AutismKB 2.0

Annotation Detail for BCAM


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Basic Information Top
Gene Symbol:BCAM ( AU,CD239,LU,MSK19 )
Gene Full Name: basal cell adhesion molecule (Lutheran blood group)
Band: 19q13.32
Quick LinksEntrez ID:4059; OMIM: 612773; Uniprot ID:BCAM_HUMAN; ENSEMBL ID: ENSG00000187244; HGNC ID: 6722
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1702Skin tumor
1842Sickle cell disease
1848Embryoma
2022Liver cancer
2237Neoplasm metastasis
No data
No data
Desease Name
Blood group, Auberger system
Blood group, Lutheran null
Blood group, Lutheran system
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of BCAM mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of BCAM mRNAaffects expression 16483693
D002945 Cisplatin BCAM protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004041 Dietary Fats Dietary Fats results in increased expression of BCAM mRNAincreases expression 18042831
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of BCAM mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of BCAM mRNAdecreases expression 19619570
D008942 Mitoxantrone BCAM protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
C041786 palm oil palm oil results in increased expression of BCAM mRNAincreases expression 18042831
C006253 pirinixic acid pirinixic acid results in increased expression of BCAM mRNAincreases expression 18445702
C025462 sulindac sulfide sulindac sulfide results in decreased expression of BCAM mRNAdecreases expression 12734198
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of BCAM mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of BCAM mRNAdecreases expression 19619570
C066340 tolcapone tolcapone binds to BCAM proteinaffects binding 19783845
C029297 vinylidene chloride vinylidene chloride results in increased expression of BCAM proteinincreases expression 14565772
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0015322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D058186 Acute Kidney Injury Cisplatin 4.0717670903 12690470 15814532
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Cisplatin 4.6517638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 4.6511473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.813712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.4711080934
MESH:D000544 Alzheimer Disease sulindac sulfide 4.9618759972
MESH:D000544 Alzheimer Disease tolcapone 4.9620150427
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D001161 Arteriosclerosis Dietary Fats 4.0315238619
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1911289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.0614601052
MESH:D001943 Breast Neoplasms Cisplatin 1.9719526202 18382427
MESH:D001943 Breast Neoplasms Dietary Fats 1.9720435547
MESH:D001943 Breast Neoplasms Estradiol 1.9719861407 12948864 16675129 14630087 17261762 17018787 18497071 17289903
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.747296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 4.7417982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7416924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 6.0716685392 12023789
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 6.0712391285
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.727296757
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.8517066447 6189445 18337622
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.917505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.9118566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.1119486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.1119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.148697196 12621046 16354765 15340226 15668235
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003866 Depressive Disorder tolcapone 4.387768276 11224284
MESH:D003865 Depressive Disorder, Major tolcapone 5.0010440460
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9411298694 12868966 14531868 11906362 18759878 8156756 2524372 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.613621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5119279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.379328219 16192314 6679447 11289319 18692083 7440962 9653073 9022650 18289764 8291058 18648102 1440618 6482804
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.3720420201
MESH:D056486 Drug-Induced Liver Injury tolcapone 9.3716604736 19783845
MESH:D056486 Drug-Induced Liver Injury vinylidene chloride 9.373697828
MESH:D004362 Drug Toxicity Cisplatin 8.4515033597 12231392 19839026 12649298
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.4511462148
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.5711455177
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D004487 Edema pirinixic acid 6.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0815322242 16714409 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 3.0519148513 11473722 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.733581430
MESH:D004938 Esophageal Neoplasms Cisplatin 4.7315464296 16785472 15173087 16481741 17638652
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 6.1219578428
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Dietary Fats 8.0719551842 18296743 19004024 17967931
MESH:D005234 Fatty Liver pirinixic acid 8.0720131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.196705139
MESH:D005355 Fibrosis Dietary Fats 9.0918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0920067830
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.157505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.7915464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.3919898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.5115464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3811294989 10048152
MESH:D006331 Heart Diseases Mitoxantrone 4.2216019553
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.646705139
MESH:D006529 Hepatomegaly pirinixic acid 8.7318467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7316120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D006689 Hodgkin Disease Cisplatin 3.6916200630 16170182
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2216959395 15340226 8697196 16354765 18606429
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0815034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418670907 18850075
MESH:D007249 Inflammation Dietary Fats 5.0920412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0912200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 12.7011836018 18457598
MESH:D007333 Insulin Resistance Estradiol 12.7016393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 12.7016306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.198074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.3115464296
MESH:D007674 Kidney Diseases Cisplatin 10.7712231392 12649298 18289764 15190930 19839026
MESH:D007674 Kidney Diseases Estradiol 10.7715618244
MESH:D007674 Kidney Diseases vinylidene chloride 10.777839370
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.676582329
MESH:D007680 Kidney Neoplasms Estradiol 7.6715610895
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.9711231351
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.8318172266
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9318296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.269327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4412878042
MESH:D008113 Liver Neoplasms pirinixic acid 4.3716377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.3716984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.95598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9512151625
MESH:D055370 Lung Injury vinylidene chloride 5.543697828
MESH:D008175 Lung Neoplasms Cisplatin 2.4917225452 11798837 6189445
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4911884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6217203775 11408345 16891317 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008545 Melanoma Cisplatin 2.4912374674 17761969 18505091 15577323 12393984 16248763 18176117 18332650 16432458 12883367 16809738 11135225 17023156
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.9315990972
MESH:D008654 Mesothelioma Cisplatin 3.2817638057
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.5316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.5316411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.513581430
MESH:D009369 Neoplasms Cisplatin 8.7316773208
MESH:D009369 Neoplasms Mitoxantrone 8.7316640825
MESH:D009369 Neoplasms pirinixic acid 8.7317405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.6715464296
MESH:D009421 Nervous System Malformations Estradiol 9.8911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.8914600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.986679447
MESH:D009447 Neuroblastoma Cisplatin 3.508761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.858761367
MESH:D009765 Obesity Dietary Fats 4.5219632207 11836018 21332399 16723640 20518802 18457598 17217161 20132043 18674790
MESH:D009765 Obesity pirinixic acid 4.5220558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.526482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.193988306
MESH:D010051 Ovarian Neoplasms Cisplatin 5.1017225452 19769630 15464296 6897625
MESH:D010051 Ovarian Neoplasms Estradiol 5.1019401270
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.0319003803
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.627296757
MESH:D010300 Parkinson Disease tolcapone 3.6319783845 9754991 20334432 17089403 11746615 7566641 8635184 9708959 11586115 10651109 18328768 9333106 11432539 11793426 19578428 20216409 1977408 16758261 8739811 9591521 9305320
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.4315464296
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.646228378
MESH:D010997 Pleural Neoplasms Cisplatin 5.5217638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411118676 11222880 11896295 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0716740699
MESH:D051437 Renal Insufficiency Cisplatin 4.5515464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.463692021
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.5514601052
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.5215464296
MESH:D013274 Stomach Neoplasms Cisplatin 2.3318396642 17522103 15958060
MESH:D013736 Testicular Neoplasms Cisplatin 4.7515464296 17225452
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.973712494 6587162 1399818 6582329 7505956
MESH:D013978 Tibial Fractures Estradiol 4.8619048282
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 6.1219578428
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.388074119
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.3817225452 15464296 12973940
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.3116803524
MESH:D014594 Uterine Neoplasms sulindac sulfide 4.7818645019
MESH:D014625 Vaginal Neoplasms Cisplatin 4.7515577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D014820 Vitiligo tolcapone 5.3210573327
MESH:D014839 Vomiting Cisplatin 4.8911897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30484
    • No data
    Releated disease ID Related disease Name
    PA165108110Dyslipidaemia
    PA446213HIV Infections
    PA444528Hyperlipidemias
    Releated drug ID Related drug Name
    PA164712505Antivirals for treatment of HIV infections, combinations
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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