AutismKB 2.0

Annotation Detail for ACCN2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ACCN2 ( ASIC,ASIC1,ASIC1A,BNaC2,hBNaC2 )
Gene Full Name: amiloride-sensitive cation channel 2, neuronal
Band: 12q12
Quick LinksEntrez ID:41; OMIM: 602866; Uniprot ID:ACCN2_HUMAN; ENSEMBL ID: ENSG00000110881; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1718Anxiety disorder
1878Ischemia
1954Stroke
2101Adenoid cystic cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ACCN2 mRNAdecreases expression 18648102
D000143 Acids [Acids binds to and affects the activity of ACCN2 protein] which results in increased secretion of Adenosine Triphosphateaffects activity|affects binding|increases secretion 19860742
D000255 Adenosine Triphosphate [Acids binds to and affects the activity of ACCN2 protein] which results in increased secretion of Adenosine Triphosphateaffects activity|affects binding|increases secretion 19860742
D000584 Amiloride Amiloride binds to and results in decreased activity of ACCN2 proteinaffects binding|decreases activity 19860742
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ACCN2 mRNAaffects expression 16483693
C040929 bafilomycin A1 bafilomycin A1 inhibits the reaction [Freund's Adjuvant results in increased expression of ACCN2 mRNA]decreases reaction|increases expression 16769263
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ACCN2 mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ACCN2 mRNAincreases expression 20713471
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ACCN2 mRNAdecreases expression 17557909
D005419 Flavonoids Flavonoids results in increased expression of ACCN2 mRNAincreases expression 18035473
D005620 Freund's Adjuvant bafilomycin A1 inhibits the reaction [Freund's Adjuvant results in increased expression of ACCN2 mRNA]decreases reaction|increases expression 16769263
D005620 Freund's Adjuvant Freund's Adjuvant results in increased expression of ACCN2 mRNAincreases expression 16769263
D005620 Freund's Adjuvant zoledronic acid inhibits the reaction [Freund's Adjuvant results in increased expression of ACCN2 mRNA]decreases reaction|increases expression 16769263
D005682 Gadolinium Gadolinium binds to and results in decreased activity of ACCN2 proteinaffects binding|decreases activity 19860742
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of ACCN2 mRNAincreases expression 20713471
D010269 Paraquat Paraquat affects the expression of ACCN2 mRNAaffects expression 15206577
D010269 Paraquat Paraquat results in increased expression of ACCN2 mRNAincreases expression 17077588
D010862 Pilocarpine Pilocarpine results in decreased expression of ACCN2 mRNAdecreases expression 11162239
C025643 vinclozolin vinclozolin affects the expression of ACCN2 mRNAaffects expression 19015723
C088658 zoledronic acid zoledronic acid inhibits the reaction [Freund's Adjuvant results in increased expression of ACCN2 mRNA]decreases reaction|increases expression 16769263
C088658 zoledronic acid zoledronic acid results in decreased expression of ACCN2 mRNAdecreases expression 17323179
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D058186 Acute Kidney Injury zoledronic acid 4.4719715164
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.5020200999
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.1820127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1814692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 11.233712494
MESH:D000236 Adenoma Benzo(a)pyrene 11.236695378
MESH:D000236 Adenoma Methylcholanthrene 11.2310545420 6695378
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.7811874814
MESH:D001008 Anxiety Disorders vinclozolin 3.6419015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4511922910
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.0511289319 1440618
MESH:D001859 Bone Neoplasms zoledronic acid 4.9617312309 11697798 16778634 16121404 19442620 15867366
MESH:D001862 Bone Resorption Freund's Adjuvant 10.2816769263
MESH:D001862 Bone Resorption zoledronic acid 10.2818496637 16769263 18404659 15845617 8053405 11869084
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1020146248 17474063
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.1017474063
MESH:D001943 Breast Neoplasms zoledronic acid 2.1016096432 18695136
MESH:D002277 Carcinoma Methylcholanthrene 3.9710545420
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.753581430 7296757
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 3.5419233551
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.817296757
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 6.8118507039
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0520419170
MESH:D002295 Carcinoma, Transitional Cell Amiloride 5.0814644129
MESH:D002386 Cataract Adenosine Triphosphate 4.6115003327
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.937505956
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 6.9316192471
MESH:D002637 Chest Pain Acids 6.4315447763
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.8719486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 7.8717110522 15861022 17333356 16919318 17681005 11677210 16105132
MESH:D003092 Colitis Amiloride 5.1212065299
MESH:D003456 Cryptorchidism vinclozolin 4.3514966744
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8211906362 12868966 11298694 14531868 18759878 2524372 8970840 8156756
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.503621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 1.9618692083 7440962 9022650 9328219 6482804 1440618 11289319 16192314 8291058 18289764 6679447 9653073 18648102
