AutismKB 2.0

Annotation Detail for SMAD4


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Basic Information Top
Gene Symbol:SMAD4 ( DPC4,JIP,MADH4 )
Gene Full Name: SMAD family member 4
Band: 18q21.2
Quick LinksEntrez ID:4089; OMIM: 600993; Uniprot ID:SMAD4_HUMAN; ENSEMBL ID: ENSG00000141646; HGNC ID: 6770
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-11BMP Signalling Pathway
Pathway IDPathway Name
hsa04310Wnt signaling pathway
hsa04350TGF-beta signaling pathway
hsa04110Cell cycle
hsa04520Adherens junction
hsa05220Chronic myeloid leukemia
hsa05212Pancreatic cancer
hsa05210Colorectal cancer
hsa05200Pathways in cancer
Pathway IDPathway Name
Signaling by TGF beta
Signaling by BMP
Pathway IDPathway Name
200171Validated targets of C-MYC transcriptional repression
200123BMP receptor signaling
200002Regulation of nuclear SMAD2/3 signaling
200138ALK2 signaling events
200152Regulation of cytoplasmic and nuclear SMAD2/3 signaling
200126ALK1 signaling events
200061LKB1 signaling events
200172HIF-1-alpha transcription factor network
200045Validated targets of C-MYC transcriptional activation
200195TGF-beta receptor signaling
Pathway IDPathway Name
P00052TGF-beta signaling pathway
P00057Wnt signaling pathway
Pathway IDPathway Name
500592Signaling by BMP
500590Signaling by TGF beta
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
Cancers of the digestive system
H00019Pancreatic cancer
H00020Colorectal cancer
Desease IDDesease Name
1724Vascular disease
1934Cancer
2162Capillaries disease
Desease Name
polyposis, gastric
juvenile polyposis syndrome
polyposis, juvenile
No data
Desease Name
Polyposis, juvenile intestinal
Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome
Pancreatic cancer
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SMAD4 mRNAaffects expression 21346803
D000079 Acetaldehyde SMAD4 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA]increases expression|increases reaction 16025520
D013196 Dihydrotestosterone Dihydrotestosterone results in decreased expression of SMAD4 mRNAdecreases expression 16597033
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SMAD4 mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in increased expression of SMAD4 proteinincreases expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SMAD4 mRNAdecreases expression 20018196
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of SMAD4 mRNAincreases expression 16570350
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of SMAD4 proteinincreases expression 17334410
D002251 Carbon Tetrachloride FR 167653 inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD4 protein]decreases reaction|increases expression 17334410
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of SMAD4 mRNAdecreases expression 16934159
D003474 Curcumin Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter]affects binding|decreases reaction 16959952
D016572 Cyclosporine Cyclosporine results in increased expression of SMAD4 mRNAincreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine affects the expression of SMAD4 proteinaffects expression 18971187
C547156 dimethylthioarsinic acid dimethylthioarsinic acid results in increased expression of SMAD4 mRNAincreases expression 19945496
D017292 Doxazosin Doxazosin results in increased expression of SMAD4 mRNAincreases expression 16007219
D017292 Doxazosin Doxazosin results in increased expression of SMAD4 proteinincreases expression 16007219
D017292 Doxazosin SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of SMAD4 mRNA]increases expression|increases reaction 16007219
D017292 Doxazosin SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of SMAD4 protein]increases expression|increases reaction 16007219
D004317 Doxorubicin Doxorubicin results in decreased expression of SMAD4 proteindecreases expression 18606404
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SMAD4 mRNAincreases expression 17606305
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMAD4 mRNAaffects cotreatment|increases expression 17942748
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of SMAD4 geneincreases mutagenesis 16724327
D011345 Fenofibrate Fenofibrate inhibits the reaction [SMAD4 protein results in increased expression of SERPINE1 mRNA]decreases reaction|increases expression 19593819
D011345 Fenofibrate NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD4 protein results in increased expression of SERPINE1 mRNA]]decreases reaction|increases expression|increases reaction 19593819
C104334 FR 167653 FR 167653 inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD4 protein]decreases reaction|increases expression 17334410
C056599 icariin icariin results in increased expression of SMAD4 mRNAincreases expression 19747809
C056599 icariin NOG protein inhibits the reaction [icariin results in increased expression of SMAD4 mRNA]decreases reaction|increases expression 19747809
C005219 methyl cellosolve methyl cellosolve results in increased expression of SMAD4 mRNAincreases expression 19643169
