AutismKB 2.0

Annotation Detail for SMAD3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SMAD3 ( DKFZp586N0721,DKFZp686J10186,HSPC193,HsT17436,JV15-2,MADH3,MGC60396 )
Gene Full Name: SMAD family member 3
Band: 15q22.33
Quick LinksEntrez ID:4088; OMIM: 603109; Uniprot ID:SMAD3_HUMAN; ENSEMBL ID: ENSG00000166949; HGNC ID: 6769
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
hsa05142Chagas disease
hsa04310Wnt signaling pathway
hsa04350TGF-beta signaling pathway
hsa04110Cell cycle
hsa04520Adherens junction
hsa05220Chronic myeloid leukemia
hsa05212Pancreatic cancer
hsa05210Colorectal cancer
hsa05200Pathways in cancer
Pathway IDPathway Name
Signaling by TGF beta
Pathway IDPathway Name
200002Regulation of nuclear SMAD2/3 signaling
200152Regulation of cytoplasmic and nuclear SMAD2/3 signaling
200172HIF-1-alpha transcription factor network
200072Regulation of Telomerase
200045Validated targets of C-MYC transcriptional activation
200195TGF-beta receptor signaling
Pathway IDPathway Name
P00052TGF-beta signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1818Systemic scleroderma
1831Prostate cancer
1848Embryoma
1850Herpes
2025Polyarthritis
1986Eating disorder
1841Stomach cancer
2120Rabies
2134Amyotrophic lateral sclerosis
2154Adenoma
2157Scleroderma
2220Dermatitis
Desease Name
CARDIOVASCULAR
Coronary Disease
INFECTION
Bacteremia
Desease Name
Coronary heart disease
Asthma
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000079 Acetaldehyde Acetaldehyde results in increased phosphorylation of SMAD3 proteinincreases phosphorylation 16025520
D000079 Acetaldehyde SMAD3 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA]increases expression|increases reaction 16025520
D000082 Acetaminophen Acetaminophen affects the expression of SMAD3 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of SMAD3 mRNAincreases expression 11752693
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of SMAD3 mRNAincreases expression 16597033
C432165 anthra(1,9-cd)pyrazol-6(2H)-one anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Diethylnitrosamine affects the phosphorylation of SMAD3 protein]affects phosphorylation|decreases reaction 19418558
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SMAD3 mRNAdecreases expression 20018196
19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride inhibits the reaction [HGF protein affects the localization of SMAD3 protein]affects localization|decreases reaction 18395096
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of SMAD3 mRNAincreases expression 18395914
D002251 Carbon Tetrachloride oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA]decreases reaction|increases expression 18395914
D002251 Carbon Tetrachloride SMAD3 protein affects the susceptibility to Carbon Tetrachlorideaffects response to substance 16382155
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased activity of SMAD3 proteinincreases activity 17009398
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of SMAD3 mRNAincreases expression 15818738
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of SMAD3 proteinincreases expression 16872305
17163593
15818738
D002251 Carbon Tetrachloride Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA]decreases reaction|increases expression 15818738
D002251 Carbon Tetrachloride Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]decreases reaction|increases expression 17163593
15818738
D002251 Carbon Tetrachloride Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]decreases reaction|increases expression 16872305
D002251 Carbon Tetrachloride valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]decreases reaction|increases expression 16872305
D003474 Curcumin Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter]affects binding|decreases reaction 16959952
D004041 Dietary Fats Dietary Fats results in decreased expression of SMAD3 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 proteinaffects cotreatment|increases phosphorylation 15368444
D004052 Diethylnitrosamine anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Diethylnitrosamine affects the phosphorylation of SMAD3 protein]affects phosphorylation|decreases reaction 19418558
D004052 Diethylnitrosamine Diethylnitrosamine affects the phosphorylation of SMAD3 proteinaffects phosphorylation 19418558
D004052 Diethylnitrosamine IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein]affects cotreatment|increases phosphorylation|increases reaction 15368444
D004317 Doxorubicin Doxorubicin inhibits the reaction [TGFB1 protein results in increased localization of SMAD3 protein]decreases reaction|increases localization 18606404
D004317 Doxorubicin Doxorubicin results in decreased expression of SMAD3 proteindecreases expression 18606404
D004365 Drugs, Chinese Herbal Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA]decreases reaction|increases expression 15818738
D004365 Drugs, Chinese Herbal Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]decreases reaction|increases expression 15818738
17163593
D004958 Estradiol Estradiol affects the expression of SMAD3 mRNAaffects expression 14699072
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SMAD3 mRNAdecreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SMAD3 mRNAaffects cotreatment|decreases expression 17942748
D011345 Fenofibrate Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]decreases reaction|increases expression 19593819
D011345 Fenofibrate NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]]decreases reaction|increases expression|increases reaction 19593819
D015073 2-Acetylaminofluorene [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 proteinaffects cotreatment|increases phosphorylation 15368444
D015073 2-Acetylaminofluorene IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein]affects cotreatment|increases phosphorylation|increases reaction 15368444
D005947 Glucose Glucose results in increased phosphorylation of and affects the localization of SMAD3 proteinaffects localization|increases phosphorylation 17597607
D005947 Glucose protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD3 protein]affects localization|decreases reaction|increases phosphorylation 17597607
C010176 halofuginone halofuginone inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]decreases reaction|increases phosphorylation 17180598
C010176 halofuginone halofuginone inhibits the reaction [TGFB1 protein results in increased phosphorylation of and results in increased activity of SMAD3 protein]decreases reaction|increases activity|increases phosphorylation 11874485
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased phosphorylation of SMAD3 proteinincreases phosphorylation 15147944
C051890 irinotecan irinotecan analog results in decreased expression of SMAD3 mRNAdecreases expression 18927307
C015329 lycopene lycopene results in increased expression of SMAD3 mRNAincreases expression 16886892
C406082 monomethylarsonous acid monomethylarsonous acid results in increased expression of SMAD3 mRNAincreases expression 19945496
D009151 Mustard Gas Mustard Gas results in decreased expression of SMAD3 mRNAdecreases expression 15674843
D009569 Nitric Oxide Nitric Oxide results in increased activity of [SMAD4 protein binds to SMAD3 protein]affects binding|increases activity 15949472
D009569 Nitric Oxide [SMAD4 protein co-treated with SMAD3 protein] affects the susceptibility to Nitric Oxideaffects cotreatment|affects response to substance 15949472
C007350 nitrofen nitrofen results in decreased expression of SMAD3 mRNAdecreases expression 12149686
C037573 oxymatrine oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA]decreases reaction|increases expression 18395914
C041786 palm oil palm oil results in decreased expression of SMAD3 mRNAdecreases expression 18042831
D020913 Perindopril Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]decreases reaction|increases expression 16872305
D020913 Perindopril Perindopril results in decreased expression of SMAD3 proteindecreases expression 15619341
D010852 Picrotoxin Picrotoxin results in increased expression of SMAD3 mRNAincreases expression 15170462
C005581 protocatechualdehyde protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD3 protein]affects localization|decreases reaction|increases phosphorylation 17597607
C005581 protocatechualdehyde protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD3 protein]affects localization|decreases reaction|increases phosphorylation 17597607
C009250 sevoflurane SMAD3 protein affects the susceptibility to sevofluraneaffects response to substance 18434384
C009250 sevoflurane TGFB1 protein affects the reaction [sevoflurane affects the localization of SMAD3 protein]affects localization|affects reaction 18434384
C110881 S-nitro-N-acetylpenicillamine S-nitro-N-acetylpenicillamine results in increased activity of [SMAD4 protein binds to SMAD3 protein]affects binding|increases activity 15949472
C017947 sodium arsenite IFNG protein inhibits the reaction [sodium arsenite results in increased expression of and results in increased phosphorylation of SMAD3 protein]decreases reaction|increases expression|increases phosphorylation 17003472
C017947 sodium arsenite sodium arsenite results in increased expression of and results in increased phosphorylation of SMAD3 proteinincreases expression|increases phosphorylation 17003472
D018038 Sodium Selenite Sodium Selenite results in increased expression of SMAD3 mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen promotes the reaction [Tretinoin results in increased phosphorylation of SMAD3 protein]increases phosphorylation|increases reaction 17098229
D013629 Tamoxifen Tamoxifen results in increased phosphorylation of SMAD3 proteinincreases phosphorylation 17098229
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SMAD3 mRNAaffects cotreatment|decreases expression 17942748
D014212 Tretinoin Tamoxifen promotes the reaction [Tretinoin results in increased phosphorylation of SMAD3 protein]increases phosphorylation|increases reaction 17098229
D014212 Tretinoin Tretinoin results in increased expression of SMAD3 mRNAincreases expression 17431108
16012519
D014212 Tretinoin Tretinoin results in increased phosphorylation of SMAD3 proteinincreases phosphorylation 17098229
D014212 Tretinoin Tretinoin results in decreased phosphorylation of SMAD3 proteindecreases phosphorylation 16410076
C081489 valsartan valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]decreases reaction|increases expression 16872305
C081489 valsartan valsartan results in decreased expression of SMAD3 proteindecreases expression 15619341
D014810 Vitamin E Vitamin E results in increased expression of SMAD3 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.4615322242 14514962 11752688
MESH:D000038 Abscess Drugs, Chinese Herbal 5.9115043669
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5417505938
MESH:D000230 Adenocarcinoma Doxorubicin 6.4217418594
MESH:D000230 Adenocarcinoma Estradiol 6.4211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.4214692618
MESH:D000236 Adenoma 2-Acetylaminofluorene 6.2510737359
MESH:D000236 Adenoma Diethylnitrosamine 6.2510737359 6695378
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.616705139
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 8.7418056438 19052882 19061943 16434500 17620307 17162532
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.7416835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5017306315 16712894
MESH:D000419 Albuminuria Doxorubicin 4.1721441931
MESH:D019973 Alcohol-Related Disorders Curcumin 4.6817887948
MESH:D000505 Alopecia Tretinoin 3.3015955085
MESH:D000544 Alzheimer Disease Curcumin 4.3815590663
MESH:D000544 Alzheimer Disease Nitric Oxide 4.3817556102
MESH:D000740 Anemia Drugs, Chinese Herbal 7.9015504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.9011748828
MESH:D000784 Aneurysm, Dissecting marker/mechanism 21217753
MESH:D000787 Angina Pectoris Drugs, Chinese Herbal 5.0211477813
MESH:D000799 Angioedema Acetaminophen 3.4410982225
MESH:D001004 Anus Diseases Drugs, Chinese Herbal 5.5615043669
MESH:D001014 Aortic Aneurysm marker/mechanism 21217753
MESH:D001161 Arteriosclerosis Dietary Fats 8.6315238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.6311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.3815885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.3816412693
MESH:D015210 Arthritis, Gouty Drugs, Chinese Herbal 5.3619655406
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.3816807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.3816292516
MESH:D001249 Asthma Acetaldehyde 7.319600491
MESH:D001249 Asthma Mustard Gas 7.3110378619
MESH:D001249 Asthma Tretinoin 7.3116456186
MESH:D050197 Atherosclerosis Curcumin 3.0918704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4618445737
MESH:D001327 Autoimmune Diseases Curcumin 4.1119761891
MESH:D001471 Barrett Esophagus Tretinoin 4.0316935849
MESH:D001768 Blister Mustard Gas 4.7619167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.7712125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 7.7716206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5115746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.3014601052
MESH:D001862 Bone Resorption Drugs, Chinese Herbal 4.479881647
MESH:D002545 Brain Ischemia Curcumin 3.9416770732
MESH:D001932 Brain Neoplasms Curcumin 7.8317596214
MESH:D001932 Brain Neoplasms Doxorubicin 7.8317150277
MESH:D001943 Breast Neoplasms Curcumin 5.3819250217 16243823 18593918 18462866
MESH:D001943 Breast Neoplasms Dietary Fats 5.3820435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.3817474063
MESH:D001943 Breast Neoplasms Doxorubicin 5.3818628466 15668708 16935488 19526202 15939500 16322301 15136595 18234424 18695136 11325840 15634643 15567936 16595493 17369602 15993339 17983394 16096432 17426702 15994142 16115903 15692762 16264153 18382427 16826403
MESH:D001943 Breast Neoplasms Estradiol 5.3818497071 17289903 17018787 16675129 14630087 12948864 17261762 19861407
MESH:D001943 Breast Neoplasms Nitric Oxide 5.3815631943
MESH:D001943 Breast Neoplasms Tamoxifen 5.3818629630 20544844 20135344 21138602 21152245 15668708 17261762 19084267 20859285 19189210 17242785 18351453 16273361 15565566 11161223 19011961 16818667 19189212 19103187 19115204 19155303 18815881 18997820 19221464 18821012 19288272 18984771 17049068 19066611 18855134 20005174 17893378 16202921 19487384 19059307 19410462 19244106 20065188 16873071 18425577 20390343 19142967 17440819 19200415 19289846
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.3820435547
MESH:D001943 Breast Neoplasms Tretinoin 5.3816873071 16166294 16443354
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.7615286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.5810378619 17687719
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2016813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 14.853786805 15700767 16192424 15673190 16124888 15721981 18705752 16227642 16011737 16050911 10355542 16097048
MESH:D002252 Carbon Tetrachloride Poisoning Perindopril 14.8516097048
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 14.8516050911
MESH:D002276 Carcinoid Tumor Doxorubicin 4.4116051944
MESH:D002277 Carcinoma Curcumin 7.2618593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.2616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1219066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7616168501
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 21.3310737359 17761372 6705139 3084413 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 21.333084413
MESH:D006528 Carcinoma, Hepatocellular anthra(1,9-cd)pyrazol-6(2H)-one 21.3319418558
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 21.3318788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 21.3319418558 19394651 20101231 16502159 20727157 17055752 19107877 17978847 18691550 19519916 20432363 16288022 19383236 10672840 16540662 20084675 18494052 19171122 18788625 20214788 16698587 18393292 10737359 17761372 18056438 19822196 20514400 17173139 18665156 17138121 16878318 20524982 17428255 19208518 18971187 16935385 18978308 19335982 16830150 16569478 20935162 16807293 16681979 19701751 17162532 3084413 20512989 18506893 16779866 19539802 20007298 11831363 19919837 19052882 3581430 18785209 16328049 21159647 18210153
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 21.3316023760 18059187 17876044 16234567
MESH:D006528 Carcinoma, Hepatocellular Estradiol 21.3316924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 21.3316507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 21.3316924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 21.331917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.8318414057
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 2.971485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Curcumin 9.7718462866
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 9.776189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 9.7718572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 9.7716051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.2717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.3718850075 18670907 16120746
MESH:D006332 Cardiomegaly valsartan 6.3719597038
MESH:D009202 Cardiomyopathies Doxorubicin 7.4415505089 16242529 17382496 17131338 16731534 17308081 16651473 17928571 16109756 17974986 17351982 16455267 16269455 16952015 15811867 16278810 15792986 15476868 18627295 16612575 17329180 16364871 17007740 17924179 17519947
MESH:D009202 Cardiomyopathies valsartan 7.4416247790
MESH:D002310 Cardiomyopathy, Alcoholic Acetaldehyde 6.0810525098
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8017334414 16243910
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 6.9816936243
MESH:D002318 Cardiovascular Diseases valsartan 6.9811230374
MESH:D002386 Cataract Acetaminophen 11.2710977129
MESH:D002386 Cataract protocatechualdehyde 11.2717597607
MESH:D002386 Cataract Tretinoin 11.2717460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 18.2220889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 18.227505956 2727394 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 18.2218566989
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 18.2219716837
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 18.2219524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2016129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.2319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.2316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3717110522 17681005 17333356 16105132 11677210 16919318 15861022
MESH:D002779 Cholestasis Nitric Oxide 7.3716919318
MESH:D002822 Choriocarcinoma Tretinoin 4.7616461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.3715894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.188697196 16354765 15668235 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 5.189407595
MESH:D003092 Colitis Curcumin 8.3718200517 16804969 16782535
MESH:D003092 Colitis Tretinoin 8.3717035595
MESH:D003103 Coloboma Curcumin 4.2018809619
MESH:D003110 Colonic Neoplasms Curcumin 3.7819359593 16340194
MESH:D003110 Colonic Neoplasms irinotecan 3.7817725105 17287894
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.6818802399 18259882
MESH:D015179 Colorectal Neoplasms irinotecan 2.6816303861 15273666 17159606 16391804 18509181 18259882 17454858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7314669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.5118497527
MESH:D003324 Coronary Artery Disease valsartan 3.7517719468
MESH:D003384 Coxsackievirus Infections valsartan 5.4520392896
MESH:D019465 Craniofacial Abnormalities marker/mechanism 15183723 21217753
MESH:D019465 Craniofacial Abnormalities nitrofen 5.0411405365
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.0415322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.0410589399 9211117 17551590 9142499 16925845 8800419 9125849 9224671 9664655 14991402
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.0419769572
MESH:D003424 Crohn Disease marker/mechanism 21102463
MESH:D015140 Dementia, Vascular Nitric Oxide 5.5617556102
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9819031437
MESH:D048909 Diabetes Complications protocatechualdehyde 6.4317597607
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.4516285004
MESH:D003921 Diabetes Mellitus, Experimental valsartan 4.2811508273
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 6.4818403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.4820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.4817107852
MESH:D003928 Diabetic Nephropathies Curcumin 24.6118204486
MESH:D003928 Diabetic Nephropathies Estradiol 24.6119279558
MESH:D003928 Diabetic Nephropathies Perindopril 24.6111427623
MESH:D003928 Diabetic Nephropathies Tamoxifen 24.6119279558
MESH:D003928 Diabetic Nephropathies valsartan 24.6111427623 18630688
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 16.6616781746 18713872 11743745 2444490 11287661 17562736 11739529 15619225 16177239 19370779 15968718 16081117 14725611 16485898 19085960 14986274 18071297 19420014 19416960 17522070 11461765 12392966 14550746 11421492 19739265 11529661 12540782 16227642 12705907 16393943 10915739 12958197 17906064 16109766 19164858 19923254 12594235 10663392 11834606 12153990 10774834
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 16.6617522070 7179309 7440962 3732212 15968718 11566570 3786805 21278145 16177239 2869522 19085960 15027814 7120509 6884620 4309450 6623471 19336974 10915739 9327722 10092053 16227642 15998439
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 16.6619107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 16.6617416283
MESH:D056486 Drug-Induced Liver Injury Drugs, Chinese Herbal 16.6615027814
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 16.6615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 16.6620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7019426721
MESH:D004362 Drug Toxicity Doxorubicin 7.1418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.1411462148
MESH:D004381 Duodenal Ulcer Curcumin 3.6817351913
MESH:D050171 Dyslipidemias Dietary Fats 8.0118367378
MESH:D050171 Dyslipidemias Fenofibrate 8.0116707586
MESH:C538011 Eales disease Vitamin E 4.309068938
MESH:D004487 Edema Mustard Gas 5.7011402378 9260866 11428631 11428647
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.6115322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.6118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.7112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.7119031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 20.6017359293
MESH:D016889 Endometrial Neoplasms Estradiol 20.6011473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Fenofibrate 20.6016569247
MESH:D016889 Endometrial Neoplasms Tamoxifen 20.6019155303 20544844 17893378 16202921
MESH:D016889 Endometrial Neoplasms Tretinoin 20.6016569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.689294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.7518037988
MESH:D004890 Erythema Mustard Gas 4.769357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7116302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 1.9720426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.8611564622
MESH:D005124 Eye Abnormalities Tretinoin 7.869664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 26.1661145 17595544 16045604 16239168 12795759 12631006 19224547 15959796
MESH:D005234 Fatty Liver Curcumin 26.1619297423
MESH:D005234 Fatty Liver Dietary Fats 26.1619004024 17967931 18296743 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 26.1621071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 26.1615345470
MESH:D005234 Fatty Liver Tamoxifen 26.1619224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.9916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1314745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 10.1319069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.1319069698
MESH:D005355 Fibrosis Carbon Tetrachloride 29.5218705752
MESH:D005355 Fibrosis Curcumin 29.5218705752
MESH:D005355 Fibrosis Dietary Fats 29.5218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 29.5220067830
MESH:D005355 Fibrosis Tretinoin 29.5217994277
MESH:D005355 Fibrosis valsartan 29.5216893502
MESH:D005756 Gastritis Acetaminophen 3.2716983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.3118462866
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.2816452187
MESH:D005909 Glioblastoma Curcumin 10.4517596214
MESH:D005909 Glioblastoma Doxorubicin 10.4517150277
MESH:D005909 Glioblastoma Tretinoin 10.4517312396
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 5.1716928621
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1910696789
MESH:D006261 Headache Nitric Oxide 4.7811284996 11554966
MESH:D006258 Head and Neck Neoplasms Curcumin 11.4618829502 18462866
MESH:D006258 Head and Neck Neoplasms Doxorubicin 11.4615692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 11.4616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7616084493
MESH:D006330 Heart Defects, Congenital nitrofen 14.2716080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 14.2710048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 14.2714991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 14.2716080930
MESH:D006331 Heart Diseases Doxorubicin 3.2116495754 16144979 16244372 16244371 18006777 17888722 17875725 16879835 18674790 16707910 14766674 16330681 12587719
MESH:D006333 Heart Failure Doxorubicin 6.8617481944
MESH:D006333 Heart Failure valsartan 6.8619027736
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 4.916705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 8.246705139
MESH:D006394 Hemangiosarcoma Doxorubicin 8.2415692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 8.4619900420 19110552
MESH:D006505 Hepatitis Drugs, Chinese Herbal 8.4618339527
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5112621046 16120746 15340226
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.6517701891
MESH:D006548 Hernia, Diaphragmatic nitrofen 5.8016490937 17270546 11409163 10898222 7760232 10370017 15136996 12547725 10370016 15707848 10646786 17618886 18280292 11588001 12407540 12746050 16863852 11051153 15756563 18280291 11057544 10541330 15185205 9476886 10898224 16473863 11329586 16080930 16292651 11685700 12759764 15793718 18958481 9575882 12194112 8863223 16720372 15764645 10359170 12505043 9473106 15088113 7520565 9859898 15578192 11076806 17245593 12021965 10693666 11584395 12904592 7576705 9698600
MESH:D006548 Hernia, Diaphragmatic Vitamin E 5.8016490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.6315709030
MESH:D006689 Hodgkin Disease Doxorubicin 6.3918501091 15147373 17606976
MESH:D006689 Hodgkin Disease sodium arsenite 6.3912676792
MESH:D019584 Hot Flashes Estradiol 8.7117088409
MESH:D019584 Hot Flashes Vitamin E 8.7114716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6416959395 15340226 16354765 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 6.6016870215
MESH:D006930 Hyperalgesia Tretinoin 6.6016870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1416899240
MESH:D006937 Hypercholesterolemia Curcumin 8.0718704882
MESH:D006937 Hypercholesterolemia Dietary Fats 8.0721332399
MESH:D006940 Hyperemia Nitric Oxide 5.2211156591
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1816778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.2621332399
MESH:D006965 Hyperplasia halofuginone 4.8611874485
MESH:D006973 Hypertension Perindopril 8.0911427623
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.0918670907 18850075
MESH:D006973 Hypertension valsartan 8.0918390891 16475468 10903974 11427623 20102058 12692753 12850387 18344623
MESH:D006974 Hypertension, Malignant valsartan 6.0111560862
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7015338365
MESH:D006976 Hypertension, Pulmonary Nitric Oxide 4.1415838368
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.7617937319
MESH:D007248 Infertility, Male sodium arsenite 5.7612646999 15346721
MESH:D007249 Inflammation Curcumin 17.1917151092 16956363 18403477
MESH:D007249 Inflammation Dietary Fats 17.1920412841
MESH:D007249 Inflammation Diethylnitrosamine 17.1918785209
MESH:D007249 Inflammation Mustard Gas 17.1917524151 8975870 9260866 9357497 11402378 11428631 11428647 11428620 16001271
MESH:D007249 Inflammation Tamoxifen 17.1919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 17.1912200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0418596194 18200517
MESH:D007251 Influenza, Human Vitamin E 3.8116624496
MESH:D007333 Insulin Resistance Dietary Fats 10.8718457598 11836018
MESH:D007333 Insulin Resistance Estradiol 10.8716393666 16627594
MESH:D007333 Insulin Resistance Sodium Selenite 10.8714714311
MESH:D007410 Intestinal Diseases Nitric Oxide 8.8311574821 11713966 10210152
MESH:D007410 Intestinal Diseases Tretinoin 8.8317994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.8810783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.7616580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.7617551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 20.8515629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 20.8515369732 15699352 16775033
MESH:D007674 Kidney Diseases Estradiol 20.8515618244
MESH:D007674 Kidney Diseases sodium arsenite 20.8520008137
MESH:D007674 Kidney Diseases valsartan 20.8516893502 12164870 10903974
MESH:D007674 Kidney Diseases Vitamin E 20.8512488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 8.9616707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 8.9616518626
MESH:D007680 Kidney Neoplasms Estradiol 6.3415610895
MESH:D007680 Kidney Neoplasms Tamoxifen 6.3418625569
MESH:D007859 Learning Disorders sevoflurane 4.3919212262
MESH:D007889 Leiomyoma Curcumin 4.2118555241
MESH:D007896 Leishmaniasis Nitric Oxide 4.3317218153
MESH:D007938 Leukemia Curcumin 5.8118462866
MESH:D007938 Leukemia Tretinoin 5.8117143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.7516085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Drugs, Chinese Herbal 3.7515802533
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.8516106398
MESH:D007948 Leukemia, Monocytic, Acute anthra(1,9-cd)pyrazol-6(2H)-one 4.9816972261
MESH:D007951 Leukemia, Myeloid Tretinoin 3.3516482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0117596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.8919642359 17339181 16788101 16331271 17294898 17712046 19029980 17368321 17506722 16935935 19035177 16766008 16823087 16140955 17649720 9834237 19075265 17107899 12679006 17217047 17361223 17301526 19225113 15748426 16891316
MESH:D015458 Leukemia, T-Cell Curcumin 4.3916106398
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.039224671
MESH:D008064 Lipidoses Tamoxifen 2.8717567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 18.4016221502 17157831 11408273 16239168 17174718 16943688 21278145 11903743 17334410
MESH:D008103 Liver Cirrhosis Dietary Fats 18.4018296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 18.4020032147 19638242 18522880 18665156 18407596
MESH:D008103 Liver Cirrhosis Drugs, Chinese Herbal 18.4017163593
MESH:D008103 Liver Cirrhosis halofuginone 18.4017180598
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 27.7518339082 18006644 12667390 12666154 17766677 16097048 17714472 17761835 15996030 14620537 15362042 15057751 16192424 14716833 14724832 15925388 18156304 15818738 17721639 18705752 12586293 16638106 12958196 18472094 18395914 12649538 15650968 18481824 12741479 15730626 10355542 17698563 18205269 16033810 18279442 12389079 17640975 17805973 18429990 14716496 20821823 15338365 15893842 18317297 12898905 18472332 17631135 16011737 18251166 14748882 12546737 17708605 15876570 15931870 12632512 14512876 18187930 15370692 17557913 17976157 13678700 18277467 16027843 17900296 18376398 18166357 17525996 18420326 18418968 17869086 18412020 12609069 11481614 12632514 12445421 17565644 15123356 17823541 17922224 15959796 18395095 15673190 16116963 12445418 16248980 17481882 18263696 18210741 16015684 15052691 18054572 17944888 16136751
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 27.7518705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 27.7516595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Drugs, Chinese Herbal 27.7518606216 15383259 17348192 17666798 18237412 17036385 15864749 15849816 12632512 15754396 15818738 15641146 18371158 15744066 17881167 15763062 15339415 16610055 18567088 17629604
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 27.7514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 27.7515474484
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 27.7516489207 11172339 12175628 14739098 18458672
MESH:D008106 Liver Cirrhosis, Experimental oxymatrine 27.7518395914 15633229
MESH:D008106 Liver Cirrhosis, Experimental Perindopril 27.7516097048 15619341 16596278 16872305
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 27.7518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 27.7512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 27.7518397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental valsartan 27.7515619341 16872305 15504291
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 27.7516169303
MESH:D008107 Liver Diseases Acetaminophen 11.3019460945 16610002 19014921 16611625 19784758 11587558 12969438 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 11.3015830285 16246199 16964402 15720792 17285989
MESH:D008107 Liver Diseases Curcumin 11.3016956363
MESH:D008107 Liver Diseases Diethylnitrosamine 11.3017034775
MESH:D008107 Liver Diseases Drugs, Chinese Herbal 11.3017207593
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.2816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.2814706259 16899240
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 23.1116273603 14678523 18001218 11376686 10737359 10672840
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 23.1119294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 23.1119090486 12112319 19996281 19073162 21167192 12771043 19850985 21278145 15885732 10737359 20434301 20452335 19551842 18648771 2422723 19638242 20583210 19690152 19294768 19426721 9163691 19427195 19833225 20405173 20501860 19499222 20118626 19254457 19256749 18644402 2862719 20492335 19642983 21047994 21071580 20137499 18978307 18977376 19255062 15175105 19812893 16942905 20101389 18754104
MESH:D008113 Liver Neoplasms Drugs, Chinese Herbal 23.1118339527
MESH:D008113 Liver Neoplasms Fenofibrate 23.1118978307
MESH:D008113 Liver Neoplasms sodium arsenite 23.1115276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 23.1116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 23.1116984957
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 20.136150874 534488 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 20.1312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 20.1319539802 18253720 19009564 18079962 2563599 17942915 17854601 19126423 16267830 18775883 21159647 18164116 9362446 3124819 19004024 18544905 16842330 19519916 18093689 18308698 17174075 18282651
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 20.1317085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 20.1318775883 18253720
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 20.1312151625
MESH:D008171 Lung Diseases Mustard Gas 15.4618161513 18702808
MESH:D008171 Lung Diseases nitrofen 15.469614859 9859898 17245593 16863852
MESH:D008171 Lung Diseases sodium arsenite 15.4619095001
MESH:D008171 Lung Diseases Vitamin E 15.4616863852
MESH:D055370 Lung Injury Nitric Oxide 4.3411395602
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 19.1811376686
MESH:D008175 Lung Neoplasms Acetaldehyde 19.1817372256
MESH:D008175 Lung Neoplasms Curcumin 19.1819359593 16243823 18462866
MESH:D008175 Lung Neoplasms Diethylnitrosamine 19.1820970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 19.1817418594 6189445
MESH:D008175 Lung Neoplasms Drugs, Chinese Herbal 19.1818339527
MESH:D008175 Lung Neoplasms Mustard Gas 19.188781369 3148597
MESH:D008175 Lung Neoplasms sodium arsenite 19.1817306315 19931552 17077188 16712894 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 19.1818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 19.1819555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 19.1811062179
MESH:D008223 Lymphoma Curcumin 11.1318462866
MESH:D008223 Lymphoma Doxorubicin 11.1316098063
MESH:D008223 Lymphoma Nitric Oxide 11.1316166326
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.7014737004
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.4717654614
MESH:D016399 Lymphoma, T-Cell Curcumin 10.2816173963
MESH:D016399 Lymphoma, T-Cell Doxorubicin 10.2815621674
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3719428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 12.2215458769
MESH:D008325 Mammary Neoplasms, Experimental Drugs, Chinese Herbal 12.2214758024
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.2211807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 12.2219196722 14580682 19196723 11731420 16827153
MESH:D020149 Manganese Poisoning Estradiol 11.3119453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.3119453300
MESH:D008527 Medulloblastoma Tretinoin 2.6217453147
MESH:D008545 Melanoma Curcumin 11.4417885582 18462866
MESH:D008545 Melanoma Doxorubicin 11.4416827129
MESH:D008545 Melanoma Glucose 11.4414993021
MESH:D008545 Melanoma sodium arsenite 11.4416487513 19082730
MESH:D008545 Melanoma Tamoxifen 11.4419393235 12393984
MESH:D008545 Melanoma Tretinoin 11.4416752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.7915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1819513568
MESH:D008569 Memory Disorders Curcumin 8.7217263510
MESH:D008569 Memory Disorders sevoflurane 8.7219212262
MESH:D008591 Meningomyelocele Tretinoin 4.0416940565
MESH:D008654 Mesothelioma Doxorubicin 2.9017638057
MESH:D008881 Migraine Disorders Nitric Oxide 4.0011701602
MESH:D020326 Migraine without Aura Nitric Oxide 4.7411304026 14659530
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.1515792986
MESH:D052016 Mucositis Doxorubicin 11.1017415656
MESH:D052016 Mucositis irinotecan 11.1017159606
MESH:D009101 Multiple Myeloma Curcumin 3.2419372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.5217962980
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8517596541
MESH:D009203 Myocardial Infarction Doxorubicin 2.7815857846 19429709
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.9816810080
MESH:D009361 Neoplasm Invasiveness Curcumin 4.0018495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 12.239029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 12.2318259882
MESH:D009362 Neoplasm Metastasis irinotecan 12.2318259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 12.2319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3819410462
MESH:D009369 Neoplasms lycopene 7.2917051425
MESH:D009369 Neoplasms sodium arsenite 7.2911559025
MESH:D009369 Neoplasms Tretinoin 7.2916594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.2920056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 9.5112497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.5119189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3417289903
MESH:D009401 Nephrosis Doxorubicin 4.3816636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.6715640375 16889571
MESH:D009421 Nervous System Malformations Estradiol 14.1616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.1614600291
MESH:D009421 Nervous System Malformations Tretinoin 14.169125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.2318462866
MESH:D009436 Neural Tube Defects sodium arsenite 6.4512854658
MESH:D009436 Neural Tube Defects Tretinoin 6.459142499
MESH:D009447 Neuroblastoma Doxorubicin 6.4515555623
MESH:D009447 Neuroblastoma irinotecan 6.458761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.1218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.1220387270
MESH:D017599 Neuroectodermal Tumors irinotecan 4.348761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7120387270
MESH:D009503 Neutropenia Mustard Gas 3.6116761898 7688884
MESH:D009765 Obesity Curcumin 4.4119297423
MESH:D009765 Obesity Dietary Fats 4.4121332399 20132043 17217161 18674790 16723640 20518802 19632207 18457598 11836018
MESH:D010003 Osteoarthritis marker/mechanism 21217753
MESH:D010024 Osteoporosis Curcumin 3.2318719352
MESH:D015663 Osteoporosis, Postmenopausal Drugs, Chinese Herbal 4.6216548355
MESH:D012516 Osteosarcoma Doxorubicin 3.8015930896
MESH:D010051 Ovarian Neoplasms Curcumin 10.1718462866 19020741
MESH:D010051 Ovarian Neoplasms Estradiol 10.1719401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.1715276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 10.1716936753
MESH:D010146 Pain Acetaminophen 5.5516870215
MESH:D010146 Pain Tretinoin 5.5516870215
MESH:D010190 Pancreatic Neoplasms Curcumin 7.7717440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 7.7716540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 7.7715976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3211578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.7112065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8512520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.7517983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.7517638057
MESH:D011015 Pneumonia, Aspiration Nitric Oxide 4.9418573544
