AutismKB 2.0

Annotation Detail for ARSA


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Basic Information Top
Gene Symbol:ARSA ( MLD )
Gene Full Name: arylsulfatase A
Band: 22q13.33
Quick LinksEntrez ID:410; OMIM: 607574; Uniprot ID:ARSA_HUMAN; ENSEMBL ID: ENSG00000100299; HGNC ID: 713
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00600Sphingolipid metabolism
hsa04142Lysosome
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Lysosomal storage diseases
H00127Metachromatic leukodystrophy
Genetic disorders
Desease IDDesease Name
1740Alzheimer's disease
1983Down syndrome
2088Leukodystrophy NOS
Desease Name
CHEMDEPENDENCY
alcoholism
metachromatic leukodystrophy
No data
Desease Name
Metachromatic leukodystrophy
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ARSA mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of ARSA mRNAdecreases expression 12958071
D000082 Acetaminophen Acetaminophen affects the expression of ARSA mRNAaffects expression 17562736
C099555 CD 437 CD 437 results in decreased expression of ARSA mRNAdecreases expression 12958071
D004041 Dietary Fats Dietary Fats results in decreased expression of ARSA mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ARSA mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ARSA mRNAdecreases expression 17942748
D001556 Lindane Lindane results in decreased activity of ARSA proteindecreases activity 16818664
C041786 palm oil palm oil results in decreased expression of ARSA mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in increased expression of ARSA mRNAincreases expression 18301758
D013629 Tamoxifen Tamoxifen affects the expression of ARSA mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ARSA mRNAdecreases expression 17942748
D013752 Tetracycline Tetracycline results in decreased expression of ARSA mRNAdecreases expression 16917069
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0015322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D000382 Agricultural Workers' Diseases Lindane 4.5212661182
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001161 Arteriosclerosis Dietary Fats 10.3815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.3811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9920435547
MESH:D001943 Breast Neoplasms Lindane 1.9914688026
MESH:D001943 Breast Neoplasms Tamoxifen 1.9920005174 20135344 20390343 18629630 19059307 19155303 21152245 11161223 17261762 18821012 19200415 20065188 19103187 16818667 19244106 17242785 19288272 19289846 16273361 18425577 20859285 18997820 18984771 18855134 17049068 19066611 19115204 17440819 15668708 19189210 19221464 19084267 18351453 16873071 15565566 17893378 19410462 16202921 19189212 19142967 19487384 19011961 18815881 21138602 20544844
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6419066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.603084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6016924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4216120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.846135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0116105132 17110522 16919318 15861022 17681005 17333356 11677210
MESH:D002779 Cholestasis pirinixic acid 8.0119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1415340226 15668235 16354765 12621046 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1618551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5019031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5719279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.2421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2412392966 17906064 12540782 12705907 16393943 19416960 2444490 14725611 11529661 19739265 12594235 11287661 19923254 16109766 19370779 16081117 10663392 11739529 17562736 18071297 11743745 11461765 16485898 16781746 14550746 10915739 19164858 18713872 12153990 11421492 16177239 19085960 12958197 15619225 10774834 15968718 17522070 19420014 16227642 11834606 14986274
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2420420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 9.2417522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D004487 Edema pirinixic acid 6.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.3712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.3719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1117893378 19155303 16202921 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Dietary Fats 25.9118296743 19551842 17967931 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.9115345470
MESH:D005234 Fatty Liver pirinixic acid 25.9119236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 25.9114986274 19224547
MESH:D005234 Fatty Liver Tetracycline 25.9119224547 16917069
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3419069698
MESH:D005355 Fibrosis Dietary Fats 9.0918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0920067830
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3810048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly pirinixic acid 8.7316221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7315340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2215340226 16354765 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Dietary Fats 8.5920412841
MESH:D007249 Inflammation Tamoxifen 8.5919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5912200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.4811836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.4816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2612587719 15629191
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.7016705839
MESH:D007680 Kidney Neoplasms Tamoxifen 7.7018625569
MESH:D007966 Leukodystrophy, Metachromatic marker/mechanism
MESH:D008064 Lipidoses Tamoxifen 3.2317567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9318296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4515474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4512878042
MESH:D008107 Liver Diseases Acetaminophen 4.3619014921 12969438 19460945 16611625 16610002 11587558 12587719 19784758
MESH:D008107 Liver Diseases Lindane 4.361715830
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3417185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.997678174
MESH:D008113 Liver Neoplasms pirinixic acid 10.9916377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 10.9916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.952876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9512151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.2818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2819555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6914580682 19196723 11731420 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.7219453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0118551238 7678174
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms Lindane 5.4312807735 16818664
MESH:D009369 Neoplasms pirinixic acid 5.4317405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1719189210 19196722 19200415
MESH:D009395 Nephritis, Interstitial Tetracycline 4.969884423
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009765 Obesity Dietary Fats 4.5218674790 21332399 19632207 18457598 17217161 16723640 20518802 11836018 20132043
MESH:D009765 Obesity pirinixic acid 4.5220558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5316049721
MESH:D010051 Ovarian Neoplasms CD 437 3.3417474084
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.6111026799
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411399792 11896295 11222880 11118676
MESH:D017096 Prion Diseases Tetracycline 5.5710903871
MESH:D011471 Prostatic Neoplasms Lindane 3.5512661182 14688026
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.5515067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012640 Seizures 2,6-dinitrotoluene 6.5118551238
MESH:D012640 Seizures Lindane 6.5115475178 7539098 12842176
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.1516709447
MESH:D013088 Spermatocele Tamoxifen 12.1516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1919457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.6716049721
MESH:D001749 Urinary Bladder Neoplasms CD 437 8.6716720286
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.678653321 16712894 17572228
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4710091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6515869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
Pathway ID Pathway Name
KEGG:04142 Lysosome
KEGG:00600 Sphingolipid metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01800 - N,4-Dihydroxy-N-Oxo-3-(Sulfooxy)Benzenaminium
DB03821 - 2-Amino-3-Hydroxy-3-Phosphonooxy-Propionic Acid
Drugbank ID Action Drug Name Description
DB01141 substrate Micafungin Antifungals;Antifungal Agents
DB03821 - 2-Amino-3-Hydroxy-3-Phosphonooxy-Propionic Acid
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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