AutismKB 2.0

Annotation Detail for ARNTL


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Basic Information Top
Gene Symbol:ARNTL ( BMAL1,BMAL1c,JAP3,MGC47515,MOP3,PASD3,TIC,bHLHe5 )
Gene Full Name: aryl hydrocarbon receptor nuclear translocator-like
Band: 11p15.3
Quick LinksEntrez ID:406; OMIM: 602550; Uniprot ID:BMAL1_HUMAN; ENSEMBL ID: ENSG00000133794; HGNC ID: 701
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04710Circadian rhythm - mammal
No data
Pathway IDPathway Name
200068Circadian rhythm pathway
Pathway IDPathway Name
P00015Circadian clock system
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
bipolar disorder
PSYCH
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ARNTL mRNAdecreases expression 19933214
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of ARNTL mRNAincreases expression 20406850
D000082 Acetaminophen Acetaminophen affects the expression of ARNTL mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ARNTL mRNAaffects expression 16483693
D019324 beta-Naphthoflavone beta-Naphthoflavone inhibits the reaction [CLOCK protein binds to ARNTL protein]affects binding|decreases reaction 20106950
D019324 beta-Naphthoflavone beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNTL protein]affects binding|increases reaction 20106950
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ARNTL mRNAaffects cotreatment|decreases expression 18164116
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ARNTL mRNAdecreases expression 19150397
D004041 Dietary Fats Dietary Fats results in decreased expression of ARNTL mRNAdecreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ARNTL mRNAaffects cotreatment|decreases expression 18164116
D005419 Flavonoids Flavonoids results in decreased expression of ARNTL mRNAdecreases expression 18035473
C041786 palm oil palm oil results in decreased expression of ARNTL mRNAdecreases expression 18042831
D010634 Phenobarbital Phenobarbital results in decreased expression of ARNTL mRNAdecreases expression 19270015
D010634 Phenobarbital Phenobarbital results in increased expression of ARNTL mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid results in decreased expression of ARNTL mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid results in increased expression of ARNTL mRNAincreases expression 18445702
C002979 selenomethylselenocysteine selenomethylselenocysteine results in decreased expression of ARNTL mRNAdecreases expression 19122877
C009250 sevoflurane sevoflurane affects the expression of ARNTL mRNAaffects expression 15967596
C017947 sodium arsenite sodium arsenite results in increased expression of ARNTL mRNAincreases expression 18812580
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ARNTL mRNAdecreases expression 18295293
19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ARNTL mRNAincreases expression 18487412
D014212 Tretinoin RARA protein inhibits the reaction [Tretinoin results in increased activity of [CLOCK protein binds to ARNTL protein]]affects binding|decreases reaction|increases activity 17069763
D014212 Tretinoin Tretinoin results in increased activity of [CLOCK protein binds to ARNTL protein]affects binding|increases activity 17069763
D014212 Tretinoin Tretinoin results in increased expression of ARNTL mRNAincreases expression 9704006
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.276195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.2715322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1018653653
MESH:D000236 Adenoma beta-Naphthoflavone 6.8419389873
MESH:D000236 Adenoma Diethylnitrosamine 6.846695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 24.8216434500 19052882 17162532 19061943 18056438 17620307
MESH:D018248 Adenoma, Liver Cell Phenobarbital 24.8217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 24.8216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 24.8216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9017306315 16712894
MESH:D000505 Alopecia Tretinoin 3.6015955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D001161 Arteriosclerosis Dietary Fats 3.8715238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.0616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2616292516
MESH:D001249 Asthma Tretinoin 2.3416456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001471 Barrett Esophagus Tretinoin 4.3916935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.1719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.1712125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.1716206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001943 Breast Neoplasms Dietary Fats 2.3520435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3517474063
MESH:D001943 Breast Neoplasms selenomethylselenocysteine 2.3518855134
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3520435547
MESH:D001943 Breast Neoplasms Tretinoin 2.3516166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5816813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1616168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.3616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.363084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.3610672840 18691550 17173139 16830150 16288022 18788625 20514400 17162532 20214788 19107877 17138121 18978308 19171122 20432363 16935385 18056438 17978847 19383236 19539802 16698587 17055752 16681979 19919837 18494052 18506893 16502159 16569478 16878318 19208518 20727157 19701751 16328049 11831363 16540662 10737359 19822196 19335982 20084675 3581430 20512989 21159647 20007298 19418558 20935162 16779866 20524982 20101231 16807293 18393292 18785209 17761372 17428255 19394651 18971187 19519916 3084413 18210153 19052882 18665156
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 11.3617173139 20935162 6705139 1701930 20007298
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.3616507464 15276417 17306315
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.361917145
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.6718572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.6716051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 7.1810977129
MESH:D002386 Cataract Tretinoin 7.1817460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.916135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.9120889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.912727394 7505956 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 15.9120056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.244080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5816129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.2619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.2616835633
MESH:D002779 Cholestasis pirinixic acid 2.8119176532
MESH:D002822 Choriocarcinoma Tretinoin 5.1616461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.7415340226 8697196 12621046 15668235 16354765
MESH:D002972 Cleft Palate Tretinoin 5.749407595
MESH:D003092 Colitis Tretinoin 3.6917035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4415322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.4416925845 8800419 17551590 9211117 10589399 14991402 9142499 9664655 9224671 9125849
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0018551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2017107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.9018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.9019370779 14550746 16227642 11287661 17522070 10915739 17562736 14725611 16081117 12705907 16781746 19739265 16177239 11529661 11421492 17906064 16109766 12540782 19085960 11743745 15968718 19420014 11834606 11739529 12958197 12153990 11461765 10663392 14986274 12594235 12392966 19164858 10774834 16393943 19416960 15619225 16485898 2444490 18071297 19923254 18713872
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.9019107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.9020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4418367378
MESH:D004421 Dystonia Phenobarbital 3.991851702
MESH:D004487 Edema pirinixic acid 6.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.9516714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.9518230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0916569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.009294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.093659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.8711558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.8820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.526401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.247750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.013659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1216302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0720426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.7811564622
MESH:D005124 Eye Abnormalities Tretinoin 8.789664655 16938888
MESH:D005234 Fatty Liver Dietary Fats 13.0019551842 18296743 19004024 17967931
MESH:D005234 Fatty Liver Diethylnitrosamine 13.0020387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 13.0020131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005355 Fibrosis Dietary Fats 14.7018296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.7020067830
MESH:D005355 Fibrosis Tretinoin 14.7017994277
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.6716452187
MESH:D005909 Glioblastoma Tretinoin 2.9917312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1616084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5011294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.509664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.5220558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006529 Hepatomegaly Phenobarbital 14.3116109766
MESH:D006529 Hepatomegaly pirinixic acid 14.3118467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.3112621046 16120746 15340226
MESH:D006689 Hodgkin Disease sodium arsenite 3.1312676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0516354765 18606429 16959395 15340226 8697196
MESH:D006930 Hyperalgesia Acetaminophen 7.5716870215
MESH:D006930 Hyperalgesia Tretinoin 7.5716870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5721332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5516778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.6021332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9018850075 18670907
MESH:D007248 Infertility, Male sodium arsenite 2.9712646999 15346721
MESH:D007249 Inflammation Dietary Fats 11.8720412841
MESH:D007249 Inflammation Diethylnitrosamine 11.8718785209
MESH:D007249 Inflammation Flavonoids 11.8717296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.8712200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.2011836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.2016306350
MESH:D007410 Intestinal Diseases Tretinoin 3.7517994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.8716580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.8717551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 5.9212587719 15629191
MESH:D007674 Kidney Diseases sodium arsenite 5.9220008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 2.9616705839
MESH:D007859 Learning Disorders sevoflurane 4.7619212262
MESH:D007938 Leukemia Tretinoin 2.7617143497
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive marker/mechanism 16999817
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6816482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0716294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1416823087 17506722 9834237 12679006 17217047 17649720 19642359 16788101 17339181 19075265 16140955 16331271 17361223 19029980 17294898 17301526 19035177 15748426 17107899 16766008 17712046 19225113 16891316 17368321 16935935
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.299224671
MESH:D008103 Liver Cirrhosis Dietary Fats 10.9618296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.9618522880 18407596 18665156 20032147 19638242
MESH:D008103 Liver Cirrhosis Phenobarbital 10.9621047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.3816248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 6.4511587558 19014921 16611625 12969438 12587719 19784758 16610002 19460945
MESH:D008107 Liver Diseases Diethylnitrosamine 6.4517034775
MESH:D008107 Liver Diseases Phenobarbital 6.4519363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2216871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 21.817678174
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 21.8121295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 21.812862719 20137499 20118626 12771043 21071580 19254457 15885732 20101389 19294768 19690152 19642983 12112319 20583210 18648771 18978307 18977376 19255062 19426721 19996281 21278145 21167192 15175105 20501860 19499222 19073162 19638242 21047994 9163691 20434301 19551842 19812893 19256749 20492335 19833225 19090486 19427195 16942905 18754104 10737359 20452335 19850985 2422723 20405173 18644402
MESH:D008113 Liver Neoplasms Phenobarbital 21.8119812893 19482888 8742319 19073162 21047994 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 21.8116377806 20007298 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 21.8116712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.8116984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 18.522876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 18.5218164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 18.5216267830 3124819 9362446 18093689 21159647 18544905 19519916 18775883 19539802 18079962 19009564 17854601 16842330 18253720 17174075 17942915 19004024 18164116 18308698 2563599 18282651 19126423
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 18.5218308698 6150874 2563599 1399818 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.5212151625
MESH:D008171 Lung Diseases sodium arsenite 3.1619095001
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.3821163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms sodium arsenite 3.3819931552 15276417 16712894 17077188 17306315
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3819555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental selenomethylselenocysteine 4.2015318939
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma sodium arsenite 3.3319082730 16487513
MESH:D008545 Melanoma Tretinoin 3.3316752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D008569 Memory Disorders sevoflurane 4.7319212262
MESH:D008591 Meningomyelocele Tretinoin 4.4116940565
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0717596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.4717484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.8518551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.569029167 3581430
MESH:D009369 Neoplasms pirinixic acid 8.1817405874
MESH:D009369 Neoplasms sodium arsenite 8.1811559025
MESH:D009369 Neoplasms Tretinoin 8.1816946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6520056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.4614600291
MESH:D009421 Nervous System Malformations Tretinoin 9.469125849
MESH:D009436 Neural Tube Defects sodium arsenite 7.2612854658
MESH:D009436 Neural Tube Defects Tretinoin 7.269142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.1218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.1220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1220387270
MESH:D009765 Obesity Dietary Fats 4.4216723640 17217161 20132043 20518802 18457598 21332399 19632207 18674790 11836018
MESH:D009765 Obesity pirinixic acid 4.4220558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4116049721
MESH:D010018 Osteomalacia Phenobarbital 4.3617016548
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.8615276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 4.8616936753
MESH:D010146 Pain Acetaminophen 6.5316870215
MESH:D010146 Pain Tretinoin 6.5316870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.5716540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.5716965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.5715976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.032563599
MESH:D011230 Precancerous Conditions Phenobarbital 9.032563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1811399792 11118676 11222880 11896295
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3116039940
MESH:D011507 Proteinuria Tretinoin 3.5916636307
MESH:D019310 Pseudolymphoma Phenobarbital 4.5012752131
MESH:D011625 Pterygium Tretinoin 4.7816723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0816283617 16116481
MESH:D012640 Seizures 2,6-dinitrotoluene 5.8818551238
MESH:D012640 Seizures Phenobarbital 5.883137016 4039156 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.816407741
MESH:D012878 Skin Neoplasms sodium arsenite 9.3718572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.3716192470
MESH:D012878 Skin Neoplasms Tretinoin 9.3716467112
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7812854658
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4118456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.4117261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.887505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 11.881399818
MESH:D013964 Thyroid Neoplasms Tretinoin 11.8816026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.7716051514
MESH:D014376 Tuberculosis Tretinoin 3.2116040207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.0716049721
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.0711723127 16452187 16712894 17306315
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3110091137
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.3511813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.3516129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.6116752155
MESH:D014652 Vascular Diseases sodium arsenite 4.4217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D014820 Vitiligo Tretinoin 4.0416761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D015430 Weight Gain Dietary Fats 3.7216723640
MESH:D009396 Wilms Tumor Tretinoin 3.9516287080
Pathway ID Pathway Name
REACT:24941 Circadian Clock
REACT:24972 Circadian Clock (mouse)
KEGG:04710 Circadian rhythm - mammal
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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