AutismKB 2.0

Annotation Detail for LUM


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Basic Information Top
Gene Symbol:LUM ( LDC,SLRR2D )
Gene Full Name: lumican
Band: 12q21.33
Quick LinksEntrez ID:4060; OMIM: 600616; Uniprot ID:LUM_HUMAN; ENSEMBL ID: ENSG00000139329; HGNC ID: 6724
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
Desease Name
VISION
Myopia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of LUM mRNAincreases expression 19933214
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of LUM proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LUM mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of LUM mRNAincreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of LUM mRNAdecreases expression 20713471
C095105 bexarotene bexarotene results in decreased expression of LUM mRNAdecreases expression 16648578
C006780 bisphenol A bisphenol A results in decreased expression of LUM mRNAdecreases expression 20739668
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of LUM mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of LUM mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of LUM mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of LUM mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of LUM mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LUM mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of LUM mRNAdecreases expression 15834898
17557909
D005038 Ethylnitrosourea Ethylnitrosourea results in increased expression of LUM mRNAincreases expression 15954086
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of LUM mRNAdecreases expression 20713471
D015735 Mifepristone Mifepristone results in increased expression of LUM mRNAincreases expression 17584828
C041786 palm oil palm oil results in decreased expression of LUM mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of LUM mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of LUM mRNAdecreases expression 19482888
C035988 procymidone procymidone results in decreased expression of LUM mRNAdecreases expression 15686871
D020849 Raloxifene Raloxifene affects the expression of LUM mRNAaffects expression 14699072
C017947 sodium arsenite sodium arsenite results in decreased expression of LUM mRNAdecreases expression 18812580
D013629 Tamoxifen Tamoxifen affects the expression of LUM mRNAaffects expression 17555576
C004648 testosterone enanthate testosterone enanthate affects the expression of LUM mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LUM mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LUM mRNAincreases expression 20067830
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LUM mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LUM mRNAincreases expression 19933214
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of LUM mRNAincreases expression 17982090
D014635 Valproic Acid Valproic Acid results in increased expression of LUM mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin results in decreased expression of LUM mRNAdecreases expression 15686871
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3814745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 13.206195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.2015322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 13.208875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7719490988
MESH:D000138 Acidosis Ammonium Chloride 3.3918287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7717505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.0320127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.0314692618
MESH:D000236 Adenoma Benzo(a)pyrene 10.786695378
MESH:D000236 Adenoma Ethylnitrosourea 10.786695378
MESH:D000236 Adenoma Methylcholanthrene 10.7810545420 6695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 9.5117620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.5116835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7317306315 16712894
MESH:D000419 Albuminuria Raloxifene 4.4317451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5015800139
MESH:D000550 Amblyopia Valproic Acid 5.0617688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8011748828
MESH:D001008 Anxiety Disorders Valproic Acid 8.4017497229
MESH:D001008 Anxiety Disorders vinclozolin 8.4019015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9019183758
MESH:D001161 Arteriosclerosis Dietary Fats 9.3415238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.3411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5615885639
MESH:D050197 Atherosclerosis Methylcholanthrene 3.3511922910
MESH:D001321 Autistic Disorder Valproic Acid 2.0218316065 18396377 15238991 18177632 20603192 17688650 18558336 17157402 18985861 17507914 18940202 19232924 19460635 18775368 16609825
MESH:D001714 Bipolar Disorder Valproic Acid 2.9917594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.8912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.6615746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.668888407
MESH:D001862 Bone Resorption bisphenol A 3.7111985600
MESH:D001927 Brain Diseases Ethylnitrosourea 4.7314991843
MESH:D001930 Brain Injuries Raloxifene 4.3016580743
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.1416651633 15144691 18412241 16357521 16436596
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.6017474063 20146248
MESH:D001943 Breast Neoplasms bexarotene 4.6016344269 16818667
MESH:D001943 Breast Neoplasms bisphenol A 4.6017123778
MESH:D001943 Breast Neoplasms Dietary Fats 4.6020435547
MESH:D001943 Breast Neoplasms Methylcholanthrene 4.6017474063
MESH:D001943 Breast Neoplasms Raloxifene 4.6016912660 15775269 16837676 17049068 15572757 15758505 17595753 17440819 17893378 17952589 17242785 17261762
MESH:D001943 Breast Neoplasms Tamoxifen 4.6017261762 17893378 19200415 15565566 19142967 20544844 19487384 19221464 21152245 15668708 19103187 18629630 18997820 19155303 19289846 20135344 20065188 18815881 19410462 11161223 18425577 19189210 16873071 19115204 16818667 19189212 18984771 18351453 18855134 19084267 20390343 19011961 20859285 19288272 18821012 17242785 19059307 17440819 21138602 20005174 16202921 19066611 19244106 16273361 17049068
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.6020435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.613786805 15721981 16192424 15673190 16097048 16227642 18705752 15700767 16124888 16011737 16050911 10355542
MESH:D002277 Carcinoma Methylcholanthrene 7.8810545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.8816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3419066611
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.5712619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.5718788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.571701930 6705139 20007298 17173139 20935162
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.5717306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.5716924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.8217123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.1716247446
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.4320419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.4318572023
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.0017572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.0017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2716120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Raloxifene 3.3315775269
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.1312371664
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 15.1316003739
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 15.1316192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 15.1319524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.084080065
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.8117160924
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6520734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D002779 Cholestasis Cyclosporine 7.3619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3616105132 15861022 17681005 17110522 16919318 17333356 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.038697196 16354765 15340226 12621046 15668235
MESH:D003072 Cognition Disorders Raloxifene 4.4515800139
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 4.3811698051 17991707 18200517 16867261 16804969 17936198 16782535 18023891 16474422
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.3917276891
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4215322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.428888407 16575769 17688650
MESH:D003456 Cryptorchidism vinclozolin 4.1714966744
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1919031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.0217474826
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6317107852
MESH:D003928 Diabetic Nephropathies Raloxifene 8.5517451421 15920148 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.5519279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.9019336974 7440962 3732212 17522070 3786805 6623471 6884620 9327722 7179309 16227642 10092053 10915739 15998439 16177239 2869522 4309450 7120509 19085960 15027814 15968718 11566570 21278145
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.9020420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 5.9019641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3318367378
MESH:D004421 Dystonia Phenobarbital 9.901851702
MESH:D004421 Dystonia Valproic Acid 9.901851702
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.8118357618
MESH:D004487 Edema Raloxifene 6.3415860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.3412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7315322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.3912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 14.3915845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.3919031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 2.9320544844 16202921 17893378 19155303
MESH:D004715 Endometriosis Mifepristone 8.6516134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.659294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 10.233659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 10.2317275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 9.403922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 9.4016628512 3922381
MESH:D004827 Epilepsy Phenobarbital 6.3820417680
MESH:D004827 Epilepsy Valproic Acid 6.3818234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 8.386401628
MESH:D004832 Epilepsy, Absence Valproic Acid 8.386426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 10.737750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 10.737750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 9.903659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 9.903659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 34.5912795759 19224547 15959796 16045604 17595544 12631006 61145 16239168
MESH:D005234 Fatty Liver Cyclosporine 34.5919224547
MESH:D005234 Fatty Liver Dietary Fats 34.5918296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 34.5915345470
MESH:D005234 Fatty Liver Raloxifene 34.5917473493
MESH:D005234 Fatty Liver Tamoxifen 34.5919224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 34.5914986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2911858732
MESH:D005315 Fetal Diseases Valproic Acid 4.7116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.968888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0119069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.7714633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 25.9318705752
MESH:D005355 Fibrosis Cyclosporine 25.9312639820 12168785
MESH:D005355 Fibrosis Dietary Fats 25.9318296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 25.9320067830
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 25.9317994277
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7616973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1316417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5116452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.058708960
MESH:D005909 Glioblastoma Ethylnitrosourea 3.7216436596
MESH:D005910 Glioma Ethylnitrosourea 3.4316357521 16651633 18412241
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4210696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1510048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.4211110106