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2012538720
MESH:D004827 Epilepsy Pilocarpine 4.6519700373 11162239 19439326
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.363581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3616530937
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.8215345470
MESH:D005264 Femoral Fractures zoledronic acid 5.8516234978
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.056705139
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.9610962813 14633661
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3316417039
MESH:D005911 Gliosis Paraquat 5.1911124998
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.047505956
MESH:D006130 Growth Disorders Amiloride 4.7519703807
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6620471113
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.526705139
MESH:D006930 Hyperalgesia bafilomycin A1 13.7916769263
MESH:D006930 Hyperalgesia Freund's Adjuvant 13.7916769263
MESH:D006930 Hyperalgesia zoledronic acid 13.7916769263
MESH:D006934 Hypercalcemia zoledronic acid 5.0519622757 18089816
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9515034207
MESH:D006973 Hypertension Amiloride 3.8719344079 18524855 15174897
MESH:D006996 Hypocalcemia zoledronic acid 6.2212669777
MESH:D020514 Hypokalemic Periodic Paralysis Amiloride 5.8719822448
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.2617937319
MESH:D007248 Infertility, Male Paraquat 11.264850670
MESH:D007248 Infertility, Male vinclozolin 11.2616467254
MESH:D007249 Inflammation Amiloride 8.7917237260
MESH:D007249 Inflammation Flavonoids 8.7917296493
MESH:D007249 Inflammation Freund's Adjuvant 8.7916793879
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.059022650 8074119
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.976582329
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 4.7718089816
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7516417039
MESH:D056929 Liddle Syndrome Amiloride 5.9819344079
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2015034207 9327722
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.0421137059 20195826
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.16598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 6.16598648 1399818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.6120064080 18569708 6695378 18816296 20135361 18520028 20869020 17053015 20464547
MESH:D008175 Lung Neoplasms Methylcholanthrene 2.6120512841 16337739 21163286 20970405 17909032 16271038 6695378 10545420 1399818 15390079 11893704 7750092 9230183
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 3.7217312309
MESH:D008654 Mesothelioma zoledronic acid 3.7516675582
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1916381670
MESH:D009101 Multiple Myeloma zoledronic acid 4.0819621390 16996129 18089719
MESH:D009361 Neoplasm Invasiveness Amiloride 5.3114644129
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.103581430
MESH:D009362 Neoplasm Metastasis zoledronic acid 6.1017312309 15867366 19139120
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1711141357
MESH:D009410 Nerve Degeneration Paraquat 3.7216893418
MESH:D009421 Nervous System Malformations Pilocarpine 5.5815987249
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.916679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.424026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.053988306
MESH:D010014 Osteolysis zoledronic acid 5.3915867366
MESH:D010024 Osteoporosis zoledronic acid 4.0317882678
MESH:D010146 Pain zoledronic acid 3.9416475674
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.507296757
MESH:D010300 Parkinson Disease Paraquat 2.8116140633 11181820 15824117 11124998 16510128 12911755 15451049 11445065
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.4416190885
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.506228378
MESH:D011014 Pneumonia Paraquat 4.4712504350
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.9218042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.9518220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.5417292933
MESH:D011471 Prostatic Neoplasms zoledronic acid 3.5419103299 12438248
MESH:D011472 Prostatitis vinclozolin 4.9518629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D011658 Pulmonary Fibrosis Paraquat 2.9117997886 16324872
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.9111700416
MESH:D012135 Respiratory Sounds Paraquat 4.0711874814
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.923692021
MESH:D012162 Retinal Degeneration Paraquat 8.9216458197
MESH:D012512 Sarcoma, Ewing's zoledronic acid 4.9416121404
MESH:D012640 Seizures Pilocarpine 4.467750514 19660546
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3710029692 19755658
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D013226 Status Epilepticus Pilocarpine 6.2919951488 19570321 11259499 15857427 19055492 15987249 19430551
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.891399818 3712494 7505956 6587162 6582329
MESH:D014202 Tremor Pilocarpine 5.8317594079
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 4.978074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.9717053015
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5415869587 14671159
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00594 blocker Riva-Amilzide 5/50 mg Sodium channel blockers;Diuretics
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved