AutismKB 2.0

Annotation Detail for MAG


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Basic Information Top
Gene Symbol:MAG ( GMA,S-MAG,SIGLEC-4A,SIGLEC4A )
Gene Full Name: myelin associated glycoprotein
Band: 19q13.1
Quick LinksEntrez ID:4099; OMIM: 159460; Uniprot ID:MAG_HUMAN; ENSEMBL ID: ENSG00000105695; HGNC ID: 6783
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04514Cell adhesion molecules (CAMs)
Pathway IDPathway Name
Signalling by NGF
Hemostasis
Pathway IDPathway Name
200103p75(NTR)-mediated signaling
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1837Polyneuropathy
1878Ischemia
1963Amyloidosis
2069Schizophrenia
2106Pancreas cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MAG mRNAaffects expression 16483693
D004041 Dietary Fats Dietary Fats results in increased expression of MAG mRNAincreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of MAG mRNAdecreases expression 20387270
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAG mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in increased expression of MAG mRNAincreases expression 18035473
D006220 Haloperidol Haloperidol results in decreased expression of MAG mRNAdecreases expression 17177202
C041786 palm oil palm oil results in increased expression of MAG mRNAincreases expression 18042831
D010634 Phenobarbital Phenobarbital affects the expression of MAG mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid affects the expression of MAG mRNAaffects expression 19136022
D011280 Pregnanolone Pregnanolone results in increased expression of MAG mRNAincreases expression 16787508
D013629 Tamoxifen Tamoxifen results in decreased expression of MAG mRNAdecreases expression 19457130
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAG mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7214745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.816195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.8115322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D000236 Adenoma Diethylnitrosamine 2.9110737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 26.2416434500 19052882 18056438 19061943 17162532 17620307
MESH:D018248 Adenoma, Liver Cell Phenobarbital 26.2417620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 26.2416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 26.2416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D001161 Arteriosclerosis Dietary Fats 10.3815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.3811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001321 Autistic Disorder Haloperidol 2.7318080171 19368416
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001930 Brain Injuries Pregnanolone 6.3515380490 15665606
MESH:D001943 Breast Neoplasms Dietary Fats 1.9420435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9417474063
MESH:D001943 Breast Neoplasms Tamoxifen 1.9421138602 19142967 18997820 19221464 21152245 19115204 19289846 15565566 20005174 18855134 20859285 18351453 18984771 20135344 20390343 18815881 20065188 17893378 19288272 19011961 18821012 16818667 17261762 19155303 19410462 19189210 19244106 16202921 19200415 19189212 16873071 20544844 16273361 19066611 17049068 11161223 17242785 18629630 19103187 19084267 19487384 15668708 19059307 18425577 17440819
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6419066611
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.6916807293 18788625 19822196 10672840 17428255 18210153 20007298 17055752 16830150 19919837 20935162 18056438 16779866 19701751 20101231 19208518 20512989 20214788 11831363 16502159 16288022 19539802 19107877 16328049 20524982 20727157 19383236 16878318 16698587 16569478 18978308 18506893 17162532 16681979 17173139 20514400 21159647 17761372 19519916 19171122 19335982 19052882 19394651 18393292 3581430 16935385 18494052 18971187 20084675 17138121 18785209 17978847 16540662 20432363 18665156 18691550 10737359 3084413 19418558
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.691701930 6705139 20935162 17173139 20007298
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6916924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218850075 18670907 16120746
MESH:D002375 Catalepsy Haloperidol 5.0615215559 1977408
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.9317174075 21159647 2727394 7505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.394080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.6519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.6516835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0111677210 16105132 17110522 16919318 17333356 17681005 15861022
MESH:D002779 Cholestasis pirinixic acid 8.0119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1412621046 15340226 16354765 15668235 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.9620210726
MESH:D003704 Dementia Haloperidol 4.6911575062
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5019031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3017107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5719279558
MESH:D003929 Diabetic Neuropathies Pregnanolone 6.5817187935
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.8219107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D004421 Dystonia Phenobarbital 4.121851702
MESH:D004487 Edema pirinixic acid 6.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0815322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.3712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.3719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1116202921 19155303 17893378 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.253659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.043922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.646401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.397750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.173659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2916302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Dietary Fats 25.8919004024 18296743 19551842 17967931
MESH:D005234 Fatty Liver Diethylnitrosamine 25.8921071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.8915345470
MESH:D005234 Fatty Liver pirinixic acid 25.8920131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 25.8919224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3419069698
MESH:D005355 Fibrosis Dietary Fats 9.0918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0920067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3811294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly Phenobarbital 15.2216109766
MESH:D006529 Hepatomegaly pirinixic acid 15.2219772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.2215340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.228697196 16959395 15340226 18606429 16354765
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Dietary Fats 16.4620412841
MESH:D007249 Inflammation Diethylnitrosamine 16.4618785209
MESH:D007249 Inflammation Flavonoids 16.4617296493
MESH:D007249 Inflammation Tamoxifen 16.4619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 16.4612200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.4811836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.4816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007680 Kidney Neoplasms Tamoxifen 3.1318625569
MESH:D008064 Lipidoses Tamoxifen 3.2315342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 11.3618296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.3618665156 18407596 20032147 19638242 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 11.3621047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4515474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4512878042
MESH:D008107 Liver Diseases Diethylnitrosamine 4.1917034775
MESH:D008107 Liver Diseases Phenobarbital 4.1919363144
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.6520501860 19427195 18978307 20137499 19690152 19850985 18977376 19833225 19090486 19073162 20118626 9163691 2422723 16942905 18644402 19255062 19294768 15885732 18648771 19256749 20101389 12771043 19638242 19996281 20452335 20583210 19499222 21167192 19812893 20492335 19254457 10737359 18754104 20405173 12112319 20434301 19426721 21047994 21278145 19642983 15175105 21071580 19551842 2862719
MESH:D008113 Liver Neoplasms Phenobarbital 14.6519812893 8742319 15975961 19073162 19482888 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 14.6520007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 14.6516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.6516984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.2019519916 19004024 21159647 16267830 19126423 18544905 18282651 17174075 18164116 19539802 16842330 18079962 18253720 19009564 17942915 18775883 18308698 9362446 18093689 2563599 3124819 17854601
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.2018308698 1399818 6150874 17172636 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.2012151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4320970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms Tamoxifen 3.4318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4319555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6911731420 19196723 14580682 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.7219453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3415990972
MESH:D001523 Mental Disorders Haloperidol 4.1616856516
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6317484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.869029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.8619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1719189210 19200415 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2920387270
MESH:D009765 Obesity Dietary Fats 4.5218674790 18457598 11836018 21332399 19632207 16723640 20132043 17217161 20518802
MESH:D009765 Obesity pirinixic acid 4.5220558911
MESH:D010018 Osteomalacia Phenobarbital 4.5217016548
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3816540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.3816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.422563599
MESH:D011230 Precancerous Conditions Phenobarbital 9.422563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411896295 11222880 11399792 11118676
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1315067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.6712752131
MESH:D011595 Psychomotor Agitation Haloperidol 5.0911575062
MESH:D011618 Psychotic Disorders Haloperidol 4.3311575062
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012559 Schizophrenia Haloperidol 2.8120107430 19369910 18513383 1830565
MESH:D012640 Seizures Phenobarbital 2.7616876388 3137016 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.986407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.1516709447
MESH:D013088 Spermatocele Tamoxifen 12.1516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1919457130
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.8320210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.467505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.461399818
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.3916712894 8653321 17572228
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
Pathway ID Pathway Name
KEGG:04514 Cell adhesion molecules (CAMs)
REACT:604 Hemostasis
REACT:11061 Signalling by NGF
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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