D008770 Methylnitrosourea SMAD4 gene mutant form results in increased susceptibility to Methylnitrosoureaincreases response to substance 12096346
D009569 Nitric Oxide Nitric Oxide results in increased activity of [SMAD4 protein binds to SMAD3 protein]affects binding|increases activity 15949472
D009569 Nitric Oxide [SMAD4 protein co-treated with SMAD3 protein] affects the susceptibility to Nitric Oxideaffects cotreatment|affects response to substance 15949472
C007350 nitrofen nitrofen results in decreased expression of SMAD4 mRNAdecreases expression 12149686
D011374 Progesterone Progesterone affects the expression of SMAD4 mRNAaffects expression 17251523
C110881 S-nitro-N-acetylpenicillamine S-nitro-N-acetylpenicillamine results in increased activity of [SMAD4 protein binds to SMAD3 protein]affects binding|increases activity 15949472
C017947 sodium arsenite sodium arsenite results in increased expression of SMAD4 mRNAincreases expression 12016162
12760830
D013311 Streptozocin Streptozocin results in increased expression of SMAD4 mRNAincreases expression 16973718
D013311 Streptozocin Trientine inhibits the reaction [Streptozocin results in increased expression of SMAD4 mRNA]decreases reaction|increases expression 16973718
C004648 testosterone enanthate testosterone enanthate affects the expression of SMAD4 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMAD4 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SMAD4 mRNAdecreases expression 11752688
D014266 Trientine Trientine inhibits the reaction [Streptozocin results in increased expression of SMAD4 mRNA]decreases reaction|increases expression 16973718
C034028 vanadyl sulfate vanadyl sulfate results in decreased expression of SMAD4 mRNAdecreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced methyl cellosolve 7.796499812 6474471 3652986
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.7911752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.2818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6617505938
MESH:D000230 Adenocarcinoma Doxorubicin 6.7817418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.7814692618
MESH:D000230 Adenocarcinoma Methylnitrosourea 6.7815113128 15688392
MESH:D000236 Adenoma Diethylnitrosamine 6.4910737359 6695378
MESH:D000236 Adenoma Ethylnitrosourea 6.496695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.1216434500 19061943 19052882 17620307 18056438 17162532
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.1216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6216712894 17306315
MESH:D000419 Albuminuria Doxorubicin 4.2821441931
MESH:D019973 Alcohol-Related Disorders Curcumin 4.8017887948
MESH:D000544 Alzheimer Disease Curcumin 6.6115590663
MESH:D000544 Alzheimer Disease icariin 6.6119782061 19858766
MESH:D000544 Alzheimer Disease Nitric Oxide 6.6117556102
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7111748828
MESH:D000748 Anemia, Macrocytic methyl cellosolve 6.063699323
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4915885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6716807698
MESH:D053627 Asthenozoospermia methyl cellosolve 5.243987992
MESH:D001249 Asthma Acetaldehyde 3.589600491
MESH:D050197 Atherosclerosis Curcumin 3.1618704882
MESH:D001284 Atrophy methyl cellosolve 4.923699323 2626667 6705890
MESH:D001327 Autoimmune Diseases Curcumin 4.2219761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.8012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5115340226
MESH:D001847 Bone Diseases icariin 6.1318295595
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5915746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.4214601052
MESH:D001927 Brain Diseases Ethylnitrosourea 4.6414991843
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0517868700
MESH:D001930 Brain Injuries Progesterone 3.9815380490 15665606 15845082
MESH:D002545 Brain Ischemia Curcumin 9.8316770732
MESH:D002545 Brain Ischemia icariin 9.8319303870
MESH:D001932 Brain Neoplasms Curcumin 13.3817596214
MESH:D001932 Brain Neoplasms Doxorubicin 13.3817150277
MESH:D001932 Brain Neoplasms Ethylnitrosourea 13.3818412241 16357521 16436596 16651633 15144691
MESH:D001943 Breast Neoplasms Curcumin 3.5819250217 18462866 18593918 16243823
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.5817474063
MESH:D001943 Breast Neoplasms Doxorubicin 3.5816935488 15136595 19526202 15993339 17983394 15692762 11325840 16096432 17369602 15567936 16115903 16322301 15634643 18382427 16595493 17426702 18234424 15994142 15668708 18628466 16826403 16264153 18695136 15939500
MESH:D001943 Breast Neoplasms Methylnitrosourea 3.5811306469 16253758 14633655
MESH:D001943 Breast Neoplasms Nitric Oxide 3.5815631943
MESH:D001943 Breast Neoplasms Progesterone 3.5815562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.5820435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5116050911 15700767 16192424 16227642 16097048 15721981 3786805 15673190 16124888 10355542 18705752 16011737
MESH:D002276 Carcinoid Tumor Doxorubicin 11.7516051944
MESH:D002276 Carcinoid Tumor Streptozocin 11.7516051944
MESH:D002277 Carcinoma Curcumin 7.5618593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.3616705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.3618788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.3618056438 21159647 18494052 16779866 17162532 17055752 18978308 18506893 16878318 11831363 19383236 18210153 19107877 20727157 19335982 19052882 20514400 16569478 20101231 3084413 16540662 19171122 16681979 17138121 19418558 20935162 20432363 20214788 20512989 16935385 18665156 20524982 16502159 10672840 20084675 17978847 16807293 19919837 3581430 19701751 16328049 17761372 16698587 18393292 10737359 19208518 19519916 16288022 18788625 17173139 18971187 20007298 16830150 17428255 18691550 19539802 19394651 19822196 18785209
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.3618059187 16023760 16234567 17876044
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.3616507464 17306315 15276417
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.8818414057
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.0316201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Curcumin 7.1518462866
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.156189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.1518572023
MESH:D006332 Cardiomegaly Doxazosin 6.9215969258
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.9218670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.3516952015 15505089 16278810 16731534 17007740 17308081 15792986 17519947 16364871 17351982 16455267 17382496 17924179 15476868 16612575 16109756 17329180 16269455 16242529 18627295 17928571 16651473 15811867 17131338 17974986
MESH:D002310 Cardiomyopathy, Alcoholic Acetaldehyde 6.2010525098
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8516243910 17334414
MESH:D002386 Cataract Methylnitrosourea 3.8312484553
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 23.8920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 23.8912371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 23.8921159647 17174075 7505956 2727394
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 23.8916003739
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 23.892727394 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 23.8920056578 19524636
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.7017160924
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.5519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.5516835633
MESH:D002764 Cholecystitis methyl cellosolve 5.526499794
MESH:D002779 Cholestasis Cyclosporine 12.3819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.3816919318 17110522 17681005 15861022 16105132 17333356 11677210
MESH:D002779 Cholestasis Nitric Oxide 12.3816919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.998697196 16354765 15340226 12621046 15668235
MESH:D003092 Colitis Curcumin 3.9016782535 16804969 18200517
MESH:D003103 Coloboma Curcumin 4.3018809619
MESH:D003110 Colonic Neoplasms Curcumin 2.4619359593 16340194
MESH:D015179 Colorectal Neoplasms marker/mechanism 16144935
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D000013 Congenital Abnormalities methyl cellosolve 8.656499821 12530607
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.6514669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.6218497527
MESH:D019465 Craniofacial Abnormalities nitrofen 2.8411405365
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8410048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.7418551238
MESH:D015140 Dementia, Vascular Nitric Oxide 5.6817556102
MESH:D017449 Dermatitis, Allergic Contact Trientine 4.918970840
MESH:D003920 Diabetes Mellitus Streptozocin 9.5616285004
MESH:D003920 Diabetes Mellitus Trientine 9.5616973718
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 8.3111055810 18603373 15298345 19496084 15831366 19586609 7637645 15862027 12644472 11260395 16684804 2177838 19960420 16286809 18715473 17874149 12093613 12446591 19298542 12083368 6379147 1374869 8740154 17442507
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 8.3116684804
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.5518603373
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 9.6918403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.6920387270
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 9.6919586609 19647726
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.6917107852
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.4416025228
MESH:D003928 Diabetic Nephropathies Curcumin 8.7318204486
MESH:D003928 Diabetic Nephropathies Streptozocin 8.7319960420 19682444
MESH:D003929 Diabetic Neuropathies Progesterone 4.2217187935
MESH:D003930 Diabetic Retinopathy Streptozocin 5.1617662242
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 14.1221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.127120509 19085960 11566570 16177239 6884620 4309450 21278145 16227642 3786805 3732212 15998439 2869522 10915739 17522070 10092053 7440962 7179309 15968718 15027814 19336974 6623471 9327722
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 14.1217851650
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 14.1219107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 14.1217416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.1220420201
MESH:D004362 Drug Toxicity Doxorubicin 7.4318602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.4311462148
MESH:D004381 Duodenal Ulcer Curcumin 3.7817351913
MESH:D050171 Dyslipidemias Fenofibrate 4.2316707586
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.7018357618
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.1412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.1512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.1517692515
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.3517359293
MESH:D016889 Endometrial Neoplasms Fenofibrate 7.3516569247
MESH:D004715 Endometriosis Progesterone 8.1316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.1310568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.8718037988
MESH:D007172 Erectile Dysfunction icariin 5.1615329286 16281085
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8316302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0020426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8111564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 22.0016239168 17595544 15959796 12795759 61145 16045604 12631006 19224547
MESH:D005234 Fatty Liver Curcumin 22.0019297423
MESH:D005234 Fatty Liver Cyclosporine 22.0019224547
MESH:D005234 Fatty Liver Diethylnitrosamine 22.0020387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.0015345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1811858732
MESH:D005327 Fetal Resorption methyl cellosolve 5.266474471 6499821 6499812 3987992
MESH:D020567 Fetal Weight methyl cellosolve 5.526474471 6499812 6499821
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.3119069698
MESH:D005354 Fibrosarcoma Methylnitrosourea 4.9511555667
MESH:D005355 Fibrosis Carbon Tetrachloride 18.9018705752
MESH:D005355 Fibrosis Curcumin 18.9018705752
MESH:D005355 Fibrosis Cyclosporine 18.9012168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.9020067830
MESH:D005532 Foot Deformities, Congenital methyl cellosolve 5.213652986
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.4218462866
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4016452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.948708960
MESH:D005909 Glioblastoma Curcumin 11.0317596214
MESH:D005909 Glioblastoma Doxorubicin 11.0317150277
MESH:D005909 Glioblastoma Ethylnitrosourea 11.0316436596
MESH:D005910 Glioma Ethylnitrosourea 6.2316357521 18412241 16651633
MESH:D005910 Glioma Methylnitrosourea 6.239825942
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3110696789
MESH:D006261 Headache Nitric Oxide 4.8911554966 11284996
MESH:D006258 Head and Neck Neoplasms Curcumin 7.4018462866 18829502
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.4015692506
MESH:D006330 Heart Defects, Congenital nitrofen 6.5316080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5310048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 7.4816879835 18006777 16244371 17875725 16144979 16495754 16330681 16244372 12587719 18674790 16707910 17888722 14766674
MESH:D006331 Heart Diseases Streptozocin 7.4812093613
MESH:D006333 Heart Failure Doxorubicin 3.1717481944
MESH:D006345 Heart Septal Defects, Ventricular methyl cellosolve 5.506499821
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6515692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1415720958
MESH:D006461 Hemolysis methyl cellosolve 5.1717874071
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0911000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3319900420 19110552
MESH:D006527 Hepatolenticular Degeneration Trientine 6.0417276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6215340226 16120746 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.7717701891
MESH:D006548 Hernia, Diaphragmatic nitrofen 3.847520565 12194112 10370016 12746050 12505043 10646786 18280292 10370017 10541330 9476886 11076806 9575882 17245593 18280291 15088113 15707848 12021965 7760232 11584395 17270546 17618886 8863223 9473106 11685700 7576705 16473863 9698600 10898222 16863852 16080930 15764645 12547725 16720372 11588001 12904592 9859898 12759764 16490937 11409163 15756563 16292651 10693666 15136996 10359170 10898224 15578192 11057544 15185205 18958481 15793718 11329586 11051153 12407540
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.4617440010
MESH:D006689 Hodgkin Disease Doxorubicin 6.7118501091 15147373 17606976
MESH:D006689 Hodgkin Disease sodium arsenite 6.7112676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7616959395 15340226 16354765 18606429 8697196
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2516899240
MESH:D006937 Hypercholesterolemia Curcumin 3.8018704882
MESH:D006940 Hyperemia Nitric Oxide 5.3311156591
