012878 Skin Neoplasms sodium arsenite 13.6119524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.618532709
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.5816767912 17203757 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 11.6616709447
MESH:D013088 Spermatocele Tamoxifen 11.6616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0619457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8012854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.422093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.4218456281
MESH:D013274 Stomach Neoplasms Paclitaxel 3.4218396642 18506536
MESH:D024801 Tauopathies Paclitaxel 4.8316930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.307505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.3016010429 17909728
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.9517053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 11.9517653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.9516712894 11723127 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.9516712894 17572228 8653321
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.7711813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D014625 Vaginal Neoplasms Vinblastine 5.0615577323
MESH:D014652 Vascular Diseases sodium arsenite 4.4417056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5415869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.2316364871 17678736 17638931 17334414
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA164741922
    • No data
    Releated disease ID Related disease Name
    PA444281Glaucoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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