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2515720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4319110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 7.8816109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.8816120746 15340226 12621046
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.5717440010
MESH:D006689 Hodgkin Disease sodium arsenite 3.0112676792
MESH:D006849 Hydrocephalus Valproic Acid 4.6917688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.878697196 16959395 15340226 18606429 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3616899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4421332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.4521332399
MESH:D006973 Hypertension Cyclosporine 8.2010903974
MESH:D006973 Hypertension Raloxifene 8.2017577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.2018850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9215338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6416569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.5517937319
MESH:D007248 Infertility, Male sodium arsenite 10.5512646999 15346721
MESH:D007248 Infertility, Male vinclozolin 10.5516467254
MESH:D007249 Inflammation Dietary Fats 7.7620412841
MESH:D007249 Inflammation Tamoxifen 7.7619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.7612200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.5118200517
MESH:D007333 Insulin Resistance bisphenol A 7.1216393666
MESH:D007333 Insulin Resistance Dietary Fats 7.1211836018 18457598
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.4417994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2715604871
MESH:D007674 Kidney Diseases Cyclosporine 5.6918776723 10903974 8314463
MESH:D007674 Kidney Diseases sodium arsenite 5.6920008137
MESH:D007680 Kidney Neoplasms Cyclosporine 11.6912371664
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 11.6917379185
MESH:D007680 Kidney Neoplasms Tamoxifen 11.6918625569
MESH:D007889 Leiomyoma Raloxifene 4.3316973256
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1217596541 16294345
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5616417039
MESH:D008064 Lipidoses Tamoxifen 3.0317567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.4811408273 17157831 16943688 16239168 16221502 17174718 11903743 17334410 21278145
MESH:D008103 Liver Cirrhosis Dietary Fats 10.4818296743
MESH:D008103 Liver Cirrhosis Phenobarbital 10.4821047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.3317481882 17721639 18376398 18279442 15931870 12958196 17557913 12741479 12546737 16027843 12649538 16192424 18472332 15959796 14512876 18429990 17869086 18156304 17922224 12632512 14716496 17976157 16248980 14716833 16136751 18263696 14620537 14724832 15730626 18418968 16015684 16011737 18210741 17525996 12898905 17944888 15338365 12586293 16638106 17900296 15818738 12445421 18317297 17766677 18395914 16097048 12666154 12609069 18472094 18395095 17823541 17631135 12389079 15996030 17805973 15362042 17761835 18187930 18277467 16033810 17698563 18420326 15370692 12667390 17565644 13678700 17714472 18205269 15673190 17640975 18412020 18339082 15925388 20821823 18006644 15876570 17708605 18481824 12445418 15123356 12632514 15057751 14748882 18705752 18251166 11481614 16116963 18166357 18054572 10355542 15650968 15052691 15893842
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.3318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3312878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9515830285 17285989 15720792 16964402 16246199
MESH:D008107 Liver Diseases Phenobarbital 3.9519363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9915123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5416899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 20.919163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.9121137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.9119294768
MESH:D008113 Liver Neoplasms Phenobarbital 20.9119073162 19812893 8742319 15975961 21047994 19482888
MESH:D008113 Liver Neoplasms sodium arsenite 20.9116712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 20.9116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.9116984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 17.538603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.5315583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 17.531399818 598648
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 17.536150874 1399818 18308698 17172636 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.5312151625
MESH:D008171 Lung Diseases sodium arsenite 3.0619095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.0917228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 12.6314755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 12.6318569708 20135361 18816296 20869020 20064080 17053015 20464547 6695378 18520028
MESH:D008175 Lung Neoplasms bexarotene 12.6317849452
MESH:D008175 Lung Neoplasms Ethylnitrosourea 12.6316019985 17703301 16271038 6695378
MESH:D008175 Lung Neoplasms Methylcholanthrene 12.6311893704 16337739 6695378 21163286 17909032 15390079 20512841 16271038 10545420 9230183 20970405 1399818 7750092
MESH:D008175 Lung Neoplasms sodium arsenite 12.6315276417 16712894 19931552 17306315 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 12.6318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.6311884234 19555203
MESH:D008223 Lymphoma Ethylnitrosourea 3.8215790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.8815375218
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.9811161223
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5919428831
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 9.5419196722 19196723 15591091
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 9.5418041768 10767621 10838139
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.5414580682 19196723 11731420 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.3819453300
MESH:D008545 Melanoma sodium arsenite 3.2219082730 16487513
MESH:D008545 Melanoma Tamoxifen 3.2212393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0115990972
MESH:D008579 Meningioma Ethylnitrosourea 5.8117943659
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6216801185
MESH:D008881 Migraine Disorders Valproic Acid 3.0718765137 18803445
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3815863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0616381670
MESH:D009101 Multiple Myeloma Raloxifene 3.3216497877
MESH:D020391 Muscular Dystrophy, Facioscapulohumeral marker/mechanism 12868502
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.878888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.0617596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8812213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3017484760
MESH:D009232 Myxoma Raloxifene 5.3816343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4619410462
MESH:D009369 Neoplasms Benzo(a)pyrene 4.7511141357
MESH:D009369 Neoplasms sodium arsenite 4.7511559025
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 8.8116707424
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.8120056578
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 10.3619196722
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 10.3619189210 19196722 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1419348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 9.0316427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.0314600291
MESH:D009436 Neural Tube Defects sodium arsenite 6.9712854658
MESH:D009436 Neural Tube Defects Valproic Acid 6.9716359493 8888407
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.2416003739 17160924 16651423
MESH:D009765 Obesity Dietary Fats 2.2518457598 17217161 16723640 21332399 20518802 19632207 11836018 18674790 20132043
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.8117160924
MESH:D010018 Osteomalacia Phenobarbital 4.1917016548
MESH:D010024 Osteoporosis Raloxifene 3.2917882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.0717823083 15758505 15579764 17893378
MESH:D010049 Ovarian Diseases bisphenol A 4.8211985600
MESH:D010051 Ovarian Neoplasms Mifepristone 4.9916525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.9915276417 17306315
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.4316965848
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.0417698068
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5311578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3918163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.4912371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.492563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 21.8210548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 21.8211222880 11896295 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 21.8220603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 21.8218220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.7618220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.0520887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8717292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8716740699
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8715731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8716039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8715067354
MESH:D011472 Prostatitis vinclozolin 4.7618629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.1416919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 11.6112752131
MESH:D019310 Pseudolymphoma Valproic Acid 11.6112752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.1716882103
MESH:D011629 Puberty, Precocious bisphenol A 4.6110548101
MESH:D011693 Purpura Raloxifene 5.3815770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6718990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.0119155313
MESH:D012559 Schizophrenia Valproic Acid 2.0515737665 19110320
MESH:D012640 Seizures Phenobarbital 5.6216876388 11442880 4039156 3137016
MESH:D012640 Seizures Valproic Acid 5.6216876388 14763951 11738929 3137016 1511512 11044598 17978042 15475178
MESH:D003294 Seizures, Febrile Phenobarbital 4.656407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.9310029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 8.9318572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.9316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.9816709447
MESH:D013088 Spermatocele Tamoxifen 10.9816709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8719457130
MESH:D016135 Spinal Dysraphism sodium arsenite 9.1112854658
MESH:D016135 Spinal Dysraphism Valproic Acid 9.1119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.3712833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5520155912 2093021
MESH:D020521 Stroke Raloxifene 3.6916837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.8116684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0115669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.9915790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7312697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 2.931399818
MESH:D013978 Tibial Fractures Raloxifene 5.0419048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.0617262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.353119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.3917053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 11.3917572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.3917306315 16452187 16712894 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.3916712894 17572228 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.478888407
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.6211813266
MESH:D014591 Uterine Diseases bisphenol A 4.8414652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1314692618
MESH:D014605 Uveitis Cyclosporine 3.811336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2517056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4212125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.0416837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3814671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3816343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0815886252
MESH:D015430 Weight Gain Dietary Fats 3.5916723640
MESH:D014985 Xerophthalmia Cyclosporine 4.2717120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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