AutismKB 2.0

Annotation Detail for LTBP3


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Basic Information Top
Gene Symbol:LTBP3 ( DKFZp586M2123,FLJ33431,FLJ39893,FLJ42533,FLJ44138,FLJ45576,LTBP-3,LTBP2,STHAG6,pp6425 )
Gene Full Name: latent transforming growth factor beta binding protein 3
Band: 11q13.1
Quick LinksEntrez ID:4054; OMIM: 602090; Uniprot ID:LTBP3_HUMAN; ENSEMBL ID: ENSG00000168056; HGNC ID: 6716
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Non-alcoholic fatty liver disease histology (lobular)
Desease Name
Tooth agenesis, selective, 6
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LTBP3 mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LTBP3 mRNAaffects cotreatment|increases expression 18164116
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of LTBP3 mRNAaffects expression 17484886
D004041 Dietary Fats Dietary Fats results in decreased expression of LTBP3 mRNAdecreases expression 18457598
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LTBP3 mRNAaffects cotreatment|increases expression 18164116
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of LTBP3 mRNAdecreases expression 17557909
D012643 Selenium Selenium results in increased expression of LTBP3 mRNAincreases expression 19244175
C004648 testosterone enanthate testosterone enanthate affects the expression of LTBP3 mRNAaffects expression 17440010
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000236 Adenoma beta-Naphthoflavone 7.3119389873
MESH:D000236 Adenoma Diethylnitrosamine 7.3110737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.2418056438 19052882 17162532 19061943 16434500 17620307
MESH:D001161 Arteriosclerosis Dietary Fats 10.9515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001943 Breast Neoplasms Dietary Fats 2.1620435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1617474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0816124888 15700767 16192424 16227642 3786805 15673190 10355542 15721981 18705752 16011737 16050911 16097048
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1118788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.1120214788 18506893 16935385 11831363 17162532 20084675 19701751 19171122 19208518 18971187 19539802 17428255 20514400 20935162 17761372 20512989 20101231 18665156 18393292 18056438 16328049 16698587 16878318 16779866 18210153 19394651 19383236 20524982 19052882 19335982 10672840 16807293 3084413 19418558 19919837 18494052 16502159 21159647 18788625 16830150 20727157 18978308 16569478 19519916 19107877 17138121 17055752 18785209 16681979 19822196 17173139 10737359 16288022 3581430 18691550 16540662 20432363 20007298 17978847
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.017505956 17174075 21159647 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0511677210 17110522 17333356 15861022 16919318 17681005 16105132
MESH:D003092 Colitis Selenium 4.0917936198
MESH:D019465 Craniofacial Abnormalities marker/mechanism 11790802 12379497
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.639327722 15998439 21278145 6884620 10915739 7179309 4309450 3732212 17522070 15968718 15027814 6623471 7440962 11566570 2869522 7120509 16227642 16177239 10092053 19336974 19085960 3786805
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.6319107877
MESH:D056486 Drug-Induced Liver Injury Selenium 6.6315131321
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.8916045604 19224547 16239168 12631006 15959796 12795759 17595544 61145
MESH:D005234 Fatty Liver Dietary Fats 20.8917967931 18296743 19004024 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 20.8921071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.8915345470
MESH:D005355 Fibrosis Carbon Tetrachloride 9.8518705752
MESH:D005355 Fibrosis Dietary Fats 9.8518296743
MESH:D006333 Heart Failure Selenium 3.2117162251
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819110552 19900420
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.1217440010
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Dietary Fats 5.4820412841
MESH:D007249 Inflammation Diethylnitrosamine 5.4818785209
MESH:D007251 Influenza, Human Selenium 4.5716624496
MESH:D007333 Insulin Resistance Dietary Fats 3.2518457598 11836018
MESH:D007676 Kidney Failure, Chronic Selenium 4.1316518626
MESH:D007738 Kyphosis marker/mechanism 11790802
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 11.7211408273 11903743 16943688 17334410 17157831 16239168 21278145 17174718 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 11.7218296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.7218407596 19638242 18522880 20032147 18665156
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7513678700 12586293 17714472 14716833 12632514 18472094 18395914 17525996 15673190 15959796 12546737 15123356 18205269 15650968 18210741 16027843 15818738 12649538 17698563 16116963 12666154 15876570 17823541 18317297 17708605 18395095 12389079 17976157 14512876 11481614 15370692 16011737 14748882 16638106 17805973 17900296 16248980 12632512 18006644 18156304 14620537 17766677 18277467 16033810 16015684 18187930 12898905 17565644 15338365 16097048 15730626 16136751 18376398 16192424 18472332 15996030 18251166 12445421 14716496 18279442 15925388 18429990 17761835 18166357 17557913 18339082 18412020 15893842 17922224 10355542 18054572 17640975 15931870 12958196 12445418 17944888 20821823 14724832 12609069 17631135 17481882 17721639 18481824 18420326 18705752 15362042 15057751 18263696 12741479 18418968 15052691 12667390 17869086
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.2417285989 16964402 16246199 15830285 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 4.2417034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9214706259 16899240
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 7.9921295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.9919294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.9912112319 19294768 21047994 18978307 16942905 19254457 20137499 19812893 20118626 15175105 19073162 18648771 19850985 20101389 21071580 20452335 20434301 18754104 20492335 18977376 19090486 19426721 12771043 19690152 19256749 18644402 20405173 20501860 19255062 19638242 10737359 19499222 21167192 20583210 19996281 19551842 21278145 19642983 2422723 15885732 9163691 19833225 19427195 2862719
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.7618164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.7612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.7617942915 18775883 17854601 16267830 18093689 19539802 9362446 18544905 18308698 18079962 18164116 21159647 18282651 19009564 3124819 17174075 19004024 19126423 18253720 19519916 2563599 16842330
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620512841 20970405 6695378 21163286
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9015318939
MESH:D008654 Mesothelioma Selenium 2.8715107826
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.653581430 9029167
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5420387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D009765 Obesity Dietary Fats 2.3321332399 16723640 17217161 11836018 20132043 20518802 19632207 18457598 18674790
MESH:D010003 Osteoarthritis marker/mechanism 11790802 12379497
MESH:D010026 Osteosclerosis marker/mechanism 11790802 12379497
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4916540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010954 Plasmacytoma Selenium 5.2715087411
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.772563599
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.167505956
OMIM:613097 TOOTH AGENESIS, SELECTIVE, 6 marker/mechanism
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7815869587 14671159
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30479
    • No data
    Releated disease ID Related disease Name
    PA164924611Partial congenital absence of teeth
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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