MESH:D006973 Hypertension Cyclosporine 8.1810903974
MESH:D006973 Hypertension Doxazosin 8.1815969258
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.1818850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8115338365
MESH:D006976 Hypertension, Pulmonary Nitric Oxide 4.2215838368
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5416569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1315869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 14.6117937319
MESH:D007248 Infertility, Male methyl cellosolve 14.613987992
MESH:D007248 Infertility, Male Methylnitrosourea 14.617193160
MESH:D007248 Infertility, Male sodium arsenite 14.6112646999 15346721
MESH:D007249 Inflammation Curcumin 10.7718403477 17151092 16956363
MESH:D007249 Inflammation Diethylnitrosamine 10.7718785209
MESH:D007249 Inflammation Progesterone 10.7715869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.7712200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1018596194 18200517
MESH:D007410 Intestinal Diseases Nitric Oxide 4.6611713966 10210152 11574821
MESH:D007414 Intestinal Neoplasms Curcumin 3.9810783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0916580747
OMIM:175050 JUVENILE POLYPOSIS/HEREDITARY HEMORRHAGIC TELANGIECTASIA SYNDROME marker/mechanism
MESH:C537702 Juvenile polyposis syndrome marker/mechanism
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1615604871
MESH:D007674 Kidney Diseases Cyclosporine 13.208314463 18776723 10903974
MESH:D007674 Kidney Diseases Doxorubicin 13.2015369732 15699352 16775033
MESH:D007674 Kidney Diseases sodium arsenite 13.2020008137
MESH:D007674 Kidney Diseases Streptozocin 13.2012093613
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.9016707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.1916705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.1912371664
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 11.1917379185
MESH:D007859 Learning Disorders icariin 5.0519782061
MESH:D007889 Leiomyoma Curcumin 4.3118555241
MESH:D007896 Leishmaniasis Nitric Oxide 4.4217218153
MESH:D007938 Leukemia Curcumin 3.1018462866
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8716085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.9616106398
MESH:D015458 Leukemia, T-Cell Curcumin 4.5016106398
MESH:D017880 Limb Deformities, Congenital methyl cellosolve 8.246499821
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 8.2415526292
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.4817157831 17174718 21278145 11408273 11903743 16943688 16239168 16221502 17334410
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.4820032147 18522880 18665156 19638242 18407596
MESH:D008103 Liver Cirrhosis FR 167653 10.4817334410
MESH:D008106 Liver Cirrhosis, Experimental marker/mechanism 16570350
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.3610355542 14724832 12632512 18395095 15876570 16136751 12445421 18006644 17721639 16011737 12586293 14620537 17631135 18472332 17944888 18263696 18279442 18420326 18339082 15959796 18481824 15650968 18395914 16033810 18317297 11481614 17640975 12632514 18418968 17481882 17766677 16638106 18166357 18054572 18156304 12445418 13678700 17869086 16027843 15931870 18205269 14748882 17557913 12609069 12546737 17900296 15362042 17976157 12958196 18210741 18412020 17714472 18187930 18251166 12741479 16015684 12898905 17708605 15818738 14716496 18429990 17805973 15996030 15730626 17565644 15052691 16192424 17761835 15057751 12649538 18705752 18277467 17525996 14512876 12667390 15370692 16116963 12666154 15123356 17823541 14716833 12389079 18472094 20821823 15673190 15893842 16097048 17922224 16248980 17698563 15338365 18376398 15925388
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 6.3617355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.3616595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 6.3615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3612878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.1516246199 15830285 17285989 16964402 15720792
MESH:D008107 Liver Diseases Curcumin 6.1516956363
MESH:D008107 Liver Diseases Diethylnitrosamine 6.1517034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8915123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4514706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.0919294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.0918977376 20434301 19833225 19551842 18644402 21167192 21278145 19850985 19426721 19090486 20405173 10737359 18754104 21071580 19427195 2862719 12112319 15885732 19256749 19996281 19638242 20501860 15175105 20118626 19294768 19642983 19073162 20492335 19690152 18978307 18648771 21047994 9163691 20583210 12771043 19255062 19812893 2422723 19254457 20101389 19499222 20452335 16942905 20137499
MESH:D008113 Liver Neoplasms Fenofibrate 13.0918978307
MESH:D008113 Liver Neoplasms sodium arsenite 13.0916712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.0916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 16.8212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 16.823124819 18093689 17854601 19126423 21159647 18164116 16267830 18253720 19539802 18544905 16842330 18079962 17942915 18775883 17174075 18308698 19009564 19004024 19519916 18282651 2563599 9362446
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 16.8217085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 16.8218253720 18775883
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.8212151625
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.1916080182
MESH:D008171 Lung Diseases nitrofen 7.2816863852 9859898 17245593 9614859
MESH:D008171 Lung Diseases sodium arsenite 7.2819095001
MESH:D055370 Lung Injury Nitric Oxide 4.4511395602
MESH:D008175 Lung Neoplasms Acetaldehyde 12.3417372256
MESH:D008175 Lung Neoplasms Curcumin 12.3418462866 16243823 19359593
MESH:D008175 Lung Neoplasms Diethylnitrosamine 12.346695378 21163286 20512841 20970405
MESH:D008175 Lung Neoplasms Doxorubicin 12.3417418594 6189445
MESH:D008175 Lung Neoplasms Ethylnitrosourea 12.3416271038 16019985 17703301 6695378
MESH:D008175 Lung Neoplasms Methylnitrosourea 12.3418062963
MESH:D008175 Lung Neoplasms sodium arsenite 12.3417306315 16712894 17077188 19931552 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.3419555203 11884234
MESH:D008223 Lymphoma Curcumin 21.4018462866
MESH:D008223 Lymphoma Doxorubicin 21.4016098063
MESH:D008223 Lymphoma Ethylnitrosourea 21.4015790496
MESH:D008223 Lymphoma Methylnitrosourea 21.4011418001 16257854
MESH:D008223 Lymphoma Nitric Oxide 21.4016166326
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.5114633661
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.5717654614
MESH:D016399 Lymphoma, T-Cell Curcumin 17.8916173963
MESH:D016399 Lymphoma, T-Cell Doxorubicin 17.8915621674
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 17.8915375218
MESH:D008231 Lymphopenia methyl cellosolve 5.503699323
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 12.9115458769
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 12.9118041768 10838139 10767621
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 12.9114999141 16051031 15688392 14633655 16944150 15113128 17131329 12931682 17020996 16619500 10767621 16827153 11807958 10838139 11751437 15313902 19196723
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 12.9117203775 11408345
MESH:D008545 Melanoma Curcumin 4.9017885582 18462866
MESH:D008545 Melanoma Doxorubicin 4.9016827129
MESH:D008545 Melanoma sodium arsenite 4.9019082730 16487513
MESH:D008569 Memory Disorders Curcumin 9.2817263510
MESH:D008569 Memory Disorders icariin 9.2819782061
MESH:D008579 Meningioma Ethylnitrosourea 5.7017943659
MESH:D008654 Mesothelioma Doxorubicin 2.9517638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5016801185
MESH:D008881 Migraine Disorders Nitric Oxide 4.0911701602
MESH:D020326 Migraine without Aura Nitric Oxide 4.8511304026 14659530
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2515792986
MESH:D052016 Mucositis Doxorubicin 4.5117415656
MESH:D009101 Multiple Myeloma Curcumin 3.3219372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.6417962980
MESH:D009203 Myocardial Infarction Doxorubicin 2.8319429709 15857846
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8012213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.5818551238
MESH:D009361 Neoplasm Invasiveness Curcumin 4.1018495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.509029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.5018259882
MESH:D009369 Neoplasms Methylnitrosourea 4.9815533788
MESH:D009369 Neoplasms sodium arsenite 4.9811559025
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 13.8816707424
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 13.8812696579
MESH:D009374 Neoplasms, Experimental sodium arsenite 13.8820056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.2512497104
MESH:D009401 Nephrosis Doxorubicin 4.4916899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.5219348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.5215640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.9514600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.3518462866
MESH:D009436 Neural Tube Defects sodium arsenite 2.9612854658
MESH:D009442 Neurilemmoma Ethylnitrosourea 12.3517160924 16003739 16651423
MESH:D009442 Neurilemmoma Methylnitrosourea 12.3511555667
MESH:D009447 Neuroblastoma Doxorubicin 3.1215555623
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8320387270
MESH:D009765 Obesity Curcumin 2.6819297423
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.1916049721 12819281
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.7017160924
MESH:D009845 Oligospermia methyl cellosolve 4.903987992
MESH:D010024 Osteoporosis Curcumin 7.2918719352
MESH:D010024 Osteoporosis icariin 7.2918236786 19747809
MESH:D012516 Osteosarcoma Doxorubicin 3.8915930896
MESH:D010051 Ovarian Neoplasms Curcumin 7.4418462866 19020741
MESH:D010051 Ovarian Neoplasms Progesterone 7.4416525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.4415276417 17306315
MESH:D010190 Pancreatic Neoplasms Curcumin 8.1919196508 19401701 17440100
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.1916540662
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 8.1916965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4311578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9612520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8717983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.8717638057
MESH:D011015 Pneumonia, Aspiration Nitric Oxide 5.0518573544
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2918163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.1712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.172563599
MESH:D011297 Prenatal Exposure Delayed Effects methyl cellosolve 8.946499817 7974496 12530607
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.9411896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Curcumin 2.2112497104 18226269 18769126 15129424 18156803 11398177 10851300
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.2115897917 16868541 16888761 15749863 16729912 18437689
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.2112376480 15682402
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.2116039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.0316919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1316882103
MESH:D011656 Pulmonary Emphysema Curcumin 4.2819168576
MESH:D051437 Renal Insufficiency Doxorubicin 3.9517922066
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.7718379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5718990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.2118155124 18172121
MESH:D012175 Retinoblastoma Methylnitrosourea 5.2111555667
MESH:D012220 Rhinitis Acetaldehyde 4.5117050345
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7618045962
MESH:D012509 Sarcoma Curcumin 8.7718462866
MESH:D012509 Sarcoma Doxorubicin 8.7718313854 16767912 15675481 17203757 17710206 15625365
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.9814601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.5117846226
MESH:D012555 Schistosomiasis mansoni Nitric Oxide 5.189673227
MESH:D012640 Seizures 2,4-dinitrotoluene 2.3518551238
MESH:D018805 Sepsis Curcumin 3.8518389075
MESH:D012878 Skin Neoplasms Doxorubicin 8.7015692506
MESH:D012878 Skin Neoplasms sodium arsenite 8.7018572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.7016192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.2916767912 17203757 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6616709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.0015862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5812854658
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6818456281
MESH:D013274 Stomach Neoplasms Methylnitrosourea 2.6818593901 15930296 16257854
MESH:D013276 Stomach Ulcer Curcumin 6.9819188055 16631530
MESH:D013276 Stomach Ulcer Nitric Oxide 6.9815138204
MESH:D013733 Testicular Diseases methyl cellosolve 4.816499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9215669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 11.3715790496
MESH:D013953 Thymus Neoplasms Methylnitrosourea 11.3711418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.927505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 10.9216010429 17909728
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 10.927505956 3078959
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.0416049721
MESH:D001749 Urinary Bladder Neoplasms Curcumin 11.0418593936
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 11.0417653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.0416712894 17306315 11723127 16452187
MESH:D014565 Urogenital Neoplasms Curcumin 4.9818462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.0410091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.5311813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0314692618
MESH:D014605 Uveitis Cyclosporine 3.701336536
MESH:D014652 Vascular Diseases sodium arsenite 4.1417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2914671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.9516364871 17334414 17678736 17638931
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9615886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1617120751
Pathway ID Pathway Name
KEGG:04520 Adherens junction
KEGG:04110 Cell cycle
KEGG:05220 Chronic myeloid leukemia
KEGG:05210 Colorectal cancer
KEGG:05212 Pancreatic cancer
KEGG:05200 Pathways in cancer
REACT:12034 Signaling by BMP
REACT:6844 Signaling by TGF beta
KEGG:04350 TGF-beta signaling pathway
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30527
    • No data
    Releated disease ID Related disease Name
    PA445218Pancreatic Neoplasms
    PA444405Hemochromatosis
    PA443756Colonic Neoplasms
    Releated drug ID Related drug Name
    PA449247dexamethasone
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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