MESH:D011041 Poisoning Mustard Gas 3.4415727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1818163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.222563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8011222880 11118676 11896295 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5320887781
MESH:D011471 Prostatic Neoplasms Curcumin 2.3518769126 15129424 11398177 18226269 12497104 10851300 18156803
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.3518437689 15897917 16729912 16888761 15749863 16868541
MESH:D011471 Prostatic Neoplasms Estradiol 2.3516740699
MESH:D011471 Prostatic Neoplasms lycopene 2.3515084515 17337101
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.3516039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.3518760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.3515067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.3515084515
MESH:D011507 Proteinuria Tretinoin 8.3916636307
MESH:D011507 Proteinuria valsartan 8.3917664856 18344623 12164870
MESH:D011537 Pruritus Ethinyl Estradiol 8.2215861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.2218058305
MESH:D011625 Pterygium Tretinoin 4.4016723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.1919168576
MESH:D011658 Pulmonary Fibrosis Drugs, Chinese Herbal 8.6316987627
MESH:D011658 Pulmonary Fibrosis Mustard Gas 8.6317720292 10334151 17266442 17894541 17620002
MESH:D011658 Pulmonary Fibrosis valsartan 8.6317241526
MESH:D012003 Rectal Fistula Drugs, Chinese Herbal 5.5615043669
MESH:D051437 Renal Insufficiency Doxorubicin 3.8417922066
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.6718379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4618990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7416283617 16116481
MESH:D012220 Rhinitis Acetaldehyde 4.4117050345
MESH:D012221 Rhinitis, Allergic, Perennial Drugs, Chinese Herbal 4.8715015336
MESH:D012509 Sarcoma Curcumin 8.4418462866
MESH:D012509 Sarcoma Doxorubicin 8.4417203757 17710206 16767912 15675481 15625365 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.8714601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4017846226
MESH:D012555 Schistosomiasis mansoni Nitric Oxide 5.079673227
MESH:D012640 Seizures Picrotoxin 3.748635557 8954991
MESH:D018805 Sepsis Curcumin 3.7518389075
MESH:D012871 Skin Diseases halofuginone 10.4711874485
MESH:D012871 Skin Diseases monomethylarsonous acid 10.4717431481
MESH:D012871 Skin Diseases Mustard Gas 10.4712880345 16961503 15451306
MESH:D012871 Skin Diseases Vitamin E 10.4718709164
MESH:D012878 Skin Neoplasms Doxorubicin 19.9615692506
MESH:D012878 Skin Neoplasms Glucose 19.9614993021
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 19.9612065085
MESH:D012878 Skin Neoplasms sodium arsenite 19.9618572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 19.9616192470
MESH:D012878 Skin Neoplasms Tretinoin 19.9616467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.1816767912 17203757 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 10.2216709447
MESH:D013088 Spermatocele Tamoxifen 10.2216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.6419457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4912854658
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.4218456281
MESH:D013274 Stomach Neoplasms Drugs, Chinese Herbal 4.4218339527
MESH:D013274 Stomach Neoplasms irinotecan 4.4215723263
MESH:D013274 Stomach Neoplasms Tretinoin 4.4217261132
MESH:D013276 Stomach Ulcer Curcumin 6.6519188055 16631530
MESH:D013276 Stomach Ulcer Nitric Oxide 6.6515138204
MESH:D020521 Stroke Vitamin E 3.2116517955
MESH:D013345 Subarachnoid Hemorrhage Drugs, Chinese Herbal 5.3617634840
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.297505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 10.2916010429 17909728
MESH:D013964 Thyroid Neoplasms Tretinoin 10.2917045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.2819048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.4516051514
MESH:D014376 Tuberculosis Tretinoin 2.9816040207
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 17.741399818 15867355 15289314
MESH:D001749 Urinary Bladder Neoplasms Curcumin 17.7418593936
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 17.7417653716
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 17.7420375083
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 17.7416712894 16452187 17306315 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 17.7416712894 17572228 8653321
MESH:D014565 Urogenital Neoplasms Curcumin 4.8718462866
MESH:D014581 Urticaria Acetaminophen 2.6210982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.2811813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.2816129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9314692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.2116752155
MESH:D014652 Vascular Diseases sodium arsenite 4.0317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1915869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.8417334414 17638931 16364871 17678736
MESH:D020257 Ventricular Remodeling valsartan 5.3019027736
MESH:D014820 Vitiligo Tretinoin 3.6816761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8515886252
MESH:D015430 Weight Gain Dietary Fats 3.4116723640
MESH:D009396 Wilms Tumor Tretinoin 3.6416287080
MESH:D014947 Wounds and Injuries Drugs, Chinese Herbal 4.2216313111
Pathway ID Pathway Name
KEGG:04520 Adherens junction
KEGG:04110 Cell cycle
KEGG:05142 Chagas disease (American trypanosomiasis)
KEGG:05220 Chronic myeloid leukemia
KEGG:05210 Colorectal cancer
KEGG:04144 Endocytosis
KEGG:05212 Pancreatic cancer
KEGG:05200 Pathways in cancer
REACT:6844 Signaling by TGF beta
KEGG:04350 TGF-beta signaling pathway
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30526
    • No data
    Releated disease ID Related disease Name
    PA443756Colonic Neoplasms
    Releated drug ID Related drug Name
    PA449247dexamethasone
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved