AutismKB 2.0

Annotation Detail for TM4SF1


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Basic Information Top
Gene Symbol:TM4SF1 ( H-L6,L6,M3S1,TAAL6 )
Gene Full Name: transmembrane 4 L six family member 1
Band: 3q25.1
Quick LinksEntrez ID:4071; OMIM: 191155; Uniprot ID:T4S1_HUMAN; ENSEMBL ID: ENSG00000169908; HGNC ID: 11853
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1848Embryoma
2237Neoplasm metastasis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of TM4SF1 mRNAincreases expression 20713471
D000082 Acetaminophen Acetaminophen affects the expression of TM4SF1 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of TM4SF1 mRNAincreases expression 11264010
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TM4SF1 proteinaffects expression 20106945
C006632 arsenic trioxide arsenic trioxide results in decreased expression of TM4SF1 mRNAdecreases expression 20458559
D001205 Ascorbic Acid [Quercetin co-treated with Ascorbic Acid] results in increased expression of TM4SF1 mRNAaffects cotreatment|increases expression 17639512
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TM4SF1 mRNAincreases expression 20064835
20106945
C095105 bexarotene bexarotene results in increased expression of TM4SF1 mRNAincreases expression 17178900
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of TM4SF1 mRNAincreases expression 12766906
15336504
D019256 Cadmium Chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of TM4SF1 mRNAaffects cotreatment|decreases expression 12634122
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TM4SF1 mRNAaffects expression 17484886
C023600 chromium oxide [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of TM4SF1 mRNAaffects cotreatment|decreases expression 12634122
C017133 chromous chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of TM4SF1 mRNAaffects cotreatment|decreases expression 12634122
D003520 Cyclophosphamide Cyclophosphamide results in increased expression of TM4SF1 mRNAincreases expression 17403535
D016572 Cyclosporine Cyclosporine results in decreased expression of TM4SF1 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of TM4SF1 mRNAincreases expression 18042831
D002117 Calcitriol Calcitriol results in decreased expression of TM4SF1 mRNAdecreases expression 16002434
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TM4SF1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TM4SF1 mRNAincreases expression 17942748
D005492 Folic Acid Folic Acid affects the expression of TM4SF1 mRNAaffects expression 17320366
C071834 glycidamide glycidamide results in decreased expression of TM4SF1 mRNAdecreases expression 17822822
D007529 Isoflavones Isoflavones affects the expression of TM4SF1 mRNAaffects expression 16365062
D007529 Isoflavones Isoflavones results in decreased expression of TM4SF1 mRNAdecreases expression 17374662
C008261 lead acetate [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of TM4SF1 mRNAaffects cotreatment|decreases expression 12634122
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of TM4SF1 mRNAincreases expression 20713471
C041786 palm oil palm oil results in increased expression of TM4SF1 mRNAincreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TM4SF1 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of TM4SF1 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of TM4SF1 mRNAincreases expression 18301758
D011794 Quercetin [Quercetin co-treated with Ascorbic Acid] results in increased expression of TM4SF1 mRNAaffects cotreatment|increases expression 17639512
C017947 sodium arsenite [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of TM4SF1 mRNAaffects cotreatment|decreases expression 12634122
C017947 sodium arsenite sodium arsenite results in decreased expression of TM4SF1 mRNAdecreases expression 12634122
C017947 sodium arsenite sodium arsenite results in increased expression of TM4SF1 mRNAincreases expression 12377979
D013629 Tamoxifen Tamoxifen affects the expression of TM4SF1 mRNAaffects expression 14699072
D013629 Tamoxifen Tamoxifen affects the expression of TM4SF1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TM4SF1 mRNAincreases expression 12377990
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3014745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6115322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6917505938
MESH:D058186 Acute Kidney Injury Folic Acid 4.1116595132 16316344 17003819
MESH:D055371 Acute Lung Injury pirinixic acid 2.8918653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.6511798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.6520127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.6514692618
MESH:D000236 Adenoma Benzo(a)pyrene 10.546695378
MESH:D000236 Adenoma Folic Acid 10.5416963246
MESH:D000236 Adenoma Methylcholanthrene 10.5410545420 6695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.0816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.0816835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6517306315 16712894
MESH:D000505 Alopecia Isoflavones 4.5217569567
MESH:D000544 Alzheimer Disease Folic Acid 2.9917116317
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7311748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.0217084956
MESH:D000799 Angioedema Acetaminophen 3.5910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8319183758
MESH:D001161 Arteriosclerosis Cyclophosphamide 15.6715014928
MESH:D001161 Arteriosclerosis Dietary Fats 15.6715238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 15.6711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5115885639
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7315336622
MESH:D050197 Atherosclerosis Methylcholanthrene 3.3111922910
MESH:D001321 Autistic Disorder Acetaminophen 2.1618445737
MESH:D001321 Autistic Disorder Folic Acid 2.1621388746
MESH:D001327 Autoimmune Diseases Quercetin 4.1719761891
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.0016206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.0019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.0012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 9.3811921183
MESH:D001943 Breast Neoplasms Ascorbic Acid 9.3816443354
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 9.3817474063 20146248
MESH:D001943 Breast Neoplasms bexarotene 9.3816344269 16818667
MESH:D001943 Breast Neoplasms Calcitriol 9.3811237771
MESH:D001943 Breast Neoplasms Cyclophosphamide 9.3817020986 11325840 16978400 18234424 15136595 12006526 15093573 17388661 18323546
MESH:D001943 Breast Neoplasms Dietary Fats 9.3820435547
MESH:D001943 Breast Neoplasms Folic Acid 9.3816777985
MESH:D001943 Breast Neoplasms Methylcholanthrene 9.3817474063
MESH:D001943 Breast Neoplasms Quercetin 9.3818628248
MESH:D001943 Breast Neoplasms Tamoxifen 9.3820005174 19084267 18984771 19410462 18855134 21152245 19244106 17440819 18815881 20390343 18997820 17049068 17893378 19200415 19115204 19288272 18351453 16873071 15565566 17261762 19289846 21138602 19059307 15668708 17242785 19487384 11161223 20859285 18629630 20135344 19103187 19011961 16818667 20544844 19189210 19066611 16202921 19189212 18425577 20065188 16273361 18821012 19221464 19155303 19142967
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 9.3820435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1011589617
MESH:D002105 Cadmium Poisoning Quercetin 5.3016962696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5415700767 16097048 10355542 15673190 16227642 16124888 3786805 16011737 16050911 18705752 16192424 15721981
MESH:D002277 Carcinoma Methylcholanthrene 7.6910545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.6916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2619066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.203084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.2021507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 16.2016217749 15073043 14691202 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 16.2018788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 16.2019701751
MESH:D006528 Carcinoma, Hepatocellular Quercetin 16.2019519916 12508355
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 16.2016507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 16.2016924424
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.6416152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.1416247446
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7117234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6319014326
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.4216201981
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9012490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.1220419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.1211237771
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.1218572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4017572228
MESH:D006332 Cardiomegaly Quercetin 6.3519794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.3518670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Folic Acid 7.4416755160
MESH:D002318 Cardiovascular Diseases Isoflavones 7.4417689850
MESH:D002386 Cataract Acetaminophen 2.4410977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.3012371664
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 10.3016192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.3019524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D002779 Cholestasis Cyclosporine 12.3019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.3017333356 17681005 16105132 11677210 17110522 16919318 15861022
MESH:D002779 Cholestasis pirinixic acid 12.3019176532
MESH:D002971 Cleft Lip Folic Acid 3.8521254359
MESH:D002972 Cleft Palate Folic Acid 5.758946559 21254359
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.758697196 12621046 16354765 15340226 15668235
MESH:D003110 Colonic Neoplasms Quercetin 2.3819440933 19056647 15741050 17191121 11134977 17148506 16640504
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.6820501625
MESH:D015179 Colorectal Neoplasms Folic Acid 4.6817087956 16985020 16963246 17116713 17245555
MESH:D015179 Colorectal Neoplasms Isoflavones 4.6817116718
MESH:D015179 Colorectal Neoplasms Quercetin 4.6818852136 18095365
MESH:D003139 Common Cold Ascorbic Acid 5.2317323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8517141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7810525206
MESH:D019465 Craniofacial Abnormalities lead acetate 3.7819769572
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7815322242 20055451 10048152
MESH:D003556 Cystitis Cyclophosphamide 4.7410700343 17979934 18372110 18483878 12388444 12913760 11948286 18433785 15276878 10498854 16989017 16614059 16651033 16413132 18710439 17010015 15643279 18295254 12161096 18093676
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8715213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3118249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 8.0115331540 11751995 10990075
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 8.0119496084
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.1518772604
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 6.9416506275
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 6.9416886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.9417107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.2719279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.6910663392 17906064 14725611 18071297 11529661 11287661 11461765 19164858 19416960 12594235 19739265 19420014 16781746 14986274 17562736 11421492 19370779 15619225 12540782 15968718 11743745 12958197 14550746 10915739 12153990 16393943 18713872 16081117 11739529 16177239 16227642 19923254 16109766 19085960 10774834 2444490 12705907 11834606 12392966 17522070 16485898
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.6919336974 10915739 3786805 6884620 11566570 15027814 7120509 10092053 15968718 7179309 6623471 17522070 9327722 7440962 15998439 21278145 3732212 16227642 16177239 19085960 2869522 4309450
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.6920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2818367378
MESH:C538011 Eales disease Ascorbic Acid 5.239068938
MESH:D004487 Edema pirinixic acid 5.8212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.8212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6515322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 13.9815138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.9812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 13.9819031437
MESH:D016889 Endometrial Neoplasms Folic Acid 7.2417301261
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.2420544844 19155303 17893378 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8110568697 9294722
MESH:D004802 Eosinophilia Cyclophosphamide 3.9811006010
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.2212903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2216530937
MESH:D017889 Exfoliation Syndrome Folic Acid 5.2416504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8311564622
MESH:D005234 Fatty Liver arsenic trioxide 33.5815073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 33.5812631006 16239168 61145 17595544 16045604 15959796 12795759 19224547
MESH:D005234 Fatty Liver Cyclosporine 33.5819224547
MESH:D005234 Fatty Liver Dietary Fats 33.5818296743 17967931 19551842 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 33.5815345470
MESH:D005234 Fatty Liver pirinixic acid 33.5820131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 33.5819224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D005317 Fetal Growth Retardation lead acetate 5.1519769572
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9419069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.6914633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 25.1618705752
MESH:D005355 Fibrosis Cyclosporine 25.1612168785 12639820
MESH:D005355 Fibrosis Dietary Fats 25.1618296743
MESH:D005355 Fibrosis Quercetin 25.1619474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 25.1620067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0316904648
MESH:D005756 Gastritis Acetaminophen 10.4416983495
MESH:D005756 Gastritis Folic Acid 10.4417171786
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4316452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.978708960
MESH:D005901 Glaucoma Folic Acid 4.8516504073
MESH:D005909 Glioblastoma Quercetin 3.2419804834
MESH:D005910 Glioma Quercetin 2.9617643826
MESH:D018316 Gliosarcoma Cyclophosphamide 5.2711389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.7911014644 16376943 15172196
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 14.9916080930
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 14.9920471113
MESH:D006330 Heart Defects, Congenital Folic Acid 14.9916524890 17286298
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 14.9910048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.3920558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1715720958
MESH:D006467 Hemophilia A Cyclophosphamide 5.0511918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.2814986274
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3619110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 7.4619772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.4612621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.3916863852 16490937
MESH:D006679 HIV Seropositivity Folic Acid 5.2417209195
MESH:D006689 Hodgkin Disease Cyclophosphamide 6.9417606976 16135485
MESH:D006689 Hodgkin Disease sodium arsenite 6.9412676792
MESH:D019584 Hot Flashes Isoflavones 4.7317290160 14716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8018606429 8697196 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.5116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2816899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3721332399
MESH:D006943 Hyperglycemia pirinixic acid 8.5320558911
MESH:D006943 Hyperglycemia Quercetin 8.5318262572 11834736
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.2916865747 16755160 16433478 16395265 16397167
MESH:D006949 Hyperlipidemias Dietary Fats 3.3921332399
MESH:D006973 Hypertension Cyclosporine 8.0310903974
MESH:D006973 Hypertension Quercetin 8.0318356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.0318850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5716569931 16945680
MESH:D007154 Immune System Diseases Cyclophosphamide 5.0816076520
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2312013081
MESH:D007248 Infertility, Male Cyclophosphamide 10.3516517039 7193160
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.3517937319
MESH:D007248 Infertility, Male sodium arsenite 10.3515346721 12646999
MESH:D007249 Inflammation Dietary Fats 7.5320412841
MESH:D007249 Inflammation Tamoxifen 7.5319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.5312200463 12878042
MESH:D007251 Influenza, Human Quercetin 4.2616624496
MESH:D007333 Insulin Resistance Dietary Fats 6.7211836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 6.7216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1216580747
MESH:D007627 Keloid Quercetin 4.7117086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1915604871
MESH:D007674 Kidney Diseases Acetaminophen 17.5712587719 15629191
MESH:D007674 Kidney Diseases Cadmium Chloride 17.5716962696
MESH:D007674 Kidney Diseases Cyclosporine 17.578314463 10903974 18776723
MESH:D007674 Kidney Diseases Quercetin 17.5716962696
MESH:D007674 Kidney Diseases sodium arsenite 17.5720008137
MESH:D007680 Kidney Neoplasms Cyclosporine 6.6412371664
MESH:D007680 Kidney Neoplasms Tamoxifen 6.6418625569
MESH:D007938 Leukemia arsenic trioxide 9.9015070760
MESH:D007938 Leukemia Cyclophosphamide 9.9010602166
MESH:D007938 Leukemia Quercetin 9.9017468513
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.3917008537 17658394 17296974 17802794 18172266 18587576
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 8.0214633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 8.0210373061
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.5419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1017050201 16968895 20471514 19850784 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.0615213294 12712474 16966277 17217047 19225113 16112521 12679006 19642359 16891316 11468182 19075265 16330433 17869043 15336539 15622746 16331271 11161223 17107899 15748426 12018890 17712046 9834237 17649720 16823087 19035177
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1216882451
MESH:D007970 Leukopenia Cyclophosphamide 4.7210052129 11830472
MESH:D008064 Lipidoses Tamoxifen 2.9817567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.1816239168 11408273 16221502 11903743 17174718 17157831 21278145 16943688 17334410
MESH:D008103 Liver Cirrhosis Dietary Fats 6.1818296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.3814724832 18412020 17481882 18156304 16011737 17525996 12609069 15338365 16136751 16248980 15052691 18187930 18279442 18251166 11481614 18418968 17721639 12632512 17698563 18395914 16097048 18006644 18054572 12632514 15893842 17640975 20821823 12898905 16015684 12445421 18420326 17805973 12741479 15818738 15931870 15730626 14716833 17714472 15959796 16192424 16638106 12667390 15996030 17766677 15650968 12546737 18395095 17761835 18205269 18376398 10355542 18210741 16033810 15673190 17944888 13678700 18317297 17557913 15123356 14620537 16027843 17708605 12666154 17631135 16116963 15925388 15057751 15876570 18705752 18472332 17823541 17976157 18472094 15370692 14512876 12445418 12958196 18277467 18339082 17565644 18166357 17900296 15362042 12586293 17922224 18481824 12389079 14716496 18429990 17869086 14748882 12649538 18263696
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.3815474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 6.3812741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.3818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3812878042
MESH:D008107 Liver Diseases Acetaminophen 6.2119460945 19784758 11587558 12969438 12587719 16611625 19014921 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.2117285989 16246199 16964402 15830285 15720792
MESH:D008107 Liver Diseases Folic Acid 6.2116877991
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.7016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.7016899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 28.319163691 15890375 18177683 2125692
MESH:D008113 Liver Neoplasms arsenic trioxide 28.3114682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 28.3121137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 28.3119294768
MESH:D008113 Liver Neoplasms pirinixic acid 28.3116377806 15890375 20007298
MESH:D008113 Liver Neoplasms Quercetin 28.3118980244
MESH:D008113 Liver Neoplasms sodium arsenite 28.3115276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 28.3116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 28.3116984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 25.948603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 25.9420377131
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 25.9418544905
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 25.9415583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 25.94598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Quercetin 25.9419519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 25.9412151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1715213294
MESH:D008171 Lung Diseases Ascorbic Acid 7.1816863852
MESH:D008171 Lung Diseases sodium arsenite 7.1819095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 17.2714755239
MESH:D008175 Lung Neoplasms arsenic trioxide 17.2711798837 19825857
MESH:D008175 Lung Neoplasms Ascorbic Acid 17.2716401635
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 17.2720064080 18520028 20869020 20464547 20135361 17053015 18816296 18569708 6695378
MESH:D008175 Lung Neoplasms bexarotene 17.2717849452
MESH:D008175 Lung Neoplasms Methylcholanthrene 17.2721163286 16271038 15390079 20970405 10545420 16337739 6695378 9230183 17909032 7750092 20512841 1399818 11893704
MESH:D008175 Lung Neoplasms Quercetin 17.2716280456
MESH:D008175 Lung Neoplasms sodium arsenite 17.2715276417 19931552 17077188 16712894 17306315
MESH:D008175 Lung Neoplasms Tamoxifen 17.2718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 17.2711884234 19555203
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.2717718048
MESH:D008223 Lymphoma Cyclophosphamide 3.6712854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.3716675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 3.9711911406
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.9011161223
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5119428831
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 9.2811921183
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 9.2815591091 19196723 19196722
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.2819196722 11731420 14580682 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.3019453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.4516832597
MESH:D008545 Melanoma sodium arsenite 3.1719082730 16487513
MESH:D008545 Melanoma Tamoxifen 3.1719393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 10.0319513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 10.0316388313
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5416801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0016381670
MESH:D009101 Multiple Myeloma arsenic trioxide 2.9315949261 11468182 14977855 19549372 19417148
MESH:D009135 Muscular Diseases pirinixic acid 3.2716239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0016882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 5.3819151258
MESH:D009203 Myocardial Infarction Quercetin 5.3819595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.8216411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 7.8219207477
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7316624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4419410462
MESH:D009369 Neoplasms Benzo(a)pyrene 14.4411141357
MESH:D009369 Neoplasms Cyclophosphamide 14.4418854779
MESH:D009369 Neoplasms pirinixic acid 14.4417405874
MESH:D009369 Neoplasms Quercetin 14.4415185748
MESH:D009369 Neoplasms sodium arsenite 14.4411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.4320056578
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 10.1019196722
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 10.1019189210 19200415 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0819348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.9814600291
MESH:D009436 Neural Tube Defects arsenic trioxide 11.3610525206
MESH:D009436 Neural Tube Defects Folic Acid 11.3617438019
MESH:D009436 Neural Tube Defects sodium arsenite 11.3612854658
MESH:D009447 Neuroblastoma Cyclophosphamide 3.5116115947 15176712 8761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6718514411
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.6412837982 8761367
MESH:D020078 Neurogenic Inflammation Quercetin 4.1317929310
MESH:D009503 Neutropenia Cyclophosphamide 8.978291058
MESH:D009503 Neutropenia Folic Acid 8.9716322990
MESH:D009765 Obesity Ascorbic Acid 7.1117217161
MESH:D009765 Obesity Dietary Fats 7.1118457598 18674790 17217161 20518802 16723640 21332399 11836018 19632207 20132043
MESH:D009765 Obesity pirinixic acid 7.1120558911
MESH:D009845 Oligospermia Cyclophosphamide 4.4716517039
MESH:D010024 Osteoporosis Isoflavones 3.9516562857
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 3.9919495926
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.4919769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Quercetin 7.4919005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.4915276417 17306315
MESH:D010146 Pain Acetaminophen 6.2016870215
MESH:D010146 Pain Cyclophosphamide 6.2012161096 18093676
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.2415580305
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 8.2411332152
MESH:D010190 Pancreatic Neoplasms Quercetin 8.2416965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4611578682
MESH:D010235 Paraganglioma arsenic trioxide 3.9319927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.4212371664
MESH:D011230 Precancerous Conditions Quercetin 8.4219056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.6721297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9511896295 11222880 11399792 11118676
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.5315572423
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.4019131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4017292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.4012479363 15754350 16289102 18247401 16644109
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.4017136230
MESH:D011471 Prostatic Neoplasms Isoflavones 2.4016365062 17374662 17219775 17571952
MESH:D011471 Prostatic Neoplasms Quercetin 2.4017292933 14715546
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.4016039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4015067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.0716919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.0814606601
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.1916636934
MESH:D051437 Renal Insufficiency Folic Acid 4.5415728788
MESH:D015427 Reperfusion Injury pirinixic acid 2.2719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.2416849425
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7316646077
MESH:D012554 Schistosomiasis japonica Quercetin 5.3016862918
MESH:D012559 Schizophrenia Folic Acid 2.8616641680
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.5916636934
MESH:D012871 Skin Diseases Ascorbic Acid 5.2918709164
MESH:D012871 Skin Diseases Folic Acid 5.2918709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.5919755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 12.5918572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.598532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.5916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.7316709447
MESH:D013088 Spermatocele Tamoxifen 10.7316709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.2716517039
MESH:D013118 Spinal Cord Diseases Folic Acid 5.2416361298
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7919457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6112854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.3217007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.322093021 20155912
MESH:D013274 Stomach Neoplasms Folic Acid 3.3217171786
MESH:D013276 Stomach Ulcer Ascorbic Acid 3.6818726076
MESH:D020521 Stroke Ascorbic Acid 8.5416403987 16517955
MESH:D020521 Stroke Folic Acid 8.5416517955
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.8112837982
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6512697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 2.9119014326
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7215213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 18.6212973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 18.6217053015
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 18.6214692829
MESH:D001749 Urinary Bladder Neoplasms Quercetin 18.6216720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 18.6211723127 16452187 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 18.6216712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 2.7510982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.5511813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0614692618
MESH:D014605 Uveitis Cyclosporine 3.731336536
MESH:D014652 Vascular Diseases sodium arsenite 4.1817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
MESH:D015430 Weight Gain Dietary Fats 3.5316723640
MESH:D014985 Xerophthalmia Cyclosporine 4.1917120751
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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